Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
TEC (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TEC a non-receptor protein-tyrosine kinases of the Tec family. Containing a pleckstrin homology domain. Involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. May be an important signal transducer for cell division and/or for differentiation in the liver system. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (non-receptor); Protein kinase, TK; EC 2.7.10.2; Kinase, protein; TK group; Tec family
Cellular Component: cytoskeleton; plasma membrane; cytosol
Molecular Function: metal ion binding; non-membrane spanning protein tyrosine kinase activity; lipid binding; ATP binding
Biological Process: integrin-mediated signaling pathway; B cell receptor signaling pathway; peptidyl-tyrosine phosphorylation; tissue regeneration; innate immune response; protein amino acid phosphorylation
Reference #:  P42680 (UniProtKB)
Alt. Names/Synonyms: MGC126760; MGC126762; PSCTK4; TEC; tec protein tyrosine kinase; Tyrosine-protein kinase Tec
Gene Symbols: TEC
Molecular weight: 73,581 Da
Basal Isoelectric point: 8.69  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TEC

Protein Structure Not Found.


STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
phosphorylation: Y519‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K51-u RAEKKYRkGFIDVSK
0 1 S129-p PKFWTDGsyQCCRQT
0 1 Y130-p KFWTDGsyQCCRQTE
0 5 K155-u LFESSIRkALPPAPE
1 1 Y206-p RLERGQEyLILEKND
0 6 Y228-p DKYGNEGyIPSNyVT
0 3 Y233-p EGyIPSNyVTGKKSN
0 1 S378-p TFMRELGsGLFGVVR
1 337 Y519-p RYVLDDQytSSSGAK
0 3 T520-p YVLDDQytSSSGAKF
0 1 Y572 PFEKYTNYEVVTMVT
  mouse

 
K51 RAEKKYRKGVIDISK
S129 PKFWADGSYQCCRQT
Y130 KFWADGSYQCCRQTE
K155 LFESSIRKTLPPAPE
Y205 RLERGQEYIILEKND
Y227 DKYGSEGYIPSNYVT
Y232 EGYIPSNYVTGKKSN
S377 TFMRELGSGLFGVVR
Y518-p RYVLDDQytSSSGAK
T519-p YVLDDQytSSSGAKF
Y571-p PFEKNTNyEVVTMVT
  rat

 
- gap
S53 PKFWADGSYQCCRQT
Y54 KFWADGSYQCCRQTE
K79 LFESSIRKTLPPAPE
Y128 RLERGQKYIILEKND
Y150 DKYGSEGYIPSNYVT
Y155 EGYIPSNYVTGKKSN
S300 TFMRELGSGLFGVVR
Y441-p RYVLDDQyTSSSGAK
T442 YVLDDQyTSSSGAKF
Y494 PFEKNTNYEVVTMVT
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.