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Protein Page:
Fer (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Fer a non-receptor tyrosine kinase of the Fer family. Regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Increased expression associated with prostate cancer proliferation, and antisense blocks soft agar growth. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Protein kinase, TK; TK group; Fer family
Cellular Component: microtubule cytoskeleton; extrinsic to internal side of plasma membrane; lamellipodium; cytoplasm; nuclear chromatin; cell cortex; cytosol; nucleus; cell junction; actin cytoskeleton
Molecular Function: protein binding; cadherin binding; gamma-catenin binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; actin binding; protein phosphatase 1 binding; protein kinase binding; lipid binding; Rab GTPase binding; ATP binding; epidermal growth factor receptor binding
Biological Process: regulation of protein amino acid phosphorylation; peptidyl-tyrosine phosphorylation; diapedesis; cytokine and chemokine mediated signaling pathway; protein amino acid autophosphorylation; tyrosine phosphorylation of Stat3 protein; response to lipopolysaccharide; platelet-derived growth factor receptor signaling pathway; negative regulation of mast cell activation during immune response; microtubule cytoskeleton organization and biogenesis; chemotaxis; protein amino acid phosphorylation; regulation of epidermal growth factor receptor signaling pathway; activation of NF-kappaB transcription factor; cell proliferation; positive regulation of actin filament polymerization; cellular response to insulin stimulus; actin cytoskeleton reorganization; positive regulation of cell proliferation; mitotic cell cycle; positive regulation of cell migration
Reference #:  P16591 (UniProtKB)
Alt. Names/Synonyms: FER; fer (fps/fes related) tyrosine kinase; p94-Fer; phosphoprotein NCP94; Proto-oncogene c-Fer; TYK3; Tyrosine kinase 3; Tyrosine-protein kinase Fer
Gene Symbols: FER
Molecular weight: 94,638 Da
Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Fer

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: Y615‑p, Y714‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S70-p YVSNVSKsWLLMIQQ
0 1 T78 WLLMIQQTEQLSRIM
0 1 S82 IQQTEQLSRIMKTHA
0 1 S113-p DKQQVKKsyIGVHQQ
0 1 Y114-p KQQVKKsyIGVHQQI
0 2 K166 AKGKETEKAKERYDK
0 2 Y200-p QLHQNQYyDITLPLL
0 1 Y229-p LKGIFDEySQITSLV
0 640 Y402-p EPPPVVNyEEDARSV
0 3 S408 NyEEDARSVtsMERK
0 3 T410-p EEDARSVtsMERKER
0 4 S411-p EDARSVtsMERKERL
0 5 S423-p ERLSKFEsIRHSIAG
0 6 S434-p SIAGIIRsPKSALGS
0 10 Y497-p GEYVLSVySDGQRRH
0 2 K610-u IKFLQEAkILKQyDH
1 1 Y615-p EAkILKQyDHPNIVK
2 657 Y714-p RQEDGGVyssSGLkQ
0 2 S715-p QEDGGVyssSGLkQI
0 2 S716-p EDGGVyssSGLkQIP
0 1 K720-u VyssSGLkQIPIKWT
0 6 Y734-p TAPEALNyGRYSSES
  mouse

► Hide Isoforms
 
S70-p YVSNVSKsWLLMIQQ
T78-p WLLMIQQtEQLsRIM
S82-p IQQtEQLsRIMKTHA
S113 DKQQVKKSYVGIHQQ
Y114 KQQVKKSYVGIHQQI
K166-a AKGKETEkAKERYDK
Y200 QLHQSQYYDTTLPLL
Y229 LKGIFDDYSQITSLV
Y402-p EPPPVVNyEEDARsV
S408-p NyEEDARsVtsMERK
T410-p EEDARsVtsMERKER
S411-p EDARsVtsMERKERL
S423 ERLSKFESIRHSIAG
S434 SIAGIIKSPKSVLGS
Y498 GEYVLSVYSDGQRRH
K611 IKFLQEAKILKQYDH
Y616 EAKILKQYDHPNIVK
Y715-p RQEDGGVysSSGLKQ
S716-p QEDGGVysSSGLKQI
S717 EDGGVysSSGLKQIP
K721 VysSSGLKQIPIKWT
Y735 TAPEALNYGRYSSES
  Fer iso4  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S54 ERLSKFESIRHSIAG
S65 SIAGIIKSPKSVLGS
Y128 GEYVLSVYSDGQRRH
K241 IKFLQEAKILKQYDH
Y246 EAKILKQYDHPNIVK
Y345-p RQEDGGVySSSGLKQ
S346 QEDGGVySSSGLKQI
S347 EDGGVySSSGLKQIP
K351 VySSSGLKQIPIKWT
Y365 TAPEALNYGRYSSES
  rat

 
S70 YVSNVSKSWLLMIQQ
T78 WLLMIQQTEQLSRIM
S82 IQQTEQLSRIMKTHA
S113 DKQQVKKSYVGIHQQ
Y114 KQQVKKSYVGIHQQI
K166 AKGKETEKAKERCDK
Y200 QLHQSQYYDTTLPLL
Y229 LKGIFDEYSEITSLV
Y402-p EPPPVVNyEEDARSV
S408 NyEEDARSVTSMERK
T410 EEDARSVTSMERKER
S411 EDARSVTSMERKERL
S423 ERLSKFESIRHSIAG
S434 SIAGIIKSPKSVLGS
Y498 GEYVLSVYSDGQRRH
K611 IKFLQEAKILKQYDH
Y616 EAKILKQYDHPNIVK
Y715-p RQEDGGVySSSGLKQ
S716 QEDGGVySSSGLKQI
S717 EDGGVySSSGLKQIP
K721 VySSSGLKQIPIKWT
Y735 TAPEALNYGRYSSES
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