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Yes (human)

Overview Yes a proto-oncogenic cytosolic tyrosine kinase of the Src family. Expressed at high levels in adult neurons, spermatozoa, platelets, and epithelial cells. Note: This description may include information from UniProtKB. Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; TK group; Src family Cellular Component: Golgi apparatus; cytoplasm; plasma membrane; microtubule organizing center; cytosol Molecular Function: enzyme binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding Biological Process: T cell costimulation; protein modification process; regulation of vascular permeability; blood coagulation; leukocyte migration Reference #:  P07947 (UniProtKB) Alt. Names/Synonyms: c-yes; cellular yes-1 protein; HsT441; p61-Yes; Proto-oncogene c-Yes; Proto-oncogene tyrosine-protein kinase Yes; v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1; viral oncogene yes-1 homolog 1; Yamaguchi sarcoma oncogene; YES; YES1 Gene Symbols: YES1 Molecular weight: 60,801 Da Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states CST Pathways:  ErbB/HER Signaling  |  GPCRs Signaling to MAPK/Erk  |  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Yes 2HDA - A=91-152 (human)

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	Sites Implicated In
enzymatic activity, inhibited: Y537‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S11-p	IKSKENKsPAIKyRP
0	1		K15	ENKsPAIKyRPENtP
0	2		Y16-p	NKsPAIKyRPENtPE
0	5		T21-p	IKyRPENtPEPVsTs
0	1		P22	KyRPENtPEPVsTsV
0	2		S26-p	ENtPEPVsTsVsHyG
0	1		S28-p	tPEPVsTsVsHyGAE
0	1		S30-p	EPVsTsVsHyGAEPT
1	94		Y32-p	VsTsVsHyGAEPTTV
0	3		S40-p	GAEPTTVsPCPSsSA
0	1		S45-p	TVsPCPSsSAKGTAV
0	1		T69	FGGSSGVTPFGGASS
0	1		S76	TPFGGASSSFSVVPS
0	1		S77	PFGGASSSFSVVPSS
0	10		Y100-p	VTIFVALyDYEARTT
0	1		S111-p	ARTTEDLsFKKGERF
0	12		Y141-p	IATGKNGyIPsNyVA
0	1		S144-p	GKNGyIPsNyVAPAD
0	4		Y146-p	NGyIPsNyVAPADSI
0	11		Y159-p	SIQAEEWyFGKMGRK
0	2		K191-u	VRESETTkGAysLSI
0	343		Y194-p	SETTkGAysLSIRDW
0	8		S195-p	ETTkGAysLSIRDWD
0	1800		Y222-p	RKLDNGGyyITTRAQ
0	682		Y223-p	KLDNGGyyITTRAQF
0	2		K235-u	AQFDTLQkLVKHYTE
0	1		K308	KVAIKTLKPGTMMPE
0	1		K326	QEAQIMKKLRHDKLV
0	8		Y336-p	HDKLVPLyAVVSEEP
0	36		Y345-p	VVSEEPIyIVTEFMS
6	3096		Y426-p	RLIEDNEytARQGAK
0	16		T427-p	LIEDNEytARQGAKF
1	522		Y446-p	TAPEAALyGRFTIKS
0	3		T533-p	LEDYFTAtEPQyQPG
4	1253		Y537-p	FTAtEPQyQPGENL_

	mouse
S11	IKSKENKSPAIkyTP
K15-u	ENKSPAIkyTPENLt
Y16-p	NKSPAIkyTPENLtE
L21	IkyTPENLtEPVsPS
T22-p	kyTPENLtEPVsPSA
S26-p	ENLtEPVsPSAsHYG
S28	LtEPVsPSAsHYGVE
S30-p	EPVsPSAsHYGVEHA
Y32	VsPSAsHYGVEHATV
A40	GVEHATVAPTsSTKG
S43-p	HATVAPTsSTKGASV
T67-p	FGGSSGVtPFGGASs
S74-p	tPFGGASssFSVVSS
S75-p	PFGGASssFSVVSSS
Y98-p	VTIFVALyDYEARTT
S109	ARTTEDLSFKKGERF
Y139	IATGKSGYIPSNYVV
S142	GKSGYIPSNYVVPAD
Y144	SGYIPSNYVVPADSI
Y157-p	SIQAEEWyFGKMGRK
K189-u	VRESETTkGAysLSI
Y192-p	SETTkGAysLSIRDW
S193-p	ETTkGAysLSIRDWD
Y220-p	RKLDNGGyyITTRAQ
Y221-p	KLDNGGyyITTRAQF
K233-u	AQFDTLQkLVKHYTE
K306-u	KVAIKTLkPGTMMPE
K324-u	QEAQIMKkLRHDKLV
Y334	HDKLVPLYAVVSEEP
Y343-p	VVSEEPIyIVTEFMS
Y424-p	RLIEDNEyTARQGAK
T425	LIEDNEyTARQGAKF
Y444-p	TAPEAALyGRFTIKS
T531	LEDYFTATEPQyQPG
Y535-p	FTATEPQyQPGENL_

	rat
S11	IKSKENKSPAIKYTP
K15	ENKSPAIKYTPENPT
Y16	NKSPAIKYTPENPTE
P21	IKYTPENPTEPVNTS
T22	KYTPENPTEPVNTSA
N26	ENPTEPVNTSAGHyG
S28	PTEPVNTSAGHyGVE
G30	EPVNTSAGHyGVEHA
Y32-p	VNTSAGHyGVEHATA
A40	GVEHATAATTSSTKG
S43	HATAATTSSTKGASA
T67	FGGSSGVTPFGGASS
S74	TPFGGASSSFSVVPS
S75	PFGGASSSFSVVPSS
Y98	VTIFVALYDYEARTT
S109	ARTTEDLSFKKGERF
Y139	IATGKNGYIPSNYVA
S142	GKNGYIPSNYVAPAD
Y144	NGYIPSNYVAPADSI
Y157	SIQAEEWYFGKMGRK
K189	VRESETTKGAySLSI
Y192-p	SETTKGAySLSIRDW
S193	ETTKGAySLSIRDWD
Y220-p	RKLDNGGyyITTRAQ
Y221-p	KLDNGGyyITTRAQF
K233	AQFDTLQKLVKHYTE
K306	KVAIKTLKPGTMMPE
K324	QEAQIMKKLRHDKLV
Y334	HDKLVPLYAVVSEEP
Y343-p	VVSEEPIyIVTEFMS
Y424-p	RLIEDNEyTARQGAK
T425	LIEDNEyTARQGAKF
Y444-p	TAPEAALyGRFTIKS
T531	LEDYFTATEPQyQPG
Y535-p	FTATEPQyQPGENL_

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