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Protein Page:
ANXA5 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ANXA5 a calcium/phospholipid-binding protein and an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. The binding of labeled ANXA5 to phosphatidylserine is used as a marker of apoptosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion. Note: This description may include information from UniProtKB.
Protein type: Lipid binding protein; Inhibitor protein; Apoptosis; Calcium-binding protein
Cellular Component: cytoplasm; intracellular; external side of plasma membrane
Molecular Function: phospholipase inhibitor activity; calcium-dependent phospholipid binding; phospholipid binding; calcium ion binding
Biological Process: response to organic substance; negative regulation of catalytic activity; blood coagulation; signal transduction; negative regulation of coagulation; negative regulation of apoptosis
Reference #:  P08758 (UniProtKB)
Alt. Names/Synonyms: Anchorin CII; Annexin A5; Annexin V; Annexin-5; ANX5; ANXA5; Calphobindin I; CBP-I; Endonexin II; ENX2; Lipocortin V; PAP-I; Placental anticoagulant protein 4; Placental anticoagulant protein I; PP4; Thromboplastin inhibitor; VAC-alpha; Vascular anticoagulant-alpha
Gene Symbols: ANXA5
Molecular weight: 35,937 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
Select Structure to View Below

ANXA5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 1 T23-p DERADAEtLRKAMkG
0 27 K29-u EtLRKAMkGLGTDEE
0 1 K29-s EtLRKAMkGLGTDEE
0 2 S37-p GLGTDEEsILTLLTS
0 4 K58-u QEISAAFkTLFGRDL
0 7 K70-a RDLLDDLkSELTGkF
0 1 K70 RDLLDDLKSELTGkF
0 1 K76-a LkSELTGkFEkLIVA
0 13 K76-u LkSELTGkFEkLIVA
0 2 K79-a ELTGkFEkLIVALMk
0 1 K79-u ELTGkFEkLIVALMk
0 6 K86-u kLIVALMkPsRLyDA
0 1 S88-p IVALMkPsRLyDAyE
0 1 Y91-p LMkPsRLyDAyELkH
0 701 Y94-p PsRLyDAyELkHALk
0 2 K97-a LyDAyELkHALkGAG
0 7 K97-u LyDAyELkHALkGAG
0 5 K101-a yELkHALkGAGTNEk
0 9 K101-u yELkHALkGAGTNEk
0 14 K108-u kGAGTNEkVLTEIIA
0 1 S116-p VLTEIIAsRTPEELR
0 1 K126-u PEELRAIkQVyEEEy
0 2 Y129-p LRAIkQVyEEEyGSS
0 2 Y133-p kQVyEEEyGSSLEDD
0 1 K186-u LFQAGELkWGTDEEk
0 2 K193-u kWGTDEEkFITIFGT
0 1 S246-p AVVKSIRsIPAYLAE
0 3 T254-p IPAYLAEtLyyAMKG
0 10 Y256-p AYLAEtLyyAMKGAG
0 15 Y257-p YLAEtLyyAMKGAGT
0 2 K290-u NIRKEFRkNFATSLy
0 26 Y297-p kNFATSLysMIkGDT
0 3 S298-p NFATSLysMIkGDTS
0 2 K301-u TSLysMIkGDTSGDY
0 11 K309-a GDTSGDYkKALLLLC
  mouse

 
V21 DGRADAEVLRKAMkG
K27-u EVLRKAMkGLGTDED
K27 EVLRKAMKGLGTDED
S35-p GLGTDEDsILNLLTS
K56-u QEIAQEFkTLFGRDL
K68-a RDLVDDLkSELTGkF
K68-u RDLVDDLkSELTGkF
K74 LkSELTGKFEkLIVA
K74-u LkSELTGkFEkLIVA
K77-a ELTGkFEkLIVAMMk
K77 ELTGkFEKLIVAMMk
K84-u kLIVAMMkPSRLYDA
S86 IVAMMkPSRLYDAyE
Y89 MMkPSRLYDAyELkH
Y92-p PSRLYDAyELkHALk
K95 LYDAyELKHALkGAG
K95-u LYDAyELkHALkGAG
K99-a yELkHALkGAGTDEk
K99-u yELkHALkGAGTDEk
K106-u kGAGTDEkVLTEIIA
S114 VLTEIIASRTPEELS
K124 PEELSAIKQVYEEEY
Y127 LSAIKQVYEEEYGSN
Y131 KQVYEEEYGSNLEDD
K184 LFQAGELKWGTDEEK
K191 KWGTDEEKFITIFGT
S244 AVVKSIRSIPAYLAE
T252 IPAYLAETLyYAMKG
Y254-p AYLAETLyYAMKGAG
Y255 YLAETLyYAMKGAGT
K288-u NIRKEFRkNFATSLy
Y295-p kNFATSLySMIKGDT
S296 NFATSLySMIKGDTS
K299 TSLySMIKGDTSGDY
K307-a GDTSGDYkKALLLLC
  rat

