a proto-oncogenic cytosolic tyrosine kinase of the Src family. Expressed at high levels in adult neurons, spermatozoa, platelets, and epithelial cells. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; Kinase, protein; EC 126.96.36.199; Protein kinase, tyrosine (non-receptor); TK group; Src family
Chromosomal Location of Human Ortholog: 18p11.31-p11.21
Cellular Component: Golgi apparatus; extrinsic to internal side of plasma membrane; focal adhesion; cytoplasm; plasma membrane; microtubule organizing center; actin filament; cytosol
Molecular Function: protein binding; enzyme binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding; epidermal growth factor receptor binding
Biological Process: axon guidance; T cell costimulation; ephrin receptor signaling pathway; protein modification process; innate immune response; regulation of vascular permeability; glucose transport; cell differentiation; blood coagulation; leukocyte migration; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.