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Protein Page:
MEKK3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
MEKK3 a protein kinase of the STE11 family. Phosphorylated and activated by MLK3 and TAK1. Phosphorylates and activates MEK5. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, STE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.25; STE group; STE11 family
Cellular Component: cytosol
Molecular Function: protein binding; MAP kinase kinase kinase activity; metal ion binding; ATP binding; protein kinase activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; activation of MAPKK activity; protein amino acid autophosphorylation; protein kinase cascade; MAPKKK cascade
Reference #:  Q99759 (UniProtKB)
Alt. Names/Synonyms: M3K3; MAP/ERK kinase kinase 3; MAP3K3; MAPK/ERK kinase kinase 3; MAPKKK3; MEK kinase 3; MEKK 3; MEKK3; Mitogen-activated protein kinase kinase kinase 3
Gene Symbols: MAP3K3
Molecular weight: 70,898 Da
Basal Isoelectric point: 8.98  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Regulation of Actin Dynamics  |  SAPK/JNK Signaling Cascades  |  Signaling Pathways Activating p38 MAPK
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MEKK3
Protein Structure Not Found.


STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
transcription, altered: S526‑p
enzymatic activity, induced: T516‑p, S520‑p, S526‑p
molecular association, regulation: T294‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 S130-p QDRNHNSssPHSGVS
0 2 S131-p DRNHNSssPHSGVSR
0 2 S145-p RQVRIKAsQsAGDIN
0 14 S147-p VRIKAsQsAGDINTI
0 64 Y155-p AGDINTIyQPPEPRs
0 1 S162-p yQPPEPRsRHLsVss
2 34 S166-p EPRsRHLsVssQNPG
0 2 S168-p RsRHLsVssQNPGRs
0 6 S169-p sRHLsVssQNPGRss
0 1 S175-p ssQNPGRssPPPGYV
0 8 S176-p sQNPGRssPPPGYVP
0 1 S194-p QHIARQGsYTSINSE
0 1 S234-p SCQSLDRsADsPSFR
0 3 S237-p SLDRsADsPSFRKSR
0 1 Q249 KSRMSRAQsFPDNRQ
0 27 S250-p SRMSRAQsFPDNRQE
0 1 R255 AQsFPDNRQEYSDRE
0 1 T274-p DKGVKGGtyPRRYHV
0 2 Y275-p KGVKGGtyPRRYHVS
1 0 T294-p DYSDGRRtFPRIRRH
0 1 S314-p TLVPSSRsLstNGEN
0 4 S316-p VPSSRsLstNGENMG
0 4 T317-p PSSRsLstNGENMGL
1 54 S337-p DPRGRLRsADsENAL
0 53 S340-p GRLRsADsENALSVQ
0 4 S355-p ERNVPTKsPsAPINW
0 1 S357-p NVPTKsPsAPINWRR
0 1 Y427-p QHERIVQyyGCLRDR
0 1 Y428-p HERIVQyyGCLRDRA
0 1 Y445-p TLTIFMEyMPGGSVK
0 1 S464-p AYGALTEsVTRKYTR
2 0 T516-p GASKRLQtICMsGTG
2 0 S520-p RLQtICMsGTGMRsV
4 1 S526-p MsGTGMRsVtGtPYW
1 0 T528-p GTGMRsVtGtPYWMS
1 0 T530-p GMRsVtGtPYWMSPE
  mouse

 
S130 QDRNHTSSSPHSGVS
S131 DRNHTSSSPHSGVSR
S145-p RQVRIKPsQsAGDIN
S147-p VRIKPsQsAGDINTI
Y155-p AGDINTIyQAPEPRS
S162 yQAPEPRSRHLsVSs
S166-p EPRSRHLsVSsQNPG
S168 RSRHLsVSsQNPGRs
S169-p SRHLsVSsQNPGRss
S175-p SsQNPGRssPPPGYV
S176-p sQNPGRssPPPGYVP
S194 QHIARQGSYTSINSE
S234 SCQSLDRSADsPSFR
S237-p SLDRSADsPSFRKSQ
R249-m1 KSQMSRArsFPDNrK
S250-p SQMSRArsFPDNrKE
R255-m1 ArsFPDNrKECSDRE
T274 DKGVKGGTYPRRYHV
Y275 KGVKGGTYPRRYHVS
T294 DYNDGRRTFPRIRRH
S314 TLVPSSRSLStNGEN
S316 VPSSRSLStNGENMG
T317-p PSSRSLStNGENMGV
S337-p DPRGRLRsADsENAL
S340-p GRLRsADsENALTVQ
S355-p ERNVPTKsPSAPINW
S357 NVPTKsPSAPINWRR
Y427 QHERIVQYYGCLRDR
Y428 HERIVQYYGCLRDRA
Y445 ILTIFMEYMPGGSVK
S464 AYGALTESVTRKYTR
T516 GASKRLQTICMSGTG
S520 RLQTICMSGTGIRsV
S526-p MSGTGIRsVTGTPYW
T528 GTGIRsVTGTPYWMS
T530 GIRsVTGTPYWMSPE
  rat

 
S130 QDRNHTSSSPHSGVS
S131 DRNHTSSSPHSGVSR
S145 RQVRVKPSQSAGDIN
S147 VRVKPSQSAGDINTI
Y155 AGDINTIYQAPEPRS
S162 YQAPEPRSRHLSVSS
S166 EPRSRHLSVSSQNPG
S168 RSRHLSVSSQNPGRS
S169 SRHLSVSSQNPGRSS
S175 SSQNPGRSSPPPGYV
S176 SQNPGRSSPPPGYVP
S194 QHIARQGSYTSINSE
S234 SCQSLDRSADSPSFR
S237 SLDRSADSPSFRKSQ
R249 KSQMSRARSFPDNRK
S250 SQMSRARSFPDNRKE
R255 ARSFPDNRKECSDRE
T274 DKGVKGGTYPRRYHV
Y275 KGVKGGTYPRRYHVS
T294 DYNDGRRTFPRIRRH
S314 TLVPSSRSLSTNGEN
S316 VPSSRSLSTNGENMG
T317 PSSRSLSTNGENMGA
S337 DPRGRLRSADSENAL
S340 GRLRSADSENALTVQ
S355 ERSVPTKSPSAPINW
S357 SVPTKSPSAPINWRR
Y427 QHERIVQYYGCLRDR
Y428 HERIVQYYGCLRDRA
Y445 ILTIFMEYMPGGSVK
S464 AYGALTESVTRKYTR
T516 GASKRLQTICMSGTG
S520 RLQTICMSGTGMRSV
S526 MSGTGMRSVTGTPYW
T528 GTGMRSVTGTPYWMS
T530 GMRSVTGTPYWMSPE
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