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Protein Page:
PIK4CA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PIK4CA Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate. Expressed ubiquitously. Highest levels in placenta and brain. Little or no expression in lung, liver, pancreas, testis or leukocytes. This is a type II PtdIns-4-kinase activated by detergents such as triton and inhibited by adenosine. Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.1.67; Carbohydrate Metabolism - inositol phosphate; Motility/polarity/chemotaxis; Kinase, lipid
Cellular Component: membrane; plasma membrane; cytosol
Molecular Function: 1-phosphatidylinositol 4-kinase activity; protein binding; ATP binding
Biological Process: phosphoinositide-mediated signaling; phosphoinositide phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process; signal transduction
Reference #:  P42356 (UniProtKB)
Alt. Names/Synonyms: FLJ16556; phosphatidylinositol 4-kinase 230; Phosphatidylinositol 4-kinase alpha; phosphatidylinositol 4-kinase, catalytic, alpha; phosphatidylinositol 4-kinase, type III, alpha; PI4-kinase alpha; PI4K-alpha; pi4K230; PI4KA; PIK4; PIK4CA; PtdIns-4-kinase alpha
Gene Symbols: PI4KA
Molecular weight: 231,319 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PIK4CA

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y139-p ISRAFGRysNMEEsL
0 1 S140-p SRAFGRysNMEEsLL
0 1 S145-p RysNMEEsLLSkLFP
0 2 K149-ub MEEsLLSkLFPKIPP
0 25 S172-p LEGVRRRsFNDFRsI
0 2 S178-p RsFNDFRsILPsNLL
0 1 S182-p DFRsILPsNLLTVCQ
0 9 T192-p LTVCQEGtLKRKtss
0 1 K194 VCQEGtLKRKtssVs
0 14 T197-p EGtLKRKtssVssIs
0 37 S198-p GtLKRKtssVssIsQ
0 19 S199-p tLKRKtssVssIsQV
0 5 S201-p KRKtssVssIsQVsP
0 12 S202-p RKtssVssIsQVsPE
0 11 S204-p tssVssIsQVsPERG
0 19 S207-p VssIsQVsPERGMPP
0 2 S371-p DRIHNELsPLKLRCQ
0 1 S444-p RFPVVVHsVtPsLRD
0 1 T446-p PVVVHsVtPsLRDFL
0 1 S448-p VVHsVtPsLRDFLVI
0 4 Y466-p VLVKLYKyHsQyHtV
0 11 S468-p VKLYKyHsQyHtVAG
0 57 Y470-p LYKyHsQyHtVAGND
0 3 T472-p KyHsQyHtVAGNDIK
0 2 N476 QyHtVAGNDIKISVT
0 1 T490-p TNEHSEStLNVMSGK
