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H2BFS (human)

Overview H2BFS a core component of the nucleoosome. The nucleosome, a basic organizational unit of chromosomal DNA, is octrameric, consisting of two molecules each of histones H2B, H2A, H3, H4. The octamer wraps approximately 147 bp of DNA. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Note: This description may include information from UniProtKB. Protein type: DNA binding protein Cellular Component: nucleosome; nucleus Molecular Function: DNA binding; protein heterodimerization activity Biological Process: nucleosome assembly; defense response to bacterium Reference #:  P57053 (UniProtKB) Alt. Names/Synonyms: H2B histone family, member S; H2B/s; H2BFS; Histone H2B type F-S; Histone H2B.s Gene Symbols: H2BFS Molecular weight: 13,944 Da Basal Isoelectric point: 10.37  Predict pI for various phosphorylation states

Select Structure to View Below H2BFS

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	123		K6-a	__MPEPAkSAPAPkk
0	5		K6-m1	__MPEPAkSAPAPkk
0	61		K6-u	__MPEPAkSAPAPkk
2	358		K12-a	AkSAPAPkkGSkkAV
2	379		K13-a	kSAPAPkkGSkkAVT
2	380		K16-a	PAPkkGSkkAVTkAQ
2	369		K17-a	APkkGSkkAVTkAQk
2	356		K21-a	GSkkAVTkAQkkDGR
0	3		K21-u	GSkkAVTkAQkkDGR
2	277		K24-a	kAVTkAQkkDGRKRK
0	56		K25-a	AVTkAQkkDGRKRKR
0	3		S33-p	DGRKRKRsRkEsysV
0	4		K35-a	RKRKRsRkEsysVyV
0	7		K35-u	RKRKRsRkEsysVyV
0	94		S37-p	RKRsRkEsysVyVyk
0	13		Y38-p	KRsRkEsysVyVykV
0	12		S39-p	RsRkEsysVyVykVL
0	338		Y41-p	RkEsysVyVykVLkQ
0	431		Y43-p	EsysVyVykVLkQVH
0	2		K44-u	sysVyVykVLkQVHP
0	108		K47-u	VyVykVLkQVHPDTG
0	4		K58-a	PDTGISSkAMGIMNs
0	20		K58-u	PDTGISSkAMGIMNs
0	28		S65-p	kAMGIMNsFVNDIFE
0	15		K109-a	LLPGELAkHAVSEGT
0	107		K109-u	LLPGELAkHAVSEGT
0	6		K117-a	HAVSEGTkAVTkYTS
0	111		K117-u	HAVSEGTkAVTkYTS
0	5		K121-a	EGTkAVTkYTSAk__
0	80		K121-u	EGTkAVTkYTSAk__
0	1		K126-a	VTkYTSAk_______

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