Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
PAR-4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PAR-4 a proapoptotic protein that drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression. Capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappaB transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Cellular Component: cytoplasm; actin filament; nucleus
Molecular Function: leucine zipper domain binding; protein binding; enzyme binding; actin binding; transcription corepressor activity
Biological Process: actin filament bundle formation; negative regulation of cell proliferation; negative regulation of T cell proliferation; interleukin-2 biosynthetic process; transcription, DNA-dependent; positive regulation of apoptosis; apoptosis; negative regulation of T cell receptor signaling pathway; negative regulation of B cell proliferation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of amyloid precursor protein biosynthetic process
Reference #:  Q96IZ0 (UniProtKB)
Alt. Names/Synonyms: Par-4; PAR4; PAWR; PRKC apoptosis WT1 regulator protein; PRKC, apoptosis, WT1, regulator; Prostate apoptosis response 4 protein; prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4; transcriptional repressor PAR4; WT1-interacting protein
Gene Symbols: PAWR
Molecular weight: 36,568 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PAR-4

Protein Structure Not Found.


STRING  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 T8-p MATGGYRtSSGLGGs
0 2 S15-p tSSGLGGsTTDFLEE
0 1 T16 SSGLGGsTTDFLEEW
0 1 T17 SGLGGsTTDFLEEWK
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 S95-p GVNCAVGsAMLtRAA
0 1 T99-p AVGsAMLtRAAPGPR
0 1 S108-p AAPGPRRsEDEPPAA
1 1 G132 RDEEEPDGVPEKGKS
0 16 S162-p KLREKRRstGVVNIP
2 29 T163-p LREKRRstGVVNIPA
0 67 Y177-p AAECLDEyEDDEAGQ
0 3 Y226-p PRTVSGRyKsttsVs
0 12 S228-p TVSGRyKsttsVsEE
0 4 T229-p VSGRyKsttsVsEED
0 1 T230-p SGRyKsttsVsEEDV
1 14 S231-p GRyKsttsVsEEDVS
0 2 S233-p yKsttsVsEEDVSSR
0 1 Y241-p EEDVSSRysRTDRSG
0 1 S242-p EDVSSRysRTDRSGF
1 0 N257 PRYNRDANVsGTLVS
0 2 S259-p YNRDANVsGTLVSSS
0 1 K296-ac LVRLMQDkEEMIGkL
0 1 K302-ac DkEEMIGkLKEEIDL
0 6 K333-ub QENKTLLkVVGQLTR
0 1 K333 QENKTLLKVVGQLTR
2329 : Phospho-PAR-4 (Thr163) Antibody
  mouse

 
S8-p MATGGYRsGGStttD
T12-p GYRsGGStttDFLEE
T13-p YRsGGStttDFLEEW
T14-p RsGGStttDFLEEWK
S47-p GGDPAAKsPAGsLtP
S51-p AAKsPAGsLtPtAVA
T53-p KsPAGsLtPtAVAGT
T55-p PAGsLtPtAVAGTSE
S87 ALNCAHGSSTLPRAA
- gap
- gap
S125 GDEEEPDSAREKGRS
S155 KLREKRRStGVVNIP
T156-p LREKRRStGVVNIPA
Y170 AAECLDEYEDDEAGQ
Y219 SRTVPGRYKSTTSAP
S221 TVPGRYKSTTSAPED
T222 VPGRYKSTTSAPEDE
T223 PGRYKSTTSAPEDEI
S224 GRYKSTTSAPEDEIS
- gap
Y234 EDEISNRYPRTDRSG
- gap
N250 SRHNRDANAPASFSS
- gap
K289 LVRLMQDKEEMIGKL
K295 DKEEMIGKLKEEIDL
K326-ub QENKTLLkVVGQLTR
K326-ac QENKTLLkVVGQLTR
2329 : Phospho-PAR-4 (Thr163) Antibody
  rat

 
S8 MATGGYRSSGSTTDF
S11 GGYRSSGSTTDFLEE
T12 GYRSSGSTTDFLEEW
T13 YRSSGSTTDFLEEWK
S46 GGDPAAKSPAGPLAQ
- gap
- gap
T54 PAGPLAQTTAAGTSE
S86 ALNCAHGSSALPRGA
- gap
- gap
S124-p GDEEEPDsAPEKGRS
S154 KLREKRRStGVVNIP
T155-p LREKRRStGVVNIPA
Y169 AAECLDEYEDDEAGQ
Y218 SRTVPGRYKSTIsAP
S220 TVPGRYKSTIsAPEE
T221 VPGRYKSTIsAPEEE
I222 PGRYKSTIsAPEEEI
S223-p GRYKSTIsAPEEEIL
- gap
Y233 EEEILNRYPRTDRSG
- gap
S249-p SRHNRDTsAPANFAS
- gap
K288 LTRLMQDKEEMIGKL
K294 DKEEMIGKLKEEIDL
K325 QENKTLLKVVGQLTR
K325 QENKTLLKVVGQLTR
2329 : Phospho-PAR-4 (Thr163) Antibody
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.