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TRPV4
a non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Channel, cation |
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Cellular Component: cortical actin cytoskeleton; growth cone; focal adhesion; adherens junction; lamellipodium; cytoplasmic microtubule; plasma membrane; integral to membrane; filopodium; cilium
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Molecular Function: calmodulin binding; actin filament binding; protein kinase C binding; osmosensor activity; calcium channel activity; microtubule binding; beta-tubulin binding; cation channel activity; SH2 domain binding; actin binding; protein kinase binding; alpha-tubulin binding
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Biological Process: cell death; intercellular junction assembly; actin filament organization; regulation of response to osmotic stress; cellular calcium ion homeostasis; osmosensory signaling pathway; vasopressin secretion; positive regulation of microtubule depolymerization; elevation of cytosolic calcium ion concentration; hyperosmotic salinity response; response to mechanical stimulus; calcium ion transport; actin cytoskeleton reorganization; cell volume homeostasis; cortical microtubule organization and biogenesis; microtubule polymerization
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Reference #:
Q9HBA0 (UniProtKB)
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| Alt. Names/Synonyms: CMT2C; HMSN2C; Osm-9-like TRP channel 4; OSM9-like transient receptor potential channel 4; osmosensitive transient receptor potential channel 4; OTRPC4; SPSMA; Transient receptor potential cation channel subfamily V member 4; transient receptor potential cation channel, subfamily V, member 4; Transient receptor potential protein 12; TRP12; TRPV4; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; vanilloid receptor-related osmotically activated channel; Vanilloid receptor-related osmotically-activated channel; VR-OAC; VRL-2; VRL2; VROAC |
| Gene Symbols: TRPV4 |
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Molecular weight: 98,281 Da
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Basal Isoelectric point: 7.83
Predict pI for various phosphorylation states
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