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PDX1 (human)

Overview PDX1 Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP. Interacts with the methyltransferase SETD7. Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells). Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor Cellular Component: nucleus; cytosol Molecular Function: sequence-specific DNA binding; chromatin binding; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; generation of precursor metabolites and energy; exocrine pancreas development; glucose metabolic process; negative regulation of transcription from RNA polymerase II promoter; liver development; glucose homeostasis; endocrine pancreas development; negative regulation of cell proliferation; organ morphogenesis; detection of glucose; morphogenesis of embryonic epithelium; gut development; insulin secretion; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; nitric oxide mediated signal transduction Reference #:  P52945 (UniProtKB) Alt. Names/Synonyms: Glucose-sensitive factor; GSF; IDX-1; Insulin promoter factor 1; insulin promoter factor 1, homeodomain transcription factor; Insulin upstream factor 1; IPF-1; IPF1; Islet/duodenum homeobox-1; IUF-1; IUF1; MODY4; Pancreas/duodenum homeobox protein 1; pancreatic and duodenal homeobox 1; pancreatic-duodenal homeobox factor 1; PDX-1; PDX1; somatostatin transcription factor 1; Somatostatin-transactivating factor 1; STF-1 Gene Symbols: PDX1 Molecular weight: 30,771 Da Basal Isoelectric point: 7.1  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PDX1

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 125853 260370 600733 606392  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
transcription, altered: S61‑p, S66‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		T11-p	EEQYYAAtQLYKDPC
3	0		S61-p	LGALEQGsPPDIsPY
3	0		S66-p	QGsPPDIsPYEVPPL
1	0		Y68	sPPDIsPYEVPPLAD
1	0		S124	LPFPWMKSTKAHAWK
1	0		T125	PFPWMKSTKAHAWKG
1	0		T151	EENKRTRTAYTRAQL
1	0		G210	KEEDKKRGGGTAVGG
1	0		T213	DKKRGGGTAVGGGGV
1	0		T230	PEQDCAVTSGEELLA
1	0		S231	EQDCAVTSGEELLAL
0	1		P263	AREGRLPPGLSAsPQ
3	0		S268-p	LPPGLSAsPQPSSVA
1	0		S272	LSAsPQPSSVAPRRP

	mouse
T11	EEQYYAATQLYKDPC
S61-p	LGSLEQGsPPDIsPY
S66-p	QGsPPDIsPYEVPPL
Y68	sPPDIsPYEVPPLAS
S125	LPFPWMKSTKAHAWK
T126	PFPWMKSTKAHAWKG
T152-p	EENKRTRtAYTRAQL
S211-p	KEEDKKRsSGtPSGG
T214-p	DKKRsSGtPSGGGGG
T231-p	PEQDCAVtsGEELLA
S232-p	EQDCAVtsGEELLAV
S264-p	VREGLLPsGLSVsPQ
S269-p	LPsGLSVsPQPSSIA
S273	LSVsPQPSSIAPLRP

	rat
T11	EEQYYAATQLYKDPC
S61	LGTLEQGSPPDIsPy
S66-p	QGSPPDIsPyEVPPL
Y68-p	SPPDIsPyEVPPLAD
S124-p	LPFPWMKstKAHAWK
T125-p	PFPWMKstKAHAWKS
T151	EENKRTRTAYTRAQL
S210	KEEDKKRSSGTTSGG
T213	DKKRSSGTTSGGGGG
T230	PEQDCAVTSGEELLA
S231	EQDCAVTSGEELLAL
S263	AREGRLPSGLSAsPQ
S268-p	LPSGLSAsPQPsSIA
S272-p	LSAsPQPsSIAPLRP

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