Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
MEKK3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MEKK3 a protein kinase of the STE11 family. Phosphorylated and activated by MLK3 and TAK1. Phosphorylates and activates MEK5. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.25; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family
Cellular Component: cytosol
Molecular Function: protein binding; MAP kinase kinase kinase activity; metal ion binding; ATP binding; protein kinase activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; activation of MAPKK activity; protein amino acid autophosphorylation; MAPKKK cascade
Reference #:  Q99759 (UniProtKB)
Alt. Names/Synonyms: M3K3; MAP/ERK kinase kinase 3; MAP3K3; MAPK/ERK kinase kinase 3; MAPKKK3; MEK kinase 3; MEKK 3; MEKK3; Mitogen-activated protein kinase kinase kinase 3
Gene Symbols: MAP3K3
Molecular weight: 70,898 Da
Basal Isoelectric point: 8.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MEKK3

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
transcription, altered: S526‑p
enzymatic activity, induced: T516‑p, S520‑p, S526‑p
molecular association, regulation: T294‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 - gap
0 1 - gap
0 1 S130-p QDRNHNSssPHSGVS
0 2 S131-p DRNHNSssPHSGVSR
0 3 S145-p RQVRIKAsQsAGDIN
0 16 S147-p VRIKAsQsAGDINTI
0 61 Y155-p AGDINTIyQPPEPRs
0 1 S162-p yQPPEPRsRHLsVss
2 56 S166-p EPRsRHLsVssQNPG
0 2 S168-p RsRHLsVssQNPGRs
0 7 S169-p sRHLsVssQNPGRss
0 2 S175-p ssQNPGRssPPPGYV
0 11 S176-p sQNPGRssPPPGYVP
0 1 S194-p QHIARQGsYTSINSE
0 1 S234-p SCQSLDRsADsPSFR
0 4 S237-p SLDRsADsPSFRKSR
0 1 Q249 KSRMSRAQsFPDNRQ
0 36 S250-p SRMSRAQsFPDNRQE
0 1 R255 AQsFPDNRQEYSDRE
0 1 T274-p DKGVKGGtyPRRYHV
0 2 Y275-p KGVKGGtyPRRYHVS
0 1 Y288-p VSVHHKDysDGRRtF
0 1 S289-p SVHHKDysDGRRtFP
1 3 T294-p DysDGRRtFPRIRRH
0 1 S312-p LFTLVPSsRsLstNG
0 1 S314-p TLVPSsRsLstNGEN
0 5 S316-p VPSsRsLstNGENMG
0 5 T317-p PSsRsLstNGENMGL
1 60 S337-p DPRGRLRsADsENAL
0 62 S340-p GRLRsADsENALsVQ
0 1 S345-p ADsENALsVQERNVP
0 6 S355-p ERNVPTKsPsAPINW
0 2 S357-p NVPTKsPsAPINWRR
0 1 Y427-p QHERIVQyyGCLRDR
0 1 Y428-p HERIVQyyGCLRDRA
0 1 Y445-p TLTIFMEyMPGGSVK
0 1 S464-p AYGALTEsVTRKYTR
2 0 T516-p GASKRLQtICMsGTG
2 0 S520-p RLQtICMsGTGMRsV
4 1 S526-p MsGTGMRsVtGtPYW
1 0 T528-p GTGMRsVtGtPYWMS
1 0 T530-p GMRsVtGtPYWMSPE
  MEKK3 iso2  
S55-p SSSALLNsPtVTTSS
T57-p SALLNsPtVTTSSCA
S161 QDRNHNSSSPHSGVS
S162 DRNHNSSSPHSGVSR
S176 RQVRIKASQSAGDIN
S178 VRIKASQSAGDINTI
Y186 AGDINTIYQPPEPRS
S193 YQPPEPRSRHLSVSS
S197 EPRSRHLSVSSQNPG
S199 RSRHLSVSSQNPGRS
S200 SRHLSVSSQNPGRSS
S206 SSQNPGRSSPPPGYV
S207 SQNPGRSSPPPGYVP
S225 QHIARQGSYTSINSE
S265 SCQSLDRSADSPSFR
S268 SLDRSADSPSFRKSR
Q280 KSRMSRAQSFPDNRQ
S281 SRMSRAQSFPDNRQE
R286 AQSFPDNRQEYSDRE
T305 DKGVKGGTYPRRYHV
Y306 KGVKGGTYPRRYHVS
Y319 VSVHHKDYSDGRRTF
S320 SVHHKDYSDGRRTFP
T325 DYSDGRRTFPRIRRH
S343 LFTLVPSSRSLSTNG
S345 TLVPSSRSLSTNGEN
S347 VPSSRSLSTNGENMG
T348 PSSRSLSTNGENMGL
S368 DPRGRLRSADSENAL
S371 GRLRSADSENALSVQ
S376 ADSENALSVQERNVP
S386 ERNVPTKSPSAPINW
S388 NVPTKSPSAPINWRR
Y458 QHERIVQYYGCLRDR
Y459 HERIVQYYGCLRDRA
Y476 TLTIFMEYMPGGSVK
S495 AYGALTESVTRKYTR
T547 GASKRLQTICMSGTG
S551 RLQTICMSGTGMRSV
S557 MSGTGMRSVTGTPYW
T559 GTGMRSVTGTPYWMS
T561 GMRSVTGTPYWMSPE
  mouse

