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Protein Page:
JMJD2A (human)

Overview
JMJD2A Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. Interacts with histone deacetylase proteins HDAC1, HDAC2 and HDAC3. Interacts with RB and NCOR1. Interacts with HTLV-1 Tax protein. Ubiquitous. Belongs to the JHDM3 histone demethylase family. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; EC 1.14.11.-; Demethylase; Transcription, coactivator/corepressor
Cellular Component: nucleus
Molecular Function: protein binding; zinc ion binding; histone demethylase activity (H3-K36 specific); ubiquitin protein ligase binding; methylated histone residue binding
Biological Process: cardiac muscle hypertrophy; histone demethylation; viral reproduction; transcription, DNA-dependent; negative regulation of transcription, DNA-dependent
Reference #:  O75164 (UniProtKB)
Alt. Names/Synonyms: JHDM3A; JmjC domain-containing histone demethylation protein 3A; JMJD2; JMJD2A; jumonji C domain-containing histone demethylase 3A; jumonji domain containing 2; jumonji domain containing 2A; Jumonji domain-containing protein 2A; KDM4A; KIAA0677; lysine (K)-specific demethylase 4A; Lysine-specific demethylase 4A
Gene Symbols: KDM4A
Molecular weight: 120,662 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

JMJD2A

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 21 T155-p WNIGRLRtILDLVEK
0 1 P360 FLKESELPPRAGNEE
0 1 S502-p VGGRLVFsGSKKKSS
0 1 S523-p SSRDSISsDSETSEP
0 1 Y547-p GVLTVHSyAKGDGRV
  mouse

 
T155 WNIGRLKTILDLVEK
T361-p LKDSGGLtPRAGSEE
S502 VGGRLVFSGSKKKSS
S523 SSQDSVSSDSETAES
Y547 GVLTVHSYARGDGKA
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