Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
SLC1A4 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SLC1A4 Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence. Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A4 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family; Transporter
Cellular Component: centrosome; cell soma; integral to plasma membrane; dendrite; melanosome; plasma membrane; integral to membrane; microtubule organizing center; intermediate filament
Molecular Function: L-serine transmembrane transporter activity; chloride channel activity; L-threonine transmembrane transporter activity; L-proline transmembrane transporter activity; L-alanine transmembrane transporter activity; L-cystine transmembrane transporter activity; L-glutamine transmembrane transporter activity; sodium:dicarboxylate symporter activity
Biological Process: synaptic transmission, glutamatergic; threonine transport; amino acid transport; L-cystine transport; ion transport; chloride transport; proline transport; cognition; glutamine transport; transmembrane transport; L-alanine transport; L-serine transport
Reference #:  P43007 (UniProtKB)
Alt. Names/Synonyms: Alanine/serine/cysteine/threonine transporter 1; ASCT-1; ASCT1; glutamate/neutral amino acid transporter; Neutral amino acid transporter A; SATT; SLC1A4; solute carrier family 1 (glutamate/neutral amino acid transporter), member 4; Solute carrier family 1 member 4
Gene Symbols: SLC1A4
Molecular weight: 55,723 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SLC1A4

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 119 Y10-p KSNETNGyLDSAQAG
0 2 A24 GPAAGPGAPGTAAGR
0 13 K483-u HLNQKATkkGEQELA
0 23 K484-u LNQKATkkGEQELAE
0 41 K493-u EQELAEVkVEAIPNC
0 35 K501-u VEAIPNCksEEEtsP
0 2 S502-p EAIPNCksEEEtsPL
0 2 T506-p NCksEEEtsPLVTHQ
0 8 S507-p CksEEEtsPLVTHQN
0 6 S521-p NPAGPVAsAPELESk
0 4 S527 AsAPELESkESVL__
0 1 K528-u sAPELESkESVL___
0 3 S530 PELESkESVL_____
  mouse

 
Y10-p KSGETNGyLDGTQAE
T24-p EPAAGPRtPETAMGK
K483 HLNQKVVKKGEQELQ
K484 LNQKVVKKGEQELQE
K493-u EQELQEVkVEAIPNS
K501 VEAIPNSKsEEEtsP
S502-p EAIPNSKsEEEtsPL
T506-p NSKsEEEtsPLVTHQ
S507-p SKsEEEtsPLVTHQN
I521 NPAGPVAIAPELEsK
S527-p AIAPELEsKEsVL__
K528 IAPELEsKEsVL___
S530-p PELEsKEsVL_____
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.