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Protein Page:
Etk (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Etk a tyrosine kinase of the Tec family. Activity is required for IL6-induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Kinase, protein; EC 2.7.10.2; TK group; Tec family
Cellular Component: cytosol
Molecular Function: signal transducer activity; protein binding; metal ion binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding
Biological Process: peptidyl-tyrosine phosphorylation; apoptosis; protein amino acid autophosphorylation; response to stress; mesoderm development; signal transduction; cell adhesion; protein amino acid phosphorylation; cell structure disassembly during apoptosis
Reference #:  P51813 (UniProtKB)
Alt. Names/Synonyms: BMX; BMX non-receptor tyrosine kinase; Bone marrow tyrosine kinase gene in chromosome X protein; Cytoplasmic tyrosine-protein kinase BMX; Epithelial and endothelial tyrosine kinase; ETK; Etk/Bmx cytosolic tyrosine kinase; NTK38; NTK38 tyrosine kinase; PSCTK2; PSCTK3
Gene Symbols: BMX
Molecular weight: 78,011 Da
Basal Isoelectric point: 8.7  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below

Etk

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
cell growth, altered: Y566‑p
cell motility, altered: Y40‑p
cytoskeletal reorganization: Y40‑p
enzymatic activity, induced: Y40‑p
intracellular localization: Y40‑p
molecular association, regulation: Y40‑p, Y566‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T34 KERLFVLTKTNLSyY
3 0 Y40-p LTKTNLSyYEYDKMK
0 1 S54 KRGSRKGSIEIKKIR
0 1 K172-ac TFPDRVLkIPRAVPV
0 1 K181-ac PRAVPVLkMDAPsSS
0 1 S186-p VLkMDAPsSSTTLAQ
1 1 Y216-p SSTSLAQyDSNSKKI
0 1 S226-p NSKKIYGsQPNFNMQ
0 3 S260-p SSSEDVAssNQKERN
0 2 S261-p SSEDVAssNQKERNV
0 1 S324-p GAFMVRNsSQVGMyT
0 1 Y330-p NsSQVGMyTVSLFSk
0 1 K337-ac yTVSLFSkAVNDKkG
0 1 K343-ac SkAVNDKkGTVkHYH
0 1 K347-ac NDKkGTVkHYHVHTN
0 15 Y365-p KLYLAENyCFDSIPK
0 2 K395-ac LRHPVSTkANKVPDS
0 1 K413-ub GNGIWELkREEITLL
0 1 S425-p TLLKELGsGQFGVVQ
0 1 Y440-p LGKWKGQyDVAVKMI
2 5 Y566-p RYVLDDQyVsSVGTK
0 1 S568-p VLDDQyVsSVGTKFP
3211 : Phospho-Etk (Tyr40) Antibody
  mouse

 
T34-p KERLFVLtKTSLSYY
Y40 LtKTSLSYYEYDKMK
S54-p KRGSRKGsIEIKKIR
K172 TFPERLLKIPRAVPV
K181 PRAVPVLKMDASSSG
S186 VLKMDASSSGAILPQ
- gap
- gap
C235 KSEEDIACSNQLERN
S236 SEEDIACSNQLERNI
S300 GAFMVRNSSQMGMYT
Y306 NSSQMGMYTVSLFSK
K313 YTVSLFSKAVNDKKG
K319 SKAVNDKKGTVKHYH
K323 NDKKGTVKHYHVHTN
Y341 KLYLAENYCFDSIPK
K371 LRHPVSTKANKVPVS
K389 GSGIWELKREEITLL
N401 TLLKELGNGQFGVVQ
Y416 LGQWKGQYDVAVKMI
Y542 RYVLDDQYVSSVGTK
S544 VLDDQYVSSVGTKFP
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