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Protein Page:
SHANK2 iso4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SHANK2 iso4 Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. Defects in SHANK2 are a cause of susceptibility to autism type 17 (AUTS17). Autism is a complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. Belongs to the SHANK family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: neuron projection; photoreceptor inner segment; brush border membrane; postsynaptic density; dendritic spine; postsynaptic membrane; photoreceptor outer segment; growth cone; cell soma; apical plasma membrane; neurofilament; plasma membrane; ionotropic glutamate receptor complex; cell junction
Molecular Function: ionotropic glutamate receptor binding; protein binding; GKAP/Homer scaffold activity; SH3 domain binding
Biological Process: synaptogenesis; adult behavior; learning; social behavior
Reference #:  Q9UPX8-4 (UniProtKB)
Alt. Names/Synonyms: cortactin SH3 domain-binding protein; Cortactin-binding protein 1; CORTBP1; CTTNBP1; GKAP/SAPAP interacting protein; KIAA1022; proline-rich synapse associated protein 1; Proline-rich synapse-associated protein 1; PROSAP1; SH3 and multiple ankyrin repeat domains 2; SH3 and multiple ankyrin repeat domains protein 2; SHAN2; SHANK; SHANK2; SPANK-3
Gene Symbols: SHANK2
Molecular weight: 134,931 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
Select Structure to View Below

SHANK2 iso4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 Y19 MAQSFSDYsVGSESD
0 1 S20-p AQSFSDYsVGSESDS
0 1 S28-p VGSESDSsKEETIYD
0 1 T79-p IRFNPDAtVWVAKQR
0 1 Y101-p SLKDVLNyGLFQPAS
0 1 T202-p ETGETPLtLAAQLDD
0 2 S420-p APRVLLRsNsDNNLN
0 9 S422-p RVLLRsNsDNNLNAS
0 1 S444-p STATSHRsLsPQLLQ
0 2 S446-p ATSHRsLsPQLLQQM
0 1 S455-p QLLQQMPsKPEGAAK
0 1 T463-p KPEGAAKtIGSyVPG
0 10 Y467-p AAKtIGSyVPGPRsR
0 1 S473-p SyVPGPRsRSPSLNR
1 0 S477 GPRsRSPSLNRLGGA
0 36 Y523-p PGPKRKLySAVPGRL
0 3 S610 FRHYTVGSYDSFDTS
0 1 Y611 RHYTVGSYDSFDTSS
0 4 S613 YTVGSYDSFDTSSDC
0 1 - gap
0 1 - gap
0 1 T718-p HLVLKVVtVtRNLDP
0 1 T720-p VLKVVtVtRNLDPDD
0 1 T728-p RNLDPDDtARKKAPP
0 2 T742-p PPPKRAPtTALtLRS
0 1 T746-p RAPtTALtLRSKsMT
0 2 S749 tTALtLRSKsMTSEL
0 5 S751-p ALtLRSKsMTSELEE
0 1 S779 PEEIVPASKPSRAAE
0 19 Y816-p GSDMNSVyERQGIAV
0 3 S831-p MTPTVPGsPKAPFLG
0 1 S849-p GTMRRQKsIDSRIFL
