a non-receptor tyrosine kinase of the Fer family. Regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Increased expression associated with prostate cancer proliferation, and antisense blocks soft agar growth. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; Kinase, protein; EC 18.104.22.168; Protein kinase, tyrosine (non-receptor); TK group; Fer family
Chromosomal Location of Human Ortholog: 5q21
Cellular Component: microtubule cytoskeleton; extrinsic to internal side of plasma membrane; lamellipodium; nuclear chromatin; cytoplasm; cell cortex; cytosol; nucleus; cell junction; actin cytoskeleton
Molecular Function: protein binding; cadherin binding; protein-tyrosine kinase activity; gamma-catenin binding; non-membrane spanning protein tyrosine kinase activity; actin binding; protein phosphatase 1 binding; protein kinase binding; lipid binding; Rab GTPase binding; ATP binding; epidermal growth factor receptor binding
Biological Process: regulation of mast cell degranulation; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; diapedesis; tyrosine phosphorylation of Stat3 protein; response to lipopolysaccharide; negative regulation of mast cell activation during immune response; platelet-derived growth factor receptor signaling pathway; chemotaxis; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; positive regulation of cell proliferation; cell differentiation; cell adhesion; regulation of protein amino acid phosphorylation; cytokine and chemokine mediated signaling pathway; microtubule cytoskeleton organization and biogenesis; regulation of epidermal growth factor receptor signaling pathway; regulation of cell proliferation; cell proliferation; cellular response to insulin stimulus; positive regulation of actin filament polymerization; actin cytoskeleton reorganization; innate immune response; mitotic cell cycle; positive regulation of cell migration
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.