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Ago4 (human)

Overview Ago4 Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B. Belongs to the argonaute family. Ago subfamily. Note: This description may include information from UniProtKB. Protein type: Translation initiation; Translation Cellular Component: cytosol Molecular Function: protein binding; RNA binding Biological Process: Notch signaling pathway; mRNA catabolic process; miRNA-mediated gene silencing, negative regulation of translation; gene expression Reference #:  Q9HCK5 (UniProtKB) Alt. Names/Synonyms: AGO4; argonaute 4; Argonaute4; eIF-2C 4; eIF2C 4; EIF2C4; Eukaryotic translation initiation factor 2C 4; eukaryotic translation initiation factor 2C, 4; hAgo4; KIAA1567; Protein argonaute-4 Gene Symbols: EIF2C4 Molecular weight: 97,097 Da Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Ago4

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S11-p	LGPGPPAsLFQPPRR
0	1		Y47-p	PKIDVYHyDVDIKPE
0	3		Y328-p	GQEQKHTyLPLEVCN
0	1		T503	MFKHLKMTYVGLQLI
0	1		T518-p	VVILPGKtPVYAEVk
0	2		K525-u	tPVYAEVkRVGDTLL
0	1		K542	ATQCVQVKNVVKTSP
0	1		K542	ATQCVQVKNVVKTSP
0	1		K562	LCLKINAKLGGINNV
0	1		S798-p	TYVRCTRsVSIPAPA

	mouse
S11	LGPGPPASLFQPPRR
Y47	PKIDVYHYDVDIKPE
Y328	GQEQKHTYLPLEVCN
T503-p	MFKHLKMtYVGLQLI
T518	VVILPGKTPVYAEVk
K525-u	TPVYAEVkRVGDTLL
K542-a	ATQCVQVkNVVKTSP
K542-u	ATQCVQVkNVVKTSP
K562-a	LCLKMNAkLGGINNV
S798	TYVRCTRSVSIPAPA

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