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albumin (human)

Overview albumin Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Plasma. Belongs to the ALB/AFP/VDB family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Secreted; Secreted, signal peptide; Carrier protein Cellular Component: extracellular space; protein complex; extracellular region; basement membrane Molecular Function: zinc ion binding; drug binding; cell surface binding; oxygen binding; pyridoxal phosphate binding; antioxidant activity; toxin binding; protein binding; enzyme binding; copper ion binding; DNA binding; chaperone binding; fatty acid binding Biological Process: platelet activation; sodium-independent organic anion transport; maintenance of mitochondrion localization; bile acid metabolic process; lipoprotein metabolic process; hemolysis by symbiont of host red blood cells; cellular response to starvation; response to organic substance; response to mercury ion; bile acid and bile salt transport; platelet degranulation; transport; negative regulation of programmed cell death; lipid metabolic process; blood coagulation; transmembrane transport; positive regulation of circadian sleep/wake cycle, non-REM sleep; response to nutrient; negative regulation of apoptosis Reference #:  P02768 (UniProtKB) Alt. Names/Synonyms: ALB; ALBU; albumin; cell growth inhibiting protein 42; DKFZp779N1935; growth-inhibiting protein 20; PRO0883; PRO0903; PRO1341; Serum albumin Gene Symbols: ALB Molecular weight: 69,367 Da Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below albumin 1AO6 - A/B=25-609 (human) 1BJ5 - A=25-609 (human) 1BKE - A=28-608 (human) 1BM0 - A/B=25-609 (human) 1E78 - A/B=25-609 (human) 1E7A - A/B=25-609 (human) 1E7B - A/B=25-609 (human) 1E7C - A=25-609 (human) 1E7E - A=25-609 (human) 1E7F - A=25-609 (human) 1E7G - A=25-609 (human) 1E7H - A=25-609 (human) 1E7I - A=25-609 (human) 1GNI - A=25-609 (human) 1GNJ - A=25-609 (human) 1H9Z - A=25-609 (human) 1HA2 - A=25-609 (human) 1HK1 - A=25-609 (human) 1HK2 - A=25-609 (human) 1HK3 - A=25-609 (human) 1HK4 - A=25-609 (human) 1HK5 - A=25-609 (human) 1N5U - A=25-609 (human) 1O9X - A=25-609 (human) 1TF0 - A=25-596 (human) 1UOR - A=25-609 (human) 1YSX - A=409-609 (human) 2BX8 - A/B=25-609 (human) 2BXA - A/B=25-609 (human) 2BXB - A/B=25-609 (human) 2BXC - A/B=25-609 (human) 2BXD - A/B=25-609 (human) 2BXE - A/B=25-609 (human) 2BXF - A/B=25-609 (human) 2BXG - A/B=25-609 (human) 2BXH - A/B=25-609 (human) 2BXI - A=25-609 (human) 2BXK - A=25-609 (human) 2BXL - A=25-609 (human) 2BXM - A=25-609 (human) 2BXN - A=25-609 (human) 2BXO - A=25-609 (human) 2BXP - A=25-609 (human) 2BXQ - A=25-609 (human) 2ESG - C=25-609 (human) 2I2Z - A=25-609 (human) 2I30 - A=25-609 (human) 2VDB - A=30-608 (human) 2VUE - A/B=25-609 (human) 2VUF - A/B=25-609 (human) 2XSI - A=25-609 (human) 2XVQ - A/B=25-609 (human) 2XVU - A/B=25-609 (human) 2XVV - A=25-609 (human) 2XVW - A=25-609 (human) 2XW0 - A/B=25-609 (human) 2XW1 - A/B=25-609 (human) 2YDF - A/B=25-609 (human) 3A73 - A/B=25-609 (human) 3B9L - A=25-609 (human) 3B9M - A=25-609 (human) 3CX9 - A=27-608 (human) 3JQZ - A/B=25-609 (human) 3JRY - A/B=25-609 (human) 3LU6 - A/B=25-609 (human) 3LU7 - A/B=25-609 (human) 3LU8 - A/B=25-609 (human) 3SQJ - A/B=27-608 (human) 3TDL - A=25-609 (human) 3UIV - H/A=25-609 (human) 4E99 - A=25-609 (human) 4EMX - A/B=25-609 (human) 4HGK - A/B=25-609 (human) 4HGM - B=25-609 (human) 4IW1 - A=25-609 (human) 4IW2 - A=25-609 (human) 4K2C - A/B=25-609 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1AO6 1BJ5 1BKE 1BM0 1E78 1E7A 1E7B 1E7C 1E7E 1E7F 1E7G 1E7H 1E7I 1GNI 1GNJ 1H9Z 1HA2 1HK1 1HK2 1HK3 1HK4 1HK5 1N5U 1O9X 1TF0 1UOR 1YSX 2BX8 2BXA 2BXB 2BXC 2BXD 2BXE 2BXF 2BXG 2BXH 2BXI 2BXK 2BXL 2BXM 2BXN 2BXO 2BXP 2BXQ 2ESG 2I2Z 2I30 2VDB 2VUE 2VUF 2XSI 2XVQ 2XVU 2XVV 2XVW 2XW0 2XW1 2YDF 3A73 3B9L 3B9M 3CX9 3JQZ 3JRY 3LU6 3LU7 3LU8 3SQJ 3TDL 3UIV 4E99 4EMX 4HGK 4HGM 4IW1 4IW2 4K2C  |  Phospho3D  |  DISEASE 103600 194470  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S14-p	ISLLFLFsSAysRGV
0	1		S15	SLLFLFsSAysRGVF
0	1		Y17-p	LFLFsSAysRGVFRR
0	2		S18-p	FLFsSAysRGVFRRD
0	1		S29	FRRDAHKSEVAHRFK
0	47		K44-a	DLGEENFkALVLIAF
0	10		Y54-p	VLIAFAQyLQQCPFE
0	1		F60	QyLQQCPFEDHVkLV
0	3		K65-a	CPFEDHVkLVNEVTE
0	1		K65	CPFEDHVKLVNEVTE
0	6		K75-a	NEVTEFAkTCVADEs
0	1		K75-m1	NEVTEFAkTCVADEs
0	13		S82-p	kTCVADEsAENCDKS
0	1		K88	EsAENCDKSLHtLFG
0	1		K88	EsAENCDKSLHtLFG
0	8		T92-p	NCDKSLHtLFGDKLC
0	1		K97	LHtLFGDKLCTVATL
0	2		T103	DKLCTVATLREtyGE
0	7		T107-p	TVATLREtyGEMADC
0	118		Y108-p	VATLREtyGEMADCC
0	1		K117-a	EMADCCAkQEPERNE
0	9		K130-a	NECFLQHkDDNPNLP
0	60		K160-a	DNEETFLkkyLyEIA
0	5		K161-a	NEETFLkkyLyEIAR
