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Protein Page:
CdGAP (human)

Overview
CdGAP Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. Interacts with ITSN1, which inhibits GAP activity. Interacts with PARVA. Interacts with GTP-loaded RHOU. Note: This description may include information from UniProtKB.
Protein type: GAPs, Rac/Rho; GAPs
Chromosomal Location of Human Ortholog: 3q13.33
Cellular Component: focal adhesion; lamellipodium; cytosol
Molecular Function: SH3 domain binding; GTPase activator activity
Biological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; positive regulation of GTPase activity
Disease: Adams-oliver Syndrome 1
Reference #:  Q2M1Z3 (UniProtKB)
Alt. Names/Synonyms: ARHGAP31; Cdc42 GTPase-activating protein; CDGAP; KIAA1204; MGC138368; MGC138370; RHG31; Rho GTPase activating protein 31; Rho GTPase-activating protein 31
Gene Symbols: ARHGAP31
Molecular weight: 156,985 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CdGAP

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T237 RPIMKSLTLPALSLP
0 14 S272-p RKERRENsLPEIVPP
0 1 T286 PMGTLFHTVLELPDN
0 2 S306-p SKSKKWKsIFNLGRS
0 2 S335 FVRGQRLSVEKAtIR
0 1 T340-p RLSVEKAtIRPAKsM
0 9 S346-p AtIRPAKsMDSLCSV
0 4 S349 RPAKsMDSLCSVPVE
0 1 T369 GNFNRTVTTGGFFIP
0 1 G384 ATKMHSTGTGsSCDL
0 1 T385 TKMHSTGTGsSCDLT
0 1 S387-p MHSTGTGsSCDLTKQ
0 1 S388 HSTGTGsSCDLTKQE
0 1 N458 LGMFYTSNDSPSKSV
0 1 S460 MFYTSNDSPSKSVFT
0 6 S476-p SLFQMEPsPRNQRKA
0 1 S499-p VSVPLRVsAVIsTNS
0 1 S503-p LRVsAVIsTNSTPCR
0 1 L599 SSLSSQHLNELEKRP
0 1 S629 ESSTLQESPRARAEA
0 1 S665 QELKIIESEEELSSL
0 1 S671 ESEEELSSLPPPALK
0 4 T679 LPPPALKTSPIQPIL
0 3 S680 PPPALKTSPIQPILE
0 1 S688 PIQPILESSLGPFIP
0 1 S701 IPSEPPGSLPCGSFP
0 1 S712 GSFPAPVSTPLEVWT
0 11 S778-p VGGPGNLsPPLPPAP
1 3 P782 GNLsPPLPPAPPPPT
3 0 T789 PPAPPPPTPLEESTP
0 1 T840-p LCQGEEAtPRHsDKQ
0 1 R842 QGEEAtPRHsDKQNs
0 1 S844-p EEAtPRHsDKQNsKN
0 1 S849-p RHsDKQNsKNAASEG
0 4 S863-p GKGCGFPsPTREVEI
0 1 T865 GCGFPsPTREVEIVS
0 1 S920-p WVTSPLHsPTLKDAH
0 3 S954-p PSLRQSHsLDSKPTV
0 5 S974 LEVPSSSSCANLETE
0 1 S1036-p QPNPAETsPISLAEG
0 2 S1105 PKGKNRPSSLNLDPA
0 3 S1106 KGKNRPSSLNLDPAI
0 18 S1178-p ALTGRRNsAPVsVsA
0 1 S1182-p RRNsAPVsVsAVRTS
0 2 S1184-p NsAPVsVsAVRTSFM
0 1 S1253 PAKDDSPSSLESSKE
0 3 S1257 DSPSSLESSKEEKPK
0 1 A1277 IKSSPVDATAPCMCE
0 1 S1312-p VQCRKRMsETEPsGD
0 1 T1314 CRKRMsETEPsGDNL
0 2 S1317-p RMsETEPsGDNLLSS
0 1 S1323 PsGDNLLSSKLERPS
0 1 S1324 sGDNLLSSKLERPSG
0 3 S1339 GSKPFHRSRPGRPQS
0 3 S1374-p TDSKVLLsPIRSPTQ
0 6 S1432 FYQPQRRSVILDGRS
  mouse

