a tyrosine kinase of the Tec family. Activity is required for IL6-induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); EC 220.127.116.11; TK group; Tec family
Chromosomal Location of Human Ortholog: Xp22.2
Cellular Component: extrinsic to internal side of plasma membrane; cytosol
Molecular Function: signal transducer activity; protein binding; protein-tyrosine kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding
Biological Process: adaptive immune response; B cell receptor signaling pathway; apoptosis; protein amino acid autophosphorylation; innate immune response; mesoderm development; cell adhesion; signal transduction; cell differentiation; T cell receptor signaling pathway; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; cell structure disassembly during apoptosis; regulation of cell proliferation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.