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Protein Page:
ALK (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ALK a tyrosine kinase of the ALK family. Plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. Translocated and expressed as a fusion protein in anaplastic lymphoma. About one third of large-cell lymphomas are caused by a t(2;5)(p23;q35) translocation that fuses ALK to nucleophosmin (NPM1A). Other cases caused by fusions of ALK to moesin, non-muscle myosin heavy chain 9, clathrin heavy chain and other genes. Several fusions also seen in inflammatory myofibroblastic tumors, and expression has been briefly noted in a range of tumors Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; Protein kinase, tyrosine (receptor); Membrane protein, integral; Kinase, protein; EC 2.7.10.1; TK group; Alk family
Cellular Component: protein complex; integral to plasma membrane
Molecular Function: NF-kappaB-inducing kinase activity; protein binding; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: regulation of apoptosis; cell proliferation; peptidyl-tyrosine phosphorylation; activation of MAPK activity; protein amino acid autophosphorylation; neuron development; signal transduction; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; activation of NF-kappaB transcription factor
Reference #:  Q9UM73 (UniProtKB)
Alt. Names/Synonyms: ALK; ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; anaplastic lymphoma receptor tyrosine kinase; CD246; CD246 antigen; NBLST3
Gene Symbols: ALK
Molecular weight: 176,442 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ALK

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: Y1604‑p
cell growth, altered: Y1359‑p
molecular association, regulation: Y1359‑p, Y1507‑p, Y1604‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y46-p QPREPLSysRLQRKS
0 1 S47-p PREPLSysRLQRKSL
0 1 S62-p AVDFVVPsLFRVYAR
0 2 S211-p LSAAIRAsQPRLLFQ
0 1 S312-p DGPGAERsKEMPRGs
0 1 S319-p sKEMPRGsFLLLNTs
0 3 S326-p sFLLLNTsADsKHTI
0 2 S329-p LLNTsADsKHTILSP
0 1 S1075-p AMQMELQsPEyKLSK
0 50 Y1078-p MELQsPEyKLSKLRT
0 2 T1090-p LRTSTIMtDyNPNyC
1 37 Y1092-p TSTIMtDyNPNyCFA
1 92 Y1096-p MtDyNPNyCFAGKTS
0 1 K1109 TSSISDLKEVPRKNI
0 22 Y1131-p HGAFGEVyEGQVSGM
1 29 Y1278-p FGMARDIyRASyyRK
1 19 Y1282-p RDIyRASyyRKGGCA
1 19 Y1283-p DIyRASyyRKGGCAM
2 4 Y1359-p KNCPGPVyRIMTQCW
0 1 Y1401-p NTALPIEyGPLVEEE
0 1 S1481-p GHVNMAFsQSNPPSE
0 1 S1495-p ELHKVHGsRNKPTSL
0 4 T1506-p PTSLWNPtyGsWFTE
1 92 Y1507-p TSLWNPtyGsWFTEK
0 2 S1509-p LWNPtyGsWFTEKPT
0 36 Y1584-p FPCGNVNyGyQQQGL
2 25 Y1586-p CGNVNyGyQQQGLPL
0 4 T1597-p GLPLEAAtAPGAGHy
4 49 Y1604-p tAPGAGHyEDTILKS
4144 : Phospho-ALK (Tyr1078) Antibody
12127 : Phospho-ALK (Tyr1078) (D28B4) Rabbit mAb
4143 : Phospho-ALK (Tyr1096) Antibody
6962 : Phospho-ALK (Tyr1096) (D96H9) Rabbit mAb
3710 : Phospho-ALK (Tyr1278) Antibody
3983 : Phospho-ALK (Tyr1278/1282/1283) Antibody
3714 : Phospho-ALK (Tyr1282/1283) Antibody
3983 : Phospho-ALK (Tyr1278/1282/1283) Antibody
9687 : Phospho-ALK (Tyr1282/1283) (D39B2) Rabbit mAb
3714 : Phospho-ALK (Tyr1282/1283) Antibody
3983 : Phospho-ALK (Tyr1278/1282/1283) Antibody
9687 : Phospho-ALK (Tyr1282/1283) (D39B2) Rabbit mAb
3343 : Phospho-ALK (Tyr1586) Antibody
3348 : Phospho-ALK (Tyr1586) (3B4) Rabbit mAb
3341 : Phospho-ALK (Tyr1604) Antibody
  mouse

 
Y46 QPREPLSYSRLQRKS
S47 PREPLSYSRLQRKSL
S62 AVDFVVPSLFRVYAR
S216 LSSAIRASQPRLLFQ
S316 DGPEAEHSQEMPRGS
S323 SQEMPRGSFLLLNTS
S330 SFLLLNTSADSKHTI
S333 LLNTSADSKHTILSP
S1079 AMQMELQSPEyKLSK
Y1082-p MELQSPEyKLSKLRT
T1094 LRTSTIMTDyNPNyC
Y1096-p TSTIMTDyNPNyCFA
Y1100-p MTDyNPNyCFAGKTS
K1113-ac TSSISDLkEVPRKNI
Y1135 HGAFGEVYEGQVSGM
Y1282 FGMARDIYRASYYRK
Y1286 RDIYRASYYRKGGCA
Y1287 DIYRASYYRKGGCAM
Y1363 KNCPGPVYRIMTQCW
Y1405 NTALPIEYGPVVEEE
S1490 GHVNMAFSQPNPPPE
S1504 ELHKGPGSRNKPTSL
T1515 PTSLWNPTYGSWFTE
Y1516 TSLWNPTYGSWFTEK
S1518 LWNPTYGSWFTEKPA
Y1590 FPCGNVNYGYQQQGL
Y1592 CGNVNYGYQQQGLPL
A1603 GLPLEATAAPGDTML
- gap
4144 : Phospho-ALK (Tyr1078) Antibody
12127 : Phospho-ALK (Tyr1078) (D28B4) Rabbit mAb
4143 : Phospho-ALK (Tyr1096) Antibody
6962 : Phospho-ALK (Tyr1096) (D96H9) Rabbit mAb
3710 : Phospho-ALK (Tyr1278) Antibody
3983 : Phospho-ALK (Tyr1278/1282/1283) Antibody
3714 : Phospho-ALK (Tyr1282/1283) Antibody
3983 : Phospho-ALK (Tyr1278/1282/1283) Antibody
9687 : Phospho-ALK (Tyr1282/1283) (D39B2) Rabbit mAb
3714 : Phospho-ALK (Tyr1282/1283) Antibody
3983 : Phospho-ALK (Tyr1278/1282/1283) Antibody
9687 : Phospho-ALK (Tyr1282/1283) (D39B2) Rabbit mAb
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