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CdGAP (human)

Overview CdGAP Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. Interacts with ITSN1, which inhibits GAP activity. Interacts with PARVA. Interacts with GTP-loaded RHOU. Note: This description may include information from UniProtKB. Protein type: GTPase activating protein, Rac/Rho Cellular Component: focal adhesion; lamellipodium; cytosol Molecular Function: SH3 domain binding; GTPase activator activity Biological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction Reference #:  Q2M1Z3 (UniProtKB) Alt. Names/Synonyms: ARHGAP31; Cdc42 GTPase-activating protein; CDGAP; KIAA1204; MGC138368; MGC138370; RHG31; Rho GTPase activating protein 31; Rho GTPase-activating protein 31 Gene Symbols: ARHGAP31 Molecular weight: 156,985 Da Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CdGAP

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T237	RPIMKSLTLPALSLP
0	9		S272	RKERRENSLPEIVPP
0	1		T286	PMGTLFHTVLELPDN
0	1		S306-p	SKSKKWKsIFNLGRs
0	1		S313-p	sIFNLGRsGSDSKSK
0	1		S335	FVRGQRLSVEKAtIR
0	1		T340-p	RLSVEKAtIRPAKsM
0	6		S346-p	AtIRPAKsMDSLCSV
0	1		S349	RPAKsMDSLCSVPVE
0	1		G384	ATKMHSTGTGsSCDL
0	1		T385	TKMHSTGTGsSCDLT
0	1		S387-p	MHSTGTGsSCDLTKQ
0	1		S388	HSTGTGsSCDLTKQE
0	1		N458	LGMFYTSNDSPSKSV
0	1		S460	MFYTSNDSPSKSVFT
0	2		S476-p	SLFQMEPsPRNQRKA
0	1		L599	SSLSSQHLNELEKRP
0	1		S665	QELKIIESEEELSSL
0	1		S671	ESEEELSSLPPPALK
0	2		T679	LPPPALKTSPIQPIL
0	1		S680	PPPALKTSPIQPILE
0	1		S701	IPSEPPGSLPCGSFP
0	1		S712	GSFPAPVSTPLEVWT
0	6		S778	VGGPGNLSPPLPPAP
1	2		P782	GNLSPPLPPAPPPPT
3	0		T789	PPAPPPPTPLEESTP
0	1		T840-p	LCQGEEAtPRHsDKQ
0	1		R842	QGEEAtPRHsDKQNs
0	1		S844-p	EEAtPRHsDKQNsKN
0	1		S849-p	RHsDKQNsKNAASEG
0	1		S863-p	GKGCGFPsPTREVEI
0	1		S954	PSLRQSHSLDSKPTV
0	5		S974	LEVPSSSSCANLETE
0	1		S1036-p	QPNPAETsPISLAEG
0	1		S1105	PKGKNRPSSLNLDPA
0	1		S1106	KGKNRPSSLNLDPAI
0	7		S1178-p	ALTGRRNsAPVsVsA
0	1		S1182-p	RRNsAPVsVsAVRTS
0	1		S1184-p	NsAPVsVsAVRTSFM
0	1		S1253	PAKDDSPSSLESSKE
0	1		S1257	DSPSSLESSKEEKPK
0	1		A1277	IKSSPVDATAPCMCE
0	1		S1312-p	VQCRKRMsETEPsGD
0	1		T1314	CRKRMsETEPsGDNL
0	2		S1317-p	RMsETEPsGDNLLSS
0	1		S1323	PsGDNLLSSKLERPS
0	1		S1324	sGDNLLSSKLERPSG
0	3		S1339	GSKPFHRSRPGRPQS
0	1		S1374-p	TDSKVLLsPIRSPTQ
0	4		S1432	FYQPQRRSVILDGRS