0 3 K549 YISQESDKDAHLIPD
0 1 K549 YISQESDKDAHLIPD
0 1 K574 VALRDTPKVMEPILQ
0 73 Y633-p VKASSVVySAtKDYK
0 1 T636-p SSVVySAtKDYKDHG
0 2 S705-p PALKASSsAGNLGVL
0 1 K780 PLLTFPSKEPLRSVL
0 4 Y789-p PLRSVLQyNSAMkND
0 2 K794-ub LQyNSAMkNDTVTPA
0 1 Y843-p LSVYRLEyMRVLRst
0 2 S849-p EyMRVLRstDPDRFQ
0 2 T850-p yMRVLRstDPDRFQV
0 1 Y861-p RFQVMFCyFEDKAIQ
0 1 K930-ac RIRRVADkYLSGLVD
0 29 Y973-p DIHKDQPyyDIPDAP
0 4 Y974-p IHKDQPyyDIPDAPY
0 1 T988 YRITVPDTYEARESI
0 1 K1019-ub KWAPTVTkSHLQEYL
0 249 Y1096-p NRYAGEVyGMIRFSG
0 1 K1278-ub SLNIGGAkGSMNRHV
0 2 T1311-p ADVVPNAtIRNVLRE
0 4 S1366-p DKKYLTAsQLVPPDN
0 14 S1378-p PDNQDTRsNLDITVG
0 1 S1386-p NLDITVGsRQQATQG
0 1 T1397-p ATQGWINtYPLSSGM
0 1 K1415 SKKSGMSKKTNRGSQ
0 1 K1416 KKSGMSKKTNRGSQL
0 1 K1505 VQLPARFKNTEAIGN
0 1 Y1605-p QIVQALRyDKMGYVR
0 1 Y1614-p KMGYVREyILWAAsK
0 1 S1620-p EyILWAAsKSQLLAH
0 3 K1691-ub TNVSAIIkPYPKGDE
0 1 K1701 PKGDERKKACLSALS
0 1 Y1731-p AIVLDIDyKSGTPMQ
0 1 T1735 DIDyKSGTPMQSAAK
0 1 Y1745-p QSAAKAPyLAKFKVK
0 2 S1770-p GLRCRSDsEDECSTQ
0 1 Y1826-p LDLFVFPyRVVATAP
0 1 S2029-p SCFLSNRsRtyDMIQ
0 1 T2031-p FLSNRsRtyDMIQYY
0 2 Y2032-p LSNRsRtyDMIQYYQ
  mouse

 
Y139 ISRSFGRYSNSEESL
S140 SRSFGRYSNSEESLL
S145 RYSNSEESLLSkLFP
K149-ub SEESLLSkLFPKVSP
S172-p LEGVRRRsFNDFRSI
S178 RsFNDFRSILPSNLL
S182 DFRSILPSNLLTVCQ
T192-p LTVCQEGtLkRKtss
K194-ub VCQEGtLkRKtssVs
T197-p EGtLkRKtssVssIs
S198-p GtLkRKtssVssIsQ
S199-p tLkRKtssVssIsQV
S201-p kRKtssVssIsQVsP
S202-p RKtssVssIsQVsPE
S204-p tssVssIsQVsPERG
S207-p VssIsQVsPERGIPP
S371 DRIHSEMSPLKLRCQ
S444 RFPVVVHSVTPSLRD
T446 PVVVHSVTPSLRDFL
S448 VVHSVTPSLRDFLVI
Y466 VLVKLYKYHSQYHTV
S468 VKLYKYHSQYHTVAG
Y470 LYKYHSQYHTVAGsD
T472 KYHSQYHTVAGsDIK
S476-p QYHTVAGsDIKISVT
T490 TNEHSESTLNVLPGK
K549-ac YISQESDkDAHLIPD
K549-ub YISQESDkDAHLIPD
K574-ub VALRDTPkVMEPILQ
Y633 VKASSVVYSATKDYK
T636 SSVVYSATKDYKDHG
S705 PALKASSSAGNLGVL
K780-ub PLLTFPSkEPLRSVL
Y789 PLRSVLQYNSAMkND
K794-ub LQYNSAMkNDTVTLA
Y843 LSVYRLEYMRVLRst
S849-p EYMRVLRstDPDRFQ
T850-p YMRVLRstDPDRFQV
Y861 RFQVMFCYFEDKAIQ
K930 RIRRVADKYLSGLVD
Y973-p DIHKDQPyYDIPDAP
Y974 IHKDQPyYDIPDAPY
T988-p YRITVPDtYEARESI
