a non-receptor protein-tyrosine kinases of the Tec family. Containing a pleckstrin homology domain. Involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. May be an important signal transducer for cell division and/or for differentiation in the liver system. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; EC 126.96.36.199; Protein kinase, tyrosine (non-receptor); Kinase, protein; TK group; Tec family
Chromosomal Location of Human Ortholog: 4p12
Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; intercellular junction; cytosol
Molecular Function: protein binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; lipid binding; ATP binding; receptor binding
Biological Process: integrin-mediated signaling pathway; B cell receptor signaling pathway; adaptive immune response; tissue regeneration; innate immune response; cell differentiation; T cell receptor signaling pathway; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.