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Protein Page:
HER3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HER3 a receptor tyrosine kinase of the EGFR family. Binds and is activated by neuregulins and NTAK. Can form homodimers or ErbB-2/ErbB-3 heterodimers. Kinase domain lacks activity but heterodimerizes with other EGFRs to transduce growth signals. May be required for HER2 activity. Elevated expression in breast and other tumors is indicative of poor outcome. A secreted form is expressed in metastatic prostate cancer Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; EC 2.7.10.1; TK group; EGFR family
Cellular Component: extracellular space; basolateral plasma membrane; integral to plasma membrane; apical plasma membrane; plasma membrane; lateral plasma membrane; receptor complex
Molecular Function: protein binding; protein homodimerization activity; transmembrane receptor activity; protein heterodimerization activity; protein-tyrosine kinase activity; growth factor binding; protein tyrosine kinase activator activity; ATP binding
Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide 3-kinase cascade; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; wound healing; heart development; cranial nerve development; negative regulation of cell adhesion; signal transduction; protein amino acid phosphorylation; peripheral nervous system development; negative regulation of signal transduction; regulation of cell proliferation; Schwann cell differentiation; positive regulation of phosphoinositide 3-kinase cascade; neuron apoptosis; innate immune response; negative regulation of secretion; negative regulation of neuron apoptosis; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P21860 (UniProtKB)
Alt. Names/Synonyms: c-erbB-3; c-erbB3; ErbB-3; ERBB3; erbB3-S; HER3; LCCS2; MDA-BF-1; MGC88033; p180-ErbB3; p45-sErbB3; p85-sErbB3; Proto-oncogene-like protein c-ErbB-3; Receptor tyrosine-protein kinase erbB-3; Tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Gene Symbols: ERBB3
Molecular weight: 148,098 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HER3

Protein Structure Not Found.


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Sites Implicated In
carcinogenesis, induced: Y1289‑p
cell growth, altered: Y1289‑p
molecular association, regulation: Y1197‑p, Y1262‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 - gap
0 1 T640-p TLVLIGKtHLTMALT
0 1 Y680-p NKRAMRRyLERGEsI
0 36 S686-p RyLERGEsIEPLDPS
0 1 K695 EPLDPSEKANKVLAR
0 1 K736 IPEGESIKIPVCIKV
0 1 K736-m1 IPEGESIkIPVCIKV
0 1 S844-p ARNVLLKsPsQVQVA
0 1 S846-p NVLLKsPsQVQVADF
0 1 K864 DLLPPDDKQLLysEA
0 3 Y868-p PDDKQLLysEAKTPI
0 1 S869-p DDKQLLysEAKTPIK
1 1 T873 LLysEAKTPIKWMAL
0 5 S982-p YLVIKREsGPGIAPG
2 22 Y1054-p LLSPSSGyMPMNQGN
0 1 S1083 ERCPRPVSLHPMPRG
0 1 A1093 PMPRGCLASESSEGH
0 1 S1094 MPRGCLASESSEGHV
1 2 S1123 RSRSRSRSPRPRGDS
0 8 Y1132-p RPRGDSAyHSQRHSL
0 1 S1147-p LTPVTPLsPPGLEEE
0 67 Y1159-p EEEDVNGyVMPDtHL
0 4 T1164-p NGyVMPDtHLKGTPS
4 26 Y1197-p EEDEDEEyEyMNRRR
1 8 Y1199-p DEDEEyEyMNRRRRH
0 1 S1207-p MNRRRRHsPPHPPRP
0 1 S1215-p PPHPPRPsSLEELGy
2 1 Y1222-p sSLEELGyEYMDVGS
2 16 Y1260-p GTTPDEDyEyMNRQR
1 3 Y1262-p TPDEDyEyMNRQRDG
2 58 Y1276-p GGGPGGDyAAMGACP
0 1 S1285-p AMGACPAsEQGyEEM
13 122 Y1289-p CPAsEQGyEEMRAFQ
0 131 Y1307-p HQAPHVHyARLKTLR
0 1 S1315-p ARLKTLRsLEAtDSA
0 1 T1319-p TLRsLEAtDSAFDNP
1 209 Y1328-p SAFDNPDyWHsRLFP
0 2 S1331-p DNPDyWHsRLFPKAN
0 1 K1336 WHsRLFPKANAQRT_
4561 : Phospho-HER3/ErbB3 (Tyr1197) (C56E4) Rabbit mAb
4784 : Phospho-HER3/ErbB3 (Tyr1222) (50C2) Rabbit mAb
2842 : Phospho-HER3/ErbB3 (Tyr1289) (D1B5) Rabbit mAb
4791 : Phospho-HER3/ErbB3 (Tyr1289) (21D3) Rabbit mAb
8017 : Phospho-HER3/ErbB3 (Tyr1328) Antibody
  HER3 iso2  
T169-p DDDPRLLtLSASsKV
S174-p LLtLSASsKVPVTLA
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- under review  
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  mouse

