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Protein Page:
GGA3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GGA3 Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. Monomer. Interacts with SORT1, SORL1, LRP3, GGA binding partner (GGABP) and P200. Interacts with GGA1 and GGA2. Binds to clathrin and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the membrane proteins M6PR/CD-MPR, IGF2R/CI-MPR and BACE1 and the accessory proteins SYNRG, EPN4, NECAP1, NECAP2 and AFTPH/aftiphilin. Interacts with TSG101 and UBC. Ubiquitously expressed. Belongs to the GGA protein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Vesicle protein
Cellular Component: clathrin adaptor complex; endosome membrane; trans-Golgi network
Molecular Function: ADP-ribosylation factor binding; protein binding
Biological Process: vesicle-mediated transport; intracellular protein transport; positive regulation of protein catabolic process
Reference #:  Q9NZ52 (UniProtKB)
Alt. Names/Synonyms: ADP-ribosylation factor-binding protein GGA3; GGA3; golgi associated, gamma adaptin ear containing, ARF binding protein 3; golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Golgi-localized, gamma ear-containing, ARF-binding protein 3; KIAA0154
Gene Symbols: GGA3
Molecular weight: 78,315 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GGA3

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S368‑p
protein conformation: S368‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K15-ub SLESWLNkATNPSNR
0 10 K38-ub GFCDQINkELEGPQI
0 10 K100-ub LIKVVSPkYLGDRVS
1 8 S159-p VDRTLIPsPPPRPkN
0 1 K165-ub PsPPPRPkNPVFDDE
0 13 K174-ub PVFDDEEkSkLLAkL
0 16 K176-ub FDDEEkSkLLAkLLK
0 10 K180-ub EkSkLLAkLLKSkNP
0 14 K185-ub LAkLLKSkNPDDLQE
0 3 K195-ub DDLQEANkLIkSMVk
0 1 K198-ub QEANkLIkSMVkEDE
0 8 K202-ub kLIkSMVkEDEARIQ
0 1 K210-ub EDEARIQkVTkRLHt
0 1 K213-ub ARIQkVTkRLHtLEE
0 10 T217-p kVTkRLHtLEEVNNN
0 7 K258-ub LFDQCENkRRTLFkL
0 12 K264-ub NkRRTLFkLAsETED
1 1 S267-p RTLFkLAsETEDNDN
0 1 S275-p ETEDNDNsLGDILQA
1 0 S368-p QASGPPRsRSSsQAE
0 1 S370 SGPPRsRSSsQAEAT
1 0 S372-p PPRsRSSsQAEATLG
0 10 S425-p HLLQREQsDLDFFSP
1 1 S538-p GLVKPTTsPLIPTTT
0 1 R548-m2 IPTTTPArPLLPFST
1 1 S559-p PFSTGPGsPLFQPLS
0 1 S572 LSFQSQGSPPKGPEL
  mouse

 
K15-ub SLESWLNkATNPSNR
K38-ub GFCDQINkELEGPQI
K100-ub LIKVVSPkYLGDRVS
S159-p MDRTLIPsPPPRPKN
K165 PsPPPRPKNPVFDDE
K174-ub PVFDDEEkSkLLARL
K176-ub FDDEEkSkLLARLLK
R180 EkSkLLARLLKSkNP
K185-ub LARLLKSkNPDDLQE
R195 DDLQEANRLIKSMVK
K198 QEANRLIKSMVKEDE
K202 RLIKSMVKEDEARIQ
K210 EDEARIQKVTKRLHT
K213 ARIQKVTKRLHTLEE
T217 KVTKRLHTLEEVNNN
K258-ub LFDRCENkRRTLFkL
K264-ub NkRRTLFkLASETED
S267 RTLFkLASETEDNDN
S275 ETEDNDNSLGDILQA
S364 QTSGPPRSRsSSQAE
S366-p SGPPRSRsSSQAEAP
S368 PPRSRsSSQAEAPPG
S421 LFQNEPPSDLDFFSP
S538 FSPGPTASPLLPASA
R548 LPASAPARPLLPFST
S559 PFSTGPGSPLFQSQG
S567-p PLFQSQGsPQKGPEL
  rat

 
K15 SLESWLNKATNPSNR
K38 GFCDQINKELEGPQI
K100 LIKVVSPKYLGDRVS
S159 MDRTLIPSPPPRPKN
K165 PSPPPRPKNPVFDDE
K174 PVFDDEEKSkLLAKL
K176-ub FDDEEKSkLLAKLLR
K180 EKSkLLAKLLRSKNP
K185 LAKLLRSKNPDDLQE
Q195 DDLQEANQLIKSMVK
K198 QEANQLIKSMVKEDE
K202 QLIKSMVKEDEARIQ
K210 EDEARIQKVTKRLHT
K213 ARIQKVTKRLHTLEE
T217 KVTKRLHTLEEVNNN
K258 LFDRCENKRRTLFkL
K264-ub NKRRTLFkLASETED
S267 RTLFkLASETEDNDN
S275 ETEDNDNSLGDILQA
S368 QTSGPPRSRSSSQAE
S370 SGPPRSRSSSQAEAP
S372 PPRSRSSSQAEAPSG
- gap
S473 FSPGPTASPLLPAST
R483 LPASTPARPLLPFST
S494 PFSTGPGSPLFQSPA
S507 PAFQSQGSPQKGPEL
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