|
NRP1
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. Homodimer, and heterodimer with NRP2. Interacts with FER. Binds PLXNB1. The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules. Belongs to the neuropilin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
|
| Protein type: Membrane protein, integral; Receptor, misc. |
|
Cellular Component: cell surface; growth cone; cell soma; integral to membrane; extracellular region; neurofilament; plasma membrane; cytoplasmic vesicle; cytosol; receptor complex
|
|
Molecular Function: heparin binding; vascular endothelial growth factor receptor activity; protein binding; semaphorin receptor activity; cytokine binding; metal ion binding; growth factor binding; coreceptor activity
|
|
Biological Process: axon guidance; heart development; axonal fasciculation; hepatocyte growth factor receptor signaling pathway; platelet-derived growth factor receptor signaling pathway; signal transduction; positive regulation of smooth muscle cell migration; negative regulation of axon extension involved in axon guidance; trigeminal nerve morphogenesis; patterning of blood vessels; positive regulation of peptidyl-tyrosine phosphorylation; organ morphogenesis; sympathetic nervous system development; cell-cell signaling; dendrite development; response to wounding; positive regulation of endothelial cell proliferation; vascular endothelial growth factor receptor signaling pathway; cell adhesion
|
|
Reference #:
O14786 (UniProtKB)
|
| Alt. Names/Synonyms: BDCA4; CD304; DKFZp686A03134; DKFZp781F1414; neuropilin 1; Neuropilin-1; NP1; NRP; NRP1; transmembrane receptor; Vascular endothelial cell growth factor 165 receptor; VEGF165R |
| Gene Symbols: NRP1 |
|
Molecular weight: 103,134 Da
|
|
Basal Isoelectric point: 5.58
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
|
