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Protein Page:
PDX1 (human)

Overview
PDX1 Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP. Interacts with the methyltransferase SETD7. Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells). Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: nucleus; cytosol
Molecular Function: protein heterodimerization activity; protein complex binding; chromatin binding; transcription factor binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; response to nicotine; central nervous system development; response to glucocorticoid stimulus; exocrine pancreas development; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; response to chlorate; response to vitamin; negative regulation of cell proliferation; detection of glucose; morphogenesis of embryonic epithelium; positive regulation of cell proliferation; response to wounding; response to iron(II) ion; positive regulation of DNA binding; response to drug; generation of precursor metabolites and energy; organ regeneration; smoothened signaling pathway; organ senescence; glucose metabolic process; positive regulation of insulin secretion; stem cell differentiation; liver development; endocrine pancreas development; organ morphogenesis; response to leucine; gut development; insulin secretion; response to cytokine stimulus; positive regulation of transcription from RNA polymerase II promoter; nitric oxide mediated signal transduction
Reference #:  P52945 (UniProtKB)
Alt. Names/Synonyms: Glucose-sensitive factor; GSF; IDX-1; Insulin promoter factor 1; insulin promoter factor 1, homeodomain transcription factor; Insulin upstream factor 1; IPF-1; IPF1; Islet/duodenum homeobox-1; IUF-1; IUF1; MODY4; Pancreas/duodenum homeobox protein 1; pancreatic and duodenal homeobox 1; pancreatic-duodenal homeobox factor 1; PDX-1; PDX1; somatostatin transcription factor 1; Somatostatin-transactivating factor 1; STF-1
Gene Symbols: PDX1
Molecular weight: 30,771 Da
Basal Isoelectric point: 7.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PDX1

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: S61‑p, S66‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 T11-p EEQYYAAtQLYKDPC
3 0 S61-p LGALEQGsPPDIsPY
3 0 S66-p QGsPPDIsPYEVPPL
1 0 Y68 sPPDIsPYEVPPLAD
1 0 S124 LPFPWMKSTKAHAWK
1 0 T125 PFPWMKSTKAHAWKG
1 0 T151 EENKRTRTAYTRAQL
1 0 G210 KEEDKKRGGGTAVGG
1 0 T213 DKKRGGGTAVGGGGV
1 0 T230 PEQDCAVTSGEELLA
1 0 S231 EQDCAVTSGEELLAL
0 1 P263 AREGRLPPGLSAsPQ
3 1 S268-p LPPGLSAsPQPSSVA
1 0 S272 LSAsPQPSSVAPRRP
  mouse

 
T11 EEQYYAATQLYKDPC
S61-p LGSLEQGsPPDIsPY
S66-p QGsPPDIsPYEVPPL
Y68 sPPDIsPYEVPPLAS
S125 LPFPWMKSTKAHAWK
T126 PFPWMKSTKAHAWKG
T152-p EENKRTRtAYTRAQL
S211-p KEEDKKRsSGtPSGG
T214-p DKKRsSGtPSGGGGG
T231-p PEQDCAVtsGEELLA
S232-p EQDCAVtsGEELLAV
S264-p VREGLLPsGLSVsPQ
S269-p LPsGLSVsPQPSSIA
S273 LSVsPQPSSIAPLRP
  rat

 
T11 EEQYYAATQLYKDPC
S61 LGTLEQGSPPDIsPy
S66-p QGSPPDIsPyEVPPL
Y68-p SPPDIsPyEVPPLAD
S124-p LPFPWMKstKAHAWK
T125-p PFPWMKstKAHAWKS
T151 EENKRTRTAYTRAQL
S210 KEEDKKRSSGTTSGG
T213 DKKRSSGTTSGGGGG
T230 PEQDCAVTSGEELLA
S231 EQDCAVTSGEELLAL
S263 AREGRLPSGLSAsPQ
S268-p LPSGLSAsPQPsSIA
S272-p LSAsPQPsSIAPLRP
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