Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
AGO4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AGO4 Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B. Belongs to the argonaute family. Ago subfamily. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Cellular Component: cytosol
Molecular Function: protein binding; miRNA binding
Biological Process: epidermal growth factor receptor signaling pathway; Notch signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; mRNA catabolic process; innate immune response; miRNA-mediated gene silencing, negative regulation of translation; gene expression
Reference #:  Q9HCK5 (UniProtKB)
Alt. Names/Synonyms: AGO4; argonaute 4; Argonaute4; eIF-2C 4; eIF2C 4; EIF2C4; Eukaryotic translation initiation factor 2C 4; eukaryotic translation initiation factor 2C, 4; hAgo4; KIAA1567; Protein argonaute-4
Gene Symbols: AGO4
Molecular weight: 97,097 Da
Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AGO4

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S11-p LGPGPPAsLFQPPRR
0 1 Y47-p PKIDVYHyDVDIKPE
0 1 T108-p DRVDMEVtLPGEGKD
0 3 Y328-p GQEQKHTyLPLEVCN
0 1 T503 MFKHLKMTYVGLQLI
0 1 T518-p VVILPGKtPVYAEVk
0 2 K525-ub tPVYAEVkRVGDTLL
0 1 K542 ATQCVQVKNVVKTSP
0 1 K542 ATQCVQVKNVVKTSP
0 1 K562 LCLKINAKLGGINNV
0 1 S798-p TYVRCTRsVSIPAPA
  mouse

 
S11 LGPGPPASLFQPPRR
Y47 PKIDVYHYDVDIKPE
T108 DRIDMEVTLPGEGKD
Y328 GQEQKHTYLPLEVCN
T503-p MFKHLKMtYVGLQLI
T518 VVILPGKTPVYAEVk
K525-ub TPVYAEVkRVGDTLL
K542-ac ATQCVQVkNVVKTSP
K542-ub ATQCVQVkNVVKTSP
K562-ac LCLKMNAkLGGINNV
S798 TYVRCTRSVSIPAPA
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.