0 1 S857-p IDSRIFLsGITEEER
0 6 T860 RIFLsGITEEERQFL
0 1 T860 RIFLsGITEEERQFL
0 1 S893 DIPPPPQSVPPSPPP
0 44 Y917-p KSPTPRVyGTIKPAF
0 4 K921 PRVyGTIKPAFNQNS
0 1 K931 FNQNSAAKVSPATRs
0 1 S938-p KVSPATRsDtVAtMM
0 1 T940-p SPATRsDtVAtMMRE
0 1 T943-p TRsDtVAtMMREKGM
0 2 Y959-p FRRELDRysLDsEDL
0 17 S960-p RRELDRysLDsEDLy
0 1 S963-p LDRysLDsEDLySRN
0 55 Y967-p sLDsEDLySRNAGPQ
0 227 Y989-p GQMPENPysEVGKIA
0 14 S990-p QMPENPysEVGKIAS
0 1 K998 EVGKIASKAVyVPAK
0 9 Y1001-p KIASKAVyVPAKPAR
0 2 S1022-p KQSNVEDsPEKTCSI
0 1 T1041-p IIVKEPStSssGKSS
0 3 S1043-p VKEPStSssGKSSQG
0 3 S1044-p KEPStSssGKSSQGS
0 3 S1099-p RLEARRNsPAFLstD
0 7 S1104-p RNsPAFLstDLGDED
0 3 T1105-p NsPAFLstDLGDEDV
0 1 S1192-p SPAVPSAsSGTAGPG
0 27 Y1201-p GTAGPGNyVHPLtGR
0 1 T1206-p GNyVHPLtGRLLDPS
0 26 Y1248-p ADLNKPLyIDTKMRP
0 2 S1256-p IDTKMRPsLDAGFPT
0 1 T1265 DAGFPTVTRQNTRGP
0 2 T1269 PTVTRQNTRGPLRRQ
0 45 T1278-p GPLRRQEtENKyETD
0 9 Y1282-p RQEtENKyETDLGRD
0 3 T1284 EtENKyETDLGRDRK
0 1 T1318-p AGLLMVHtVDAtKLD
0 1 T1322-p MVHtVDAtKLDNALQ
0 1 T1355 VPEGVSETEGALQIS
0 1 S1380-p RTIVAVGsMEEAVIL
0 1 S1430-p IPDDRAAsVPALSDL
0 1 S1443-p DLVKQKKsDTPQsPs
0 6 S1448-p KKsDTPQsPsLNSSQ
0 2 S1450-p sDTPQsPsLNSSQPT
0 1 S1459-p NSSQPTNsADSKKPA
0 5 S1613-p GDVTEIKsPILSGPK
0 1 S1648-p KPGEGLDsPMGAKSA
0 2 S1666 PRSPEIMSTISGTRS
0 2 T1667 RSPEIMSTISGTRST
0 1 T1667 RSPEIMSTISGTRST
0 1 S1669 PEIMSTISGTRSTTV
0 1 T1671 IMSTISGTRSTTVTF
0 10 S1709-p SGTRRAPsPVVsPTE
0 11 S1713-p RAPsPVVsPTEMNKE
0 4 T1715 PsPVVsPTEMNKETL
0 2 S1761-p GLNPAGRsRsPsPSI
0 2 S1763-p NPAGRsRsPsPSILQ
0 1 S1765-p AGRsRsPsPSILQQP
0 1 R1841 GHRMNIERALKQLLD
  SHANK2 iso4  
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T16 GAAAVMMTGYNNGRC
Y29 RCPRNSLYSDCIIEE
T130 HLVLKVVTVTRNLDP
T132 VLKVVTVTRNLDPDD
T140 RNLDPDDTARKKAPP
T154 PPPKRAPTTALTLRS
T158 RAPTTALTLRSKSMT
S161 TTALTLRSKSMTSEL
S163 ALTLRSKSMTSELEE
S184 PEEIVPASKPSRAAE
Y221 GSDMNSVYERQGIAV
S236 MTPTVPGSPKAPFLG
S254 GTMRRQKSIDSRIFL
S262 IDSRIFLSGITEEER
T265 RIFLSGITEEERQFL
T265 RIFLSGITEEERQFL
S298 DIPPPPQSVPPSPPP
Y322 KSPTPRVYGTIKPAF
K326 PRVYGTIKPAFNQNS
K336 FNQNSAAKVSPATRS
S343 KVSPATRSDTVATMM
T345 SPATRSDTVATMMRE
T348 TRSDTVATMMREKGM
Y364 FRRELDRYSLDSEDL
S365 RRELDRYSLDSEDLy
S368 LDRYSLDSEDLySRN
Y372-p SLDSEDLySRNAGPQ
Y394-p GQMPENPySEVGKIA
S395 QMPENPySEVGKIAS
K403 EVGKIASKAVYVPAK
Y406 KIASKAVYVPAKPAR
S427 KQSNVEDSPEKTCSI