0	19		Y162-p	EETFLkkyLyEIARR
0	361		Y164-p	TFLkkyLyEIARRHP
0	25		Y172-p	EIARRHPyFyAPELL
0	45		Y174-p	ARRHPyFyAPELLFF
0	27		K183-a	PELLFFAkRYkAAFT
0	3		K186-a	LFFAkRYkAAFTECC
0	1		K198-a	ECCQAADkAACLLPK
0	1		K205	kAACLLPKLDELRDE
0	1		E212	KLDELRDEGkASsAk
0	32		K214-a	DELRDEGkASsAkQR
0	2		S217-p	RDEGkASsAkQRLkC
0	7		K219-a	EGkASsAkQRLkCAS
1	5		K223-a	SsAkQRLkCASLQkF
0	56		K229-a	LkCASLQkFGERAFK
0	2		K229-u	LkCASLQkFGERAFK
0	1		K236	kFGERAFKAWAVARL
0	1		K236	kFGERAFKAWAVARL
0	3		K249-a	RLSQRFPkAEFAEVS
0	1		K257-a	AEFAEVSkLVtDLTk
0	1		K257	AEFAEVSKLVtDLTk
0	1		T260-p	AEVSkLVtDLTkVHT
0	1		K264-a	kLVtDLTkVHTECCH
0	1		K264	kLVtDLTKVHTECCH
0	2		K286-a	DDRADLAkyICENQD
0	9		Y287-p	DRADLAkyICENQDS
0	2		S294	yICENQDSISSkLkE
0	1		S297	ENQDSISSkLkECCE
0	10		K298-a	NQDSISSkLkECCEk
0	4		K298-u	NQDSISSkLkECCEk
0	3		K300-a	DSISSkLkECCEkPL
0	1		E301	SISSkLkECCEkPLL
0	8		K305-a	kLkECCEkPLLEKSH
0	1		K305	kLkECCEKPLLEKSH
0	6		E309	CCEkPLLEKSHCIAE
0	1		A315	LEKSHCIAEVENDEM
0	1		S328-p	EMPADLPsLAADFVE
0	2		S336-p	LAADFVEsKDVCKNy
0	14		Y343-p	sKDVCKNyAEAkDVF
0	1		K347-a	CKNyAEAkDVFLGMF
0	66		Y365-p	YARRHPDysVVLLLR
0	5		S366-p	ARRHPDysVVLLLRL
0	7		V368	RHPDysVVLLLRLAK
0	13		T376-p	LLLRLAKtyEtTLEK
0	1		T376	LLLRLAKTyEtTLEK
0	78		Y377-p	LLRLAKtyEtTLEKC
0	4		T379-p	RLAKtyEtTLEKCCA
0	188		Y394-p	AADPHECyAkVFDEF
0	11		K396-a	DPHECyAkVFDEFkP
0	1		K402-a	AkVFDEFkPLVEEPQ
0	2		K413	EEPQNLIKQNCELFE
0	63		Y425-p	LFEQLGEykFQNALL
0	35		K426-a	FEQLGEykFQNALLV
1	21		K438-a	LLVRYTKkVPQVstP
0	1		K438	LLVRYTKKVPQVstP
0	12		S443-p	TKkVPQVstPtLVEV
0	9		T444-p	KkVPQVstPtLVEVs
0	1		T444-ga	KkVPQVstPtLVEVs
0	2		T446-p	VPQVstPtLVEVsRN
0	1		S451-p	tPtLVEVsRNLGkVG
0	1		K456-a	EVsRNLGkVGSkCCK
0	1		K460-u	NLGkVGSkCCKHPEA
0	23		K468-a	CCKHPEAkRMPCAED
0	3		Y476-p	RMPCAEDyLSVVLNQ
0	2		K490	QLCVLHEKTPVSDRV
0	2		K490	QLCVLHEKTPVSDRV
0	7		K499-a	PVSDRVTkCCTESLV
0	1		K499	PVSDRVTKCCTESLV
0	2		T520-p	SALEVDEtyVPkEFN
0	18		Y521-p	ALEVDEtyVPkEFNA
0	5		K524-a	VDEtyVPkEFNAETF
0	1		A535	AETFTFHADICTLSE
0	1		K549-a	EKERQIKkQtALVEL
0	1		K549	EKERQIKKQtALVEL
0	1		T551-p	ERQIKkQtALVELVk
0	1		K558-a	tALVELVkHKPkAtK
0	5		K558-m1	tALVELVkHKPkAtK
0	1		K562-a	ELVkHKPkAtKEQLK
0	1		T564-p	VkHKPkAtKEQLKAV
0	1		T590-p	CKADDKEtCFAEEGk
0	2		A593	DDKEtCFAEEGkkLV
0	1		E594	DKEtCFAEEGkkLVA
0	63		K597-a	tCFAEEGkkLVAAsQ
0	19		K598-a	CFAEEGkkLVAAsQA
0	1		S603-p	GkkLVAAsQAALGL_

