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Protein Page:
Fer (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Fer a non-receptor tyrosine kinase of the Fer family. Regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Increased expression associated with prostate cancer proliferation, and antisense blocks soft agar growth. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; Fer family
Cellular Component: microtubule cytoskeleton; extrinsic to internal side of plasma membrane; lamellipodium; cytoplasm; nuclear chromatin; cell cortex; cytosol; nucleus; cell junction; actin cytoskeleton
Molecular Function: protein binding; cadherin binding; gamma-catenin binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; actin binding; lipid binding; protein kinase binding; protein phosphatase 1 binding; Rab GTPase binding; ATP binding; epidermal growth factor receptor binding
Biological Process: regulation of protein amino acid phosphorylation; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; diapedesis; tyrosine phosphorylation of Stat3 protein; response to lipopolysaccharide; negative regulation of mast cell activation during immune response; platelet-derived growth factor receptor signaling pathway; microtubule cytoskeleton organization and biogenesis; chemotaxis; protein amino acid phosphorylation; regulation of epidermal growth factor receptor signaling pathway; activation of NF-kappaB transcription factor; cell proliferation; cellular response to insulin stimulus; positive regulation of actin filament polymerization; positive regulation of cell proliferation; actin cytoskeleton reorganization; mitotic cell cycle; positive regulation of cell migration
Reference #:  P16591 (UniProtKB)
Alt. Names/Synonyms: FER; fer (fps/fes related) tyrosine kinase; p94-Fer; phosphoprotein NCP94; Proto-oncogene c-Fer; TYK3; Tyrosine kinase 3; Tyrosine-protein kinase Fer
Gene Symbols: FER
Molecular weight: 94,638 Da
Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Fer

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: Y615‑p, Y714‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T27-p WELRLLEtVKKFMAL
0 2 S70-p YVSNVSKsWLLMIQQ
0 1 T78 WLLMIQQTEQLSRIM
0 1 S82 IQQTEQLSRIMKTHA
0 1 S113-p DKQQVKKsyIGVHQQ
0 1 Y114-p KQQVKKsyIGVHQQI
0 2 K166 AKGKETEKAKERYDk
0 1 K173-ac KAKERYDkATMKLHM
0 1 Y199-p AQLHQNQyyDITLPL
0 3 Y200-p QLHQNQyyDITLPLL
0 1 Y229-p LKGIFDEySQITSLV
0 1 K326-ac TQQMLLNkEEAVLEL
0 1 K347-ac SSETCEKkSDIVLLL
0 615 Y402-p EPPPVVNyEEDARSV
0 3 S408 NyEEDARSVtsMERK
0 3 T410-p EEDARSVtsMERKER
0 5 S411-p EDARSVtsMERKERL
0 5 S423-p ERLSKFEsIRHsIAG
0 1 S427-p KFEsIRHsIAGIIRs
0 8 S434-p sIAGIIRsPKSALGS
0 1 Y461-p PLAEQDWyHGAIPRI
0 1 Y492-p SHGKPGEyVLSVysD
0 10 Y497-p GEyVLSVysDGQRRH
0 1 S498-p EyVLSVysDGQRRHF
0 1 T586-p KGTLKDKtsVAVKtC
0 1 S587-p GTLKDKtsVAVKtCK
0 1 T592-p KtsVAVKtCKEDLPQ
0 2 K610-ub IKFLQEAkILKQyDH
1 1 Y615-p EAkILKQyDHPNIVK
2 620 Y714-p RQEDGGVyssSGLkQ
0 3 S715-p QEDGGVyssSGLkQI
0 2 S716-p EDGGVyssSGLkQIP
0 1 K720-ub VyssSGLkQIPIKWT
0 6 Y734-p TAPEALNyGRYSSES
0 1 K795-ac DISKIMMkCWDYKPE
  mouse