T446 IIVKEPSTSSSGKSS
S448 VKEPSTSSSGKSSQG
S449 KEPSTSSSGKSSQGS
S504 RLEARRNSPAFLSTD
S509 RNSPAFLSTDLGDED
T510 NSPAFLSTDLGDEDV
S597 SPAVPSASSGTAGPG
Y606 GTAGPGNYVHPLTGR
T611 GNYVHPLTGRLLDPS
Y653 ADLNKPLYIDTKMRP
S661 IDTKMRPSLDAGFPT
T670 DAGFPTVTRQNTRGP
T674 PTVTRQNTRGPLRRQ
T683-p GPLRRQEtENKYETD
Y687 RQEtENKYETDLGRD
T689 EtENKYETDLGRDRK
T723 AGLLMVHTVDATKLD
T727 MVHTVDATKLDNALQ
T760 VPEGVSETEGALQIS
S785 RTIVAVGSMEEAVIL
S835 IPDDRAASVPALSDL
S848 DLVKQKKSDTPQsPS
S853-p KKSDTPQsPSLNSSQ
S855 SDTPQsPSLNSSQPT
S864 NSSQPTNSADSKKPA
S1018 GDVTEIKSPILSGPK
S1053-p KPGEGLDsPMGAKSA
S1071 PRSPEIMSTISGTRS
T1072 RSPEIMSTISGTRST
T1072 RSPEIMSTISGTRST
S1074 PEIMSTISGTRSTTV
T1076 IMSTISGTRSTTVTF
S1114 SGTRRAPSPVVSPTE
S1118 RAPSPVVSPTEMNKE
T1120 PSPVVSPTEMNKETL
S1166 GLNPAGRSRSPSPSI
S1168 NPAGRSRSPSPSILQ
S1170 AGRSRSPSPSILQQP
R1246 GHRMNIERALKQLLD
  SHANK2 iso7  
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- gap
T16 GAAAVMMTGYNNGRC
Y29 RCPRNSLYSDCIIEE
T130 HLVLKVVTVTRNLDP
T132 VLKVVTVTRNLDPDD
T140 RNLDPDDTARKKAPP
T154 PPPKRAPTTALTLRS
T158 RAPTTALTLRSKsMT
S161 TTALTLRSKsMTSEL
S163-p ALTLRSKsMTSELEE
S181 PEEIVPASKPSRAAE
Y218 GSDMNSVYERQGIAV
S233 MTPTVPGSPKAPFLG
S251 GTMRRQKSIGKKCGT
- gap
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- gap
- gap
- gap
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- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

► Hide Isoforms
 
- gap
- gap
- gap
- gap
- gap
- gap
S41-p APRVLLRsNsDNNLN
S43-p RVLLRsNsDNNLNAG
S65 SAATSHRSLsPQLLQ
S67-p ATSHRSLsPQLLQQT
S76 QLLQQTPSKPDGATK
S84 KPDGATKSLGSYTPG
Y88 ATKSLGSYTPGPRSR
S94 SYTPGPRSRSPSLNR
S98 GPRSRSPSLNRLGGT
Y144-p PGPRRKLySAVPGRL
S231-p FRHYTVGsyDsFDAA
Y232-p RHYTVGsyDsFDAAS
S234-p YTVGsyDsFDAASDC
- gap
- gap
T339 HLILKVVTVTRNLDP
T341 ILKVVTVTRNLDPDD
T349 RNLDPDDTARKKAPP
T363-p PPPKRAPtTALtLRs
T367-p RAPtTALtLRsKsMT
S370-p tTALtLRsKsMTAEL
S372-p ALtLRsKsMTAELEE
S404-gl PEEIVPAsKPSRTAE
Y441 ASDVNSVYERQGIAV
S456-p MTPTVPGsPKGPFLG
S474 GTMRRQKSIDSRIFL
S482 IDSRIFLSGItEEER
T485-p RIFLSGItEEERQFL
T485-gl RIFLSGItEEERQFL
S518-p DIPPPPQsVPPSPPP
Y542-p RSPTPRVyGTIKPAF
K546 PRVyGTIKPAFNQNP
K557 NQNPVVAKVPPATRS
S564 KVPPATRSDTVATMM
T566 PPATRSDTVATMMRE
T569 TRSDTVATMMREKGM
F585 YRRELDRFsLDsEDV
S586-p RRELDRFsLDsEDVy
S589-p LDRFsLDsEDVySRS
Y593-p sLDsEDVySRSPAPQ
Y615-p GQMPENPysEVGKIA
S616-p QMPENPysEVGKIAS
