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Protein Page:
FLOT1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
FLOT1 May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECM29. Belongs to the band 7/mec-2 family. Flotillin subfamily. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: signalosome; melanosome; integral to membrane; microtubule organizing center; caveola; flotillin complex; endosome; sarcolemma; lipid raft
Molecular Function: protein binding
Biological Process: axonogenesis; regulation of Rho protein signal transduction
Reference #:  O75955 (UniProtKB)
Alt. Names/Synonyms: FLOT1; flotillin 1; Flotillin-1; integral membrane component of caveolae
Gene Symbols: FLOT1
Molecular weight: 47,355 Da
Basal Isoelectric point: 7.08  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FLOT1
Protein Structure Not Found.


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Sites Implicated In
endocytosis, altered: Y160‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 S19-p VVSGFCRsPPVMVAG
0 1 K51-u NTLTLNVkSEKVYTR
0 1 K78 VKIQGQNKEMLAAAC
0 1 S128-p YKDRQKFsEQVFKVA
1 43 Y160-p DIHDDQDyLHSLGKA
0 1 K195-u GIREAKAkQEKVSAQ
0 170 Y203-p QEKVSAQyLSEIEMA
0 10 Y223-p YELKKAAyDIEVNTR
0 35 Y238-p RAQADLAyQLQVAKT
0 1 Y292-p KPAEAERyKLERLAE
1 0 S315-p QAEAEAAsVRMRGEA
0 2 Y348-p KAEAFQLyQEAAQLD
0 1 S383-p NKITLVSsGsGtMGA
0 2 S385-p ITLVSsGsGtMGAAk
0 1 T387-p LVSsGsGtMGAAkVT
0 18 K392-u sGtMGAAkVTGEVLD
0 1 S407-p ILTRLPEsVERLTGV
0 2 K422-u SISQVNHkPLRTA__
  mouse

 
S19 VVSGFCRSPPVMVAG
K51 NTLTLNVKSEKVYTR
K78-u VKIQGQNkEMLAAAC
S128 YKDRQKFSEQVFKVA
Y160 DIHDDQDYLHSLGKA
K195 GIREAKAKQEKVSAQ
C203 QEKVSAQCLSEIEMA
Y223 YELKKATYDIEVNTR
Y238 RAQADLAYQLQVAKT
Y292 KPAEAERYRLERLAE
S315 QAEAEAESVRMRGEA
Y348 KAEAFQMYQEAAQLD
S383 NKITLVSSGsGTMGA
S385-p ITLVSSGsGTMGAAk
T387 LVSSGsGTMGAAkVT
K392-u sGTMGAAkVTGEVLD
S407 ILSRLPESVERLTGV
K423-u ISQVNHNkPLRTA__
  rat

 
S19 VVSGFCRSPPVMVAG
K51 NTLTLNVKSEKVYTR
K78 VKIQGQNKEMLAAAC
S128 YKDRQKFSEQVFKVA
Y160-p DIHDDQDyLHSLGKA
K195 GIREAKAKQEKVSAQ
C203 QEKVSAQCLSEIEMA
Y223 YELKKATYDIEVNTR
Y238 RAQADLAYQLQVAKT
Y292 KPAEAERYRLERLAE
S315 QAEAEAESVRMRGEA
Y348 KAEAFQMYQEAAQLD
S383 NKITLVSSGSGTMGA
S385 ITLVSSGSGTMGAAK
T387 LVSSGSGTMGAAKVT
K392 SGTMGAAKVTGEVLD
S407 ILSRLPESVERLTGV
K423 ISQVNHNKPLRTA__
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