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ANXA5 (human)

Overview ANXA5 a calcium/phospholipid-binding protein and an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. The binding of labeled ANXA5 to phosphatidylserine is used as a marker of apoptosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion. Note: This description may include information from UniProtKB. Protein type: Calcium-binding protein; Inhibitor protein; Lipid binding protein; Apoptosis Cellular Component: cell projection; cytoplasm; intracellular; sarcolemma; external side of plasma membrane Molecular Function: phospholipase inhibitor activity; eukaryotic cell surface binding; calcium-dependent phospholipid binding; phospholipid binding; calcium ion binding; receptor tyrosine kinase binding Biological Process: response to organic substance; positive regulation of apoptosis; blood coagulation; negative regulation of coagulation; signal transduction; protein homooligomerization; negative regulation of apoptosis Reference #:  P08758 (UniProtKB) Alt. Names/Synonyms: Anchorin CII; Annexin A5; Annexin V; Annexin-5; ANX5; ANXA5; Calphobindin I; CBP-I; Endonexin II; ENX2; Lipocortin V; PAP-I; Placental anticoagulant protein 4; Placental anticoagulant protein I; PP4; Thromboplastin inhibitor; VAC-alpha; Vascular anticoagulant-alpha Gene Symbols: ANXA5 Molecular weight: 35,937 Da Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states

Select Structure to View Below ANXA5 1ANW - A/B=1-320 (human) 1ANX - A/B/C=1-320 (human) 1AVH - A/B=1-320 (human) 1AVR - A=1-320 (human) 1HAK - A/B=1-320 (human) 1HVD - A=1-320 (human) 1HVE - A=1-320 (human) 1HVF - A=1-320 (human) 1HVG - A=1-320 (human) 1SAV - A=1-320 (human) 2XO2 - A=1-320 (human) 2XO3 - A=1-320 (human) 1A8A - A=1-318 (rat) 1A8B - A=1-318 (rat) 1BC0 - A=1-318 (rat) 1BC1 - A=1-318 (rat) 1BC3 - A=1-318 (rat) 1BCW - A=1-318 (rat) 1BCY - A=1-318 (rat) 1BCZ - A=1-318 (rat) 1G5N - A=1-318 (rat) 1N41 - A=1-319 (rat) 1N42 - A=1-319 (rat) 1N44 - A=1-319 (rat) 2H0K - A/B=1-318 (rat) 2H0L - A=1-318 (rat) 2H0M - A=1-317 (rat) 2IE6 - A=1-318 (rat) 2IE7 - A=1-318 (rat) 2RAN - A=1-316 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1ANW 1ANX 1AVH 1AVR 1HAK 1HVD 1HVE 1HVF 1HVG 1SAV 2XO2 2XO3  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	1		T23-p	DERADAEtLRkAMkG
0	1		K26-u	ADAEtLRkAMkGLGT
0	27		K29-u	EtLRkAMkGLGTDEE
0	1		K29-s	EtLRkAMkGLGTDEE
0	2		S37	GLGTDEESILTLLTS
0	4		K58-u	QEISAAFkTLFGRDL
0	7		K70-a	RDLLDDLkSELTGkF
0	1		K70	RDLLDDLKSELTGkF
0	1		K76-a	LkSELTGkFEkLIVA
0	13		K76-u	LkSELTGkFEkLIVA
0	2		K79-a	ELTGkFEkLIVALMk
0	1		K79-u	ELTGkFEkLIVALMk
0	1		K86-a	kLIVALMkPsRLyDA
0	6		K86-u	kLIVALMkPsRLyDA
0	1		S88-p	IVALMkPsRLyDAyE
0	1		Y91-p	LMkPsRLyDAyELkH
0	698		Y94-p	PsRLyDAyELkHALk
0	2		K97-a	LyDAyELkHALkGAG
0	7		K97-u	LyDAyELkHALkGAG
0	5		K101-a	yELkHALkGAGTNEk
0	9		K101-u	yELkHALkGAGTNEk
0	14		K108-u	kGAGTNEkVLTEIIA
0	1		S116-p	VLTEIIAsRTPEELR
0	1		K126-u	PEELRAIkQVyEEEy
0	2		Y129-p	LRAIkQVyEEEyGSS
0	2		Y133-p	kQVyEEEyGSSLEDD
0	1		K186-u	LFQAGELkWGTDEEk
0	2		K193-u	kWGTDEEkFITIFGT
0	1		S246-p	AVVKSIRsIPAYLAE
0	3		T254-p	IPAYLAEtLyyAMKG
0	10		Y256-p	AYLAEtLyyAMKGAG
0	15		Y257-p	YLAEtLyyAMKGAGT
0	1		S275-p	TLIRVMVsRSEIDLF
0	2		K290-u	NIRKEFRkNFATSLy
0	26		Y297-p	kNFATSLysMIkGDT
0	3		S298-p	NFATSLysMIkGDTS
0	2		K301-u	TSLysMIkGDTSGDY
0	11		K309-a	GDTSGDYkKALLLLC

