The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. Homodimer, and heterodimer with NRP2. Interacts with FER. Binds PLXNB1. The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules. Belongs to the neuropilin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Cellular Component: extracellular space; growth cone; cell surface; cell soma; axon; early endosome; integral to membrane; neurofilament; plasma membrane; cytoplasmic vesicle; cytosol; receptor complex
Molecular Function: heparin binding; vascular endothelial growth factor receptor activity; protein binding; semaphorin receptor activity; cytokine binding; metal ion binding; growth factor binding; coreceptor activity
Biological Process: axon guidance; neuron migration; platelet-derived growth factor receptor signaling pathway; signal transduction; positive regulation of smooth muscle cell migration; negative regulation of axon extension involved in axon guidance; trigeminal nerve morphogenesis; positive chemotaxis; cell-cell signaling; response to wounding; dendrite development; angiogenesis; negative regulation of neuron apoptosis; cell adhesion; axonal fasciculation; hepatocyte growth factor receptor signaling pathway; axon extension involved in axon guidance; patterning of blood vessels; organ morphogenesis; positive regulation of peptidyl-tyrosine phosphorylation; cell migration during sprouting angiogenesis; positive regulation of axon extension involved in axon guidance; artery morphogenesis; nerve development; positive regulation of endothelial cell proliferation; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; retinal ganglion cell axon guidance
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.