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Protein Page:
SLC7A11 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SLC7A11 Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. Note: This description may include information from UniProtKB.
Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: cytoskeleton; rough endoplasmic reticulum; plasma membrane; integral to membrane
Molecular Function: protein binding; cystine:glutamate antiporter activity
Biological Process: response to nicotine; L-glutamate transport; amino acid transport; response to toxin; ion transport; response to oxidative stress; brain development; blood coagulation; transmembrane transport; leukocyte migration
Reference #:  Q9UPY5 (UniProtKB)
Alt. Names/Synonyms: amino acid transport system xc calcium channel blocker resistance protein CCBR1; Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; CCBR1; Cystine/glutamate transporter; SLC7A11; Solute carrier family 7 member 11; solute carrier family 7, (cationic amino acid transporter, y+ system) member 11; xCT
Gene Symbols: SLC7A11
Molecular weight: 55,423 Da
Basal Isoelectric point: 9.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SLC7A11

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K4-u ____MVRkPVVStIS
0 1 T9-p VRkPVVStISkGGyL
0 9 K12-u PVVStISkGGyLQGN
0 150 Y15-p StISkGGyLQGNVNG
0 1 N21 GyLQGNVNGRLPsLG
0 20 S26-p NVNGRLPsLGNkEPP
0 1 K30-u RLPsLGNkEPPGQEk
0 1 K37-u kEPPGQEkVQLKRKV
0 2 S51-p VTLLRGVsIIIGTII
0 3 K222-u KGQTQNFkDAFSGRD
0 5 K483-u WFRIMSEkITRTLQI
  mouse

 
K4 ____MVRKPVVATIS
T9 VRKPVVATISKGGYL
K12 PVVATISKGGYLQGN
Y15 ATISKGGYLQGNMsG
S21-p GYLQGNMsGRLPsMG
S26-p NMsGRLPsMGDQEPP
Q30 RLPsMGDQEPPGQEK
K37 QEPPGQEKVVLKKKI
S51 ITLLRGVSIIIGTVI
K222 KGQTHHFKDAFSGRD
R483 WFRRLSDRITRTLQI
  rat

 
K4 ____MVRKPVVATIS
T9 VRKPVVATISKGGYL
K12 PVVATISKGGYLQGN
Y15 ATISKGGYLQGNVSG
S21 GYLQGNVSGRLPsVG
S26-p NVSGRLPsVGDQEPP
Q30 RLPsVGDQEPPGHEK
K37 QEPPGHEKVVLKKKI
S51 ITLLRGVSIIIGTVI
K222 KGQTHHFKDAFSGRD
R483 WFRRLSDRITRTLQI
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