	mouse
V21	DGRADAEVLRKAMkG
K24	ADAEVLRKAMkGLGT
K27-u	EVLRKAMkGLGTDED
K27	EVLRKAMKGLGTDED
S35-p	GLGTDEDsILNLLTS
K56-u	QEIAQEFkTLFGRDL
K68-a	RDLVDDLkSELTGkF
K68-u	RDLVDDLkSELTGkF
K74	LkSELTGKFEkLIVA
K74-u	LkSELTGkFEkLIVA
K77-a	ELTGkFEkLIVAMMk
K77	ELTGkFEKLIVAMMk
K84	kLIVAMMKPSRLYDA
K84-u	kLIVAMMkPSRLYDA
S86	IVAMMkPSRLYDAyE
Y89	MMkPSRLYDAyELkH
Y92-p	PSRLYDAyELkHALk
K95	LYDAyELKHALkGAG
K95-u	LYDAyELkHALkGAG
K99-a	yELkHALkGAGTDEk
K99-u	yELkHALkGAGTDEk
K106-u	kGAGTDEkVLTEIIA
S114	VLTEIIASRTPEELS
K124	PEELSAIKQVYEEEY
Y127	LSAIKQVYEEEYGSN
Y131	KQVYEEEYGSNLEDD
K184	LFQAGELKWGTDEEK
K191	KWGTDEEKFITIFGT
S244	AVVKSIRSIPAYLAE
T252	IPAYLAETLyYAMKG
Y254-p	AYLAETLyYAMKGAG
Y255	YLAETLyYAMKGAGT
S273	TLIRVVVSRSEIDLF
K288-u	NIRKEFRkNFATSLy
Y295-p	kNFATSLySMIKGDT
S296	NFATSLySMIKGDTS
K299	TSLySMIKGDTSGDY
K307-a	GDTSGDYkKALLLLC

	rat
V21	DGRADAEVLRKAMKG
K24	ADAEVLRKAMKGLGT
K27	EVLRKAMKGLGTDED
K27	EVLRKAMKGLGTDED
S35	GLGTDEDSILNLLTA
K56	QQIAEEFKTLFGRDL
K68	RDLVNDMKSELTGKF
K68	RDLVNDMKSELTGKF
K74	MKSELTGKFEKLIVA
K74	MKSELTGKFEKLIVA
K77	ELTGKFEKLIVALMK
K77	ELTGKFEKLIVALMK
K84	KLIVALMKPSRLYDA
K84	KLIVALMKPSRLYDA
S86	IVALMKPSRLYDAyE
Y89	LMKPSRLYDAyELKH
Y92-p	PSRLYDAyELKHALK
K95	LYDAyELKHALKGAG
K95	LYDAyELKHALKGAG
K99	yELKHALKGAGTDEK
K99	yELKHALKGAGTDEK
K106	KGAGTDEKVLTEIIA
S114	VLTEIIASRTPEELR
K124	PEELRAIKQAYEEEY
Y127	LRAIKQAYEEEYGSN
Y131	KQAYEEEYGSNLEDD
K184	LFQAGELKWGTDEEK
K191	KWGTDEEKFITILGT
S244	AVVKSIRSIPAYLAE
T252	IPAYLAETLYYAMKG
Y254	AYLAETLYYAMKGAG
Y255	YLAETLYYAMKGAGT
S273	TLIRVIVSRSEIDLF
K288	NIRKEFRKNFATSLY
Y295	KNFATSLYSMIKGDT
S296	NFATSLYSMIKGDTS
K299	TSLYSMIKGDTSGDY
K307	GDTSGDYKKALLLLC