K624 EVGKIASKAVYVPAK
Y627 KIASKAVYVPAKPAR
S648-p KQSNVEDsPEKTCSI
T667 IIVKEPSTSSSGKSS
S669 VKEPSTSSSGKSSQG
S670 KEPSTSSSGKSSQGS
S724-p RLEARRNsPAFLstD
S729-p RNsPAFLstDLGDED
T730-p NsPAFLstDLGDEDV
S817 GPAAPLKSSSPAGPE
Y826 SPAGPENYVHPLTGR
T831 ENYVHPLTGRLLDPS
Y873 ADLNKPLYIDTKMRP
S881-p IDTKMRPsVESGFPP
T890-gl ESGFPPVtRQNtRGP
T894-p PPVtRQNtRGPLRRQ
T903-p GPLRRQEtENKYETD
Y907 RQEtENKYETDLGKD
T909 EtENKYETDLGKDRR
T943 AGLLMVHTVDVPMAG
P947 MVHTVDVPMAGPPLE
T980-gl VPEGVPKtEGALQIS
S1005-p RTIVAAGsVEEAVIL
S1055 IPDDRAASVPALADL
N1068 DLVKQKKNDTSQPPT
P1073 KKNDTSQPPTLNSSQ
T1075 NDTSQPPTLNSSQPA
S1084 NSSQPANSTDSKKPA
S1238-p GDVPEVKsPILSGPK
L1273 KPGEGLELPVGAKSA
S1291-gl PRSPEVMstVsGtRS
T1292-gl RSPEVMstVsGtRST
T1292-p RSPEVMstVsGtRST
S1294-gl PEVMstVsGtRSTTV
T1296-gl VMstVsGtRSTTVTF
S1334-p SGPRRAPsPVVsPtE
S1338-p RAPsPVVsPtELSKE
T1340-p PsPVVsPtELSKEIL
S1388 GLNPAGRSRSPSPSI
S1390 NPAGRSRSPSPSILQ
S1392 AGRSRSPSPSILQQP
R1468-m1 GHRMNIErALKQLLD
  SHANK2 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
S41 APRVLLRSNSDNNLN
S43 RVLLRSNSDNNLNAG
S65 SAATSHRSLSPQLLQ
S67 ATSHRSLSPQLLQQT
S76 QLLQQTPSKPDGATK
S84 KPDGATKSLGSYTPG
Y88 ATKSLGSYTPGPRSR
S94 SYTPGPRSRSPSLNR
S98 GPRSRSPSLNRLGGT
Y144 PGPRRKLYSAVPGRL
S231 FRHYTVGSYDSFDAA
Y232 RHYTVGSYDSFDAAS
S234 YTVGSYDSFDAASDC
- gap
- gap
T339 HLILKVVTVTRNLDP
T341 ILKVVTVTRNLDPDD
T349 RNLDPDDTARKKAPP
T363 PPPKRAPTTALTLRs
T367 RAPTTALTLRsKsMT
S370-p TTALTLRsKsMTAEL
S372-p ALTLRsKsMTAELEE
S400 PEEIVPASKPSRTAE
Y437 ASDVNSVYERQGIAV
S452 MTPTVPGSPKGPFLG
S470 GTMRRQKSIDSRIFL
S478 IDSRIFLSGITEEER
T481 RIFLSGITEEERQFL
T481 RIFLSGITEEERQFL
S514 DIPPPPQSVPPSPPP
Y538 RSPTPRVYGTIKPAF
K542 PRVYGTIKPAFNQNP
K553 NQNPVVAKVPPATRS
S560 KVPPATRSDTVATMM
T562 PPATRSDTVATMMRE
T565 TRSDTVATMMREKGM
F581 YRRELDRFSLDSEDV
S582 RRELDRFSLDSEDVY
S585 LDRFSLDSEDVYSRS
Y589 SLDSEDVYSRSPAPQ
Y611 GQMPENPYSEVGKIA
S612 QMPENPYSEVGKIAS
K620 EVGKIASKAVYVPAK
Y623 KIASKAVYVPAKPAR
S644 KQSNVEDSPEKTCSI
T663 IIVKEPSTSSSGKSS
S665 VKEPSTSSSGKSSQG
S666 KEPSTSSSGKSSQGS
S720 RLEARRNSPAFLSTD
S725 RNSPAFLSTDLGDED
T726 NSPAFLSTDLGDEDV
S813 GPAAPLKSSSPAGPE
Y822 SPAGPENYVHPLTGR
T827 ENYVHPLTGRLLDPS
Y869 ADLNKPLYIDTKMRP
S877 IDTKMRPSVESGFPP
T886 ESGFPPVTRQNTRGP
T890 PPVTRQNTRGPLRRQ
T899-p GPLRRQEtENKYETD
Y903 RQEtENKYETDLGKD
T905 EtENKYETDLGKDRR
T939 AGLLMVHTVDVPMAG
P943 MVHTVDVPMAGPPLE
T976 VPEGVPKTEGALQIS
S1001 RTIVAAGSVEEAVIL
