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Protein Page:
TEC (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TEC a non-receptor protein-tyrosine kinases of the Tec family. Containing a pleckstrin homology domain. Involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. May be an important signal transducer for cell division and/or for differentiation in the liver system. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Kinase, protein; EC 2.7.10.2; TK group; Tec family
Cellular Component: cytoskeleton; plasma membrane; cytosol
Molecular Function: protein binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; lipid binding; ATP binding
Biological Process: integrin-mediated signaling pathway; B cell receptor signaling pathway; peptidyl-tyrosine phosphorylation; tissue regeneration; innate immune response; protein amino acid phosphorylation
Reference #:  P42680 (UniProtKB)
Alt. Names/Synonyms: MGC126760; MGC126762; PSCTK4; TEC; tec protein tyrosine kinase; Tyrosine-protein kinase Tec
Gene Symbols: TEC
Molecular weight: 73,581 Da
Basal Isoelectric point: 8.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TEC

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: Y519‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K51-ub RAEKKYRkGFIDVSK
0 1 T88-p QVVHDANtLyIFAPS
0 1 Y90-p VHDANtLyIFAPSPQ
0 1 Y120-p NNNIMIKyHPKFWTD
0 1 S129-p PKFWTDGsyQCCRQT
0 1 Y130-p KFWTDGsyQCCRQTE
0 5 K155-ub LFESSIRkALPPAPE
1 1 Y188-p EEIVVAMyDFQAAEG
1 1 Y206-p RLERGQEyLILEKND
0 1 Y223-p WWRARDKyGNEGyIP
0 6 Y228-p DKyGNEGyIPSNyVT
0 3 Y233-p EGyIPSNyVTGKKSN
0 1 K311 ETTTSPKKYYLAEKH
0 1 Y343-p GLVTRLRyPVSVKGK
0 1 Y360-p PTTAGFSyEKWEINP
0 1 S378-p TFMRELGsGLFGVVR
2 336 Y519-p RYVLDDQytSSSGAK
0 4 T520-p YVLDDQytSSSGAKF
0 1 Y572 PFEKYTNYEVVTMVT
  mouse

 
K51 RAEKKYRKGVIDISK
T88 QVVHDANTLYIFAPS
Y90 VHDANTLYIFAPSPQ
Y120 NNNIMIKYHPKFWAD
S129 PKFWADGSYQCCRQT
Y130 KFWADGSYQCCRQTE
K155 LFESSIRKTLPPAPE
Y187 EEIVVAMYDFQATEA
Y205 RLERGQEYIILEKND
Y222 WWRARDKYGSEGYIP
Y227 DKYGSEGYIPSNYVT
Y232 EGYIPSNYVTGKKSN
K310-ac ETATSPKkYYLAEKH
Y342 GLVTRLRYPVSTKGK
Y359 PTTAGFSYDKWEINP
S377 TFMRELGSGLFGVVR
Y518-p RYVLDDQytSSSGAK
T519-p YVLDDQytSSSGAKF
Y571-p PFEKNTNyEVVTMVT
  rat

 
- gap
T12 SRCSDANTLYIFAPS
Y14 CSDANTLYIFAPSPQ
Y44 NNNIMIKYHPKFWAD
S53 PKFWADGSYQCCRQT
Y54 KFWADGSYQCCRQTE
K79 LFESSIRKTLPPAPE
Y110 EEIVVAMYDFQATEA
Y128 RLERGQKYIILEKND
Y145 RWRARDKYGSEGYIP
Y150 DKYGSEGYIPSNYVT
Y155 EGYIPSNYVTGKKSN
K233 ETATSPKKYYLAKKH
Y265 GLVTRLRYPVSTKGK
Y282 PTTAGFSYDKWEINP
S300 TFMRELGSGLFGVVR
Y441-p RYVLDDQyTSSSGAK
T442 YVLDDQyTSSSGAKF
Y494 PFEKNTNYEVVTMVT
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