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Protein Page:
Yes (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Yes a proto-oncogenic cytosolic tyrosine kinase of the Src family. Expressed at high levels in adult neurons, spermatozoa, platelets, and epithelial cells. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; EC 2.7.10.2; TK group; Src family
Cellular Component: Golgi apparatus; cytoplasm; plasma membrane; microtubule organizing center; cytosol
Molecular Function: protein binding; enzyme binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; epidermal growth factor receptor binding
Biological Process: peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; T cell costimulation; innate immune response; protein modification process; regulation of vascular permeability; glucose transport; blood coagulation; leukocyte migration
Reference #:  P07947 (UniProtKB)
Alt. Names/Synonyms: c-yes; cellular yes-1 protein; HsT441; p61-Yes; Proto-oncogene c-Yes; Proto-oncogene tyrosine-protein kinase Yes; v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1; viral oncogene yes-1 homolog 1; Yamaguchi sarcoma oncogene; YES; YES1
Gene Symbols: YES1
Molecular weight: 60,801 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Yes

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, inhibited: Y537‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S11-p IKSKENKsPAIKyRP
0 1 K15 ENKsPAIKyRPENtP
0 2 Y16-p NKsPAIKyRPENtPE
0 6 T21-p IKyRPENtPEPVsTs
0 2 P22 KyRPENtPEPVsTsV
0 2 S26-p ENtPEPVsTsVsHyG
0 1 S28-p tPEPVsTsVsHyGAE
0 1 S30-p EPVsTsVsHyGAEPt
1 93 Y32-p VsTsVsHyGAEPttV
0 1 T37-p sHyGAEPttVsPCPS
0 1 T38-p HyGAEPttVsPCPSs
0 4 S40-p GAEPttVsPCPSssA
0 1 S45-p tVsPCPSssAKGTAV
0 1 S46-p VsPCPSssAKGTAVN
0 1 T69 FGGSSGVTPFGGASS
0 1 S76 TPFGGASSSFSVVPS
0 1 S77 PFGGASSSFSVVPSS
0 9 Y100-p VTIFVALyDYEARTT
0 1 S111-p ARTTEDLsFKKGERF
0 12 Y141-p IATGKNGyIPsNyVA
0 1 S144-p GKNGyIPsNyVAPAD
0 4 Y146-p NGyIPsNyVAPADSI
0 11 Y159-p SIQAEEWyFGKMGRK
0 2 K191-ub VRESETTkGAysLSI
0 344 Y194-p SETTkGAysLSIRDW
0 9 S195-p ETTkGAysLSIRDWD
0 1768 Y222-p RKLDNGGyyITTRAQ
0 665 Y223-p KLDNGGyyITTRAQF
0 2 K235-ub AQFDTLQkLVKHYTE
0 1 K308 KVAIKTLKPGTMMPE
0 1 K326 QEAQIMKKLRHDKLV
0 8 Y336-p HDKLVPLyAVVSEEP
0 34 Y345-p VVSEEPIyIVTEFMS
5 2986 Y426-p RLIEDNEytARQGAK
0 15 T427-p LIEDNEytARQGAKF
1 511 Y446-p TAPEAALyGRFTIKS
0 3 T533-p LEDYFTAtEPQyQPG
4 1228 Y537-p FTAtEPQyQPGENL_
2101 : Phospho-Src Family (Tyr416) Antibody
6943 : Phospho-Src Family (Tyr416) (D49G4) Rabbit mAb
  mouse

 
S11 IKSKENKSPAIkyTP
K15-ub ENKSPAIkyTPENLt
Y16-p NKSPAIkyTPENLtE
- gap
T22-p kyTPENLtEPVsPSA
S26-p ENLtEPVsPSAsHYG
S28 LtEPVsPSAsHYGVE
S30-p EPVsPSAsHYGVEHA
Y32 VsPSAsHYGVEHATV
- gap
T38 HYGVEHATVAPTssT
- gap
S43-p HATVAPTssTKGASV
S44-p ATVAPTssTKGASVN
T67-p FGGSSGVtPFGGASs
S74-p tPFGGASssFSVVSS
S75-p PFGGASssFSVVSSS
Y98-p VTIFVALyDYEARTT
S109 ARTTEDLSFKKGERF
Y139 IATGKSGYIPSNYVV
S142 GKSGYIPSNYVVPAD
Y144 SGYIPSNYVVPADSI
Y157-p SIQAEEWyFGKMGRK
K189-ub VRESETTkGAysLSI
Y192-p SETTkGAysLSIRDW
S193-p ETTkGAysLSIRDWD
Y220-p RKLDNGGyyITTRAQ
Y221-p KLDNGGyyITTRAQF
K233-ub AQFDTLQkLVKHYTE
K306-ub KVAIKTLkPGTMMPE
K324-ub QEAQIMKkLRHDKLV
Y334 HDKLVPLYAVVSEEP
Y343-p VVSEEPIyIVTEFMS
Y424-p RLIEDNEytARQGAK
T425-p LIEDNEytARQGAKF
Y444-p TAPEAALyGRFTIKS
T531 LEDYFTATEPQyQPG
Y535-p FTATEPQyQPGENL_
2101 : Phospho-Src Family (Tyr416) Antibody
6943 : Phospho-Src Family (Tyr416) (D49G4) Rabbit mAb
  rat

 
S11 IKSKENKSPAIKYTP
K15 ENKSPAIKYTPENPT
Y16 NKSPAIKYTPENPTE
- gap
T22 KYTPENPTEPVNTSA
N26 ENPTEPVNTSAGHyG
S28 PTEPVNTSAGHyGVE
G30 EPVNTSAGHyGVEHA
Y32-p VNTSAGHyGVEHATA
- gap
T38 HyGVEHATAATTSST
- gap
S43 HATAATTSSTKGASA
S44 ATAATTSSTKGASAN
T67 FGGSSGVTPFGGASS
S74 TPFGGASSSFSVVPS
S75 PFGGASSSFSVVPSS
Y98 VTIFVALYDYEARTT
S109 ARTTEDLSFKKGERF
Y139 IATGKNGYIPSNYVA
S142 GKNGYIPSNYVAPAD
Y144 NGYIPSNYVAPADSI
Y157 SIQAEEWYFGKMGRK
K189 VRESETTKGAySLSI
Y192-p SETTKGAySLSIRDW
S193 ETTKGAySLSIRDWD
Y220-p RKLDNGGyyITTRAQ
Y221-p KLDNGGyyITTRAQF
K233 AQFDTLQKLVKHYTE
K306 KVAIKTLKPGTMMPE
K324 QEAQIMKKLRHDKLV
Y334 HDKLVPLYAVVSEEP
Y343-p VVSEEPIyIVTEFMS
Y424-p RLIEDNEyTARQGAK
T425 LIEDNEyTARQGAKF
Y444-p TAPEAALyGRFTIKS
T531 LEDYFTATEPQyQPG
Y535-p FTATEPQyQPGENL_
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