S1051 IPDDRAASVPALADL
N1064 DLVKQKKNDTSQPPT
P1069 KKNDTSQPPTLNSSQ
T1071 NDTSQPPTLNSSQPA
S1080 NSSQPANSTDSKKPA
S1234 GDVPEVKSPILSGPK
L1269 KPGEGLELPVGAKSA
S1287 PRSPEVMSTVSGTRS
T1288 RSPEVMSTVSGTRST
T1288 RSPEVMSTVSGTRST
S1290 PEVMSTVSGTRSTTV
T1292 VMSTVSGTRSTTVTF
S1330 SGPRRAPSPVVSPTE
S1334 RAPSPVVSPTELSKE
T1336 PSPVVSPTELSKEIL
S1384 GLNPAGRSRSPSPSI
S1386 NPAGRSRSPSPSILQ
S1388 AGRSRSPSPSILQQP
R1464 GHRMNIERALKQLLD
  SHANK2 iso3  
Y19-p MAQSFSDySVGSESD
S20 AQSFSDySVGSESDS
S28 VGSESDSSKEETIYD
T79 IRFNPDATVWVAKQR
Y101 GLKDVLNYGLFQPAS
T202 ETGETPLTLAAQLDD
S420 APRVLLRSNSDNNLN
S422 RVLLRSNSDNNLNAG
S444 SAATSHRSLSPQLLQ
S446 ATSHRSLSPQLLQQT
S455 QLLQQTPSKPDGATK
S463 KPDGATKSLGSYTPG
Y467 ATKSLGSYTPGPRSR
S473 SYTPGPRSRSPSLNR
S477 GPRSRSPSLNRLGGT
Y523 PGPRRKLYSAVPGRL
S610 FRHYTVGSYDSFDAA
Y611 RHYTVGSYDSFDAAS
S613 YTVGSYDSFDAASDC
- gap
- gap
T718 HLILKVVTVTRNLDP
T720 ILKVVTVTRNLDPDD
T728 RNLDPDDTARKKAPP
T742 PPPKRAPTTALTLRS
T746 RAPTTALTLRSKSMT
S749 TTALTLRSKSMTAEL
S751 ALTLRSKSMTAELEE
S769 PEEIVPASKPSRTAE
Y806 ASDVNSVYERQGIAV
S821 MTPTVPGSPKGPFLG
S839 GTMRRQKSIDSRIFL
S847 IDSRIFLSGITEEER
T850 RIFLSGITEEERQFL
T850 RIFLSGITEEERQFL
S883 DIPPPPQSVPPSPPP
Y907 RSPTPRVYGTIKPAF
K911 PRVYGTIKPAFNQNP
K922 NQNPVVAKVPPATRS
S929 KVPPATRSDTVATMM
T931 PPATRSDTVATMMRE
T934 TRSDTVATMMREKGM
F950 YRRELDRFSLDSEDV
S951 RRELDRFSLDSEDVY
S954 LDRFSLDSEDVYSRS
Y958 SLDSEDVYSRSPAPQ
Y980 GQMPENPYSEVGKIA
S981 QMPENPYSEVGKIAS
K989 EVGKIASKAVYVPAK
Y992 KIASKAVYVPAKPAR
S1013 KQSNVEDSPEKTCSI
T1032 IIVKEPSTSSSGKSS
S1034 VKEPSTSSSGKSSQG
S1035 KEPSTSSSGKSSQGS
S1089 RLEARRNSPAFLSTD
S1094 RNSPAFLSTDLGDED
T1095 NSPAFLSTDLGDEDV
S1182 GPAAPLKSSSPAGPE
Y1191 SPAGPENYVHPLTGR
T1196 ENYVHPLTGRLLDPS
Y1238 ADLNKPLYIDTKMRP
S1246 IDTKMRPSVESGFPP
T1255 ESGFPPVTRQNTRGP
T1259 PPVTRQNTRGPLRRQ
T1268 GPLRRQETENKYETD
Y1272 RQETENKYETDLGKD
T1274 ETENKYETDLGKDRR
T1308 AGLLMVHTVDVPMAG
P1312 MVHTVDVPMAGPPLE
T1345 VPEGVPKTEGALQIS
S1370 RTIVAAGSVEEAVIL
S1420 IPDDRAASVPALADL
N1433 DLVKQKKNDTSQPPT
P1438 KKNDTSQPPTLNSSQ
T1440 NDTSQPPTLNSSQPA
S1449 NSSQPANSTDSKKPA
S1603 GDVPEVKSPILSGPK
L1638 KPGEGLELPVGAKSA
S1656 PRSPEVMSTVSGTRS
T1657 RSPEVMSTVSGTRST
T1657 RSPEVMSTVSGTRST
S1659 PEVMSTVSGTRSTTV
T1661 VMSTVSGTRSTTVTF
S1699 SGPRRAPSPVVSPTE
S1703 RAPSPVVSPTELSKE
T1705 PSPVVSPTELSKEIL
S1753 GLNPAGRSRSPSPSI
S1755 NPAGRSRSPSPSILQ
S1757 AGRSRSPSPSILQQP
