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Protein Page:
TBK1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TBK1 a protein kinase of the IKK family. Can mediate NFkB activation in response to certain growth factors. Forms a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Other group; IKK family
Cellular Component: cytoplasm; endosome membrane; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; nucleic acid binding; phosphoprotein binding; ATP binding; protein kinase activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; response to virus; MyD88-independent toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; positive regulation of peptidyl-serine phosphorylation; protein amino acid phosphorylation; defense response to Gram-positive bacterium; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-beta production; positive regulation of interferon type I production; toll-like receptor signaling pathway; interferon type I production; innate immune response; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; negative regulation of interferon type I production; toll-like receptor 4 signaling pathway; defense response to virus; positive regulation of interferon-alpha production
Reference #:  Q9UHD2 (UniProtKB)
Alt. Names/Synonyms: FLJ11330; NAK; NF-kappa-B-activating kinase; NF-kB-activating kinase; Serine/threonine-protein kinase TBK1; T2K; TANK-binding kinase 1; TBK1
Gene Symbols: TBK1
Molecular weight: 83,642 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TBK1

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
transcription, induced: K30‑ub, S172‑p, K401‑ub
enzymatic activity, induced: K30‑ub, S172‑p, K401‑ub
ubiquitination: K30‑ub, K401‑ub

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K30-ub VFRGRHKkTGDLFAI
0 1 K38 TGDLFAIKVFNNISF
1 0 K69-ub LNHKNIVkLFAIEEE
0 1 S151-p VIGEDGQsVykLTDF
0 3 Y153-p GEDGQsVykLTDFGA
1 2 K154-ub EDGQsVykLTDFGAA
6 47 S172-p EDDEQFVsLyGTEEY
0 3 Y174-p DEQFVsLyGTEEYLH
0 1 K241-ub MYKIITGkPSGAIsG
0 1 S247-p GkPSGAIsGVQKAEN
0 1 K291-ub ILEADQEkCWGFDQF
0 1 K344-ub ELVYKQTkIISSNQE
0 2 Y354-p SSNQELIyEGRRLVL
1 0 K372-ub RLAQHFPkTTEENPI
0 1 K396-ub TIGLIYEkISLPkVH
1 0 K401-ub YEkISLPkVHPRYDL
0 1 T503-p GEISDIHtkLLRLSS
0 1 K504-ub EISDIHtkLLRLSSs
0 1 S511-p kLLRLSSsQGTIETS
0 1 Y577-p KAERRLAyNEEQIHk
0 1 K584-ub yNEEQIHkFDKQKLY
0 1 K661-ub LQETLPQkMFtASSG
0 1 T664-p TLPQkMFtASSGIKH
1 13 S716-p HILERFGsLTMDGGL
5483 : Phospho-TBK1/NAK (Ser172) (D52C2) XP(R) Rabbit mAb
13498 : Phospho-TBK1/NAK (Ser172) (D52C2) XP(R) Rabbit mAb (PE Conjugate)
  mouse

 
K30 VFRGRHKKTGDLYAV
K38-ub TGDLYAVkVFNNISF
K69 LNHKNIVKLFAIEEE
S151 VIGEDGQSVYKLTDF
Y153 GEDGQSVYKLTDFGA
K154 EDGQSVYKLTDFGAA
S172-p EDDEQFVsLYGTEEY
Y174 DEQFVsLYGTEEYLH
K241 MYKIITGKPSGAISG
S247 GKPSGAISGVQKAEN
K291 ILEADQEKCWGFDQF
K344 ELVYKQTKIVSSNQE
Y354 SSNQELIYEGRRLVL
K372 RLAQHFPKTTEENPI
K396 TVGLRYEKISLPKIH
K401 YEKISLPKIHPRYDL
T503 GEISDIHTKLLRLSS
K504 EISDIHTKLLRLSSS
S511 KLLRLSSSQGTIESS
Y577 KAERRLAYNEEQIHK
K584 YNEEQIHKFDKQKLY
K661 LQETLPQKMLAASGG
A664 TLPQKMLAASGGVKH
S716-p HILERFGsLTMDGGL
5483 : Phospho-TBK1/NAK (Ser172) (D52C2) XP(R) Rabbit mAb
13498 : Phospho-TBK1/NAK (Ser172) (D52C2) XP(R) Rabbit mAb (PE Conjugate)
  rat

 
K30 VFRGRHKKTGDLYAV
K38 TGDLYAVKVFNNISF
K69 LNHKNIVKLFAIEEE
S151 VIGEDGQSVyKLTDF
Y153-p GEDGQSVyKLTDFGA
K154 EDGQSVyKLTDFGAA
S172 EDDEQFVSLYGTEEY
Y174 DEQFVSLYGTEEYLH
K241 MYKIITGKPSGAISG
S247 GKPSGAISGVQKAEN
K291 ILEADQEKCWGFDQF
K344 ELVYKQTKIISSNQE
Y354 SSNQELIYEGRRLVL
K372 RLAQHFPKTTEENPI
K396 SIGLRYEKISLPKIH
K401 YEKISLPKIHPRYDL
T503 GEISDIHTKLLRLSS
K504 EISDIHTKLLRLSSS
S511 KLLRLSSSQGTIESS
Y577 KAERRLAYNEEQIHK
K584 YNEEQIHKFDKQKLY
K661 LQETLPQKMLAASSG
A664 TLPQKMLAASSGIKH
S716 HILERFGSLTMDGGL
5483 : Phospho-TBK1/NAK (Ser172) (D52C2) XP(R) Rabbit mAb
13498 : Phospho-TBK1/NAK (Ser172) (D52C2) XP(R) Rabbit mAb (PE Conjugate)
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