 
- gap
- gap
S130 QDRNHTSSSPHSGVS
S131 DRNHTSSSPHSGVSR
S145-p RQVRIKPsQsAGDIN
S147-p VRIKPsQsAGDINTI
Y155-p AGDINTIyQAPEPRS
S162 yQAPEPRSRHLsVSs
S166-p EPRSRHLsVSsQNPG
S168 RSRHLsVSsQNPGRs
S169-p SRHLsVSsQNPGRss
S175-p SsQNPGRssPPPGYV
S176-p sQNPGRssPPPGYVP
S194 QHIARQGSYTSINSE
S234 SCQSLDRSADsPSFR
S237-p SLDRSADsPSFRKSQ
R249-m1 KSQMSRArsFPDNrK
S250-p SQMSRArsFPDNrKE
R255-m1 ArsFPDNrKECSDRE
T274-p DKGVKGGtYPRRYHV
Y275 KGVKGGtYPRRYHVS
Y288 VSVHHKDYNDGRRTF
N289 SVHHKDYNDGRRTFP
T294 DYNDGRRTFPRIRRH
S312-p LFTLVPSsRSLStNG
S314 TLVPSsRSLStNGEN
S316 VPSsRSLStNGENMG
T317-p PSsRSLStNGENMGV
S337-p DPRGRLRsADsENAL
S340-p GRLRsADsENALTVQ
T345 ADsENALTVQERNVP
S355-p ERNVPTKsPsAPINW
S357-p NVPTKsPsAPINWRR
Y427 QHERIVQYYGCLRDR
Y428 HERIVQYYGCLRDRA
Y445 ILTIFMEYMPGGSVK
S464 AYGALTESVTRKYTR
T516 GASKRLQTICMSGTG
S520 RLQTICMSGTGIRsV
S526-p MSGTGIRsVTGTPYW
T528 GTGIRsVTGTPYWMS
T530 GIRsVTGTPYWMSPE
  rat

 
- gap
- gap
S130 QDRNHTSSSPHSGVS
S131 DRNHTSSSPHSGVSR
S145 RQVRVKPSQSAGDIN
S147 VRVKPSQSAGDINTI
Y155 AGDINTIYQAPEPRS
S162 YQAPEPRSRHLSVSS
S166 EPRSRHLSVSSQNPG
S168 RSRHLSVSSQNPGRS
S169 SRHLSVSSQNPGRSS
S175 SSQNPGRSSPPPGYV
S176 SQNPGRSSPPPGYVP
S194 QHIARQGSYTSINSE
S234 SCQSLDRSADSPSFR
S237 SLDRSADSPSFRKSQ
R249 KSQMSRARSFPDNRK
S250 SQMSRARSFPDNRKE
R255 ARSFPDNRKECSDRE
T274 DKGVKGGTYPRRYHV
Y275 KGVKGGTYPRRYHVS
Y288 VSVHHKDYNDGRRTF
N289 SVHHKDYNDGRRTFP
T294 DYNDGRRTFPRIRRH
S312 LFTLVPSSRSLSTNG
S314 TLVPSSRSLSTNGEN
S316 VPSSRSLSTNGENMG
T317 PSSRSLSTNGENMGA
S337-p DPRGRLRsADsENAL
S340-p GRLRsADsENALTVQ
T345 ADsENALTVQERSVP
S355 ERSVPTKSPSAPINW
S357 SVPTKSPSAPINWRR
Y427 QHERIVQYYGCLRDR
Y428 HERIVQYYGCLRDRA
Y445 ILTIFMEYMPGGSVK
S464 AYGALTESVTRKYTR
T516 GASKRLQTICMSGTG
S520 RLQTICMSGTGMRSV
S526 MSGTGMRSVTGTPYW
T528 GTGMRSVTGTPYWMS
T530 GMRSVTGTPYWMSPE
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.