Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and SAR1. SEC24B is capable of forming heterodimers with SEC24A. Interacts with RNF139. Interacts with TMED2 and TMED10. Expressed in fibroblasts, hepatocytes, and lymphocytes. Belongs to the SEC23/SEC24 family. SEC24 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Vesicle protein
Chromosomal Location of Human Ortholog: 4q25
Cellular Component: Golgi membrane; endoplasmic reticulum membrane; membrane; COPII vesicle coat; perinuclear region of cytoplasm; cytosol
Molecular Function: protein binding; zinc ion binding; transporter activity
Biological Process: COPII coating of Golgi vesicle; vesicle-mediated transport; cochlear nucleus development; intracellular protein transport; antigen processing and presentation of peptide antigen via MHC class I; ER to Golgi vesicle-mediated transport; cellular protein metabolic process; neural tube closure; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; auditory receptor cell stereocilium organization and biogenesis; post-translational protein modification
Alt. Names/Synonyms: MGC48822; Protein transport protein Sec24B; SC24B; SEC24; SEC24 (S. cerevisiae) homolog B; SEC24 family, member B (S. cerevisiae); SEC24 related gene family, member B; SEC24-related protein B; SEC24B; secretory protein 24
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.