Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
SPRED1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SPRED1 Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. Defects in SPRED1 are the cause of neurofibromatosis type 1-like syndrome (NFLS). It is a disorder characterized mainly by cafe au lait macules without neurofibromas or other tumor manifestations of neurofibromatosis type 1, axillary freckling, and macrocephaly. Additional clinical manifestations include Noonan-like facial dysmorphism, lipomas, learning disabilities and attention deficit-hyperactivity. Note: This description may include information from UniProtKB.
Protein type: Inhibitor protein
Cellular Component: cytoplasm; nucleolus; caveola; nucleus
Molecular Function: protein serine/threonine kinase inhibitor activity; protein binding; stem cell factor receptor binding; protein kinase binding; phosphatase binding
Biological Process: multicellular organismal development; positive regulation of DNA damage response, signal transduction by p53 class mediator; inactivation of MAPK activity
Reference #:  Q7Z699 (UniProtKB)
Alt. Names/Synonyms: EVH1/Sprouty domain containing protein; FLJ33903; hSpred1; NFLS; SPRE1; Spred-1; SPRED1; sprouty-related, EVH1 domain containing 1; Sprouty-related, EVH1 domain-containing protein 1; suppressor of Ras/MAPK activation
Gene Symbols: SPRED1
Molecular weight: 50,477 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Microtubule Dynamics
Select Structure to View Below

SPRED1

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S2-p ______MsEEtATSD
0 1 T5-p ___MsEEtATSDNDN
0 1 Y82-p MLKKDLIyNKVTPTF
0 1 S105-p KFGLTFQsPADARAF
0 1 S165 QQETVVTSEPyRSSN
0 2 Y168-p TVVTSEPyRSSNIRP
0 4 Y211-p IQSRSMEyVQRQISK
0 1 K224-m1 SKECGSLkSQNRVPL
0 13 S238-p LKSIRHVsFQDEDEI
0 1 K284 DSSIQFSKPDSKKSD
0 31 Y292-p PDSKKSDyLysCGDE
0 29 Y294-p SKKSDyLysCGDETK
0 1 S295-p KKSDyLysCGDETKL
0 1 S308-p KLSSPKDsVVFKTQP
0 1 S316-p VVFKTQPssLKIKKS
0 1 S317-p VFKTQPssLKIKKSK
1 0 Y377 LCAESMLYHCMSDSE
1 0 Y420 IVPCMCCYVPLRMCH
  mouse

 
S2 ______MSEETATSD
T5 ___MSEETATSDNDN
Y82 MLKKDLIYNKVTPTF
S105 KFGLTFQSPADARAF
S166-gl QQETVVTsEPYRSSD
Y169 TVVTsEPYRSSDIRP
Y212 IQSRSMEYVQRQISK
K225 SKECGSLKSQTRVPL
S239-p LKSIRHVsFQDEDEI
K285-ub DSSVPFSkQDSKKSD
Y293-p QDSKKSDyLyHCGDE
Y295-p SKKSDyLyHCGDETK
H296 KKSDyLyHCGDETKL
S309 KLSSLKDSVVFKTQP
P317 VVFKTQPPSLKFKSK
S318 VFKTQPPSLKFKSKR
Y377-p LCAESMLyHCMSDSE
Y420-p IVPCMCCyVPLRMCH
  rat

 
S2 ______MSEETATSD
T5 ___MSEETATSDNDN
Y82 MLKKDLIYNKVTPTF
S105 KFGLTFQSPADARAF
C166 QQETVVTCDPYRSSD
Y169 TVVTCDPYRSSDIRP
Y212 IQSRSMEYVQRQISK
K225 SKECGSLKSQARVPL
S239 LKSIRHVSFQDEDEI
K285 DSSVPFSKQDSKKSD
Y293-p QDSKKSDyFyHCGDE
Y295-p SKKSDyFyHCGDETK
H296 KKSDyFyHCGDETKL
S309 KLSSLKDSVVFKTQP
P317 VVFKTQPPSLKFKSK
S318 VFKTQPPSLKFKSKR
Y377 LCAESMLYHCMSDSE
Y420 IVPCMCCYVPLRMCH
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.