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PAR-4 (human)

Overview PAR-4 a proapoptotic protein that drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression. Capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappaB transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. Note: This description may include information from UniProtKB. Protein type: Apoptosis Cellular Component: cytoplasm; plasma membrane; actin filament; nucleus Molecular Function: protein binding; leucine zipper domain binding; enzyme binding; actin binding; transcription corepressor activity Biological Process: actin filament bundle formation; negative regulation of cell proliferation; negative regulation of T cell proliferation; interleukin-2 biosynthetic process; transcription, DNA-dependent; positive regulation of apoptosis; apoptosis; induction of apoptosis; negative regulation of T cell receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of B cell proliferation; positive regulation of amyloid precursor protein biosynthetic process Reference #:  Q96IZ0 (UniProtKB) Alt. Names/Synonyms: Par-4; PAR4; PAWR; PRKC apoptosis WT1 regulator protein; PRKC, apoptosis, WT1, regulator; Prostate apoptosis response 4 protein; prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4; transcriptional repressor PAR4; WT1-interacting protein Gene Symbols: PAWR Molecular weight: 36,568 Da Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PAR-4 2JK9 - B=67-81 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		T8-p	MATGGYRtSSGLGGS
0	1		S15	tSSGLGGSTTDFLEE
0	1		T16	SSGLGGSTTDFLEEW
0	1		T17	SGLGGSTTDFLEEWK
0	1		S95-p	GVNCAVGsAMLtRAA
0	1		T99-p	AVGsAMLtRAAPGPR
0	16		S162-p	KLREKRRstGVVNIP
2	27		T163-p	LREKRRstGVVNIPA
0	70		Y177-p	AAECLDEyEDDEAGQ
0	4		Y226-p	PRTVSGRyKsttsVs
0	12		S228-p	TVSGRyKsttsVsEE
0	4		T229-p	VSGRyKsttsVsEED
0	1		T230-p	SGRyKsttsVsEEDV
0	13		S231-p	GRyKsttsVsEEDVS
0	1		S233-p	yKsttsVsEEDVSSR
0	2		Y241-p	EEDVSSRysRTDRSG
0	1		S242-p	EDVSSRysRTDRSGF
1	0		N257	PRYNRDANVsGTLVS
0	1		S259-p	YNRDANVsGTLVSSS
0	1		K296-a	LVRLMQDkEEMIGkL
0	1		K302-a	DkEEMIGkLKEEIDL
0	6		K333-u	QENKTLLkVVGQLTR
0	1		K333	QENKTLLKVVGQLTR

	mouse
S8-p	MATGGYRsGGStttD
T12-p	GYRsGGStttDFLEE
T13-p	YRsGGStttDFLEEW
T14-p	RsGGStttDFLEEWK
S87	ALNCAHGSSTLPRAA
P91	AHGSSTLPRAAPGSR
S155	KLREKRRStGVVNIP
T156-p	LREKRRStGVVNIPA
Y170	AAECLDEYEDDEAGQ
Y219	SRTVPGRYKSTTSAP
S221	TVPGRYKSTTSAPED
T222	VPGRYKSTTSAPEDE
T223	PGRYKSTTSAPEDEI
S224	GRYKSTTSAPEDEIS
P226	YKSTTSAPEDEISNR
Y234	EDEISNRYPRTDRSG
P235	DEISNRYPRTDRSGF
N250	SRHNRDANAPASFSS
P252	HNRDANAPASFSSSS
K289	LVRLMQDKEEMIGKL
K295	DKEEMIGKLKEEIDL
K326-u	QENKTLLkVVGQLTR
K326-a	QENKTLLkVVGQLTR

	rat
S8	MATGGYRSSGSTTDF
-	gap
T12	GYRSSGSTTDFLEEW
T13	YRSSGSTTDFLEEWK
S86	ALNCAHGSSALPRGA
P90	AHGSSALPRGAPGSR
S154	KLREKRRStGVVNIP
T155-p	LREKRRStGVVNIPA
Y169	AAECLDEYEDDEAGQ
Y218	SRTVPGRYKSTISAP
S220	TVPGRYKSTISAPEE
T221	VPGRYKSTISAPEEE
I222	PGRYKSTISAPEEEI
S223	GRYKSTISAPEEEIL
P225	YKSTISAPEEEILNR
Y233	EEEILNRYPRTDRSG
P234	EEILNRYPRTDRSGF
S249-p	SRHNRDTsAPANFAS
P251	HNRDTsAPANFASSS
K288	LTRLMQDKEEMIGKL
K294	DKEEMIGKLKEEIDL
K325	QENKTLLKVVGQLTR
K325	QENKTLLKVVGQLTR

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