R1833 GHRMNIERALKQLLD
  SHANK2 iso5  
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T15-p GAATVMMtGYNNGRY
Y28 RYPRNSLYSDCIIED
T129 HLILKVVTVTRNLDP
T131 ILKVVTVTRNLDPDD
T139 RNLDPDDTARKKAPP
T153 PPPKRAPTTALTLRs
T157 RAPTTALTLRsKsMT
S160-p TTALTLRsKsMTAEL
S162-p ALTLRsKsMTAELEE
S190 PEEIVPASKPSRTAE
Y227 ASDVNSVYERQGIAV
S242 MTPTVPGSPKGPFLG
S260 GTMRRQKSIDSRIFL
S268 IDSRIFLSGITEEER
T271 RIFLSGITEEERQFL
T271 RIFLSGITEEERQFL
S304 DIPPPPQSVPPSPPP
Y328 RSPTPRVYGTIKPAF
K332 PRVYGTIKPAFNQNP
K343 NQNPVVAKVPPATRS
S350 KVPPATRSDTVATMM
T352 PPATRSDTVATMMRE
T355 TRSDTVATMMREKGM
F371 YRRELDRFSLDSEDV
S372 RRELDRFSLDSEDVY
S375 LDRFSLDSEDVYSRS
Y379 SLDSEDVYSRSPAPQ
Y401 GQMPENPYSEVGKIA
S402 QMPENPYSEVGKIAS
K410 EVGKIASKAVYVPAK
Y413 KIASKAVYVPAKPAR
S434 KQSNVEDSPEKTCSI
T453 IIVKEPSTSSSGKSS
S455 VKEPSTSSSGKSSQG
S456 KEPSTSSSGKSSQGS
S510 RLEARRNSPAFLSTD
S515 RNSPAFLSTDLGDED
T516 NSPAFLSTDLGDEDV
S603 GPAAPLKSSSPAGPE
Y612 SPAGPENYVHPLTGR
T617 ENYVHPLTGRLLDPS
Y659 ADLNKPLYIDTKMRP
S667 IDTKMRPSVESGFPP
T676 ESGFPPVTRQNTRGP
T680 PPVTRQNTRGPLRRQ
T689 GPLRRQETENKYETD
Y693 RQETENKYETDLGKD
T695 ETENKYETDLGKDRR
T729 AGLLMVHTVDVPMAG
P733 MVHTVDVPMAGPPLE
T766 VPEGVPKTEGALQIS
S791 RTIVAAGSVEEAVIL
S841 IPDDRAASVPALADL
N854 DLVKQKKNDTPQPPT
P859 KKNDTPQPPTLNSSQ
T861 NDTPQPPTLNSSQPA
S870 NSSQPANSTDSKKPA
S1024 GDVPEVKSPILSGPK
L1059 KPGEGLELPVGAKSA
S1077 PRSPEVMSTVSGTRS
T1078 RSPEVMSTVSGTRST
T1078 RSPEVMSTVSGTRST
S1080 PEVMSTVSGTRSTTV
T1082 VMSTVSGTRSTTVTF
S1120 SGPRRAPSPVVSPTE
S1124 RAPSPVVSPTELSKE
T1126 PSPVVSPTELSKEIL
S1174 GLNPAGRSRSPSPSI
S1176 NPAGRSRSPSPSILQ
S1178 AGRSRSPSPSILQQP
R1254 GHRMNIERALKQLLD
  rat

► Hide Isoforms
 
- gap
- gap
- gap
- gap
- gap
- gap
S41 APRVLLRSNSDNNLN
S43 RVLLRSNSDNNLNAG
S65 SAATSHRSLSPQLLQ
S67 ATSHRSLSPQLLQQT
S76 QLLQQTPSKPDGATK
S84 KPDGATKSLGSyAPG
Y88-p ATKSLGSyAPGPRSR
S94 SyAPGPRSRSPSLNR
S98 GPRSRSPSLNRLGGA
Y145-p PGPRRKLySAVPGRL
S232 FRHYTVGSYDSFDAA
Y233 RHYTVGSYDSFDAAS
S235 YTVGSYDSFDAASDC
- gap
- gap
T340 HLVLKVVTVTRNLDP
T342 VLKVVTVTRNLDPDD
T350 RNLDPDDTARKKAPP
T364 PPPKRAPTTALTLRS
T368 RAPTTALTLRSKSMT
S371 TTALTLRSKSMTAEL
S373 ALTLRSKSMTAELEE
S405 PEEIVPASKPSRTAE
Y442-p ASDVNSVyERQGIAV
S457-p MTPTVPGsPKGPFLG
S475 GTMRRQKSIDSRIFL
S483 IDSRIFLSGITEEER
T486 RIFLSGITEEERQFL
T486 RIFLSGITEEERQFL
S519 DIPPPPQSVPPSPPP
Y543-p RSPTPRVyGTIkPAF
K547-ub PRVyGTIkPAFNQNP
K557-ub FNQNPVAkVPPATRS
