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Protein Page:
CdGAP (human)

Overview
CdGAP Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. Interacts with ITSN1, which inhibits GAP activity. Interacts with PARVA. Interacts with GTP-loaded RHOU. Note: This description may include information from UniProtKB.
Protein type: GAPs; GAPs, Rac/Rho
Cellular Component: focal adhesion; lamellipodium; cytosol
Molecular Function: SH3 domain binding; GTPase activator activity
Biological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; positive regulation of GTPase activity
Reference #:  Q2M1Z3 (UniProtKB)
Alt. Names/Synonyms: ARHGAP31; Cdc42 GTPase-activating protein; CDGAP; KIAA1204; MGC138368; MGC138370; RHG31; Rho GTPase activating protein 31; Rho GTPase-activating protein 31
Gene Symbols: ARHGAP31
Molecular weight: 156,985 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CdGAP

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T237 RPIMKSLTLPALSLP
0 10 S272-p RKERRENsLPEIVPP
0 1 T286 PMGTLFHTVLELPDN
0 2 S306-p SKSKKWKsIFNLGRS
0 1 S335 FVRGQRLSVEKAtIR
0 1 T340-p RLSVEKAtIRPAKsM
0 8 S346-p AtIRPAKsMDSLCSV
0 3 S349 RPAKsMDSLCSVPVE
0 1 T369 GNFNRTVTTGGFFIP
0 1 G384 ATKMHSTGTGsSCDL
0 1 T385 TKMHSTGTGsSCDLT
0 1 S387-p MHSTGTGsSCDLTKQ
0 1 S388 HSTGTGsSCDLTKQE
0 1 N458 LGMFYTSNDSPSKSV
0 1 S460 MFYTSNDSPSKSVFT
0 3 S476-p SLFQMEPsPRNQRKA
0 1 S499-p VSVPLRVsAVIsTNS
0 1 S503-p LRVsAVIsTNSTPCR
0 1 L599 SSLSSQHLNELEKRP
0 1 S665 QELKIIESEEELSSL
0 1 S671 ESEEELSSLPPPALK
0 3 T679 LPPPALKTSPIQPIL
0 2 S680 PPPALKTSPIQPILE
0 1 S688 PIQPILESSLGPFIP
0 1 S701 IPSEPPGSLPCGSFP
0 1 S712 GSFPAPVSTPLEVWT
0 8 S778-p VGGPGNLsPPLPPAP
1 3 P782 GNLsPPLPPAPPPPT
3 0 T789 PPAPPPPTPLEESTP
0 1 T840-p LCQGEEAtPRHsDKQ
0 1 R842 QGEEAtPRHsDKQNs
0 1 S844-p EEAtPRHsDKQNsKN
0 1 S849-p RHsDKQNsKNAASEG
0 2 S863-p GKGCGFPsPTREVEI
0 1 T865 GCGFPsPTREVEIVS
0 1 S920-p WVTSPLHsPTLKDAH
0 1 S954-p PSLRQSHsLDSKPTV
0 5 S974 LEVPSSSSCANLETE
0 1 S1036-p QPNPAETsPISLAEG
0 2 S1105 PKGKNRPSSLNLDPA
0 3 S1106 KGKNRPSSLNLDPAI
0 11 S1178-p ALTGRRNsAPVsVsA
0 1 S1182-p RRNsAPVsVsAVRTS
0 1 S1184-p NsAPVsVsAVRTSFM
0 1 S1253 PAKDDSPSSLESSKE
0 1 S1257 DSPSSLESSKEEKPK
0 1 A1277 IKSSPVDATAPCMCE
0 1 S1312-p VQCRKRMsETEPsGD
0 1 T1314 CRKRMsETEPsGDNL
0 2 S1317-p RMsETEPsGDNLLSS
0 1 S1323 PsGDNLLSSKLERPS
0 1 S1324 sGDNLLSSKLERPSG
0 3 S1339 GSKPFHRSRPGRPQS
0 1 S1374-p TDSKVLLsPIRSPTQ
0 5 S1432 FYQPQRRSVILDGRS
  mouse

