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Protein Page:
NUMB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NUMB Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. Interacts with CDH1 and TFAP2B. Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor; Cell development/differentiation
Chromosomal Location of Human Ortholog: 14q24.3
Cellular Component: extrinsic to plasma membrane; apical part of cell; integral to plasma membrane; basolateral plasma membrane; early endosome; plasma membrane; nucleus
Molecular Function: protein binding; cadherin binding; beta-catenin binding; alpha-catenin binding
Biological Process: positive regulation of polarized epithelial cell differentiation; axon guidance; Notch signaling pathway; positive regulation of neurogenesis; negative regulation of Notch signaling pathway; neuroblast division in the subventricular zone; lateral ventricle development
Reference #:  P49757 (UniProtKB)
Alt. Names/Synonyms: h-Numb; NUMB; numb homolog (Drosophila); Protein numb homolog; Protein S171; S171
Gene Symbols: NUMB
Molecular weight: 70,804 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NUMB

Protein Structure Not Found.


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Sites Implicated In
endocytosis, altered: T102‑p
activity, induced: T102‑p
intracellular localization: T102‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
2 2 S7-p _MNKLRQsFRRKKDV
0 23 Y15-p FRRKKDVyVPEAsRP
0 2 S20-p DVyVPEAsRPHQWQT
0 1 K63 HICEDAVKRLKAERK
0 2 S91-p VKAVLWVsADGLRVV
1 0 T102-p LRVVDEKtKDLIVDQ
0 1 K174 ERKQKREKECGVTAT
0 1 T187-p ATFDASRtTFtREGs
0 1 T190-p DASRtTFtREGsFRV
0 21 S194-p tTFtREGsFRVTTAT
0 1 K211 AEREEIMKQMQDAKK
0 1 I224 KKAETDKIVVGSSVA
0 1 S229 DKIVVGSSVAPGNTA
0 3 S238-p APGNTAPsPssPtsP
0 1 S240-p GNTAPsPssPtsPtS
0 10 S241-p NTAPsPssPtsPtSD
0 11 T243-p APsPssPtsPtSDAT
0 2 S244-p PsPssPtsPtSDATt
0 2 T246-p PssPtsPtSDATtSL
0 2 T250 tsPtSDATtSLEMNN
0 1 T251-p sPtSDATtSLEMNNP
0 1 S252 PtSDATtSLEMNNPH
0 1 L253 tSDATtSLEMNNPHA
4 13 S276-p EQLARQGsFRGFPAL
0 1 S284-p FRGFPALsQkMsPFK
0 2 K286-ub GFPALsQkMsPFKRQ
0 4 S288-p PALsQkMsPFKRQLs
4 18 S295-p sPFKRQLsLRINELP
0 4 S361-p VTVVAPQsPTFQANG
0 1 T363 VVAPQsPTFQANGTD
0 1 T415 IAATCSGTEWGQSSG
0 26 S425-p GQSSGAAsPGLFQAG
0 38 T436-p FQAGHRRtPsEADRW
0 71 S438-p AGHRRtPsEADRWLE
0 7 T561-p PSLVRQQtFPHYEAS
0 3 T631-p ENKSKQRtNPsPTNP
0 17 S634-p SKQRtNPsPTNPFSS
0 1 T636 QRtNPsPTNPFSSDL
4140 : Phospho-Numb (Ser276) Antibody
9878 : Phospho-Numb (Ser276) (D5C2) Rabbit mAb
  NUMB iso2  
S7 _MNKLRQSFRRKKDV
Y15 FRRKKDVYVPEASRP
S20 DVYVPEASRPHQWQT
K63 HICEDAVKRLKAERK
S91 VKAVLWVSADGLRVV
T102 LRVVDEKTKDLIVDQ
K174 ERKQKREKECGVTAT
T187 ATFDASRTTFTREGS
T190 DASRTTFTREGSFRV
S194 TTFTREGSFRVTTAT
K211 AEREEIMKQMQDAKK
I224 KKAETDKIVVGSSVA
S229 DKIVVGSSVAPGNTA
S238-p APGNTAPsPSSPTSP
S240 GNTAPsPSSPTSPTS
S241 NTAPsPSSPTSPTSD
T243 APsPSSPTSPTSDAT
S244 PsPSSPTSPTSDATT
T246 PSSPTSPTSDATTSL
T250 TSPTSDATTSLEMNN
T251 SPTSDATTSLEMNNP
S252 PTSDATTSLEMNNPH
L253 TSDATTSLEMNNPHA
S276 EQLARQGSFRGFPAL
S284 FRGFPALSQKMsPFK
K286 GFPALSQKMsPFKRQ
S288-p PALSQKMsPFKRQLS
S295 sPFKRQLSLRINELP
S361-p VTVVAPQsPtFQGtE
T363-p VVAPQsPtFQGtEWG
T367-p QsPtFQGtEWGQSSG
S377-p GQSSGAAsPGLFQAG
T388 FQAGHRRTPSEADRW
S390 AGHRRTPSEADRWLE
T513 PSLVRQQTFPHYEAS
T583 ENKSKQRTNPSPTNP
S586 SKQRTNPSPTNPFSS
T588 QRTNPSPTNPFSSDL
4140 : Phospho-Numb (Ser276) Antibody
9878 : Phospho-Numb (Ser276) (D5C2) Rabbit mAb
  NUMB iso3  
S7-p _MNKLRQsFRRKKDV
Y15 FRRKKDVYVPEASRP
S20 DVYVPEASRPHQWQT
K63-m1 HICEDAVkRLKATGK
S80 VKAVLWVSADGLRVV
T91 LRVVDEKTKDLIVDQ
K163 ERKQKREKECGVTAT
T176 ATFDASRTTFTREGS
T179 DASRTTFTREGSFRV
S183 TTFTREGSFRVTTAT
K200 AEREEIMKQMQDAKK
I213 KKAETDKIVVGSSVA
S218 DKIVVGSSVAPGNTA
S227-p APGNTAPsPSSPTSP
S229 GNTAPsPSSPTSPTS
S230 NTAPsPSSPTSPTSD
T232 APsPSSPTSPTSDAT
S233 PsPSSPTSPTSDATT
T235 PSSPTSPTSDATTSL
T239 TSPTSDATTSLEMNN
T240 SPTSDATTSLEMNNP
S241 PTSDATTSLEMNNPH
L242 TSDATTSLEMNNPHA
S265-p EQLARQGsFRGFPAL
S273 FRGFPALSQKMsPFK
K275 GFPALSQKMsPFKRQ
S277-p PALSQKMsPFKRQLs
S284-p sPFKRQLsLRINELP
S350 VTVVAPQSPTFQANG
T352 VVAPQSPTFQANGTD
T404 IAATCSGTEWGQSSG
S414 GQSSGAASPGLFQAG
T425-p FQAGHRRtPsEADRW
S427-p AGHRRtPsEADRWLE
T550-p PSLVRQQtFPHYEAS
T620 ENKSKQRTNPSPTNP
S623 SKQRTNPSPTNPFSS
T625 QRTNPSPTNPFSSDL
4140 : Phospho-Numb (Ser276) Antibody
9878 : Phospho-Numb (Ser276) (D5C2) Rabbit mAb
  mouse

