Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
Yes (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Yes a proto-oncogenic cytosolic tyrosine kinase of the Src family. Expressed at high levels in adult neurons, spermatozoa, platelets, and epithelial cells. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (non-receptor); Protein kinase, TK; EC 2.7.10.2; Kinase, protein; TK group; Src family
Cellular Component: Golgi apparatus; cytoplasm; plasma membrane; microtubule organizing center; cytosol
Molecular Function: protein binding; enzyme binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; epidermal growth factor receptor binding
Biological Process: peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; T cell costimulation; protein modification process; innate immune response; glucose transport; regulation of vascular permeability; blood coagulation; leukocyte migration
Reference #:  P07947 (UniProtKB)
Alt. Names/Synonyms: c-yes; cellular yes-1 protein; HsT441; p61-Yes; Proto-oncogene c-Yes; Proto-oncogene tyrosine-protein kinase Yes; v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1; viral oncogene yes-1 homolog 1; Yamaguchi sarcoma oncogene; YES; YES1
Gene Symbols: YES1
Molecular weight: 60,801 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Yes

Protein Structure Not Found.


STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
enzymatic activity, inhibited: Y537‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S11-p IKSKENKsPAIKyRP
0 1 K15 ENKsPAIKyRPENtP
0 2 Y16-p NKsPAIKyRPENtPE
0 5 T21-p IKyRPENtPEPVsTS
0 1 P22 KyRPENtPEPVsTSV
0 2 S26-p ENtPEPVsTSVsHyG
0 1 S30-p EPVsTSVsHyGAEPT
1 94 Y32-p VsTSVsHyGAEPTTV
0 3 S40-p GAEPTTVsPCPSsSA
0 1 S45-p TVsPCPSsSAKGTAV
0 10 Y100-p VTIFVALyDYEARTT
0 1 S111-p ARTTEDLsFKKGERF
0 12 Y141-p IATGKNGyIPSNyVA
0 4 Y146-p NGyIPSNyVAPADSI
0 11 Y159-p SIQAEEWyFGKMGRK
0 2 K191-u VRESETTkGAysLSI
0 346 Y194-p SETTkGAysLSIRDW
0 8 S195-p ETTkGAysLSIRDWD
0 1802 Y222-p RKLDNGGyyITTRAQ
0 684 Y223-p KLDNGGyyITTRAQF
0 2 K235-u AQFDTLQkLVKHYTE
0 8 Y336-p HDKLVPLyAVVSEEP
0 36 Y345-p VVSEEPIyIVTEFMS
5 3101 Y426-p RLIEDNEytARQGAK
0 17 T427-p LIEDNEytARQGAKF
1 526 Y446-p TAPEAALyGRFTIKS
0 3 T533-p LEDYFTAtEPQyQPG
4 1254 Y537-p FTAtEPQyQPGENL_
2101 : Phospho-Src Family (Tyr416) Antibody
6943 : Phospho-Src Family (Tyr416) (D49G4) Rabbit mAb
  mouse

 
S11 IKSKENKSPAIkyTP
K15-u ENKSPAIkyTPENLt
Y16-p NKSPAIkyTPENLtE
- gap
T22-p kyTPENLtEPVsPSA
S26-p ENLtEPVsPSAsHYG
S30-p EPVsPSAsHYGVEHA
Y32 VsPSAsHYGVEHATV
- gap
S43-p HATVAPTsSTKGASV
Y98-p VTIFVALyDYEARTT
S109 ARTTEDLSFKKGERF
Y139 IATGKSGYIPSNYVV
Y144 SGYIPSNYVVPADSI
Y157-p SIQAEEWyFGKMGRK
K189-u VRESETTkGAysLSI
Y192-p SETTkGAysLSIRDW
S193-p ETTkGAysLSIRDWD
Y220-p RKLDNGGyyITTRAQ
Y221-p KLDNGGyyITTRAQF
K233-u AQFDTLQkLVKHYTE
Y334 HDKLVPLYAVVSEEP
Y343-p VVSEEPIyIVTEFMS
Y424-p RLIEDNEytARQGAK
T425-p LIEDNEytARQGAKF
Y444-p TAPEAALyGRFTIKS
T531 LEDYFTATEPQyQPG
Y535-p FTATEPQyQPGENL_
2101 : Phospho-Src Family (Tyr416) Antibody
6943 : Phospho-Src Family (Tyr416) (D49G4) Rabbit mAb
  rat

 
S11 IKSKENKSPAIKYTP
K15 ENKSPAIKYTPENPT
Y16 NKSPAIKYTPENPTE
- gap
T22 KYTPENPTEPVNTSA
N26 ENPTEPVNTSAGHyG
G30 EPVNTSAGHyGVEHA
Y32-p VNTSAGHyGVEHATA
- gap
S43 HATAATTSSTKGASA
Y98 VTIFVALYDYEARTT
S109 ARTTEDLSFKKGERF
Y139 IATGKNGYIPSNYVA
Y144 NGYIPSNYVAPADSI
Y157 SIQAEEWYFGKMGRK
K189 VRESETTKGAySLSI
Y192-p SETTKGAySLSIRDW
S193 ETTKGAySLSIRDWD
Y220-p RKLDNGGyyITTRAQ
Y221-p KLDNGGyyITTRAQF
K233 AQFDTLQKLVKHYTE
Y334 HDKLVPLYAVVSEEP
Y343-p VVSEEPIyIVTEFMS
Y424-p RLIEDNEyTARQGAK
T425 LIEDNEyTARQGAKF
Y444-p TAPEAALyGRFTIKS
T531 LEDYFTATEPQyQPG
Y535-p FTATEPQyQPGENL_
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.