Home

Sec24B (human)

Overview Sec24B Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and SAR1. SEC24B is capable of forming heterodimers with SEC24A. Interacts with RNF139. Interacts with TMED2 and TMED10. Expressed in fibroblasts, hepatocytes, and lymphocytes. Belongs to the SEC23/SEC24 family. SEC24 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Vesicle protein; Motility/polarity/chemotaxis Cellular Component: Golgi membrane; endoplasmic reticulum membrane; COPII vesicle coat; membrane; perinuclear region of cytoplasm; cytosol Molecular Function: protein binding; zinc ion binding; transporter activity Biological Process: vesicle-mediated transport; COPII coating of Golgi vesicle; intracellular protein transport; antigen processing and presentation of peptide antigen via MHC class I; ER to Golgi vesicle-mediated transport; cellular protein metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; membrane organization and biogenesis Reference #:  O95487 (UniProtKB) Alt. Names/Synonyms: MGC48822; Protein transport protein Sec24B; SC24B; SEC24; SEC24 (S. cerevisiae) homolog B; SEC24 family, member B (S. cerevisiae); SEC24 related gene family, member B; SEC24-related protein B; SEC24B; secretory protein 24 Gene Symbols: SEC24B Molecular weight: 137,418 Da Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Sec24B 3EH1 - A=518-1268 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S7	_MSAPAGSSHPAASA
0	1		S55-p	QNQMQVPsGYGLHHQ
0	10		Y64-p	YGLHHQNyIAPsGHy
0	2		S68-p	HQNyIAPsGHysQGP
0	8		Y71-p	yIAPsGHysQGPGKM
0	1		S72-p	IAPsGHysQGPGKMT
0	5		Y90-p	LDTQCGDyYSALyTV
0	3		Y95-p	GDyYSALyTVPTQNV
0	23		Y117-p	QPGAQQLySRGPPAP
0	1		Y165	HYNSPAMYSASSSVA
0	1		S166	YNSPAMYSASSSVAS
0	1		S173	SASSSVASQGFPSTC
0	1		Y207-p	SLPAGDTyGQMFTSQ
0	1		T329-p	SGSSSTRtPPTANHP
0	20		T537-p	ERNILPMtPVWAPVP
0	1		K551-a	PNLNADLkKLNCSPD
0	1		Y670-p	EFIASSDyMLRPPQP
0	1		T804-p	AFKLMSPtGGRVSVF
0	1		S817-p	VFQTQLPsLGAGLLQ
0	1		S834-p	EDPNQRSsTKVVQHL
0	1		K849	GPATDFYKKLALDCS
0	2		Y883-p	SLACMSKySAGCIYy
0	2		Y890-p	ySAGCIYyYPSFHYT
0	2		K988-a	ALLYTSSkGERRIRV
0	75		Y1100-p	TRLDDRVyAMCQIKS
0	1		S1220	FITWLRDSRPLsPIL
0	14		S1224-p	LRDSRPLsPILHIVK

	mouse
S7-p	_MSAPAGsPHPAAGA
S44	QSPMQVPSGYGLPHQ
Y53	YGLPHQNYMVPsGHY
S57-p	HQNYMVPsGHYSQGP
Y60	YMVPsGHYSQGPGKM
S61	MVPsGHYSQGPGKMT
Y79-p	LDSQCDSyYSRPYTV
Y84	DSyYSRPYTVPTQNS
Y106	QPGAQQMYGRGPSAP
Y154-p	RYSSPTTysANASVA
S155-p	YSSPTTysANASVAs
S162-p	sANASVAsQGYPSTC
Y196	SLPASEPYGQMFTSQ
M315	PGPSSTRMPPAPSHP
T520	EKNILPPTPIWAPVP
S534	PNLSAELSKLNCSPD
Y653	EFIASSDYMLRPPQP
T787	AFKLMSPTGGRVSVF
S800	VFQTQLPSLGAGLLQ
S817	EDPNQRSSTKVVHHL
K832-u	GPATDFYkKLALDCS
Y866	SLACMSKYSAGCIFY
Y873	YSAGCIFYYPSFHST
K971	ALLYTSSKGERRIRV
Y1083-p	TRLDDRVyAMCQMKS
S1203-p	FVTWLRDsRPLsPVL
S1207-p	LRDsRPLsPVLHLVK

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.