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Protein Page:
SEC24B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SEC24B Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and SAR1. SEC24B is capable of forming heterodimers with SEC24A. Interacts with RNF139. Interacts with TMED2 and TMED10. Expressed in fibroblasts, hepatocytes, and lymphocytes. Belongs to the SEC23/SEC24 family. SEC24 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Vesicle protein
Chromosomal Location of Human Ortholog: 4q25
Cellular Component: Golgi membrane; endoplasmic reticulum membrane; membrane; COPII vesicle coat; perinuclear region of cytoplasm; cytosol
Molecular Function: protein binding; zinc ion binding; transporter activity
Biological Process: COPII coating of Golgi vesicle; vesicle-mediated transport; intracellular protein transport; antigen processing and presentation of peptide antigen via MHC class I; ER to Golgi vesicle-mediated transport; cellular protein metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
Reference #:  O95487 (UniProtKB)
Alt. Names/Synonyms: MGC48822; Protein transport protein Sec24B; SC24B; SEC24; SEC24 (S. cerevisiae) homolog B; SEC24 family, member B (S. cerevisiae); SEC24 related gene family, member B; SEC24-related protein B; SEC24B; secretory protein 24
Gene Symbols: SEC24B
Molecular weight: 137,418 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SEC24B

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 S2-p ______MsAPAGSSH
0 2 S7 _MsAPAGSSHPAAsA
0 1 S13-p GSSHPAAsARIPPKF
0 1 - gap
0 1 S55-p QNQMQVPsGYGLHHQ
0 12 Y64-p YGLHHQNyIAPsGHy
0 2 S68-p HQNyIAPsGHysQGP
0 10 Y71-p yIAPsGHysQGPGKM
0 3 S72-p IAPsGHysQGPGKMT
0 7 Y90-p LDTQCGDyYSALyTV
0 3 Y95-p GDyYSALyTVPTQNV
0 23 Y117-p QPGAQQLySRGPPAP
0 1 S139-ga GSFQGAAsSASHLHT
0 1 S149-ga SHLHTSAsQPYSSFV
0 1 Y165 HYNSPAMYSASSSVA
0 1 S166 YNSPAMYSASSSVAS
0 1 S173 SASSSVASQGFPSTC
0 1 Y207-p SLPAGDTyGQMFTSQ
0 4 T329-p SGSSSTRtPPtANHP
0 1 T332-p SSTRtPPtANHPVEP
0 1 S400 SSTTSSASPMPNSYD
0 20 T537-p ERNILPMtPVWAPVP
0 1 K551-ac PNLNADLkKLNCsPD
0 1 S556-p DLkKLNCsPDSFRCT
0 1 Y670-p EFIASSDyMLRPPQP
0 1 T804-p AFKLMSPtGGRVSVF
0 1 S817-p VFQTQLPsLGAGLLQ
0 1 S834-p EDPNQRSsTKVVQHL
0 1 K849 GPATDFYKKLALDCS
0 2 Y883-p SLACMSKySAGCIYy
0 2 Y890-p ySAGCIYyYPSFHYT
0 2 K988-ac ALLYTSSkGERRIRV
0 74 Y1100-p TRLDDRVyAMCQIKS
0 1 S1220-p FITWLRDsRPLsPIL
0 21 S1224-p LRDsRPLsPILHIVK
  SEC24B iso3  
S2 ______MSAPAGSSH
S7 _MSAPAGSSHPAASA
S13 GSSHPAASARIPPKF
S55-p FHHVAQAsLELLDPS
S86 QNQMQVPSGYGLHHQ
Y95 YGLHHQNYIAPSGHY
S99 HQNYIAPSGHYSQGP
Y102 YIAPSGHYSQGPGKM
S103 IAPSGHYSQGPGKMT
Y121 LDTQCGDYYSALYTV
Y126 GDYYSALYTVPTQNV
Y148 QPGAQQLYSRGPPAP
S170 GSFQGAASSASHLHT
S180 SHLHTSASQPYSSFV
Y196 HYNSPAMYSASSSVA
S197 YNSPAMYSASSSVAS
S204 SASSSVASQGFPSTC
Y238 SLPAGDTYGQMFTSQ
T360 SGSSSTRTPPTANHP
T363 SSTRTPPTANHPVEP
S431 SSTTSSASPMPNSYD
T567 ERNILPMTPVWAPVP
K581 PNLNADLKKLNCSPD
S586 DLKKLNCSPDSFRCT
Y700 EFIASSDYMLRPPQP
T834 AFKLMSPTGGRVSVF
S847 VFQTQLPSLGAGLLQ
S864 EDPNQRSSTKVVQHL
K879 GPATDFYKKLALDCS
Y913 SLACMSKYSAGCIYY
Y920 YSAGCIYYYPSFHYT
K1018 ALLYTSSKGERRIRV
Y1130 TRLDDRVYAMCQIKS
S1250 FITWLRDSRPLSPIL
S1254 LRDSRPLSPILHIVK
  mouse

