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SLC1A4 (human)

Overview SLC1A4 Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence. Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A4 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Transporter; Membrane protein, integral Cellular Component: integral to plasma membrane; plasma membrane; melanosome; integral to membrane; intermediate filament Molecular Function: L-serine transmembrane transporter activity; chloride channel activity; L-threonine transmembrane transporter activity; L-proline transmembrane transporter activity; L-alanine transmembrane transporter activity; L-cystine transmembrane transporter activity; L-glutamine transmembrane transporter activity; sodium:dicarboxylate symporter activity Biological Process: synaptic transmission, glutamatergic; threonine transport; L-cystine transport; amino acid transport; chloride transport; ion transport; glutamine transport; proline transport; cognition; transmembrane transport; L-serine transport; L-alanine transport Reference #:  P43007 (UniProtKB) Alt. Names/Synonyms: Alanine/serine/cysteine/threonine transporter 1; ASCT-1; ASCT1; glutamate/neutral amino acid transporter; Neutral amino acid transporter A; SATT; SLC1A4; solute carrier family 1 (glutamate/neutral amino acid transporter), member 4; Solute carrier family 1 member 4 Gene Symbols: SLC1A4 Molecular weight: 55,723 Da Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SLC1A4

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T7-p	_MEKSNEtNGyLDSA
0	119		Y10-p	KSNEtNGyLDSAQAG
0	2		A24	GPAAGPGAPGTAAGR
0	1		K196-u	RTYATDYkVVTQNSS
0	13		K483-u	HLNQKATkkGEQELA
0	23		K484-u	LNQKATkkGEQELAE
0	41		K493-u	EQELAEVkVEAIPNC
0	35		K501-u	VEAIPNCksEEETsP
0	2		S502-p	EAIPNCksEEETsPL
0	1		T506	NCksEEETsPLVTHQ
0	7		S507-p	CksEEETsPLVTHQN
0	5		S521-p	NPAGPVAsAPELESk
0	4		S527	AsAPELESkESVL__
0	1		K528-u	sAPELESkESVL___
0	3		S530	PELESkESVL_____

	mouse
T7	_MEKSGETNGyLDGT
Y10-p	KSGETNGyLDGTQAE
T24-p	EPAAGPRtPETAMGK
T196	TTSATDYTVVTHNTS
K483	HLNQKVVKKGEQELQ
K484	LNQKVVKKGEQELQE
K493-u	EQELQEVkVEAIPNS
K501	VEAIPNSKsEEEtsP
S502-p	EAIPNSKsEEEtsPL
T506-p	NSKsEEEtsPLVTHQ
S507-p	SKsEEEtsPLVTHQN
I521	NPAGPVAIAPELEsK
S527-p	AIAPELEsKEsVL__
K528	IAPELEsKEsVL___
S530-p	PELEsKEsVL_____

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