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IFNG (human)

Overview IFNG Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. Homodimer. Released primarily from activated T lymphocytes. Belongs to the type II (or gamma) interferon family. Note: This description may include information from UniProtKB. Protein type: Secreted; Membrane protein, integral; Secreted, signal peptide; Cytokine Cellular Component: extracellular space; extracellular region; external side of plasma membrane Molecular Function: interferon-gamma receptor binding; cytokine activity Biological Process: positive regulation of isotype switching to IgG isotypes; positive regulation of nitric oxide biosynthetic process; positive regulation of cell adhesion; apoptosis; positive regulation of osteoclast differentiation; positive regulation of interleukin-12 production; negative regulation of smooth muscle cell proliferation; positive regulation of interleukin-23 production; positive regulation of interleukin-6 biosynthetic process; positive regulation of killing of cells of another organism; positive regulation of interleukin-1 beta secretion; negative regulation of transcription from RNA polymerase II promoter; positive regulation of membrane protein ectodomain proteolysis; cell surface receptor linked signal transduction; positive regulation of MHC class II biosynthetic process; positive regulation of mesenchymal cell proliferation; positive regulation of T cell proliferation; cell cycle arrest; defense response to virus; regulation of the force of heart contraction; positive regulation of peptidyl-serine phosphorylation of STAT protein; response to drug; positive regulation of synaptic transmission, cholinergic; neutrophil chemotaxis; adaptive immune response; negative regulation of myelination; CD8-positive, alpha-beta T cell differentiation during immune response; unfolded protein response; cytokine and chemokine mediated signaling pathway; response to virus; defense response to protozoan; positive regulation of tumor necrosis factor production; humoral immune response; antigen processing and presentation; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of chemokine biosynthetic process; positive regulation of interleukin-12 biosynthetic process; negative regulation of interleukin-17 production; protein import into nucleus, translocation; defense response to bacterium; neutrophil apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation; cell motility; regulation of insulin secretion Reference #:  P01579 (UniProtKB) Alt. Names/Synonyms: IFG; IFI; IFN-gamma; IFNG; Immune interferon; Interferon gamma; interferon, gamma Gene Symbols: IFNG Molecular weight: 19,348 Da Basal Isoelectric point: 9.5  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IFNG 1EKU - A/B=1-161 (human) 1FG9 - A/B=24-156 (human) 1FYH - A/D=1-156 (human) 1HIG - A/B/C/D=24-161 (human) 3BES - L=24-161 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1EKU 1FG9 1FYH 1HIG 3BES  |  Phospho3D  |  DISEASE 147570 191100 607948 609135 609423 609532  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y6-p	__MKYTSyILAFQLC
0	1		Y22-p	VLGSLGCyCQDPYVK

	mouse
C6	__MNATHCILALQLF
Y21	LMAVSGCYCHGTVIE

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