a tyrosine kinase of the Tec family. Activity is required for IL6-induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 188.8.131.52; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tec family
Cellular Component: extrinsic to internal side of plasma membrane; cytosol
Molecular Function: protein binding; signal transducer activity; metal ion binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding
Biological Process: adaptive immune response; apoptosis; protein amino acid autophosphorylation; signal transduction; T cell receptor signaling pathway; protein amino acid phosphorylation; regulation of cell proliferation; B cell receptor signaling pathway; innate immune response; mesoderm development; cell differentiation; cell adhesion; transmembrane receptor protein tyrosine kinase signaling pathway; cell structure disassembly during apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.