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Protein Page:
SLC1A4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SLC1A4 Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence. Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A4 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Transporter, SLC family; Transporter; Membrane protein, multi-pass
Cellular Component: centrosome; cell soma; membrane; integral to plasma membrane; dendrite; plasma membrane; integral to membrane; melanosome; microtubule organizing center; intermediate filament
Molecular Function: L-serine transmembrane transporter activity; chloride channel activity; L-threonine transmembrane transporter activity; L-proline transmembrane transporter activity; L-alanine transmembrane transporter activity; L-glutamine transmembrane transporter activity; L-cystine transmembrane transporter activity; sodium:dicarboxylate symporter activity
Biological Process: synaptic transmission, glutamatergic; threonine transport; L-cystine transport; dicarboxylic acid transport; amino acid transport; ion transport; chloride transport; glutamine transport; proline transport; cognition; transmembrane transport; L-alanine transport; L-serine transport
Reference #:  P43007 (UniProtKB)
Alt. Names/Synonyms: Alanine/serine/cysteine/threonine transporter 1; ASCT-1; ASCT1; glutamate/neutral amino acid transporter; Neutral amino acid transporter A; SATT; SLC1A4; solute carrier family 1 (glutamate/neutral amino acid transporter), member 4; Solute carrier family 1 member 4
Gene Symbols: SLC1A4
Molecular weight: 55,723 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SLC1A4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T7-p _MEKSNEtNGyLDSA
0 105 Y10-p KSNEtNGyLDSAQAG
0 2 A24 GPAAGPGAPGTAAGR
0 1 K196-ub RTYATDYkVVTQNSS
0 13 K483-ub HLNQKATkkGEQELA
0 23 K484-ub LNQKATkkGEQELAE
0 41 K493-ub EQELAEVkVEAIPNC
0 35 K501-ub VEAIPNCksEEEtsP
0 2 S502-p EAIPNCksEEEtsPL
0 4 T506-p NCksEEEtsPLVTHQ
0 10 S507-p CksEEEtsPLVTHQN
0 1 T511 EEtsPLVTHQNPAGP
0 6 S521-p NPAGPVAsAPELESk
0 4 S527 AsAPELESkESVL__
0 1 K528-ub sAPELESkESVL___
0 3 S530 PELESkESVL_____
  mouse

 
T7 _MEKSGETNGyLDGT
Y10-p KSGETNGyLDGTQAE
T24-p EPAAGPRtPETAMGK
T196 TTSATDYTVVTHNTS
K483 HLNQKVVKKGEQELQ
K484 LNQKVVKKGEQELQE
K493-ub EQELQEVkVEAIPNS
K501 VEAIPNSKsEEEtsP
S502-p EAIPNSKsEEEtsPL
T506-p NSKsEEEtsPLVtHQ
S507-p SKsEEEtsPLVtHQN
T511-p EEtsPLVtHQNPAGP
I521 NPAGPVAIAPELEsK
S527-p AIAPELEsKEsVL__
K528 IAPELEsKEsVL___
S530-p PELEsKEsVL_____
  rat

 
T4 ____MEETNGYLDGA
Y7 _MEETNGYLDGAQAQ
T21 QPAARPRTPETGTSK
T193 STSATSYTVVVHNSS
K480 HLNQRTVKKGEQELQ
K481 LNQRTVKKGEQELQE
K490 EQELQEVKVEAIPNS
K498 VEAIPNSKSEEETSP
S499 EAIPNSKSEEETSPL
T503 NSKSEEETSPLVTHQ
S504 SKSEEETSPLVTHQN
T508 EETSPLVTHQNRAGP
V518 NRAGPVAVAPELESK
S524 AVAPELESKESVL__
K525 VAPELESKESVL___
S527 PELESKESVL_____
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