K1019 KWAPTVTKSHLQEYL
H1096 NRYAGEVHGMIRFSG
R1278 SLNIGGARGSMNRHV
T1311-p ADVVPNAtIRNVLRE
S1366-p DKKYLTAsQLVPPDN
S1378-p PDNQDTRsNLDITVG
S1386 NLDITVGSRQQATQG
T1397 ATQGWINTYPLSSGM
K1415-m1 SKKSGMSkkTNRGSQ
K1416-m1 KKSGMSkkTNRGSQL
K1505-ub VQLPARFkNTEAIGN
Y1605 QIVQALRYDKMGYVR
Y1614 KMGYVREYILWAAAK
A1620 EYILWAAAKSQLLAH
K1691-ub TNVSAIIkPYPKGDE
K1701-ub PKGDERKkACLSALS
Y1731 AIVLDIDYKSGtPMQ
T1735-p DIDYKSGtPMQSAAK
Y1745 QSAAKAPYLAKFKVK
A1770 GLQCRSDAEDECFSQ
Y1826 LDLFVFPYRVVATAP
S2029 NCFLSNRSRTYDMIQ
T2031 FLSNRSRTYDMIQYY
Y2032 LSNRSRTYDMIQYYQ
  rat

 
Y139 ISKSFGRYSNSEESL
S140 SKSFGRYSNSEESLL
S145 RYSNSEESLLSKLFP
K149 SEESLLSKLFPKVPP
S172-p LEGVRRRsFNDFRSI
S178 RsFNDFRSILPSNLL
S182 DFRSILPSNLLTVCQ
T192 LTVCQEGTLKRKtss
K194 VCQEGTLKRKtssVS
T197-p EGTLKRKtssVSsIS
S198-p GTLKRKtssVSsISQ
S199-p TLKRKtssVSsISQV
S201 KRKtssVSsISQVsP
S202-p RKtssVSsISQVsPE
S204 tssVSsISQVsPERG
S207-p VSsISQVsPERGMPP
S371 DRIHSEMSPLKLRCQ
S444 RFPVVVHSVTPSLRD
T446 PVVVHSVTPSLRDFL
S448 VVHSVTPSLRDFLVI
Y466 VLVKLYKYHSQYHTV
S468 VKLYKYHSQYHTVAG
Y470 LYKYHSQYHTVAGSD
T472 KYHSQYHTVAGSDIK
S476 QYHTVAGSDIKISVT
T490 TNEHSESTLNVLPGK
K549-ac YISQESDkDAHLIPD
K549 YISQESDKDAHLIPD
K574 VALRDTPKVMEPILQ
Y630 VKASSVVYSATKDYK
T633 SSVVYSATKDYKDHG
S702 PALKASSSAGNLGVL
K777 PLLTFPSKEPLRSVL
Y786 PLRSVLQYNSAMKND
K791 LQYNSAMKNDTVTPA
Y840 LSVYRLEYMRVLRST
S846 EYMRVLRSTDPDRFQ
T847 YMRVLRSTDPDRFQV
Y858 RFQVMFCYFEDKAIQ
K927 RIRRVADKYLSGLVD
Y970 DIHKDQPYYDIPDAP
Y971 IHKDQPYYDIPDAPY
T985 YRITVPDTYEARESI
K1016 KWAPTVTKSHLQEYL
H1093 NRYAGEVHGMIRFSG
R1275 SLHIGGARGSMNRHV
T1308 ADVVPNATIRNVLRE
S1363 DKKYLTASQLVPPDN
S1375-p PDNQDTRsNLDITVG
S1383 NLDITVGSRQQATQG
T1394 ATQGWINTYPLSSGM
K1412 SKKSGMSKKTNRGSQ
K1413 KKSGMSKKTNRGSQL
K1502 VQLPARFKNTEAIGN
Y1602 QIVQALRYDKMGYVR
Y1611 KMGYVREYILWAAAK
A1617 EYILWAAAKSQLLAH
K1688 TNVSAIIKPYPKGDE
K1698 PKGDERKKACLSALS
Y1728 AIVLDIDYKSGTPMQ
T1732 DIDYKSGTPMQSAAK
Y1742 QSAAKAPYLAKFKVK
T1767 GLQCRSDTEDECRRQ
Y1823 LDLFVFPYRVVATAP
S2026 NCFLSNRSRTYDMIQ
T2028 FLSNRSRTYDMIQYY
Y2029 LSNRSRTYDMIQYYQ
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