	mouse
T237-p	RTITKSLtLPALSLP
S272-p	RKERRENsLPEIVPP
T283-p	IVPPPFHtVLELPDN
S303-p	SKSKKWKsIFNLGRS
S310	sIFNLGRSGSDSKSK
S332-p	FVRGQRLsVEKATIR
T337	RLsVEKATIRPAKsM
S343-p	ATIRPAKsMDsLCSV
S346-p	RPAKsMDsLCSVPVE
S381-p	ATKMHASstGssCDL
T382-p	TKMHASstGssCDLS
S384-p	MHASstGssCDLSKE
S385-p	HASstGssCDLSKEG
S446-p	LGMFYTSsDsPGKSV
S448-p	MFYTSsDsPGKSVFT
S464-p	SLFQMEPsPRHQRKA
S586-p	VSLGSQVsKEAEKRP
S652-p	QELKIIEsEEEFSsL
S658-p	EsEEEFSsLPPAAQK
T666-p	LPPAAQKtsPIPESS
S667-p	PPAAQKtsPIPESSP
S685-p	PFPEAPGsLPSSsAP
S690-p	PGsLPSSsAPREVWT
S765-p	IGGPRNLsPPLtPAP
T769-p	RNLsPPLtPAPPPPt
T776-p	tPAPPPPtPLEEEPE
I827	PCQREEAIAsPNEKQ
S829-p	QREEAIAsPNEKQNA
N831	EEAIAsPNEKQNARH
A836	sPNEKQNARHAVPEN
S850-p	NKGPGLPsPTKEVDI
S941-p	PSLRQSHsLDSKTTG
S961-p	LEAPFSSsCANLETE
N1023	QPKPVETNFMGLAEG
S1092-p	SKGKHRPssLNLDSA
S1093-p	KGKHRPssLNLDSAT
S1163-p	TLTGRRNsAPVSVSA
S1167	RRNsAPVSVSAVRTS
S1169	NsAPVSVSAVRTSFM
S1238-p	STKDDSPsSLGsPEE
S1242-p	DSPsSLGsPEEEQPK
S1262	SASRRQASITSCMYE
S1297	VQCRKRTSETEPSGD
T1299	CRKRTSETEPSGDNL
S1302	RTSETEPSGDNLLSS
S1308	PSGDNLLSSKLERAS
S1309	SGDNLLSSKLERASG
S1324-p	GPKAFHRsRPGRPQS
S1355-p	IDSKVLLsPIRSPTQ
S1413-p	FYQPQRRsVILDGRS

	rat
T237	RTITKSLTLPALSLP
S272	RKERRENSLPEIVPS
T286	SMGTPFHTVLELPDN
S306	SKSKKWKSIFNLGRS
S313	SIFNLGRSGSDSKSK
S335	FVRGQRLSVEKATIR
T340	RLSVEKATIRPAKSM
S346	ATIRPAKSMDSLCSV
S349	RPAKSMDSLCSVPVE
S384	ATKMHASSTGSSCDL
T385	TKMHASSTGSSCDLS
S387	MHASSTGSSCDLSKE
S388	HASSTGSSCDLSKEG
S449	LGMFYTSSDSPGKSV
S451	MFYTSSDSPGKSVFT
S467	SLFQMEPSPRHQRKA
S589	ISLGSQLSKEPEKWP
S655	QELKIIESEEEFSSL
S661	ESEEEFSSLPPPAQK
T669	LPPPAQKTSPMTESS
S670	PPPAQKTSPMTESSP
S688	PSPEAPESLPSSSAP
S693	PESLPSSSAPLEVWT
S768	IGGPGNLSPPLPPAP
P772	GNLSPPLPPAPPPPT
T779	PPAPPPPTPLEEEPQ
I830	LCQREEAIASPNEKQ
S832	QREEAIASPNEKQDA
N834	EEAIASPNEKQDAKQ
A839	SPNEKQDAKQAVPES
S853	SKDPGLPSPTKEVEV
S944	PSLRQSHSLDSKTTG
S964	LEAPFSSSCASLETE
N1026	QPKPVETNFISLTEG
S1095	SKGKHRPSSLNLDSA
S1096	KGKHRPSSLNLDSAI
S1166	ALTGRRNSAPVSVSA
S1170	RRNSAPVSVSAVRTS
S1172	NSAPVSVSAVRTSFM
S1241	PTKDDSPSSLGSPEE
S1245	DSPSSLGSPEEEQPK
S1265-p	SASRRKAsTTSCVAE
S1300	GQCRKRTSEtEPsED
T1302-p	CRKRTSEtEPsEDNL
S1305-p	RTSEtEPsEDNLLss
S1311-p	PsEDNLLssKLERAS
S1312-p	sEDNLLssKLERASG
P1327	GPKPTHRPRPGRPQS
S1358	IDSKVLLSPIRSPSQ
S1416	FYQPQRRSVILDGRS

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