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Protein Page:
NUMB (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
NUMB Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. Interacts with CDH1 and TFAP2B. Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Tumor suppressor
Cellular Component: extrinsic to plasma membrane; integral to plasma membrane; basolateral plasma membrane; apical part of cell; early endosome; plasma membrane; nucleus
Molecular Function: protein binding; cadherin binding; beta-catenin binding; alpha-catenin binding
Biological Process: positive regulation of polarized epithelial cell differentiation; axon guidance; positive regulation of neurogenesis; Notch signaling pathway; negative regulation of Notch signaling pathway; neuroblast division in the subventricular zone; lateral ventricle development
Reference #:  P49757 (UniProtKB)
Alt. Names/Synonyms: h-Numb; NUMB; numb homolog (Drosophila); Protein numb homolog; Protein S171; S171
Gene Symbols: NUMB
Molecular weight: 70,804 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NUMB

Protein Structure Not Found.


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Sites Implicated In
endocytosis, altered: T102‑p
activity, induced: T102‑p
intracellular localization: T102‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
2 1 S7-p _MNKLRQsFRRKKDV
0 22 Y15-p FRRKKDVyVPEAsRP
0 2 S20-p DVyVPEAsRPHQWQT
0 2 S91-p VKAVLWVsADGLRVV
1 0 T102-p LRVVDEKtKDLIVDQ
0 1 K174 ERKQKREKECGVTAT
0 19 S194-p TTFTREGsFRVTTAT
0 1 K211 AEREEIMKQMQDAKK
0 1 S240-p GNTAPSPssPtsPtS
0 8 S241-p NTAPSPssPtsPtSD
0 9 T243-p APSPssPtsPtSDAT
0 1 S244-p PSPssPtsPtSDATT
0 1 T246-p PssPtsPtSDATTSL
0 1 T250 tsPtSDATTSLEMNN
4 9 S276-p EQLARQGsFRGFPAL
0 1 S284-p FRGFPALsQkMsPFK
0 2 K286-u GFPALsQkMsPFKRQ
0 4 S288-p PALsQkMsPFKRQLs
4 17 S295-p sPFKRQLsLRINELP
0 3 S361 VTVVAPQSPTFQANG
0 24 S425-p GQSSGAAsPGLFQAG
0 36 T436-p FQAGHRRtPsEADRW
0 67 S438-p AGHRRtPsEADRWLE
0 5 T561-p PSLVRQQtFPHYEAS
0 10 S634-p SKQRTNPsPTNPFSS
4140 : Phospho-Numb (Ser276) Antibody
9878 : Phospho-Numb (Ser276) (D5C2) Rabbit mAb
  NUMB iso2  
S7 _MNKLRQSFRRKKDV
Y15 FRRKKDVYVPEASRP
S20 DVYVPEASRPHQWQT
S91 VKAVLWVSADGLRVV
T102 LRVVDEKTKDLIVDQ
K174 ERKQKREKECGVTAT
S194 TTFTREGSFRVTTAT
K211 AEREEIMKQMQDAKK
S240 GNTAPSPSSPTSPTS
S241 NTAPSPSSPTSPTSD
T243 APSPSSPTSPTSDAT
S244 PSPSSPTSPTSDATT
T246 PSSPTSPTSDATTSL
T250 TSPTSDATTSLEMNN
S276 EQLARQGSFRGFPAL
S284 FRGFPALSQKMsPFK
K286 GFPALSQKMsPFKRQ
S288-p PALSQKMsPFKRQLS
S295 sPFKRQLSLRINELP
S361-p VTVVAPQsPTFQGTE
S377-p GQSSGAAsPGLFQAG
T388 FQAGHRRTPSEADRW
S390 AGHRRTPSEADRWLE
T513 PSLVRQQTFPHYEAS
S586 SKQRTNPSPTNPFSS
4140 : Phospho-Numb (Ser276) Antibody
9878 : Phospho-Numb (Ser276) (D5C2) Rabbit mAb
  NUMB iso3  
S7-p _MNKLRQsFRRKKDV
Y15 FRRKKDVYVPEASRP
S20 DVYVPEASRPHQWQT
S80 VKAVLWVSADGLRVV
T91 LRVVDEKTKDLIVDQ
K163 ERKQKREKECGVTAT
S183 TTFTREGSFRVTTAT
K200 AEREEIMKQMQDAKK
S229 GNTAPSPSSPTSPTS
S230 NTAPSPSSPTSPTSD
T232 APSPSSPTSPTSDAT
S233 PSPSSPTSPTSDATT
T235 PSSPTSPTSDATTSL
T239 TSPTSDATTSLEMNN
S265-p EQLARQGsFRGFPAL
S273 FRGFPALSQKMsPFK
K275 GFPALSQKMsPFKRQ
S277-p PALSQKMsPFKRQLs
S284-p sPFKRQLsLRINELP
S350 VTVVAPQSPTFQANG
S414 GQSSGAASPGLFQAG
T425-p FQAGHRRtPsEADRW
S427-p AGHRRtPsEADRWLE
T550-p PSLVRQQtFPHYEAS
S623 SKQRTNPSPTNPFSS
4140 : Phospho-Numb (Ser276) Antibody
9878 : Phospho-Numb (Ser276) (D5C2) Rabbit mAb
  mouse

