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Fer (human)

Overview Fer a non-receptor tyrosine kinase of the Fer family. Regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Increased expression associated with prostate cancer proliferation, and antisense blocks soft agar growth. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; EC 2.7.10.2; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Fer family Cellular Component: microtubule cytoskeleton; extrinsic to internal side of plasma membrane; lamellipodium; nuclear chromatin; cytoplasm; cell cortex; nucleus; cytosol; cell junction; actin cytoskeleton Molecular Function: cadherin binding; gamma-catenin binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; actin binding; protein kinase binding; protein phosphatase 1 binding; lipid binding; Rab GTPase binding; ATP binding; epidermal growth factor receptor binding Biological Process: regulation of protein amino acid phosphorylation; peptidyl-tyrosine phosphorylation; cytokine and chemokine mediated signaling pathway; diapedesis; protein amino acid autophosphorylation; tyrosine phosphorylation of Stat3 protein; response to lipopolysaccharide; platelet-derived growth factor receptor signaling pathway; negative regulation of mast cell activation during immune response; microtubule cytoskeleton organization and biogenesis; chemotaxis; protein amino acid phosphorylation; regulation of epidermal growth factor receptor signaling pathway; activation of NF-kappaB transcription factor; cell proliferation; positive regulation of actin filament polymerization; cellular response to insulin stimulus; actin cytoskeleton reorganization; positive regulation of cell proliferation; mitotic cell cycle; positive regulation of cell migration Reference #:  P16591 (UniProtKB) Alt. Names/Synonyms: FER; fer (fps/fes related) tyrosine kinase; p94-Fer; phosphoprotein NCP94; Proto-oncogene c-Fer; TYK3; Tyrosine kinase 3; Tyrosine-protein kinase Fer Gene Symbols: FER Molecular weight: 94,638 Da Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states CST Pathways:  Tyrosine Kinases  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Fer 2KK6 - A=453-557 (human)

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	Sites Implicated In
enzymatic activity, induced: Y615‑p, Y714‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T27-p	WELRLLEtVKKFMAL
0	1		S70-p	YVSNVSKsWLLMIQQ
0	1		S113-p	DKQQVKKsyIGVHQQ
0	1		Y114-p	KQQVKKsyIGVHQQI
0	2		K166-a	AKGKETEkAKERYDk
0	1		K173-a	kAKERYDkATMKLHM
0	1		Y199-p	AQLHQNQyyDITLPL
0	2		Y200-p	QLHQNQyyDITLPLL
0	1		Y229-p	LKGIFDEySQITSLV
0	1		K326-a	TQQMLLNkEEAVLEL
0	1		K347-a	SSETCEKkSDIVLLL
0	636		Y402-p	EPPPVVNyEEDARSV
0	3		S408	NyEEDARSVtsMERK
0	3		T410-p	EEDARSVtsMERKER
0	4		S411-p	EDARSVtsMERKERL
0	4		S423-p	ERLSKFEsIRHSIAG
0	4		S434-p	SIAGIIRsPKSALGS
0	1		Y492-p	SHGKPGEyVLSVysD
0	10		Y497-p	GEyVLSVysDGQRRH
0	1		S498-p	EyVLSVysDGQRRHF
0	1		T586-p	KGTLKDKtsVAVKtC
0	1		S587-p	GTLKDKtsVAVKtCK
0	1		T592-p	KtsVAVKtCKEDLPQ
0	2		K610-u	IKFLQEAkILKQyDH
1	1		Y615-p	EAkILKQyDHPNIVK
2	653		Y714-p	RQEDGGVyssSGLkQ
0	2		S715-p	QEDGGVyssSGLkQI
0	2		S716-p	EDGGVyssSGLkQIP
0	1		K720-u	VyssSGLkQIPIKWT
0	4		Y734-p	TAPEALNyGRYSSES
0	1		K795-a	DISKIMMkCWDYKPE

	mouse ► Hide Isoforms
T27	WELRLLETVKKFMAL
S70	YVSNVSKSWLLMIQQ
S113	DKQQVKKSYVGIHQQ
Y114	KQQVKKSYVGIHQQI
K166-a	AKGKETEkAKERYDK
K173	kAKERYDKATMKLHM
Y199	AQLHQSQYYDTTLPL
Y200	QLHQSQYYDTTLPLL
Y229	LKGIFDDYSQITSLV
K326	TQQMLLHKEAAVLEL
K347	SFETCEKKSDIVLLL
Y402-p	EPPPVVNyEEDARsV
S408-p	NyEEDARsVtsMERK
T410-p	EEDARsVtsMERKER
S411-p	EDARsVtsMERKERL
S423	ERLSKFESIRHSIAG
S434	SIAGIIKSPKSVLGS
Y493	SHGKPGEYVLSVYSD
Y498	GEYVLSVYSDGQRRH
S499	EYVLSVYSDGQRRHF
T587	KGTLKDKTPVAIKTC
P588	GTLKDKTPVAIKTCK
T593	KTPVAIKTCKEDLPQ
K611	IKFLQEAKILKQYDH
Y616	EAKILKQYDHPNIVK
Y715-p	RQEDGGVysSSGLKQ
S716-p	QEDGGVysSSGLKQI
S717	EDGGVysSSGLKQIP
K721	VysSSGLKQIPIKWT
Y735	TAPEALNYGRYSSES
K796	EVFTIMMKCWDYKPE

	Fer iso4
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
S54	ERLSKFESIRHSIAG
S65	SIAGIIKSPKSVLGS
Y123	SHGKPGEYVLSVYSD
Y128	GEYVLSVYSDGQRRH
S129	EYVLSVYSDGQRRHF
T217	KGTLKDKTPVAIKTC
P218	GTLKDKTPVAIKTCK
T223	KTPVAIKTCKEDLPQ
K241	IKFLQEAKILKQYDH
Y246	EAKILKQYDHPNIVK
Y345-p	RQEDGGVySSSGLKQ
S346	QEDGGVySSSGLKQI
S347	EDGGVySSSGLKQIP
K351	VySSSGLKQIPIKWT
Y365	TAPEALNYGRYSSES
K426	EVFTIMMKCWDYKPE

	rat
T27	WELRLLETVKKFMAL
S70	YVSNVSKSWLLMIQQ
S113	DKQQVKKSYVGIHQQ
Y114	KQQVKKSYVGIHQQI
K166	AKGKETEKAKERCDK
K173	KAKERCDKATMKLHM
Y199	AQLHQSQYYDTTLPL
Y200	QLHQSQYYDTTLPLL
Y229	LKGIFDEYSEITSLV
K326	TQQMLLHKEAAVLEL
K347	SSETCAKKSDIVLLL
Y402-p	EPPPVVNyEEDARSV
S408	NyEEDARSVTSMERK
T410	EEDARSVTSMERKER
S411	EDARSVTSMERKERL
S423	ERLSKFESIRHSIAG
S434	SIAGIIKSPKSVLGS
Y493	SHGKPGEYVLSVYSD
Y498	GEYVLSVYSDGQRRH
S499	EYVLSVYSDGQRRHF
T587	KGTLKDKTPVAVKTC
P588	GTLKDKTPVAVKTCK
T593	KTPVAVKTCKEDLPQ
K611	IKFLQEAKILKQYDH
Y616	EAKILKQYDHPNIVK
Y715-p	RQEDGGVySSSGLKQ
S716	QEDGGVySSSGLKQI
S717	EDGGVySSSGLKQIP
K721	VySSSGLKQIPIKWT
Y735	TAPEALNYGRYSSES
K796	EIFTIMMKCWDYKPE

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