 
T237-p RTITKSLtLPALSLP
S272-p RKERRENsLPEIVPP
T283-p IVPPPFHtVLELPDN
S303-p SKSKKWKsIFNLGRS
S332-p FVRGQRLsVEKATIR
T337 RLsVEKATIRPAKsM
S343-p ATIRPAKsMDsLCSV
S346-p RPAKsMDsLCSVPVE
T366-p GNFSRTVtTGGFFIP
S381-p ATKMHASstGssCDL
T382-p TKMHASstGssCDLS
S384-p MHASstGssCDLSKE
S385-p HASstGssCDLSKEG
S446-p LGMFYTSsDsPGKSV
S448-p MFYTSsDsPGKSVFT
S464-p SLFQMEPsPRHQRKA
S487 VSVPLRVSAVISTNS
S491 LRVSAVISTNSTPCR
S586-p VSLGSQVsKEAEKRP
- under review  
S652-p QELKIIEsEEEFSsL
S658-p EsEEEFSsLPPAAQK
T666-p LPPAAQKtsPIPEsS
S667-p PPAAQKtsPIPEsSP
S672-p KtsPIPEsSPAPFPF
S685-p PFPEAPGsLPSSsAP
S690-p PGsLPSSsAPREVWT
S765-p IGGPRNLsPPLtPAP
T769-p RNLsPPLtPAPPPPt
T776-p tPAPPPPtPLEEEPE
I827 PCQREEAIAsPNEKQ
S829-p QREEAIAsPNEKQNA
N831 EEAIAsPNEKQNARH
A836 sPNEKQNARHAVPEN
S850-p NKGPGLPsPtKEVDI
T852-p GPGLPsPtKEVDIIP
S907 WVTSPLHSPTLKEVQ
S941-p PSLRQSHsLDSKTTG
S961-p LEAPFSSsCANLETE
N1023 QPKPVETNFMGLAEG
S1092-p SKGKHRPssLNLDSA
S1093-p KGKHRPssLNLDSAT
S1163-p TLTGRRNsAPVSVsA
S1167 RRNsAPVSVsAVRTS
S1169-p NsAPVSVsAVRTSFM
S1238-p STKDDSPsSLGsPEE
S1242-p DSPsSLGsPEEEQPK
S1262 SASRRQASITSCMYE
S1297 VQCRKRTSETEPSGD
T1299 CRKRTSETEPSGDNL
S1302 RTSETEPSGDNLLSS
S1308 PSGDNLLSSKLERAS
S1309 SGDNLLSSKLERASG
S1324-p GPKAFHRsRPGRPQS
S1355-p IDSKVLLsPIRSPTQ
S1413-p FYQPQRRsVILDGRS
  rat

 
T237 RTITKSLTLPALSLP
S272-p RKERRENsLPEIVPS
T286 SMGTPFHTVLELPDN
S306 SKSKKWKSIFNLGRS
S335-p FVRGQRLsVEKATIR
T340 RLsVEKATIRPAKSM
S346 ATIRPAKSMDSLCSV
S349 RPAKSMDSLCSVPVE
T369 GNFNRTVTTGGFFIP
S384 ATKMHASSTGSSCDL
T385 TKMHASSTGSSCDLS
S387 MHASSTGSSCDLSKE
S388 HASSTGSSCDLSKEG
S449 LGMFYTSSDSPGKSV
S451 MFYTSSDSPGKSVFT
S467-p SLFQMEPsPRHQRKA
S490 VSVPLRVSAVISTNS
S494 LRVSAVISTNSTPCR
S589 ISLGSQLSKEPEKWP
S619-p KLSTPQEsPRARTKP
S655 QELKIIESEEEFSSL
S661 ESEEEFSSLPPPAQK
T669 LPPPAQKTSPMTESS
S670 PPPAQKTSPMTESSP
S675 KTSPMTESSPAPFPS
S688 PSPEAPESLPSSSAP
S693 PESLPSSSAPLEVWT
S768 IGGPGNLSPPLPPAP
P772 GNLSPPLPPAPPPPT
T779 PPAPPPPTPLEEEPQ
I830 LCQREEAIASPNEKQ
S832 QREEAIASPNEKQDA
N834 EEAIASPNEKQDAKQ
A839 SPNEKQDAKQAVPES
S853-p SKDPGLPsPTKEVEV
T855 DPGLPsPTKEVEVIP
S910 WVTSPLHSPTLKEIQ
S944 PSLRQSHSLDSKTTG
S964 LEAPFSSSCASLETE
N1026 QPKPVETNFISLTEG
S1095 SKGKHRPSSLNLDSA
S1096 KGKHRPSSLNLDSAI
S1166-p ALTGRRNsAPVSVSA
S1170 RRNsAPVSVSAVRTS
S1172 NsAPVSVSAVRTSFM
S1241 PTKDDSPSSLGsPEE
S1245-p DSPSSLGsPEEEQPK
S1265-p SASRRKAsTTSCVAE
S1300 GQCRKRTSEtEPsED
T1302-p CRKRTSEtEPsEDNL
S1305-p RTSEtEPsEDNLLss
S1311-p PsEDNLLssKLERAS
S1312-p sEDNLLssKLERASG
P1327 GPKPTHRPRPGRPQS
S1358-p IDSKVLLsPIRSPSQ
S1416 FYQPQRRSVILDGRS
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