	mouse
G14	LLLLFVSGsAFsRGV
S15-p	LLLFVSGsAFsRGVF
F17	LFVSGsAFsRGVFRR
S18-p	FVSGsAFsRGVFRRE
S29-p	FRREAHKsEIAHRYN
K44-a	DLGEQHFkGLVLIAF
Y54	VLIAFSQYLQKCSyD
Y60-p	QYLQKCSyDEHAkLV
K65	CSyDEHAKLVQEVTD
K65-u	CSyDEHAkLVQEVTD
K75-a	QEVTDFAkTCVADES
K75	QEVTDFAKTCVADES
S82	kTCVADESAANCDkS
K88-a	ESAANCDkSLHTLFG
K88-u	ESAANCDkSLHTLFG
T92	NCDkSLHTLFGDkLC
K97-u	LHTLFGDkLCAIPNL
N103	DkLCAIPNLRENYGE
N107	AIPNLRENYGELADC
Y108	IPNLRENYGELADCC
K117	ELADCCTKQEPERNE
K130	NECFLQHKDDNPSLP
G160	ENPTTFMGHYLHEVA
H161	NPTTFMGHYLHEVAR
Y162	PTTFMGHYLHEVARR
H164	TFMGHYLHEVARRHP
Y172	EVARRHPYFYAPELL
Y174	ARRHPYFYAPELLYY
E183	PELLYYAEQYNEILT
N186	LYYAEQYNEILTQCC
K198	QCCAEADKESCLTPk
K205-u	KESCLTPkLDGVKEk
K212-u	kLDGVKEkALVSSVR
L214	DGVKEkALVSSVRQR
S217	KEkALVSSVRQRMKC
R219	kALVSSVRQRMKCSS
K223	SSVRQRMKCSSMQkF
K229-a	MKCSSMQkFGERAFk
K229	MKCSSMQKFGERAFk
K236-u	kFGERAFkAWAVARL
K236-a	kFGERAFkAWAVARL
N249	RLSQTFPNADFAEIT
K257	ADFAEITKLATDLTk
K257-u	ADFAEITkLATDLTk
T260	AEITkLATDLTkVNK
K264	kLATDLTKVNKECCH
K264-u	kLATDLTkVNKECCH
K286	DDRAELAKYMCENQA
Y287	DRAELAKYMCENQAt
T294-p	YMCENQAtISsKLQt
S297-p	ENQAtISsKLQtCCD
K298	NQAtISsKLQtCCDk
K298	NQAtISsKLQtCCDk
Q300	AtISsKLQtCCDkPL
T301-p	tISsKLQtCCDkPLL
K305-a	KLQtCCDkPLLkKAH
K305-u	KLQtCCDkPLLkKAH
K309-a	CCDkPLLkKAHCLsE
S315-p	LkKAHCLsEVEHDTM
A328	TMPADLPAIAADFVE
D336	IAADFVEDQEVCKNY
Y343	DQEVCKNYAEAKDVF
K347	CKNYAEAKDVFLGTF
Y365	YSRRHPDYSVsLLLR
S366	SRRHPDYSVsLLLRL
S368-p	RHPDYSVsLLLRLAK
K376	LLLRLAKKYEATLEK
K376-u	LLLRLAKkYEATLEK
Y377	LLRLAKkYEATLEKC
A379	RLAKkYEATLEKCCA
Y394	EANPPACYGTVLAEF
T396	NPPACYGTVLAEFQP
Q402	GTVLAEFQPLVEEPK
K413-u	EEPKNLVkTNCDLYE
Y425-p	LYEKLGEyGFQNAIL
G426	YEKLGEyGFQNAILV
K438	ILVRYTQKAPQVstP
K438-u	ILVRYTQkAPQVstP
S443-p	TQkAPQVstPTLVEA
T444-p	QkAPQVstPTLVEAA
T444	QkAPQVsTPTLVEAA
T446	APQVstPTLVEAARN
A451	tPTLVEAARNLGRVG
R456	EAARNLGRVGTkCCT
K460-u	NLGRVGTkCCTLPED
Q468	CCTLPEDQRLPCVED
Y476	RLPCVEDYLSAILNR
K490-a	RVCLLHEkTPVSEHV
K490-u	RVCLLHEkTPVSEHV
K499-a	PVSEHVTkCCSGSLV
K499-u	PVSEHVTkCCSGSLV
T520	SALTVDETYVPkEFK
Y521	ALTVDETYVPkEFKA
K524-a	VDETYVPkEFKAETF
S535-p	AETFTFHsDICTLPE
K549	EKEKQIKKQTALAEL
K549-u	EKEKQIKkQTALAEL
T551	EKQIKkQTALAELVK
K558	TALAELVKHKPKATA
K558	TALAELVKHKPKATA
K562	ELVKHKPKATAEQLK
T564	VKHKPKATAEQLKTV
T590	CKAADKDTCFstEGP
S593-p	ADKDTCFstEGPNLV
T594-p	DKDTCFstEGPNLVT
P597	TCFstEGPNLVTRCK
N598	CFstEGPNLVTRCKD