	cow ► Hide Isoforms
T23	DERADAETLRKAMKG
K26	ADAETLRKAMKGLGT
K29	ETLRKAMKGLGTDEE
K29	ETLRKAMKGLGTDEE
T37	GLGTDEETILTLLTS
K58	QEIAVAFKTLFGRDL
K70	RDLLDDLKSELTGKF
K70	RDLLDDLKSELTGKF
K76	LKSELTGKFEKLIVA
K76	LKSELTGKFEKLIVA
K79	ELTGKFEKLIVALMK
K79	ELTGKFEKLIVALMK
K86	KLIVALMKPSRLYDA
K86	KLIVALMKPSRLYDA
S88	IVALMKPSRLYDAYE
Y91	LMKPSRLYDAYELKH
Y94	PSRLYDAYELKHALK
K97	LYDAYELKHALKGAG
K97	LYDAYELKHALKGAG
K101	YELKHALKGAGTDEK
K101	YELKHALKGAGTDEK
K108	KGAGTDEKVLTEIIA
S116	VLTEIIASRTPEELR
E126	PEELRAIEQVYEEEY
Y129	LRAIEQVYEEEYGSS
Y133	EQVYEEEYGSSLEDD
K186	LFQAGELKWGTDEEK
K193	KWGTDEEKFITIFGT
S246	AVVKSIRSIPAYLAE
T254	IPAYLAETLYYAMKG
Y256	AYLAETLYYAMKGAG
Y257	YLAETLYYAMKGAGT
S275	TLIRVVVSRSEIDLY
K290	NIRKEFRKNFGTSLY
Y297	KNFGTSLYSMIKGDT
S298	NFGTSLYSMIKGDTS
K301	TSLYSMIKGDTSGDY
K309	GDTSGDYKKALLLLC

	ANXA5 iso2
T22-p	DERADAEtLRKAMKG
K25	ADAEtLRKAMKGLGT
K28	EtLRKAMKGLGTDEE
K28	EtLRKAMKGLGTDEE
S36	GLGTDEESILTLLTS
K57	QEIAVAFKTLFGRDL
K69	RDLLDDLKSELTGKF
K69	RDLLDDLKSELTGKF
K75	LKSELTGKFEKLIVA
K75	LKSELTGKFEKLIVA
K78	ELTGKFEKLIVALMK
K78	ELTGKFEKLIVALMK
K85	KLIVALMKPSRLYDA
K85	KLIVALMKPSRLYDA
S87	IVALMKPSRLYDAYE
Y90	LMKPSRLYDAYELKH
Y93	PSRLYDAYELKHALK
K96	LYDAYELKHALKGAG
K96	LYDAYELKHALKGAG
K100	YELKHALKGAGTDEK
K100	YELKHALKGAGTDEK
K107	KGAGTDEKVLTEIIA
S115	VLTEIIASRTPEELR
K125	PEELRAIKQVYEEEY
Y128	LRAIKQVYEEEYGSS
Y132	KQVYEEEYGSSLEDD
K185	LFQAGELKWGTDEEK
K192	KWGTDEEKFITIFGT
S245	AVVKSIRSIPAYLAE
T253	IPAYLAETLYYAMKG
Y255	AYLAETLYYAMKGAG
Y256	YLAETLYYAMKGAGT
S274	TLIRVVVSRSEIDLY
K289	NIRKEFRKNFGTSLY
Y296	KNFGTSLYSMIKGDT
S297	NFGTSLYSMIKGDTS
K300	TSLYSMIKGDTSGDY
K308	GDTSGDYKKALLLLC

	ANXA5 iso3
T22-p	DERADAEtLRKAMKG
K25	ADAEtLRKAMKGLGT
K28	EtLRKAMKGLGTDEE
K28	EtLRKAMKGLGTDEE
T36	GLGTDEETILTLLTS
K57	QEIAVAFKTLFGRDL
K69	RDLLDDLKSELTGKF
K69	RDLLDDLKSELTGKF
K75	LKSELTGKFEKLIVA
K75	LKSELTGKFEKLIVA
K78	ELTGKFEKLIVALMK
K78	ELTGKFEKLIVALMK
K85	KLIVALMKPSRLYDA
K85	KLIVALMKPSRLYDA
S87	IVALMKPSRLYDAYE
Y90	LMKPSRLYDAYELKH
Y93	PSRLYDAYELKHALK
K96	LYDAYELKHALKGAG
K96	LYDAYELKHALKGAG
K100	YELKHALKGAGTDEK
K100	YELKHALKGAGTDEK
K107	KGAGTDEKVLTEIIA
S115	VLTEIIASRTPEELR
E125	PEELRAIEQVYEEEY
Y128	LRAIEQVYEEEYGSS
Y132	EQVYEEEYGSSLEDD
K185	LFQAGELKWGTDEEK
K192	KWGTDEEKFITIFGT
S245	AVVKSIRSIPAYLAE
T253	IPAYLAETLYYAMKG
Y255	AYLAETLYYAMKGAG
Y256	YLAETLYYAMKGAGT
S274	TLIRVVVSRSEIDLY
K289	NIRKEFRKNFGTSLY
Y296	KNFGTSLYSMIKGDT
S297	NFGTSLYSMIKGDTS
K300	TSLYSMIKGDTSGDY
K308	GDTSGDYKKALLLLC

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