► Hide Isoforms
 
S7-p _MNKLRQsFRRKKDV
Y15 FRRKKDVYVPEASRP
S20 DVYVPEASRPHQWQT
S91 VKAVLWVSADGLRVV
T102 LRVVDEKTKDLIVDQ
K174-u ERKQKREkECGVTAT
S194-p TTFTREGsFRVTTAT
K211-u AEREEIMkQLQDAKK
S240 GNTAPSPSsPtSPtP
S241-p NTAPSPSsPtSPtPD
T243-p APSPSsPtSPtPDGt
S244 PSPSsPtSPtPDGtA
T246-p PSsPtSPtPDGtASS
T250-p tSPtPDGtASSEMNN
S276-p EQLARQGsFRGFPAL
S284 FRGFPALSQkMsPFK
K286-u GFPALSQkMsPFKRQ
S288-p PALSQkMsPFKRQLs
S295-p sPFKRQLsLRINELP
S362 VTLVAPQSPVLQANG
S427-p GQSSGAAsPGLFQAG
T438-p FQAGHRRtPsEADRW
S440-p AGHRRtPsEADRWLE
T563 PSLAKQQTFPQYETS
S636-p SKQRTNPsPTNPFSS
4140 : Phospho-Numb (Ser276) Antibody
9878 : Phospho-Numb (Ser276) (D5C2) Rabbit mAb
  NUMB iso2  
S7 _MNKLRQSFRRKKDV
Y15 FRRKKDVYVPEASRP
S20 DVYVPEASRPHQWQT
S91 VKAVLWVSADGLRVV
T102 LRVVDEKTKDLIVDQ
K174 ERKQKREKECGVTAT
S194 TTFTREGSFRVTTAT
K211 AEREEIMKQLQDAKK
S240 GNTAPSPSSPTSPTP
S241 NTAPSPSSPTSPTPD
T243 APSPSSPTSPTPDGT
S244 PSPSSPTSPTPDGTA
T246 PSSPTSPTPDGTASS
T250 TSPTPDGTASSEMNN
S276 EQLARQGSFRGFPAL
S284 FRGFPALSQKMSPFK
K286 GFPALSQKMSPFKRQ
S288 PALSQKMSPFKRQLS
S295 SPFKRQLSLRINELP
S362-p VTLVAPQsPVLQGTE
S378 GQSSGAASPGLFQAG
T389 FQAGHRRTPSEADRW
S391 AGHRRTPSEADRWLE
T514 PSLAKQQTFPQYETS
S587 SKQRTNPSPTNPFSS
4140 : Phospho-Numb (Ser276) Antibody
9878 : Phospho-Numb (Ser276) (D5C2) Rabbit mAb
  rat

 
S7 _MNKLRQSFRRKKDV
Y15 FRRKKDVYVPEASRP
S20 DVYVPEASRPHQWQT
S91 VKAVLWVSADGLRVV
T102 LRVVDEKTKDLIVDQ
K174 ERKQKREKECGVTAT
S194 TTFTREGSFRVTTAT
K211 AEREEIMKQLQDAKK
S239 GNSAPSPSSPTSPTL
S240 NSAPSPSSPTSPTLD
T242 APSPSSPTSPTLDPT
S243 PSPSSPTSPTLDPTA
T245 PSSPTSPTLDPTASL
T249 TSPTLDPTASLEMNN
S275-p EQLARQGsFRGFPAL
S283 FRGFPALSQKMSPFK
K285 GFPALSQKMSPFKRQ
S287 PALSQKMSPFKRQLs
S294-p SPFKRQLsLRINELP
S361 VTLVAPQSPVLQANG
S426 GQSSGAASPGLFQAG
T437 FQAGHRRTPSEADRW
S439 AGHRRTPSEADRWLE
T562 PSLAKQQTFPQYETS
S635-p PKQRTNPsPTNPFSS
4140 : Phospho-Numb (Ser276) Antibody
9878 : Phospho-Numb (Ser276) (D5C2) Rabbit mAb
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