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Protein Page:
MEKK3 (human)

Overview
MEKK3 a protein kinase of the STE11 family. Phosphorylated and activated by MLK3 and TAK1. Phosphorylates and activates MEK5. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.25; Protein kinase, STE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family
Cellular Component: cytosol
Molecular Function: protein binding; MAP kinase kinase kinase activity; metal ion binding; ATP binding; protein kinase activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; activation of MAPKK activity; protein amino acid autophosphorylation; MAPKKK cascade
Reference #:  Q99759 (UniProtKB)
Alt. Names/Synonyms: M3K3; MAP/ERK kinase kinase 3; MAP3K3; MAPK/ERK kinase kinase 3; MAPKKK3; MEK kinase 3; MEKK 3; MEKK3; Mitogen-activated protein kinase kinase kinase 3
Gene Symbols: MAP3K3
Molecular weight: 70,898 Da
Basal Isoelectric point: 8.98  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MEKK3

Protein Structure Not Found.


STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
transcription, altered: S526‑p
enzymatic activity, induced: T516‑p, S520‑p, S526‑p
molecular association, regulation: T294‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S130-p QDRNHNSssPHSGVS
0 2 S131-p DRNHNSssPHSGVSR
0 3 S145-p RQVRIKAsQsAGDIN
0 15 S147-p VRIKAsQsAGDINTI
0 65 Y155-p AGDINTIyQPPEPRS
2 37 S166-p EPRSRHLsVssQNPG
0 2 S168-p RSRHLsVssQNPGRs
0 6 S169-p SRHLsVssQNPGRss
0 2 S175-p ssQNPGRssPPPGYV
0 9 S176-p sQNPGRssPPPGYVP
0 1 S234-p SCQSLDRsADsPSFR
0 3 S237-p SLDRsADsPSFRKSR
0 30 S250-p SRMSRAQsFPDNRQE
0 1 T274-p DKGVKGGtyPRRYHV
0 2 Y275-p KGVKGGtyPRRYHVS
1 1 T294-p DYSDGRRtFPRIRRH
0 1 S312-p LFTLVPSsRSLstNG
0 5 S316-p VPSsRSLstNGENMG
0 4 T317-p PSsRSLstNGENMGL
1 57 S337-p DPRGRLRsADsENAL
0 57 S340-p GRLRsADsENALSVQ
0 4 S355-p ERNVPTKsPsAPINW
0 1 S357-p NVPTKsPsAPINWRR
0 1 Y427-p QHERIVQyyGCLRDR
0 1 Y428-p HERIVQyyGCLRDRA
0 1 Y445-p TLTIFMEyMPGGSVK
0 1 S464-p AYGALTEsVTRKYTR
2 0 T516-p GASKRLQtICMsGTG
2 0 S520-p RLQtICMsGTGMRsV
4 1 S526-p MsGTGMRsVtGtPYW
1 0 T528-p GTGMRsVtGtPYWMS
1 0 T530-p GMRsVtGtPYWMSPE
  mouse

 
S130 QDRNHTSSSPHSGVS
S131 DRNHTSSSPHSGVSR
S145-p RQVRIKPsQsAGDIN
S147-p VRIKPsQsAGDINTI
Y155-p AGDINTIyQAPEPRS
S166-p EPRSRHLsVSsQNPG
S168 RSRHLsVSsQNPGRs
S169-p SRHLsVSsQNPGRss
S175-p SsQNPGRssPPPGYV
S176-p sQNPGRssPPPGYVP
S234 SCQSLDRSADsPSFR
S237-p SLDRSADsPSFRKSQ
S250-p SQMSRARsFPDNRKE
T274-p DKGVKGGtYPRRYHV
Y275 KGVKGGtYPRRYHVS
T294 DYNDGRRTFPRIRRH
S312-p LFTLVPSsRSLStNG
S316 VPSsRSLStNGENMG
T317-p PSsRSLStNGENMGV
S337-p DPRGRLRsADsENAL
S340-p GRLRsADsENALTVQ
S355-p ERNVPTKsPsAPINW
S357-p NVPTKsPsAPINWRR
Y427 QHERIVQYYGCLRDR
Y428 HERIVQYYGCLRDRA
Y445 ILTIFMEYMPGGSVK
S464 AYGALTESVTRKYTR
T516 GASKRLQTICMSGTG
S520 RLQTICMSGTGIRsV
S526-p MSGTGIRsVTGTPYW
T528 GTGIRsVTGTPYWMS
T530 GIRsVTGTPYWMSPE
  rat

 
S130 QDRNHTSSSPHSGVS
S131 DRNHTSSSPHSGVSR
S145 RQVRVKPSQSAGDIN
S147 VRVKPSQSAGDINTI
Y155 AGDINTIYQAPEPRS
S166 EPRSRHLSVSSQNPG
S168 RSRHLSVSSQNPGRS
S169 SRHLSVSSQNPGRSS
S175 SSQNPGRSSPPPGYV
S176 SQNPGRSSPPPGYVP
S234 SCQSLDRSADSPSFR
S237 SLDRSADSPSFRKSQ
S250 SQMSRARSFPDNRKE
T274 DKGVKGGTYPRRYHV
Y275 KGVKGGTYPRRYHVS
T294 DYNDGRRTFPRIRRH
S312 LFTLVPSSRSLSTNG
S316 VPSSRSLSTNGENMG
T317 PSSRSLSTNGENMGA
S337 DPRGRLRSADSENAL
S340 GRLRSADSENALTVQ
S355 ERSVPTKSPSAPINW
S357 SVPTKSPSAPINWRR
Y427 QHERIVQYYGCLRDR
Y428 HERIVQYYGCLRDRA
Y445 ILTIFMEYMPGGSVK
S464 AYGALTESVTRKYTR
T516 GASKRLQTICMSGTG
S520 RLQTICMSGTGMRSV
S526 MSGTGMRSVTGTPYW
T528 GTGMRSVTGTPYWMS
T530 GMRSVTGTPYWMSPE
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