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Protein Page:
SLC7A11 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SLC7A11 Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family
Cellular Component: cytoskeleton; rough endoplasmic reticulum; integral to membrane; plasma membrane
Molecular Function: protein binding; cystine:glutamate antiporter activity
Biological Process: response to nicotine; L-glutamate transport; amino acid transport; response to toxin; ion transport; brain development; response to oxidative stress; blood coagulation; transmembrane transport; leukocyte migration
Reference #:  Q9UPY5 (UniProtKB)
Alt. Names/Synonyms: amino acid transport system xc calcium channel blocker resistance protein CCBR1; Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; CCBR1; Cystine/glutamate transporter; SLC7A11; Solute carrier family 7 member 11; solute carrier family 7, (cationic amino acid transporter, y+ system) member 11; xCT
Gene Symbols: SLC7A11
Molecular weight: 55,423 Da
Basal Isoelectric point: 9.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SLC7A11

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K4-ub ____MVRkPVVStIS
0 2 T9-p VRkPVVStISkGGyL
0 9 K12-ub PVVStISkGGyLQGN
0 171 Y15-p StISkGGyLQGNVNG
0 1 N21 GyLQGNVNGRLPsLG
0 23 S26-p NVNGRLPsLGNkEPP
0 1 K30-ub RLPsLGNkEPPGQEk
0 1 K37-ub kEPPGQEkVQLKRKV
0 2 S51-p VTLLRGVsIIIGTII
0 1 T139 LIIRPAATAVISLAF
0 3 K222-ub KGQTQNFkDAFSGRD
0 1 T364 MIHVRKHTPLPAVIV
0 5 K483-ub WFRIMSEkITRTLQI
  mouse

 
K4 ____MVRKPVVATIS
T9 VRKPVVATISKGGYL
K12 PVVATISKGGYLQGN
Y15 ATISKGGYLQGNMsG
S21-p GYLQGNMsGRLPsMG
S26-p NMsGRLPsMGDQEPP
Q30 RLPsMGDQEPPGQEK
K37 QEPPGQEKVVLKKKI
S51 ITLLRGVSIIIGTVI
T139-p LVIRPGAtAVISLAF
K222 KGQTHHFKDAFSGRD
T364-p MIHVHKHtPLPAVIV
R483 WFRRLSDRITRTLQI
  rat

 
K4 ____MVRKPVVATIS
T9 VRKPVVATISKGGYL
K12 PVVATISKGGYLQGN
Y15 ATISKGGYLQGNVSG
S21 GYLQGNVSGRLPsVG
S26-p NVSGRLPsVGDQEPP
Q30 RLPsVGDQEPPGHEK
K37 QEPPGHEKVVLKKKI
S51 ITLLRGVSIIIGTVI
T139 LVIRPGATAVISLAF
K222 KGQTHHFKDAFSGRD
T364 MIHVHKHTPLPAVIV
R483 WFRRLSDRITRTLQI
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