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Protein Page:
NRP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NRP1 The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. Homodimer, and heterodimer with NRP2. Interacts with FER. Binds PLXNB1. The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules. Belongs to the neuropilin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Cellular Component: extracellular space; growth cone; cell surface; cell soma; axon; early endosome; integral to membrane; neurofilament; plasma membrane; cytoplasmic vesicle; cytosol; receptor complex
Molecular Function: heparin binding; vascular endothelial growth factor receptor activity; protein binding; semaphorin receptor activity; cytokine binding; metal ion binding; growth factor binding; coreceptor activity
Biological Process: axon guidance; neuron migration; platelet-derived growth factor receptor signaling pathway; signal transduction; positive regulation of smooth muscle cell migration; negative regulation of axon extension involved in axon guidance; trigeminal nerve morphogenesis; positive chemotaxis; cell-cell signaling; response to wounding; dendrite development; angiogenesis; negative regulation of neuron apoptosis; cell adhesion; axonal fasciculation; hepatocyte growth factor receptor signaling pathway; axon extension involved in axon guidance; patterning of blood vessels; organ morphogenesis; positive regulation of peptidyl-tyrosine phosphorylation; cell migration during sprouting angiogenesis; positive regulation of axon extension involved in axon guidance; artery morphogenesis; nerve development; positive regulation of endothelial cell proliferation; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; retinal ganglion cell axon guidance
Reference #:  O14786 (UniProtKB)
Alt. Names/Synonyms: BDCA4; CD304; DKFZp686A03134; DKFZp781F1414; neuropilin 1; Neuropilin-1; NP1; NRP; NRP1; transmembrane receptor; Vascular endothelial cell growth factor 165 receptor; VEGF165R
Gene Symbols: NRP1
Molecular weight: 103,134 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NRP1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T30-p RNDKCGDtIKIESPG
0 1 S47-p TSPGYPHsYHPsEkC
0 1 S51-p YPHsYHPsEkCEWLI
0 1 K53-ub HsYHPsEkCEWLIQA
0 1 K106-ub FRGKFCGkIAPPPVV
0 1 K166-ub KSPGFPEkYPNSLEC
0 1 S267-p ANYSVLQsSVSEDFK
1 0 Y297-p QITASSQySTNWSAE
0 1 Y310-p AERSRLNyPENGWtP
0 1 T316-p NyPENGWtPGEDsyR
0 1 S321-p GWtPGEDsyREWIQV
0 2 Y322-p WtPGEDsyREWIQVD
0 1 T337 LGLLRFVTAVGTQGA
0 1 T341 RFVTAVGTQGAISKE
0 1 T349 QGAISKETKKKyyVK
0 2 Y353-p SKETKKKyyVKTyKI
0 1 Y354-p KETKKKyyVKTyKID
0 1 Y358-p KKyyVKTyKIDVSSN
0 1 K377 ITIKEGNKPVLFQGN
0 1 S432-p KITDYPCsGMLGMVS
0 1 T448-p LISDSQItSSNQGDR
0 2 K504 GIIIQGGKHRENKVF
0 1 S524-p IGYSNNGsDWKMIMD
0 1 T827-p PEIKIDEtGstPGYE
0 1 T827-ga PEIKIDEtGstPGYE
0 1 S829-ga IKIDEtGstPGYEGE
0 1 T830-ga KIDEtGstPGYEGEG
0 1 S844-ga GEGDKNIsRKPGNVL
0 2 S894-p GMSERNLsALENyNF
0 11 Y899-p NLsALENyNFELVDG
0 1 K908-ub FELVDGVkLKKDkLN
0 15 K913-ub GVkLKKDkLNTQSty
0 5 T919-p DkLNTQStysEA___
0 484 Y920-p kLNTQStysEA____
0 2 S921-p LNTQStysEA_____
  mouse

 
T30 RSDKCGGTIKIENPG
S47 TSPGYPHSYHPSEKC
S51 YPHSYHPSEKCEWLI
K53 HSYHPSEKCEWLIQA
K106 LWGKFCGKIAPSPVV
K166 KSPGFPEKYPNSLEC
S267 ANYSVLQSSISEDFK
Y297 QITASSQYGTNWSVE
Y310 VERSRLNYPENGWTP
T316 NYPENGWTPGEDSYK
S321 GWTPGEDSYKEWIQV
Y322 WTPGEDSYKEWIQVD
T337-p LGLLRFVtAVGtQGA
T341-p RFVtAVGtQGAISKE
T349-p QGAISKEtKKKYYVK
Y353 SKEtKKKYYVKTYRV
Y354 KEtKKKYYVKTYRVD
Y358 KKYYVKTYRVDISSN
K377-ub ISLKEGNkAIIFQGN
S432 KITDYPCSGMLGMVS
T448 LISDSQITASNQADR
K504-m1 GVIIQGGkHRENKVF
S524 IAYSNNGSDWKTIMD
T827 TEIKIDETGSTPGYE
T827 TEIKIDETGSTPGYE
S829 IKIDETGSTPGYEGE
T830 KIDETGSTPGYEGEG
S844 GEGDKNISRKPGNVL
S894-p GMSERNLsALENYNF
Y899 NLsALENYNFELVDG
K908 FELVDGVKLKKDkLN
K913-ub GVKLKKDkLNPQSNy
N919 DkLNPQSNySEA___
Y920-p kLNPQSNySEA____
S921 LNPQSNySEA_____
  rat

 
T30 RSDKCGGTIKIENPG
S47 TSPGYPHSYHPSEKC
S51 YPHSYHPSEKCEWLI
K53 HSYHPSEKCEWLIQA
K106 LWGKFCGKIAPSPVV
K166 KSPGFPEKYPNSLEC
S267 ANYSVLQSSISEDFK
Y297 QITASSQYGTNWSVE
Y310 VERSRLNYPENGWTP
T316 NYPENGWTPGEDSyR
S321 GWTPGEDSyREWIQV
Y322-p WTPGEDSyREWIQVD
T337 LGLLRFVTAVGTQGA
T341 RFVTAVGTQGAISKE
T349 QGAISKETKKKYYVK
Y353 SKETKKKYYVKTYRV
Y354 KETKKKYYVKTYRVD
Y358 KKYYVKTYRVDISSN
K377 ITLKEGNKAIIFQGN
S432 KITDYPCSGMLGMVS
T448 LISDSQITASNQGDR
K504 GVIIQGGKHRENKVF
S524 IAYSNNGSDWKMIMD
T827 TEIKIDETGSTPGYE
T827 TEIKIDETGSTPGYE
S829 IKIDETGSTPGYEEG
T830 KIDETGSTPGYEEGK
S843 GKGDKNISRKPGNVL
S893 GMSERNLSALENYNF
Y898 NLSALENYNFELVDG
K907 FELVDGVKLKKDKLN
K912 GVKLKKDKLNPQSNy
N918 DKLNPQSNySEA___
Y919-p KLNPQSNySEA____
S920 LNPQSNySEA_____
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