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ALK (human)

Overview ALK a tyrosine kinase of the ALK family. Plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. Translocated and expressed as a fusion protein in anaplastic lymphoma. About one third of large-cell lymphomas are caused by a t(2;5)(p23;q35) translocation that fuses ALK to nucleophosmin (NPM1A). Other cases caused by fusions of ALK to moesin, non-muscle myosin heavy chain 9, clathrin heavy chain and other genes. Several fusions also seen in inflammatory myofibroblastic tumors, and expression has been briefly noted in a range of tumors Note: This description may include information from UniProtKB. Protein type: Protein kinase, TK; Kinase, protein; EC 2.7.10.1; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; Alk family Cellular Component: integral to plasma membrane Molecular Function: NF-kappaB-inducing kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: regulation of apoptosis; cell proliferation; activation of MAPK activity; protein amino acid autophosphorylation; neuron development; signal transduction; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; activation of NF-kappaB transcription factor Reference #:  Q9UM73 (UniProtKB) Alt. Names/Synonyms: ALK; ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; anaplastic lymphoma receptor tyrosine kinase; CD246; CD246 antigen; NBLST3; TFG/ALK Gene Symbols: ALK Molecular weight: 176,442 Da Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states CST Pathways:  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ALK 2KUP - B=1571-1589 (human) 2KUQ - A=1571-1589 (human) 2XB7 - A=1094-1407 (human) 2XBA - A=1094-1407 (human) 2YHV - A=1093-1411 (human) 2YJR - A=1093-1411 (human) 2YJS - A=1093-1411 (human) 2YS5 - B=1571-1589 (human) 2YT2 - A=1571-1589 (human) 3AOX - A=1069-1411 (human) 3L9P - A=1072-1410 (human) 3LCS - A=1072-1410 (human) 3LCT - A=1072-1410 (human) 4ANL - A=1093-1411 (human) 4ANQ - A=1093-1411 (human) 4ANS - A=1093-1411 (human) 4DCE - A/B=1078-1410 (human) 4FNW - A=1084-1410 (human) 4FNX - A=1084-1410 (human) 4FNY - A=1084-1410 (human) 4FNZ - A=1084-1410 (human) 4FOB - A=1058-1410 (human) 4FOC - A=1058-1410 (human) 4FOD - A=1078-1410 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2KUP 2KUQ 2XB7 2XBA 2YHV 2YJR 2YJS 2YS5 2YT2 3AOX 3L9P 3LCS 3LCT 4ANL 4ANQ 4ANS 4DCE 4FNW 4FNX 4FNY 4FNZ 4FOB 4FOC 4FOD  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell cycle regulation: Y1604‑p cell growth, altered: Y1359‑p molecular association, regulation: Y1359‑p, Y1507‑p, Y1604‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y46-p	QPREPLSysRLQRKS
0	1		S47-p	PREPLSysRLQRKSL
0	1		S62-p	AVDFVVPsLFRVYAR
0	1		S211-p	LSAAIRAsQPRLLFQ
0	1		S312-p	DGPGAERsKEMPRGs
0	1		S319-p	sKEMPRGsFLLLNTs
0	3		S326-p	sFLLLNTsADsKHTI
0	2		S329-p	LLNTsADsKHTILSP
0	1		S1075-p	AMQMELQsPEyKLSK
0	48		Y1078-p	MELQsPEyKLSKLRT
0	1		T1087-p	LSKLRTStIMtDyNP
0	1		T1090-p	LRTStIMtDyNPNyC
1	38		Y1092-p	TStIMtDyNPNyCFA
1	89		Y1096-p	MtDyNPNyCFAGKTS
0	1		K1109	TSSISDLKEVPRKNI
0	22		Y1131-p	HGAFGEVyEGQVSGM
1	29		Y1278-p	FGMARDIyRASyyRK
0	20		Y1282-p	RDIyRASyyRKGGCA
0	20		Y1283-p	DIyRASyyRKGGCAM
2	4		Y1359-p	KNCPGPVyRIMTQCW
0	1		Y1401-p	NTALPIEyGPLVEEE
0	5		T1506-p	PTSLWNPtyGsWFtE
1	93		Y1507-p	TSLWNPtyGsWFtEK
0	3		S1509-p	LWNPtyGsWFtEKPT
0	1		T1512-p	PtyGsWFtEKPTKKN
0	36		Y1584-p	FPCGNVNyGyQQQGL
1	26		Y1586-p	CGNVNyGyQQQGLPL
0	4		T1597-p	GLPLEAAtAPGAGHy
3	49		Y1604-p	tAPGAGHyEDtILKS
0	1		T1607-p	GAGHyEDtILKSKNS

	mouse
Y46	QPREPLSYSRLQRKS
S47	PREPLSYSRLQRKSL
S62	AVDFVVPSLFRVYAR
S216	LSSAIRASQPRLLFQ
S316	DGPEAEHSQEMPRGS
S323	SQEMPRGSFLLLNTS
S330	SFLLLNTSADSKHTI
S333	LLNTSADSKHTILSP
S1079	AMQMELQSPEyKLSK
Y1082-p	MELQSPEyKLSKLRT
T1091	LSKLRTSTIMTDyNP
T1094	LRTSTIMTDyNPNyC
Y1096-p	TSTIMTDyNPNyCFA
Y1100-p	MTDyNPNyCFAGKTS
K1113-a	TSSISDLkEVPRKNI
Y1135	HGAFGEVYEGQVSGM
Y1282	FGMARDIYRASYYRK
Y1286	RDIYRASYYRKGGCA
Y1287	DIYRASYYRKGGCAM
Y1363	KNCPGPVYRIMTQCW
Y1405	NTALPIEYGPVVEEE
T1515	PTSLWNPTYGSWFTE
Y1516	TSLWNPTYGSWFTEK
S1518	LWNPTYGSWFTEKPA
T1521	PTYGSWFTEKPAKKT
Y1590	FPCGNVNYGYQQQGL
Y1592	CGNVNYGYQQQGLPL
A1603	GLPLEATAAPGDTML
-	gap
T1608	ATAAPGDTMLKSKNK

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