 
T237-p RTITKSLtLPALSLP
S272-p RKERRENsLPEIVPP
T283-p IVPPPFHtVLELPDN
S303-p SKSKKWKsIFNLGRS
S332-p FVRGQRLsVEKATIR
T337 RLsVEKATIRPAKsM
S343-p ATIRPAKsMDsLCSV
S346-p RPAKsMDsLCSVPVE
T366-p GNFSRTVtTGGFFIP
S381-p ATKMHASstGssCDL
T382-p TKMHASstGssCDLS
S384-p MHASstGssCDLSKE
S385-p HASstGssCDLSKEG
S446-p LGMFYTSsDsPGKSV
S448-p MFYTSsDsPGKSVFT
S464-p SLFQMEPsPRHQRKA
S487 VSVPLRVSAVISTNS
S491 LRVSAVISTNSTPCR
S586-p VSLGSQVsKEAEKRP
S652-p QELKIIEsEEEFSsL
S658-p EsEEEFSsLPPAAQK
T666-p LPPAAQKtsPIPEsS
S667-p PPAAQKtsPIPEsSP
S672-p KtsPIPEsSPAPFPF
S685-p PFPEAPGsLPSSsAP
S690-p PGsLPSSsAPREVWT
S765-p IGGPRNLsPPLtPAP
T769-p RNLsPPLtPAPPPPt
T776-p tPAPPPPtPLEEEPE
I827 PCQREEAIAsPNEKQ
S829-p QREEAIAsPNEKQNA
N831 EEAIAsPNEKQNARH
A836 sPNEKQNARHAVPEN
S850-p NKGPGLPsPtKEVDI
T852-p GPGLPsPtKEVDIIP
S907 WVTSPLHSPTLKEVQ
S941-p PSLRQSHsLDSKTTG
S961-p LEAPFSSsCANLETE
N1023 QPKPVETNFMGLAEG
S1092-p SKGKHRPssLNLDSA
S1093-p KGKHRPssLNLDSAT
S1163-p TLTGRRNsAPVSVSA
S1167 RRNsAPVSVSAVRTS
S1169 NsAPVSVSAVRTSFM
S1238-p STKDDSPsSLGsPEE
S1242-p DSPsSLGsPEEEQPK
S1262 SASRRQASITSCMYE
S1297 VQCRKRTSETEPSGD
T1299 CRKRTSETEPSGDNL
S1302 RTSETEPSGDNLLSS
S1308 PSGDNLLSSKLERAS
S1309 SGDNLLSSKLERASG
S1324-p GPKAFHRsRPGRPQS
S1355-p IDSKVLLsPIRSPTQ
S1413-p FYQPQRRsVILDGRS
  rat

 
T237 RTITKSLTLPALSLP
S272 RKERRENSLPEIVPS
T286 SMGTPFHTVLELPDN
S306 SKSKKWKSIFNLGRS
S335 FVRGQRLSVEKATIR
T340 RLSVEKATIRPAKSM
S346 ATIRPAKSMDSLCSV
S349 RPAKSMDSLCSVPVE
T369 GNFNRTVTTGGFFIP
S384 ATKMHASSTGSSCDL
T385 TKMHASSTGSSCDLS
S387 MHASSTGSSCDLSKE
S388 HASSTGSSCDLSKEG
S449 LGMFYTSSDSPGKSV
S451 MFYTSSDSPGKSVFT
S467 SLFQMEPSPRHQRKA
S490 VSVPLRVSAVISTNS
S494 LRVSAVISTNSTPCR
S589 ISLGSQLSKEPEKWP
S655 QELKIIESEEEFSSL
S661 ESEEEFSSLPPPAQK
T669 LPPPAQKTSPMTESS
S670 PPPAQKTSPMTESSP
S675 KTSPMTESSPAPFPS
S688 PSPEAPESLPSSSAP
S693 PESLPSSSAPLEVWT
S768 IGGPGNLSPPLPPAP
P772 GNLSPPLPPAPPPPT
T779 PPAPPPPTPLEEEPQ
I830 LCQREEAIASPNEKQ
S832 QREEAIASPNEKQDA
N834 EEAIASPNEKQDAKQ
A839 SPNEKQDAKQAVPES
S853 SKDPGLPSPTKEVEV
T855 DPGLPSPTKEVEVIP
S910 WVTSPLHSPTLKEIQ
S944 PSLRQSHSLDSKTTG
S964 LEAPFSSSCASLETE
N1026 QPKPVETNFISLTEG
S1095 SKGKHRPSSLNLDSA
S1096 KGKHRPSSLNLDSAI
S1166 ALTGRRNSAPVSVSA
S1170 RRNSAPVSVSAVRTS
S1172 NSAPVSVSAVRTSFM
S1241 PTKDDSPSSLGSPEE
S1245 DSPSSLGSPEEEQPK
S1265-p SASRRKAsTTSCVAE
S1300 GQCRKRTSEtEPsED
T1302-p CRKRTSEtEPsEDNL
S1305-p RTSEtEPsEDNLLss
S1311-p PsEDNLLssKLERAS
S1312-p sEDNLLssKLERASG
P1327 GPKPTHRPRPGRPQS
S1358 IDSKVLLSPIRSPSQ
S1416 FYQPQRRSVILDGRS
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