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Fes (human)

Overview Fes a non-receptor tyrosine kinase of the Fer family. Appears to be involved in normal hematopoiesis as well as the development of acute promyelocytic leukemia. Contains one SH2 and one FCH domain. Four LOF point mutations seen in colorectal cancer. Orthologous to v-fes from feline leukemia virus and v-fps from avian transforming virus. Mutant forms are angiogenic. Promotes survival during differentiation, and may act both to promote and inhibit tumors. May be disrupted in the t(15q+;17q-) found in acute promyelocytic leukemia, but the breakpoint does not occur within the gene. Note: This description may include information from UniProtKB. Protein type: Protein kinase, TK; Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Kinase, protein; TK group; Fer family Cellular Component: microtubule cytoskeleton; Golgi apparatus; extrinsic to internal side of plasma membrane; focal adhesion; cytoplasmic membrane-bound vesicle; cytoplasm; cytoplasmic vesicle; cytosol Molecular Function: protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; phosphoinositide binding Biological Process: regulation of mast cell degranulation; regulation of cell adhesion; axon guidance; peptidyl-tyrosine phosphorylation; positive regulation of myeloid cell differentiation; positive regulation of microtubule polymerization; protein amino acid autophosphorylation; multicellular organismal development; protein amino acid phosphorylation; regulation of cell proliferation; regulation of cell shape; cell proliferation; regulation of cell differentiation Reference #:  P07332 (UniProtKB) Alt. Names/Synonyms: c-fes/fps protein; feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog; feline sarcoma oncogene; FES; FPS; Oncogene FES, feline sarcoma virus; Proto-oncogene c-Fes; Proto-oncogene c-Fps; proto-oncogene tyrosine-protein kinase Fes/Fps; Tyrosine-protein kinase Fes/Fps Gene Symbols: FES Molecular weight: 93,497 Da Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states CST Pathways:  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Fes 1WQU - A=450-550 (human) 2DCR - A=450-550 (human) 3BKB - A=448-822 (human) 3CBL - A=448-822 (human) 3CD3 - A=448-822 (human) 4DYL - A=1-405 (human) 4E93 - A=448-822 (human)

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	Sites Implicated In
cell differentiation, altered: Y713‑p cell growth, altered: Y713‑p enzymatic activity, induced: Y713‑p molecular association, regulation: Y713‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S64-p	GGQSRAIsPDsPISQ
0	1		S67-p	SRAIsPDsPISQSWA
0	1		S100-p	DLNSGPLsKLSLLIR
0	2		Y156-p	SAQAKRKyQEASKDK
0	16		Y261-p	RIQPEAEyQGFLRQY
0	1		S373-p	GLQVALCsQAKLQAQ
0	1		S408-p	LLQDDRHstsssEQE
0	1		T409-p	LQDDRHstsssEQER
0	1		S410-p	QDDRHstsssEQERE
0	1		S411-p	DDRHstsssEQEREG
0	1		S412-p	DRHstsssEQEREGG
0	2		T421-p	QEREGGRtPtLEILK
0	1		T423-p	REGGRtPtLEILKSH
0	21		H456	PEVQKPLHEQLWYHG
0	1		Y461	PLHEQLWYHGAIPRA
0	1		S477-p	VAELLVHsGDFLVRE
0	1		T538	LSTQQPLTKKSGVVL
0	1		T595-p	AVKSCREtLPPDLKA
0	2		Y614-p	EARILKQySHPNIVR
6	119		Y713-p	REEADGVyAAsGGLR
0	1		S716-p	ADGVyAAsGGLRQVP
0	2		K725-u	GLRQVPVkWTAPEAL
0	5		Y734-p	TAPEALNyGRYSSES
1	1		Y811-p	RPSFSTIyQELQSIR

	mouse
G64	GGQSWSSGPDSPVSQ
S67	SWSSGPDSPVSQSWA
S100	DLNSGPLSKLSVLIR
Y156	STQARRKYQEASKDK
Y261	RIQPEFEYLGFLRQY
S373	GLQIALCSQDKLQAQ
S408	LLQDDRHSTSSTEQE
T409	LQDDRHSTSSTEQER
S410	QDDRHSTSSTEQERE
S411	DDRHSTSSTEQEREG
T412	DRHSTSSTEQEREGG
T421	QEREGGRTPTLEILK
T423	REGGRTPTLEILKSH
Y456-p	PEVQKPLyEQLWyHG
Y461-p	PLyEQLWyHGAIPRA
S477	VAELLTHSGDFLVRE
T538-p	LSSQQPLtKKSGVVL
T595	AVKSCRETLPPDLKA
Y614	EARILKQYNHPNIVR
Y713-p	REEADGIyAASAGLR
S716	ADGIyAASAGLRQVP
K725	GLRQVPVKWTAPEAL
Y734	TAPEALNYGRYSSES
C811	RPSFSIICQELHSIR

	rat
G64	GGQSWSSGPDSPVSQ
S67	SWSSGPDSPVSQSWA
S100	DLNSGPLSKLSVLIR
Y156	SAQARRKYQEASKDK
Y261	RIQPEFEYLGFLRQY
N373	GLQVALCNQDKLQAQ
S408	LLQDDRHSTSSTEQE
T409	LQDDRHSTSSTEQER
S410	QDDRHSTSSTEQERD
S411	DDRHSTSSTEQERDG
T412	DRHSTSSTEQERDGG
T421	QERDGGRTPTLEIIK
T423	RDGGRTPTLEIIKSH
H456	PEVQKPLHEQLWYHG
Y461	PLHEQLWYHGAIPRA
S477	VAELLTHSGDFLVRE
T538	LSSQQPLTKKSGVVL
T595	AVKSCRETLPPDLKA
Y614	EARILKQYNHPNIVR
Y713	REEADGIYAASAGLR
S716	ADGIYAASAGLRQVP
K725	GLRQVPVKWTAPEAL
Y734	TAPEALNYGRYSSES
C811	RPSFSTICQELQSIR

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