S564 kVPPATRSDTVATMM
T566 PPATRSDTVATMMRE
T569 TRSDTVATMMREKGM
F585 YRRELDRFsLDSEDV
S586-p RRELDRFsLDSEDVy
S589 LDRFsLDSEDVySRS
Y593-p sLDSEDVySRSPAPQ
Y615-p GQMPENPysEVGKIA
S616-p QMPENPysEVGKIAS
K624-ub EVGKIASkAVyVPAK
Y627-p KIASkAVyVPAKPAR
S648-p KQSNVEDsPEKTCSI
T667 IIVKEPSTSSSGKSS
S669 VKEPSTSSSGKSSQG
S670 KEPSTSSSGKSSQGS
S724 RLEARRNSPAFLSTD
S729 RNSPAFLSTDLGDED
T730 NSPAFLSTDLGDEDV
S817 GPAAALKSSSPASPE
Y826 SPASPENYVHPLTGR
T831 ENYVHPLTGRLLDPS
Y873-p ADLNKPLyIDTKMRP
S881 IDTKMRPSVESGFPP
T890 ESGFPPVTRQNTRGP
T894 PPVTRQNTRGPLRRQ
T903 GPLRRQETENKyEtD
Y907-p RQETENKyEtDLSKD
T909-p ETENKyEtDLSKDRR
T943 AGLLMVHTVDIPVAG
P947 MVHTVDIPVAGPPLE
T980 VPEGVPKTEGALQIS
S1005 RTIVAAGSVEEAVIL
S1055 IPDDRAASVPALADL
S1068 DLVKQKKSDTPQPPS
P1073 KKSDTPQPPSLNSSQ
S1075 SDTPQPPSLNSSQPA
S1084 NSSQPANSTDSKKPA
S1238 GDVTEVKSPILSGPK
L1273 KPGEGLELPVGAKSA
S1291 PRSPEVMSTVSGTRS
T1292 RSPEVMSTVSGTRST
T1292 RSPEVMSTVSGTRST
S1294 PEVMSTVSGTRSTTV
T1296 VMSTVSGTRSTTVTF
S1334-p SGPRRAPsPVVsPTE
S1338-p RAPsPVVsPTELSKE
T1340 PsPVVsPTELSKEIL
S1386 GLNPAGRSRSPSPSI
S1388 NPAGRSRSPSPSILQ
S1390 AGRSRSPSPSILQQP
R1466 GHRMNIERALKQLLD
  SHANK2 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T15 GAATVMMTGYNNGRY
Y28-p RYPRNSLySDCIIED
T129 HLVLKVVTVTRNLDP
T131 VLKVVTVTRNLDPDD
T139 RNLDPDDTARKKAPP
T153 PPPKRAPTTALTLRS
T157 RAPTTALTLRSKsMT
S160 TTALTLRSKsMTAEL
S162-p ALTLRSKsMTAELEE
S190 PEEIVPASKPSRTAE
Y227-p ASDVNSVyERQGIAV
S242 MTPTVPGSPKGPFLG
S260 GTMRRQKSIDSRIFL
S268 IDSRIFLSGITEEER
T271 RIFLSGITEEERQFL
T271 RIFLSGITEEERQFL
S304 DIPPPPQSVPPSPPP
Y328 RSPTPRVYGTIkPAF
K332-ub PRVYGTIkPAFNQNP
K342-ub FNQNPVAkVPPATRS
S349 kVPPATRSDTVATMM
T351 PPATRSDTVATMMRE
T354 TRSDTVATMMREKGM
F370 YRRELDRFSLDSEDV
S371 RRELDRFSLDSEDVy
S374 LDRFSLDSEDVySRS
Y378-p SLDSEDVySRSPAPQ
Y400-p GQMPENPySEVGKIA
S401 QMPENPySEVGKIAS
K409-ub EVGKIASkAVYVPAK
Y412 KIASkAVYVPAKPAR
S433 KQSNVEDSPEKTCSI
T452 IIVKEPSTSSSGKSS
S454 VKEPSTSSSGKSSQG
S455 KEPSTSSSGKSSQGS
S509 RLEARRNSPAFLSTD
S514 RNSPAFLSTDLGDED
T515 NSPAFLSTDLGDEDV
S602 GPAAALKSSSPASPE
Y611 SPASPENYVHPLTGR
T616 ENYVHPLTGRLLDPS
Y658 ADLNKPLYIDTKMRP
S666 IDTKMRPSVESGFPP
T675 ESGFPPVTRQNTRGP
T679 PPVTRQNTRGPLRRQ
T688 GPLRRQETENKYETD
Y692 RQETENKYETDLSKD
T694 ETENKYETDLSKDRR
T728 AGLLMVHTVDIPVAG
P732 MVHTVDIPVAGPPLE
T765 VPEGVPKTEGALQIS
S790 RTIVAAGSVEEAVIL
S840 IPDDRAASVPALADL
S853 DLVKQKKSDTPQPPS