C603	GPNLVTRCKDALA__

	rat
G14	LLLLFISGSAFSRGV
S15	LLLFISGSAFSRGVF
F17	LFISGSAFSRGVFRR
S18	FISGSAFSRGVFRRE
S29	FRREAHKSEIAHRFK
K44	DLGEQHFKGLVLIAF
Y54	VLIAFSQYLQKCPYE
Y60	QYLQKCPYEEHIKLV
K65	CPYEEHIKLVQEVTD
K65	CPYEEHIKLVQEVTD
K75	QEVTDFAKTCVADEN
K75	QEVTDFAKTCVADEN
N82	KTCVADENAENCDKS
K88	ENAENCDKSIHTLFG
K88	ENAENCDKSIHTLFG
T92	NCDKSIHTLFGDKLC
K97	IHTLFGDKLCAIPkL
K103-a	DKLCAIPkLRDNYGE
N107	AIPkLRDNYGELADC
Y108	IPkLRDNYGELADCC
K117	ELADCCAKQEPERNE
K130	NECFLQHKDDNPNLP
G160	ENPTSFLGHYLHEVA
H161	NPTSFLGHYLHEVAR
Y162	PTSFLGHYLHEVARR
H164	SFLGHYLHEVARRHP
Y172	EVARRHPYFYAPELL
Y174	ARRHPYFYAPELLYY
E183	PELLYYAEKYNEVLT
N186	LYYAEKYNEVLTQCC
K198	QCCTESDKAACLTPK
K205	KAACLTPKLDAVKEK
K212	KLDAVKEKALVAAVR
L214	DAVKEKALVAAVRQR
A217	KEKALVAAVRQRMKC
R219	KALVAAVRQRMKCSS
K223	AAVRQRMKCSSMQRF
R229	MKCSSMQRFGERAFK
R229	MKCSSMQRFGERAFK
K236	RFGERAFKAWAVARM
K236	RFGERAFKAWAVARM
N249	RMSQRFPNAEFAEIT
K257	AEFAEITKLATDVTK
K257	AEFAEITKLATDVTK
T260	AEITKLATDVTKINK
K264	KLATDVTKINKECCH
K264	KLATDVTKINKECCH
K286	DDRAELAKYMCENQA
Y287	DRAELAKYMCENQAT
T294	YMCENQATISSKLQA
S297	ENQATISSKLQACCD
K298	NQATISSKLQACCDK
K298	NQATISSKLQACCDK
Q300	ATISSKLQACCDKPV
A301	TISSKLQACCDKPVL
K305	KLQACCDKPVLQKSQ
K305	KLQACCDKPVLQKSQ
Q309	CCDKPVLQKSQCLAE
A315	LQKSQCLAEIEHDNI
S328	NIPADLPSIAADFVE
D336	IAADFVEDKEVCKNY
Y343	DKEVCKNYAEAKDVF
K347	CKNYAEAKDVFLGTF
Y365	YSRRHPDYSVSLLLR
S366	SRRHPDYSVSLLLRL
S368	RHPDYSVSLLLRLAK
K376	LLLRLAKKYEATLEK
K376	LLLRLAKKYEATLEK
Y377	LLRLAKKYEATLEKC
A379	RLAKKYEATLEKCCA
Y394	EGDPPACYGTVLAEF
T396	DPPACYGTVLAEFQP
Q402	GTVLAEFQPLVEEPK
K413	EEPKNLVKTNCELYE
Y425-p	LYEKLGEyGFQNAVL
G426	YEKLGEyGFQNAVLV
K438	VLVRYTQKAPQVSTP
K438	VLVRYTQKAPQVSTP
S443	TQKAPQVSTPTLVEA
T444	QKAPQVSTPTLVEAA
T444	QKAPQVSTPTLVEAA
T446	APQVSTPTLVEAARN
A451	TPTLVEAARNLGRVG
R456	EAARNLGRVGTKCCT
K460	NLGRVGTKCCTLPEA
Q468	CCTLPEAQRLPCVED
Y476	RLPCVEDYLSAILNR
K490	RLCVLHEKTPVSEKV
K490	RLCVLHEKTPVSEKV
K499	PVSEKVTKCCSGSLV
K499	PVSEKVTKCCSGSLV
T520	SALTVDETYVPKEFK
Y521	ALTVDETYVPKEFKA
K524	VDETYVPKEFKAETF
S535	AETFTFHSDICTLPD
K549	DKEKQIKKQTALAEL
K549	DKEKQIKKQTALAEL
T551	EKQIKKQTALAELVK
K558	TALAELVKHKPKATE
K558	TALAELVKHKPKATE
K562	ELVKHKPKATEDQLK
T564	VKHKPKATEDQLKTV
N590	CKAADKDNCFATEGP
A593	ADKDNCFATEGPNLV
T594	DKDNCFATEGPNLVA
P597	NCFATEGPNLVARSK
N598	CFATEGPNLVARSKE
S603	GPNLVARSKEALA__

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