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GGA3 (human)

Overview GGA3 Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. Monomer. Interacts with SORT1, SORL1, LRP3, GGA binding partner (GGABP) and P200. Interacts with GGA1 and GGA2. Binds to clathrin and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the membrane proteins M6PR/CD-MPR, IGF2R/CI-MPR and BACE1 and the accessory proteins SYNRG, EPN4, NECAP1, NECAP2 and AFTPH/aftiphilin. Interacts with TSG101 and UBC. Ubiquitously expressed. Belongs to the GGA protein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold; Vesicle protein Cellular Component: clathrin adaptor complex; endosome membrane; trans-Golgi network Molecular Function: ADP-ribosylation factor binding; protein binding Biological Process: vesicle-mediated transport; intracellular protein transport Reference #:  Q9NZ52 (UniProtKB) Alt. Names/Synonyms: ADP-ribosylation factor-binding protein GGA3; GGA3; golgi associated, gamma adaptin ear containing, ARF binding protein 3; golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Golgi-localized, gamma ear-containing, ARF-binding protein 3; KIAA0154 Gene Symbols: GGA3 Molecular weight: 78,315 Da Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below GGA3 1JPL - A/B/C/D=1-166 (human) 1JUQ - A/B/C/D=1-166 (human) 1LF8 - A/B/C/D=1-166 (human) 1P4U - A=571-723 (human) 1WR6 - A/B/C/D=209-319 (human) 1YD8 - G/H=208-301 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
molecular association, regulation: S368‑p protein conformation: S368‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		K15-u	SLESWLNkATNPSNR
0	10		K38-u	GFCDQINkELEGPQI
0	10		K100-u	LIKVVSPkYLGDRVS
1	5		S159-p	VDRTLIPsPPPRPkN
0	1		K165-u	PsPPPRPkNPVFDDE
0	13		K174-u	PVFDDEEkSkLLAkL
0	16		K176-u	FDDEEkSkLLAkLLK
0	10		K180-u	EkSkLLAkLLKSkNP
0	14		K185-u	LAkLLKSkNPDDLQE
0	3		K195-u	DDLQEANkLIkSMVk
0	1		K198-u	QEANkLIkSMVkEDE
0	8		K202-u	kLIkSMVkEDEARIQ
0	1		K210-u	EDEARIQkVTkRLHt
0	1		K213-u	ARIQkVTkRLHtLEE
0	10		T217-p	kVTkRLHtLEEVNNN
0	7		K258-u	LFDQCENkRRTLFkL
0	12		K264-u	NkRRTLFkLAsETED
1	1		S267-p	RTLFkLAsETEDNDN
1	0		S368-p	QASGPPRsRSSsQAE
0	1		S370	SGPPRsRSSsQAEAT
1	0		S372-p	PPRsRSSsQAEATLG
0	1		S425-p	HLLQREQsDLDFFSP
1	1		S538-p	GLVKPTTsPLIPTTT
0	1		R548-m2	IPTTTPArPLLPFST
1	1		S559-p	PFSTGPGsPLFQPLS
0	1		S572	LSFQSQGSPPKGPEL

	mouse
K15-u	SLESWLNkATNPSNR
K38-u	GFCDQINkELEGPQI
K100-u	LIKVVSPkYLGDRVS
S159-p	MDRTLIPsPPPRPKN
K165	PsPPPRPKNPVFDDE
K174-u	PVFDDEEkSkLLARL
K176-u	FDDEEkSkLLARLLK
R180	EkSkLLARLLKSkNP
K185-u	LARLLKSkNPDDLQE
R195	DDLQEANRLIKSMVK
K198	QEANRLIKSMVKEDE
K202	RLIKSMVKEDEARIQ
K210	EDEARIQKVTKRLHT
K213	ARIQKVTKRLHTLEE
T217	KVTKRLHTLEEVNNN
K258-u	LFDRCENkRRTLFkL
K264-u	NkRRTLFkLASETED
S267	RTLFkLASETEDNDN
S364	QTSGPPRSRsSSQAE
S366-p	SGPPRSRsSSQAEAP
S368	PPRSRsSSQAEAPPG
S421	LFQNEPPSDLDFFSP
S538	FSPGPTASPLLPASA
R548	LPASAPARPLLPFST
S559	PFSTGPGSPLFQSQG
S567-p	PLFQSQGsPQKGPEL

	rat
K15	SLESWLNKATNPSNR
K38	GFCDQINKELEGPQI
K100	LIKVVSPKYLGDRVS
S159	MDRTLIPSPPPRPKN
K165	PSPPPRPKNPVFDDE
K174	PVFDDEEKSkLLAKL
K176-u	FDDEEKSkLLAKLLR
K180	EKSkLLAKLLRSKNP
K185	LAKLLRSKNPDDLQE
Q195	DDLQEANQLIKSMVK
K198	QEANQLIKSMVKEDE
K202	QLIKSMVKEDEARIQ
K210	EDEARIQKVTKRLHT
K213	ARIQKVTKRLHTLEE
T217	KVTKRLHTLEEVNNN
K258	LFDRCENKRRTLFkL
K264-u	NKRRTLFkLASETED
S267	RTLFkLASETEDNDN
S368	QTSGPPRSRSSSQAE
S370	SGPPRSRSSSQAEAP
S372	PPRSRSSSQAEAPSG
-	gap
S473	FSPGPTASPLLPAST
R483	LPASTPARPLLPFST
S494	PFSTGPGSPLFQSPA
S507	PAFQSQGSPQKGPEL

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