 
V21 DGRADAEVLRKAMKG
K27 EVLRKAMKGLGTDED
K27 EVLRKAMKGLGTDED
S35 GLGTDEDSILNLLTA
K56 QQIAEEFKTLFGRDL
K68 RDLVNDMKSELTGKF
K68 RDLVNDMKSELTGKF
K74 MKSELTGKFEKLIVA
K74 MKSELTGKFEKLIVA
K77 ELTGKFEKLIVALMK
K77 ELTGKFEKLIVALMK
K84 KLIVALMKPSRLYDA
S86 IVALMKPSRLYDAyE
Y89 LMKPSRLYDAyELKH
Y92-p PSRLYDAyELKHALK
K95 LYDAyELKHALKGAG
K95 LYDAyELKHALKGAG
K99 yELKHALKGAGTDEK
K99 yELKHALKGAGTDEK
K106 KGAGTDEKVLTEIIA
S114 VLTEIIASRTPEELR
K124 PEELRAIKQAYEEEY
Y127 LRAIKQAYEEEYGSN
Y131 KQAYEEEYGSNLEDD
K184 LFQAGELKWGTDEEK
K191 KWGTDEEKFITILGT
S244 AVVKSIRSIPAYLAE
T252 IPAYLAETLYYAMKG
Y254 AYLAETLYYAMKGAG
Y255 YLAETLYYAMKGAGT
K288 NIRKEFRKNFATSLY
Y295 KNFATSLYSMIKGDT
S296 NFATSLYSMIKGDTS
K299 TSLYSMIKGDTSGDY
K307 GDTSGDYKKALLLLC
  cow

► Hide Isoforms
 
T23 DERADAETLRKAMKG
K29 ETLRKAMKGLGTDEE
K29 ETLRKAMKGLGTDEE
T37 GLGTDEETILTLLTS
K58 QEIAVAFKTLFGRDL
K70 RDLLDDLKSELTGKF
K70 RDLLDDLKSELTGKF
K76 LKSELTGKFEKLIVA
K76 LKSELTGKFEKLIVA
K79 ELTGKFEKLIVALMK
K79 ELTGKFEKLIVALMK
K86 KLIVALMKPSRLYDA
S88 IVALMKPSRLYDAYE
Y91 LMKPSRLYDAYELKH
Y94 PSRLYDAYELKHALK
K97 LYDAYELKHALKGAG
K97 LYDAYELKHALKGAG
K101 YELKHALKGAGTDEK
K101 YELKHALKGAGTDEK
K108 KGAGTDEKVLTEIIA
S116 VLTEIIASRTPEELR
E126 PEELRAIEQVYEEEY
Y129 LRAIEQVYEEEYGSS
Y133 EQVYEEEYGSSLEDD
K186 LFQAGELKWGTDEEK
K193 KWGTDEEKFITIFGT
S246 AVVKSIRSIPAYLAE
T254 IPAYLAETLYYAMKG
Y256 AYLAETLYYAMKGAG
Y257 YLAETLYYAMKGAGT
K290 NIRKEFRKNFGTSLY
Y297 KNFGTSLYSMIKGDT
S298 NFGTSLYSMIKGDTS
K301 TSLYSMIKGDTSGDY
K309 GDTSGDYKKALLLLC
  ANXA5 iso2  
T22-p DERADAEtLRKAMKG
K28 EtLRKAMKGLGTDEE
K28 EtLRKAMKGLGTDEE
S36 GLGTDEESILTLLTS
K57 QEIAVAFKTLFGRDL
K69 RDLLDDLKSELTGKF
K69 RDLLDDLKSELTGKF
K75 LKSELTGKFEKLIVA
K75 LKSELTGKFEKLIVA
K78 ELTGKFEKLIVALMK
K78 ELTGKFEKLIVALMK
K85 KLIVALMKPSRLYDA
S87 IVALMKPSRLYDAYE
Y90 LMKPSRLYDAYELKH
Y93 PSRLYDAYELKHALK
K96 LYDAYELKHALKGAG
K96 LYDAYELKHALKGAG
K100 YELKHALKGAGTDEK
K100 YELKHALKGAGTDEK
K107 KGAGTDEKVLTEIIA
S115 VLTEIIASRTPEELR
K125 PEELRAIKQVYEEEY
Y128 LRAIKQVYEEEYGSS
Y132 KQVYEEEYGSSLEDD
K185 LFQAGELKWGTDEEK
K192 KWGTDEEKFITIFGT
S245 AVVKSIRSIPAYLAE
T253 IPAYLAETLYYAMKG
Y255 AYLAETLYYAMKGAG
Y256 YLAETLYYAMKGAGT
K289 NIRKEFRKNFGTSLY
Y296 KNFGTSLYSMIKGDT
S297 NFGTSLYSMIKGDTS
K300 TSLYSMIKGDTSGDY
K308 GDTSGDYKKALLLLC
  ANXA5 iso3  
T22-p DERADAEtLRKAMKG
K28 EtLRKAMKGLGTDEE
K28 EtLRKAMKGLGTDEE
T36 GLGTDEETILTLLTS
K57 QEIAVAFKTLFGRDL
K69 RDLLDDLKSELTGKF
K69 RDLLDDLKSELTGKF
K75 LKSELTGKFEKLIVA
K75 LKSELTGKFEKLIVA
K78 ELTGKFEKLIVALMK
K78 ELTGKFEKLIVALMK
K85 KLIVALMKPSRLYDA
S87 IVALMKPSRLYDAYE
Y90 LMKPSRLYDAYELKH
Y93 PSRLYDAYELKHALK
K96 LYDAYELKHALKGAG
K96 LYDAYELKHALKGAG
K100 YELKHALKGAGTDEK
K100 YELKHALKGAGTDEK
K107 KGAGTDEKVLTEIIA
S115 VLTEIIASRTPEELR
E125 PEELRAIEQVYEEEY
Y128 LRAIEQVYEEEYGSS
Y132 EQVYEEEYGSSLEDD
K185 LFQAGELKWGTDEEK
K192 KWGTDEEKFITIFGT
S245 AVVKSIRSIPAYLAE
T253 IPAYLAETLYYAMKG
Y255 AYLAETLYYAMKGAG
Y256 YLAETLYYAMKGAGT
K289 NIRKEFRKNFGTSLY
Y296 KNFGTSLYSMIKGDT
S297 NFGTSLYSMIKGDTS
K300 TSLYSMIKGDTSGDY
K308 GDTSGDYKKALLLLC
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