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Protein Page:
atlastin (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
atlastin GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. Defects in ATL1 are the cause of spastic paraplegia autosomal dominant type 3 (SPG3); also known as Strumpell-Lorrain syndrome. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Defects in ATL1 are the cause of hereditary sensory neuropathy type 1D (HSN1D). HSN1D is a disease characterized by adult-onset distal axonal sensory neuropathy leading to mutilating ulcerations as well as hyporeflexia. Some patients may show features suggesting upper neuron involvement. Belongs to the GBP family. Atlastin subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Vesicle protein; EC 3.6.5.-
Chromosomal Location of Human Ortholog: 14q22.1
Cellular Component: Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; endoplasmic reticulum; axon; integral to membrane; Golgi cis cisterna
Molecular Function: GTPase activity; identical protein binding; protein binding; GTP binding
Biological Process: endoplasmic reticulum organization and biogenesis; cell death; axonogenesis; GTP catabolic process; protein homooligomerization
Reference #:  Q8WXF7 (UniProtKB)
Alt. Names/Synonyms: AD-FSP; ATL1; ATLA1; atlastin GTPase 1; Atlastin-1; atlastin1; Brain-specific GTP-binding protein; FSP1; GBP-3; GBP3; GTP-binding protein 3; Guanine nucleotide-binding protein 3; guanylate-binding protein 3; hGBP3; Spastic paraplegia 3 protein A; SPG3; SPG3A
Gene Symbols: ATL1
Molecular weight: 63,544 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

atlastin

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 12 S10-p KNRRDRNsWGGFsEK
0 4 S15-p RNsWGGFsEKTYEWs
0 2 T18 WGGFsEKTYEWssEE
0 3 Y19 GGFsEKTYEWssEEE
0 23 S22-p sEKTYEWssEEEEPV
0 24 S23-p EKTYEWssEEEEPVK
0 1 S45-p LIVKDDHsFELDETA
0 1 S71-p DKEVVAVsVAGAFRK
0 1 K364 LAAVATAKDTYNKKM
0 1 K395 QTKHLQLKEESVKLF
0 1 S414-p KMGGEEFsRRYLQQL
0 1 Y429-p ESEIDELyIQyIKHN
0 1 Y432-p IDELyIQyIKHNDSK
  mouse

 
S10-p KSRRDRNsWGGFsEK
S15-p RNsWGGFsEKssDWs
S18-p WGGFsEKssDWssEE
S19-p GGFsEKssDWssEEE
S22-p sEKssDWssEEEEPV
S23-p EKssDWssEEEEPVR
S45 LIVKDDHSFELDEAA
S71 DKEVVAVSVAGAFRK
K364-ub LAAVATAkDTYNKKM
K395-ub QSKHLQLkEESVKLF
S414 KMGGEEFSRRYLQQL
Y429 ESEIDELYIQYIKHN
Y432 IDELYIQYIKHNDSK
  rat

 
S10-p KSRRDRNsWGGFsEK
S15-p RNsWGGFsEKSsDWs
S18 WGGFsEKSsDWssEE
S19-p GGFsEKSsDWssEEE
S22-p sEKSsDWssEEEEPV
S23-p EKSsDWssEEEEPVR
S45 LIVKDDHSFELDEAA
S71 DKEVVAVSVAGAFRK
K364 LAAVATAKDTYNKKM
K395 QTKHLQLKEDSVKLF
S414 KMGGEEFSRRYLQQL
Y429 ESEIDELYIQYIKHN
Y432 IDELYIQYIKHNDSK
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