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Protein Page:
TBP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TBP General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Binds DNA as monomer. Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B TAF1C and TAF1D. Association of TBP to form either TFIID or SL1/TIF-IB appears to be mutually exclusive. Interacts with TAF1A, TAF1B and TAF1C. Interacts with TFIIB, NCOA6, DRAP1, DR1 and ELF3. Interacts with SPIB, SNAPC1, SNAPC2 and SNAPC4. Interacts with UTF1. Interacts with BRF2. Interacts with UBTF. Interacts with GPBP1. Interacts with CITED2. Interacts with ATF7IP. Interacts with HIV-1 Tat. Widely expressed, with levels highest in the testis and ovary. Belongs to the TBP family. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; DNA binding protein; Transcription initiation complex
Chromosomal Location of Human Ortholog: 6q27
Cellular Component: nucleoplasm; transcription factor TFIID complex; male pronucleus; cytoplasm; female pronucleus; transcription factor TFIIA complex
Molecular Function: protein binding; transcription factor binding
Biological Process: transcription from RNA polymerase II promoter; cell death; transcription initiation from RNA polymerase II promoter; viral reproduction; positive regulation of transcription, DNA-dependent; RNA elongation from RNA polymerase I promoter; transcription from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription from RNA polymerase III promoter; RNA elongation from RNA polymerase II promoter; gene expression; spermatogenesis; transcription initiation from RNA polymerase I promoter
Reference #:  P20226 (UniProtKB)
Alt. Names/Synonyms: GTF2D; GTF2D1; MGC117320; MGC126054; MGC126055; SCA17; TATA box binding protein; TATA sequence-binding protein; TATA-binding factor; TATA-box binding protein N-terminal domain; TATA-box factor; TATA-box-binding protein; TBP; TF2D; TFIID; Transcription initiation factor TFIID TBP subunit
Gene Symbols: TBP
Molecular weight: 37,698 Da
Basal Isoelectric point: 9.8  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TBP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K181-ub LGCKLDLktIALRAR
0 1 T182-p GCKLDLktIALRARN
0 1 K243-ub KYARVVQkLGFPAkF
0 2 K249-ub QkLGFPAkFLDFKIQ
0 1 S261-p KIQNMVGsCDVKFPI
0 1 Y322-p AKVRAEIyEAFENIy
0 2 Y329-p yEAFENIyPILkGFR
0 4 K333-ub ENIyPILkGFRKTT_
  mouse

► Hide Isoforms
 
K158 LGCKLDLKTIALRAR
T159 GCKLDLKTIALRARN
K220 KYARVVQKLGFPAKF
K226 QKLGFPAKFLDFKIQ
S238 KIQNMVGSCDVKFPI
Y299 AKVRAEIYEAFENIY
Y306 YEAFENIYPILkGFR
K310-ub ENIYPILkGFRKTT_
  TBP iso2  
K158 LGCKLDLKTIALRAR
T159 GCKLDLKTIALRARN
- gap
- gap
- gap
Y243 AKVRAEIYEAFENIY
Y250 YEAFENIYPILKGFR
K254 ENIYPILKGFRKTT_
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