Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
Etk (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Etk a tyrosine kinase of the Tec family. Activity is required for IL6-induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; Tec family
Cellular Component: cytosol
Molecular Function: protein binding; signal transducer activity; metal ion binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding
Biological Process: peptidyl-tyrosine phosphorylation; apoptosis; protein amino acid autophosphorylation; response to stress; mesoderm development; signal transduction; cell adhesion; protein amino acid phosphorylation; cell structure disassembly during apoptosis
Reference #:  P51813 (UniProtKB)
Alt. Names/Synonyms: BMX; BMX non-receptor tyrosine kinase; Bone marrow tyrosine kinase gene in chromosome X protein; Cytoplasmic tyrosine-protein kinase BMX; Epithelial and endothelial tyrosine kinase; ETK; Etk/Bmx cytosolic tyrosine kinase; NTK38; NTK38 tyrosine kinase; PSCTK2; PSCTK3
Gene Symbols: BMX
Molecular weight: 78,011 Da
Basal Isoelectric point: 8.7  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below

Etk

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
cell growth, altered: Y566‑p
cell motility, altered: Y40‑p
cytoskeletal reorganization: Y40‑p
enzymatic activity, induced: Y40‑p
intracellular localization: Y40‑p
molecular association, regulation: Y40‑p, Y566‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T34 KERLFVLTKTNLSyY
3 0 Y40-p LTKTNLSyYEYDKMK
1 1 Y216-p SSTSLAQyDSNSKKI
0 2 S260-p SSSEDVAsSNQKERN
0 16 Y365-p KLYLAENyCFDSIPK
0 2 K395-a LRHPVSTkANKVPDS
0 1 K413-u GNGIWELkREEITLL
2 6 Y566-p RYVLDDQyVSSVGTK
3211 : Phospho-Etk (Tyr40) Antibody
  mouse

 
T34-p KERLFVLtKTSLSYY
Y40 LtKTSLSYYEYDKMK
- gap
C235 KSEEDIACSNQLERN
Y341 KLYLAENYCFDSIPK
K371 LRHPVSTKANKVPVS
K389 GSGIWELKREEITLL
Y542 RYVLDDQYVSSVGTK
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.