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JMJD2A (human)

Overview JMJD2A Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. Interacts with histone deacetylase proteins HDAC1, HDAC2 and HDAC3. Interacts with RB and NCOR1. Interacts with HTLV-1 Tax protein. Ubiquitous. Belongs to the JHDM3 histone demethylase family. Note: This description may include information from UniProtKB. Protein type: Transcription, coactivator/corepressor; Oxidoreductase; Demethylase; EC 1.14.11.- Cellular Component: centrosome; cytoplasm; nucleolus; nucleus Molecular Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; protein binding; zinc ion binding; histone demethylase activity (H3-K36 specific); ubiquitin protein ligase binding; methylated histone residue binding Biological Process: histone demethylation; transcription, DNA-dependent; virus-host interaction; negative regulation of transcription, DNA-dependent Reference #:  O75164 (UniProtKB) Alt. Names/Synonyms: JHDM3A; JmjC domain-containing histone demethylation protein 3A; JMJD2; JMJD2A; jumonji C domain-containing histone demethylase 3A; jumonji domain containing 2; jumonji domain containing 2A; Jumonji domain-containing protein 2A; KDM4A; KIAA0677; lysine (K)-specific demethylase 4A; Lysine-specific demethylase 4A Gene Symbols: KDM4A Molecular weight: 120,662 Da Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states CST Pathways:  Histone Methylation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below JMJD2A 2GF7 - A/B/C/D=895-1011 (human) 2GFA - A/B=895-1011 (human) 2GP3 - A/B=2-350 (human) 2GP5 - A/B=2-350 (human) 2OQ6 - A/B=1-359 (human) 2OQ7 - A/B=1-359 (human) 2OS2 - A/B=1-359 (human) 2OT7 - A/B=1-359 (human) 2OX0 - A/B=1-359 (human) 2P5B - A/B=1-350 (human) 2PXJ - A/B=2-348 (human) 2Q8C - A/B=1-350 (human) 2Q8D - A/B=1-350 (human) 2Q8E - A/B=1-350 (human) 2QQR - A/B=897-1011 (human) 2QQS - A/B=897-1011 (human) 2VD7 - A/B=1-359 (human) 2WWJ - A/B=7-353 (human) 2YBK - A/B=1-359 (human) 2YBP - A/B=1-359 (human) 2YBS - A/B=1-359 (human) 3NJY - A/B=1-359 (human) 3PDQ - A/B=1-359 (human) 3RVH - A/B=1-359 (human) 3U4S - A/B=1-359 (human) 4AI9 - A/B=1-359 (human) 4GD4 - A/B=1-359 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2GF7 2GFA 2GP3 2GP5 2OQ6 2OQ7 2OS2 2OT7 2OX0 2P5B 2PXJ 2Q8C 2Q8D 2Q8E 2QQR 2QQS 2VD7 2WWJ 2YBK 2YBP 2YBS 3NJY 3PDQ 3RVH 3U4S 4AI9 4GD4  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T7-p	_MASESEtLNPsARI
0	1		S11-p	ESEtLNPsARIMtFY
0	1		T16-p	NPsARIMtFYPTMEE
0	21		T155-p	WNIGRLRtILDLVEK
0	1		K241-a	CEAFLRHkMTLISPL
0	1		K251-a	LISPLMLkKYGIPFD
0	1		S307	GKQAVLCSCRKDMVK
0	1		P360	FLKESELPPRAGNEE
0	1		S502-p	VGGRLVFsGSkKKSS
0	1		K505-a	RLVFsGSkKKSSSSL
0	1		Y547-p	GVLTVHSyAKGDGRV
0	1		T732	PYLEEDGTSILVSCK
0	1		S733	YLEEDGTSILVSCKK
0	1		Y1059-p	DYIEPALyRAIME__

	mouse
T7	_MASESETLNPSARI
S11	ESETLNPSARIMTFY
T16	NPSARIMTFYPTMEE
T155	WNIGRLKTILDLVEK
K241	CEAFLRHKMTLISPL
K251	LISPLMLKKYGIPFD
S307-p	GKQAVLCsCRKDMVK
T361-p	LKDSGGLtPRAGSEE
S502	VGGRLVFSGSKKKSS
K505	RLVFSGSKKKSSSSL
Y547	GVLTVHSYARGDGKA
T732-p	PYLEEDGtsMLVSCK
S733-p	YLEEDGtsMLVSCKK
Y1059	DYIEPALYRAIME__

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