Home

K17 (human)

Overview K17 a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K6. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein Cellular Component: cytoplasm; intermediate filament Molecular Function: MHC class II receptor activity; protein binding; structural constituent of cytoskeleton; MHC class II protein binding Biological Process: positive regulation of hair follicle development; epidermis development; positive regulation of translation; keratinization; intermediate filament organization; morphogenesis of an epithelium; signal transduction; positive regulation of cell growth Reference #:  Q04695 (UniProtKB) Alt. Names/Synonyms: 39.1; CK-17; Cytokeratin-17; K17; K1C17; keratin 17; Keratin, type I cytoskeletal 17; Keratin-17; KRT17; PC; PC2; PCHC1 Gene Symbols: KRT17 Molecular weight: 48,106 Da Basal Isoelectric point: 4.97  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below K17

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 148069 167210 184500  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		T9	TTSIRQFTsSSsIkG
0	1		S10-p	TSIRQFTsSSsIkGs
0	1		S12	IRQFTsSSsIkGssG
0	5		S13-p	RQFTsSSsIkGssGL
0	2		K15-u	FTsSSsIkGssGLGG
0	1		S17-p	sSSsIkGssGLGGGs
0	1		S18-p	SSsIkGssGLGGGss
0	2		S24-p	ssGLGGGssRTSCRL
0	2		S25-p	sGLGGGssRTSCRLs
0	11		S32-p	sRTSCRLsGGLGAGs
0	2		G34	TSCRLsGGLGAGsCR
0	3		S39-p	sGGLGAGsCRLGSAG
2	0		S44	AGsCRLGSAGGLGST
0	1		Y69-p	SFGSGGGyGSSFGGV
0	77		Y98-p	LNDRLASyLDkVRAL
0	6		K101-u	RLASyLDkVRALEEA
0	3		Y134-p	PARDYSQyyRTIEEL
0	2		Y135-p	ARDYSQyyRTIEELQ
0	1		Q142	yRTIEELQNKILTAT
0	7		K172-u	AADDFRTkFETEQAL
0	7		Y260-p	LNEMRDQyEKMAEKN
0	2		K269-u	KMAEKNRkDAEDWFF
0	2		K278-u	AEDWFFSkTEELNRE
0	2		K297-u	SELVQSGkSEISELR
0	1		S319	IELQSQLSMKASLEG
0	1		K368-u	EQQNQEYkILLDVKT
0	9		Y384-p	LEQEIATyRRLLEGE
0	8		Y398-p	EDAHLTQykkEPVTT
0	2		K399-u	DAHLTQykkEPVTTR
0	3		K400-u	AHLTQykkEPVTTRQ
0	2		K419-u	VEEVQDGkVISSREQ

	mouse
T9-p	TTTIRQFtSSssIKG
S10	TTIRQFtSSssIKGS
S12-p	IRQFtSSssIKGSSG
S13-p	RQFtSSssIKGSSGL
K15	FtSSssIKGSSGLGG
S17	SSssIKGSSGLGGGs
S18	SssIKGSSGLGGGss
S24-p	SSGLGGGssRTSCRL
S25-p	SGLGGGssRTSCRLs
S32-p	sRTSCRLsGsLGAGs
S34-p	TSCRLsGsLGAGsCR
S39-p	sGsLGAGsCRLGsAS
S44-p	AGsCRLGsASGLGSA
Y69	SFGTGSGYGGNFGGV
Y98	LNDRLASYLDKVRAL
K101	RLASYLDKVRALEEA
Y134	PARDYSAYYHTIEDL
Y135	ARDYSAYYHTIEDLk
K142-u	YHTIEDLkNKILVAT
K172-u	AADDFRTkFETEQAL
Y260	LSEMRDQYEKMAEKN
K269	KMAEKNRKDAEDWFF
K278	AEDWFFSKTEELNRE
K297	SELVQSGKSEISELR
S319-p	IELQSQLsMKASLEG
K368	EQQNQEYKILLDVKT
Y384	LEQEIATYRRLLEGE
Y398	EDAHLTQYKPkEPVT
K399	DAHLTQYKPkEPVTT
K401-u	HLTQYKPkEPVTTRQ
K420	VEEVQDGKVISSREQ

	rat
T9	TTTIRQFTSSSSIKG
S10	TTIRQFTSSSSIKGS
S12	IRQFTSSSSIKGSSG
S13	RQFTSSSSIKGSSGL
K15	FTSSSSIKGSSGLGG
S17	SSSSIKGSSGLGGGS
S18	SSSIKGSSGLGGGSS
S24	SSGLGGGSSRTSCRL
S25	SGLGGGSSRTSCRLS
S32	SRTSCRLSGSLGAGS
S34	TSCRLSGSLGAGSCR
S39	SGSLGAGSCRLGSAS
S44	AGSCRLGSASGLGSA
Y69	SFGTGSGYGGNFGGV
Y98	LNDRLASYLDKVRAL
K101	RLASYLDKVRALEEA
Y134	PARDYSAYYQTIEDL
Y135	ARDYSAYYQTIEDLK
K142	YQTIEDLKNKILVAT
K172	AADDFRTKFETEQAL
Y260	LSEMRDQYEKMAEKN
K269	KMAEKNRKDAEDWFF
K278	AEDWFFSKTEELNRE
K297	SELVQSGKSEISELR
S319	IELQSQLSMKASLEG
K368	EQQNQEYKILLDVKT
Y384	LEQEIATYRRLLEGE
Y398	EDAHLTQYKPKEPVT
K399	DAHLTQYKPKEPVTT
K401	HLTQYKPKEPVTTRQ
K420	VEEVQDGKVISSREQ

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.