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Protein Page:
SEC24B (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SEC24B Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and SAR1. SEC24B is capable of forming heterodimers with SEC24A. Interacts with RNF139. Interacts with TMED2 and TMED10. Expressed in fibroblasts, hepatocytes, and lymphocytes. Belongs to the SEC23/SEC24 family. SEC24 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Vesicle protein
Cellular Component: Golgi membrane; endoplasmic reticulum membrane; membrane; COPII vesicle coat; perinuclear region of cytoplasm; cytosol
Molecular Function: protein binding; zinc ion binding; transporter activity
Biological Process: vesicle-mediated transport; COPII coating of Golgi vesicle; intracellular protein transport; antigen processing and presentation of peptide antigen via MHC class I; ER to Golgi vesicle-mediated transport; cellular protein metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
Reference #:  O95487 (UniProtKB)
Alt. Names/Synonyms: MGC48822; Protein transport protein Sec24B; SC24B; SEC24; SEC24 (S. cerevisiae) homolog B; SEC24 family, member B (S. cerevisiae); SEC24 related gene family, member B; SEC24-related protein B; SEC24B; secretory protein 24
Gene Symbols: SEC24B
Molecular weight: 137,418 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SEC24B

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S7 _MSAPAGSSHPAASA
0 10 Y64-p YGLHHQNyIAPsGHy
0 2 S68-p HQNyIAPsGHySQGP
0 8 Y71-p yIAPsGHySQGPGKM
0 5 Y90-p LDTQCGDyYSALyTV
0 3 Y95-p GDyYSALyTVPTQNV
0 23 Y117-p QPGAQQLySRGPPAP
0 1 S139-ga GSFQGAAsSASHLHT
0 1 S149-ga SHLHTSAsQPYSSFV
0 2 T329-p SGSSSTRtPPTANHP
0 1 S400 SSTTSSASPMPNSYD
0 20 T537-p ERNILPMtPVWAPVP
0 1 K849 GPATDFYKKLALDCS
0 2 Y883-p SLACMSKySAGCIYy
0 2 Y890-p ySAGCIYyYPSFHYT
0 2 K988-a ALLYTSSkGERRIRV
0 75 Y1100-p TRLDDRVyAMCQIKS
0 1 S1220-p FITWLRDsRPLsPIL
0 16 S1224-p LRDsRPLsPILHIVK
  mouse

 
S7-p _MSAPAGsPHPAAGA
Y53 YGLPHQNYMVPsGHY
S57-p HQNYMVPsGHYSQGP
Y60 YMVPsGHYSQGPGKM
Y79-p LDSQCDSyYSRPYTV
Y84 DSyYSRPYTVPTQNS
Y106 QPGAQQMYGRGPSAP
A128 GSFQGIPASASHSYS
S138 SHSYSSASQPYSSLG
M315 PGPSSTRMPPAPSHP
S386 SSTTSSASPLPNSYD
T520 EKNILPPTPIWAPVP
K832-u GPATDFYkKLALDCS
Y866 SLACMSKYSAGCIFY
Y873 YSAGCIFYYPSFHST
K971 ALLYTSSKGERRIRV
Y1083-p TRLDDRVyAMCQMKS
S1203-p FVTWLRDsRPLsPVL
S1207-p LRDsRPLsPVLHLVK
  rat

 
S7 _MSAPAGSPHPAAGA
Y53 YGLPHQNYMAPSGHY
S57 HQNYMAPSGHYSQGP
Y60 YMAPSGHYSQGPGKM
Y79 LDNQCENYYSRPYTA
Y84 ENYYSRPYTAPTQNV
Y106 QPGAQLMYGRGPSAP
A128 GPFQGAPASASHSYP
S138 SHSYPSASQPYSSLG
M313 PGPSSTRMPPAPSHP
S384-p SSTTSSAsPLPNSYD
T511 EKNILPATPIWAPVP
K823 GPATDFYKKLALDCS
Y857 SLACMSKYSAGCIFY
Y864 YSAGCIFYYPSFHST
K962 ALLYTSSKGERRIRV
Y1074 TRLDDRVYAMCQMKS
S1194 FVTWLRDSRPLSPVL
S1198 LRDSRPLSPVLHVVK
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