 
S2 ______MSAPAGsPH
S7-p _MSAPAGsPHPAAGA
G13 GsPHPAAGARMPPKL
- gap
S44 QSPMQVPSGYGLPHQ
Y53 YGLPHQNYMVPsGHY
S57-p HQNYMVPsGHYSQGP
Y60 YMVPsGHYSQGPGKM
S61 MVPsGHYSQGPGKMT
Y79-p LDSQCDSyYSRPYTV
Y84 DSyYSRPYTVPTQNS
Y106 QPGAQQMYGRGPSAP
A128 GSFQGIPASASHSYS
S138 SHSYSSASQPYSSLG
Y154-p RYSSPTTysANASVA
S155-p YSSPTTysANASVAs
S162-p sANASVAsQGYPSTC
Y196 SLPASEPYGQMFTSQ
M315 PGPSSTRMPPAPSHP
A318 SSTRMPPAPSHPVGP
S386 SSTTSSASPLPNSYD
T520 EKNILPPTPIWAPVP
S534 PNLSAELSKLNCSPD
S539 ELSKLNCSPDSFRCT
Y653 EFIASSDYMLRPPQP
T787 AFKLMSPTGGRVSVF
S800 VFQTQLPSLGAGLLQ
S817 EDPNQRSSTKVVHHL
K832-ub GPATDFYkKLALDCS
Y866 SLACMSKYSAGCIFY
Y873 YSAGCIFYYPSFHST
K971 ALLYTSSKGERRIRV
Y1083-p TRLDDRVyAMCQMKS
S1203-p FVTWLRDsRPLsPVL
S1207-p LRDsRPLsPVLHLVK
  rat

 
S2 ______MSAPAGSPH
S7 _MSAPAGSPHPAAGA
G13 GSPHPAAGARMPPKL
- gap
S44 QSQMQVPSGYGLPHQ
Y53 YGLPHQNYMAPSGHY
S57 HQNYMAPSGHYSQGP
Y60 YMAPSGHYSQGPGKM
S61 MAPSGHYSQGPGKMT
Y79 LDNQCENYYSRPYTA
Y84 ENYYSRPYTAPTQNV
Y106 QPGAQLMYGRGPSAP
A128 GPFQGAPASASHSYP
S138 SHSYPSASQPYSSLG
Y154 RYSSPATYSATASVA
S155 YSSPATYSATASVAS
S162 SATASVASQGYPSTC
Y196 SLPASEPYGQMFTSQ
M313 PGPSSTRMPPAPSHP
A316 SSTRMPPAPSHPVGP
S384-p SSTTSSAsPLPNSYD
T511 EKNILPATPIWAPVP
S525 PNLSAELSKLNCSPD
S530 ELSKLNCSPDSFRCT
Y644 EFIASSDYMLRPPQP
T778 AFKLMSPTGGRVSVF
S791 VFQTQLPSLGAGLLQ
S808 EDPNQRSSTKVVHHL
K823 GPATDFYKKLALDCS
Y857 SLACMSKYSAGCIFY
Y864 YSAGCIFYYPSFHST
K962 ALLYTSSKGERRIRV
Y1074 TRLDDRVYAMCQMKS
S1194 FVTWLRDSRPLSPVL
S1198 LRDSRPLSPVLHVVK
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