P858 KKSDTPQPPSLNSSQ
S860 SDTPQPPSLNSSQPA
S869 NSSQPANSTDSKKPA
S1023 GDVTEVKSPILSGPK
L1058 KPGEGLELPVGAKSA
S1076 PRSPEVMSTVSGTRS
T1077 RSPEVMSTVSGTRST
T1077 RSPEVMSTVSGTRST
S1079 PEVMSTVSGTRSTTV
T1081 VMSTVSGTRSTTVTF
S1119 SGPRRAPSPVVSPTE
S1123 RAPSPVVSPTELSKE
T1125 PSPVVSPTELSKEIL
S1171 GLNPAGRSRSPSPSI
S1173 NPAGRSRSPSPSILQ
S1175 AGRSRSPSPSILQQP
R1251 GHRMNIERALKQLLD
  SHANK2 iso7  
Y19 MAQSFSDYSVGSESD
S20 AQSFSDYSVGSESDS
S28 VGSESDSSKEETIYD
T79 IRFNPDATVWVAKQR
Y101 GLKDVLNYGLFQPAS
T202 ETGETPLTLAAQLDG
S420 APRVLLRSNSDNNLN
S422 RVLLRSNSDNNLNAG
S444 SAATSHRSLSPQLLQ
S446 ATSHRSLSPQLLQQT
S455 QLLQQTPSKPDGATK
S463 KPDGATKSLGSYAPG
Y467 ATKSLGSYAPGPRSR
S473 SYAPGPRSRSPsLNR
S477-p GPRSRSPsLNRLGGA
Y524 PGPRRKLYSAVPGRL
S611 FRHYTVGSYDSFDAA
Y612 RHYTVGSYDSFDAAS
S614 YTVGSYDSFDAASDC
- gap
- gap
T719 HLVLKVVTVTRNLDP
T721 VLKVVTVTRNLDPDD
T729 RNLDPDDTARKKAPP
T743 PPPKRAPTTALTLRS
T747 RAPTTALTLRSKSMT
S750 TTALTLRSKSMTAEL
S752 ALTLRSKSMTAELEE
S770 PEEIVPASKPSRTAE
Y807 ASDVNSVYERQGIAV
S822 MTPTVPGSPKGPFLG
S840 GTMRRQKSIDSRIFL
S848 IDSRIFLSGITEEER
T851 RIFLSGITEEERQFL
T851 RIFLSGITEEERQFL
S884 DIPPPPQSVPPSPPP
Y908 RSPTPRVYGTIKPAF
K912 PRVYGTIKPAFNQNP
K922 FNQNPVAKVPPATRS
S929 KVPPATRSDTVATMM
T931 PPATRSDTVATMMRE
T934 TRSDTVATMMREKGM
F950 YRRELDRFSLDSEDV
S951 RRELDRFSLDSEDVY
S954 LDRFSLDSEDVYSRS
Y958 SLDSEDVYSRSPAPQ
Y980 GQMPENPYSEVGKIA
S981 QMPENPYSEVGKIAS
K989 EVGKIASKAVYVPAK
Y992 KIASKAVYVPAKPAR
S1013 KQSNVEDSPEKTCSI
T1032 IIVKEPSTSSSGKSS
S1034 VKEPSTSSSGKSSQG
S1035 KEPSTSSSGKSSQGS
S1089 RLEARRNSPAFLSTD
S1094 RNSPAFLSTDLGDED
T1095 NSPAFLSTDLGDEDV
S1182 GPAAALKSSSPASPE
Y1191 SPASPENYVHPLTGR
T1196 ENYVHPLTGRLLDPS
Y1238 ADLNKPLYIDTKMRP
S1246 IDTKMRPSVESGFPP
T1255 ESGFPPVTRQNTRGP
T1259 PPVTRQNTRGPLRRQ
T1268 GPLRRQETENKYETD
Y1272 RQETENKYETDLSKD
T1274 ETENKYETDLSKDRR
T1308 AGLLMVHTVDIPVAG
P1312 MVHTVDIPVAGPPLE
T1345 VPEGVPKTEGALQIS
S1370 RTIVAAGSVEEAVIL
S1420 IPDDRAASVPALADL
S1433 DLVKQKKSDTPQPPS
P1438 KKSDTPQPPSLNSSQ
S1440 SDTPQPPSLNSSQPA
S1449 NSSQPANSTDSKKPA
S1603 GDVTEVKSPILSGPK
L1638 KPGEGLELPVGAKSA
S1656 PRSPEVMSTVSGTRS
T1657 RSPEVMSTVSGTRST
T1657 RSPEVMSTVSGTRST
S1659 PEVMSTVSGTRSTTV
T1661 VMSTVSGTRSTTVTF
S1699 SGPRRAPSPVVSPTE
S1703 RAPSPVVSPTELSKE
T1705 PSPVVSPTELSKEIL
S1751 GLNPAGRSRSPSPSI
S1753 NPAGRSRSPSPSILQ
S1755 AGRSRSPSPSILQQP
R1831 GHRMNIERALKQLLD
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