 
- gap
- gap
S638 GQAEVLMSKPHLVIA
Y678 NKRAMRRYLERGEsI
S684-p RYLERGEsIEPLDPS
K693-ub EPLDPSEkANKVLAR
K734-ub IPEGESIkIPVCIKV
K734 IPEGESIKIPVCIKV
S842 LRNVMLKSPSQVQVA
S844 NVMLKSPSQVQVADF
K862-ub DLLPPDDkQLLHSEA
H866 PDDkQLLHSEAKTPI
S867 DDkQLLHSEAKTPIK
T871 LLHSEAKTPIKWMAL
S980-p YLVIKRAsGPGIPPA
Y1051 LLSPSSGYMPMNQSN
S1080-p EQFSRPIsLHPIPRG
T1090-p PIPRGRQtsESSEGH
S1091-p IPRGRQtsESSEGHV
S1120-p RSRSRSRsPRPRGDS
Y1129 RPRGDSAYHSQRHSL
S1144 LTPVTPLSPPGLEEE
Y1156-p EEEDGNGyVMPDTHL
T1161 NGyVMPDTHLRGTSS
Y1194 EEDEDEEYEYMNRKR
Y1196 DEDEEYEYMNRKRRG
S1204 MNRKRRGSPARPPRP
G1212 PARPPRPGSLEELGY
Y1219 GSLEELGYEYMDVGS
Y1257 GTTPDEDYEyMNRRR
Y1259-p TPDEDYEyMNRRRGA
Y1273 AGGSGGDYAAMGACP
A1282 AMGACPAAEQGyEEM
Y1286-p CPAAEQGyEEMRAFQ
Y1304 HQAPHVRYARLKTLR
S1312 ARLKTLRSLEATDSA
T1316 TLRSLEATDSAFDNP
Y1325-p SAFDNPDyWHsRLFP
S1328-p DNPDyWHsRLFPkAN
K1333-ub WHsRLFPkANAQRI_
2842 : Phospho-HER3/ErbB3 (Tyr1289) (D1B5) Rabbit mAb
4791 : Phospho-HER3/ErbB3 (Tyr1289) (21D3) Rabbit mAb
8017 : Phospho-HER3/ErbB3 (Tyr1328) Antibody
  rat

 
- gap
- gap
S638 GQAEVLMSKPHLVIA
Y678 NKRAMRRYLERGESI
S684 RYLERGESIEPLDPS
K693 EPLDPSEKANKVLAR
K734 IPEGESIKIPVCIKV
K734 IPEGESIKIPVCIKV
S842 LRNVMLKSPSQVQVA
S844 NVMLKSPSQVQVADF
K862 DLLPPDDKQLLHSEA
H866 PDDKQLLHSEAKtPI
S867 DDKQLLHSEAKtPIK
T871-p LLHSEAKtPIKWMAL
S980 YLVIKRASGPGTPPA
Y1051-p LLSPSSGyMPMNQSS
S1080 EQFSRPISLHPIPRG
A1090 PIPRGRPASESSEGH
S1091 IPRGRPASESSEGHV
S1120-p RSRSRSRsPRPRGDS
Y1129 RPRGDSAYHSQRHSL
S1144 LTPVTPLSPPGLEEE
Y1156 EEEDGNGYVMPDTHL
T1161 NGYVMPDTHLRGASS
Y1194-p EEDEDEEyEYMNRKR
Y1196 DEDEEyEYMNRKRRG
S1204 MNRKRRGSPPRPPRP
G1212 PPRPPRPGSLEELGy
Y1219-p GSLEELGyEYMDVGS
Y1257-p GTTPDEDyEYMNRRR
Y1259 TPDEDyEYMNRRRGA
Y1273-p AGGAGGDyAAMGACP
A1282 AMGACPAAEQGyEEM
Y1286-p CPAAEQGyEEMRAFQ
Y1304 HHAPHVRYARLKTLR
S1312 ARLKTLRSLEATDSA
T1316 TLRSLEATDSAFDNP
Y1325-p SAFDNPDyWHSRLFP
S1328 DNPDyWHSRLFPKAN
K1333 WHSRLFPKANAQRT_
2842 : Phospho-HER3/ErbB3 (Tyr1289) (D1B5) Rabbit mAb
4791 : Phospho-HER3/ErbB3 (Tyr1289) (21D3) Rabbit mAb
8017 : Phospho-HER3/ErbB3 (Tyr1328) Antibody
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