Home

TEC (human)

Overview TEC a non-receptor protein-tyrosine kinases of the Tec family. Containing a pleckstrin homology domain. Involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. May be an important signal transducer for cell division and/or for differentiation in the liver system. Note: This description may include information from UniProtKB. Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tec family Cellular Component: cytoskeleton; cytoplasm; plasma membrane; cytosol Molecular Function: metal ion binding; non-membrane spanning protein tyrosine kinase activity; phospholipid binding; ATP binding Biological Process: integrin-mediated signaling pathway; B cell receptor signaling pathway; protein kinase cascade; protein amino acid phosphorylation Reference #:  P42680 (UniProtKB) Alt. Names/Synonyms: MGC126760; MGC126762; PSCTK4; TEC; tec protein tyrosine kinase; Tyrosine-protein kinase Tec Gene Symbols: TEC Molecular weight: 73,581 Da Basal Isoelectric point: 8.69  Predict pI for various phosphorylation states CST Pathways:  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TEC 2LUL - A=1-154 (human) 1GL5 - A=181-244 (mouse)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
phosphorylation: Y519‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K51-u	RAEKKYRkGFIDVSK
0	1		T88-p	QVVHDANtLyIFAPS
0	1		Y90-p	VHDANtLyIFAPSPQ
0	1		Y120-p	NNNIMIKyHPKFWTD
0	5		K155-u	LFESSIRkALPPAPE
0	1		Y188-p	EEIVVAMyDFQAAEG
1	1		Y206-p	RLERGQEyLILEKND
0	1		Y223-p	WWRARDKyGNEGyIP
0	6		Y228-p	DKyGNEGyIPSNyVT
0	3		Y233-p	EGyIPSNyVTGKKSN
0	1		Y281-p	DSSQPGLyTVSLyTK
0	1		Y286-p	GLyTVSLyTKFGGEG
0	1		K311	ETTTSPKKYYLAEKH
0	1		Y343-p	GLVTRLRyPVSVKGK
0	1		Y360-p	PTTAGFSyEKWEINP
1	333		Y519-p	RYVLDDQytSSSGAK
0	3		T520-p	YVLDDQytSSSGAKF
0	1		Y572	PFEKYTNYEVVTMVT

	mouse
K51	RAEKKYRKGVIDISK
T88	QVVHDANTLYIFAPS
Y90	VHDANTLYIFAPSPQ
Y120	NNNIMIKYHPKFWAD
K155	LFESSIRKTLPPAPE
Y187	EEIVVAMYDFQATEA
Y205	RLERGQEYIILEKND
Y222	WWRARDKYGSEGYIP
Y227	DKYGSEGYIPSNYVT
Y232	EGYIPSNYVTGKKSN
Y280	DSSQPGLYTVSLYTK
Y285	GLYTVSLYTKFGGEG
K310-a	ETATSPKkYYLAEKH
Y342	GLVTRLRYPVSTKGK
Y359	PTTAGFSYDKWEINP
Y518-p	RYVLDDQyTSSSGAK
T519	YVLDDQyTSSSGAKF
Y571-p	PFEKNTNyEVVTMVT

	rat
-	gap
T12	SRCSDANTLYIFAPS
Y14	CSDANTLYIFAPSPQ
Y44	NNNIMIKYHPKFWAD
K79	LFESSIRKTLPPAPE
Y110	EEIVVAMYDFQATEA
Y128	RLERGQKYIILEKND
Y145	RWRARDKYGSEGYIP
Y150	DKYGSEGYIPSNYVT
Y155	EGYIPSNYVTGKKSN
Y203	DSSQPGLYTVSLYTK
Y208	GLYTVSLYTKFGGEG
K233	ETATSPKKYYLAKKH
Y265	GLVTRLRYPVSTKGK
Y282	PTTAGFSYDKWEINP
Y441-p	RYVLDDQyTSSSGAK
T442	YVLDDQyTSSSGAKF
Y494	PFEKNTNYEVVTMVT

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.