a receptor tyrosine kinase of the EGFR family. Binds and is activated by neuregulins and NTAK. Can form homodimers or ErbB-2/ErbB-3 heterodimers. Kinase domain lacks activity but heterodimerizes with other EGFRs to transduce growth signals. May be required for HER2 activity. Elevated expression in breast and other tumors is indicative of poor outcome. A secreted form is expressed in metastatic prostate cancer Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; Oncoprotein; EC 18.104.22.168; Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; EGFR family
Molecular Function: identical protein binding; protein binding; transmembrane receptor activity; protein homodimerization activity; protein heterodimerization activity; protein-tyrosine kinase activity; growth factor binding; protein tyrosine kinase activator activity; ATP binding
Biological Process: axon guidance; phosphoinositide 3-kinase cascade; wound healing; nerve growth factor receptor signaling pathway; activation of MAPKK activity; heart development; negative regulation of cell adhesion; signal transduction; small GTPase mediated signal transduction; negative regulation of neuron apoptosis; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; cranial nerve development; MAPKKK cascade; peripheral nervous system development; regulation of cell proliferation; negative regulation of signal transduction; positive regulation of phosphoinositide 3-kinase cascade; Schwann cell differentiation; neuron apoptosis; Ras protein signal transduction; insulin receptor signaling pathway; innate immune response; negative regulation of secretion; vascular endothelial growth factor receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.