► Hide Isoforms
 
T27 WELRLLETVKKFMAL
S70-p YVSNVSKsWLLMIQQ
T78-p WLLMIQQtEQLsRIM
S82-p IQQtEQLsRIMKTHA
S113 DKQQVKKSYVGIHQQ
Y114 KQQVKKSYVGIHQQI
K166-ac AKGKETEkAKERYDK
K173 kAKERYDKATMKLHM
Y199 AQLHQSQYYDTTLPL
Y200 QLHQSQYYDTTLPLL
Y229 LKGIFDDYSQITSLV
K326 TQQMLLHKEAAVLEL
K347 SFETCEKKSDIVLLL
Y402-p EPPPVVNyEEDARsV
S408-p NyEEDARsVtsMERK
T410-p EEDARsVtsMERKER
S411-p EDARsVtsMERKERL
S423 ERLSKFESIRHSIAG
S427 KFESIRHSIAGIIKS
S434 SIAGIIKSPKSVLGS
Y462 PLAEHDWYHGAIPRI
Y493 SHGKPGEYVLSVYSD
Y498 GEYVLSVYSDGQRRH
S499 EYVLSVYSDGQRRHF
T587 KGTLKDKTPVAIKTC
P588 GTLKDKTPVAIKTCK
T593 KTPVAIKTCKEDLPQ
K611 IKFLQEAKILKQYDH
Y616 EAKILKQYDHPNIVK
Y715-p RQEDGGVysSSGLKQ
S716-p QEDGGVysSSGLKQI
S717 EDGGVysSSGLKQIP
K721 VysSSGLKQIPIKWT
Y735 TAPEALNYGRYSSES
K796 EVFTIMMKCWDYKPE
  Fer iso4  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S54 ERLSKFESIRHSIAG
S58 KFESIRHSIAGIIKS
S65 SIAGIIKSPKSVLGS
Y92 PLAEHDWYHGAIPRI
Y123 SHGKPGEYVLSVYSD
Y128 GEYVLSVYSDGQRRH
S129 EYVLSVYSDGQRRHF
T217 KGTLKDKTPVAIKTC
P218 GTLKDKTPVAIKTCK
T223 KTPVAIKTCKEDLPQ
K241 IKFLQEAKILKQYDH
Y246 EAKILKQYDHPNIVK
Y345-p RQEDGGVySSSGLKQ
S346 QEDGGVySSSGLKQI
S347 EDGGVySSSGLKQIP
K351 VySSSGLKQIPIKWT
Y365 TAPEALNYGRYSSES
K426 EVFTIMMKCWDYKPE
  rat

 
T27 WELRLLETVKKFMAL
S70 YVSNVSKSWLLMIQQ
T78 WLLMIQQTEQLSRIM
S82 IQQTEQLSRIMKTHA
S113 DKQQVKKSYVGIHQQ
Y114 KQQVKKSYVGIHQQI
K166 AKGKETEKAKERCDK
K173 KAKERCDKATMKLHM
Y199 AQLHQSQYYDTTLPL
Y200 QLHQSQYYDTTLPLL
Y229 LKGIFDEYSEITSLV
K326 TQQMLLHKEAAVLEL
K347 SSETCAKKSDIVLLL
Y402-p EPPPVVNyEEDARSV
S408 NyEEDARSVTSMERK
T410 EEDARSVTSMERKER
S411 EDARSVTSMERKERL
S423 ERLSKFESIRHSIAG
S427 KFESIRHSIAGIIKS
S434 SIAGIIKSPKSVLGS
Y462 PLAEHDWYHGAIPRI
Y493 SHGKPGEYVLSVYSD
Y498 GEYVLSVYSDGQRRH
S499 EYVLSVYSDGQRRHF
T587 KGTLKDKTPVAVKTC
P588 GTLKDKTPVAVKTCK
T593 KTPVAVKTCKEDLPQ
K611 IKFLQEAKILKQYDH
Y616 EAKILKQYDHPNIVK
Y715-p RQEDGGVysSSGLKQ
S716-p QEDGGVysSSGLKQI
S717 EDGGVysSSGLKQIP
K721 VysSSGLKQIPIKWT
Y735 TAPEALNYGRYSSES
K796 EIFTIMMKCWDYKPE
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