► Hide Isoforms
 
S7-p _MNKLRQsFRRKKDV
Y15 FRRKKDVYVPEASRP
S20 DVYVPEASRPHQWQT
K63 HICEDAVKRLKAERK
S91 VKAVLWVSADGLRVV
T102 LRVVDEKTKDLIVDQ
K174-ub ERKQKREkECGVTAT
T187 ATFDASRTTFTREGs
T190 DASRTTFTREGsFRV
S194-p TTFTREGsFRVTTAT
K211-ub AEREEIMkQLQDAKK
T224-p KKAETDKtVVGPsVA
S229-p DKtVVGPsVAPGNTA
S238-p APGNTAPsPSsPtSP
S240 GNTAPsPSsPtSPtP
S241-p NTAPsPSsPtSPtPD
T243-p APsPSsPtSPtPDGt
S244 PsPSsPtSPtPDGtA
T246-p PSsPtSPtPDGtAss
T250-p tSPtPDGtAssEMNN
A251 SPtPDGtAssEMNNP
S252-p PtPDGtAssEMNNPH
S253-p tPDGtAssEMNNPHA
S276-p EQLARQGsFRGFPAL
S284 FRGFPALSQkMsPFK
K286-ub GFPALSQkMsPFKRQ
S288-p PALSQkMsPFKRQLs
S295-p sPFKRQLsLRINELP
S362 VTLVAPQSPVLQANG
V364 LVAPQSPVLQANGTD
T417 IAAIHPGTEWGQSSG
S427-p GQSSGAAsPGLFQAG
T438-p FQAGHRRtPsEADRW
S440-p AGHRRtPsEADRWLE
T563 PSLAKQQTFPQYETS
T633 ESKSKQRTNPsPtNP
S636-p SKQRTNPsPtNPFSS
T638-p QRTNPsPtNPFSSDL
4140 : Phospho-Numb (Ser276) Antibody
9878 : Phospho-Numb (Ser276) (D5C2) Rabbit mAb
  NUMB iso2  
S7 _MNKLRQSFRRKKDV
Y15 FRRKKDVYVPEASRP
S20 DVYVPEASRPHQWQT
K63 HICEDAVKRLKAERK
S91 VKAVLWVSADGLRVV
T102 LRVVDEKTKDLIVDQ
K174 ERKQKREKECGVTAT
T187 ATFDASRTTFTREGS
T190 DASRTTFTREGSFRV
S194 TTFTREGSFRVTTAT
K211 AEREEIMKQLQDAKK
T224 KKAETDKTVVGPSVA
S229 DKTVVGPSVAPGNTA
S238 APGNTAPSPSSPTSP
S240 GNTAPSPSSPTSPTP
S241 NTAPSPSSPTSPTPD
T243 APSPSSPTSPTPDGT
S244 PSPSSPTSPTPDGTA
T246 PSSPTSPTPDGTASS
T250 TSPTPDGTASSEMNN
A251 SPTPDGTASSEMNNP
S252 PTPDGTASSEMNNPH
S253 TPDGTASSEMNNPHA
S276 EQLARQGSFRGFPAL
S284 FRGFPALSQKMSPFK
K286 GFPALSQKMSPFKRQ
S288 PALSQKMSPFKRQLS
S295 SPFKRQLSLRINELP
S362-p VTLVAPQsPVLQGTE
V364 LVAPQsPVLQGTEWG
T368 QsPVLQGTEWGQSSG
S378 GQSSGAASPGLFQAG
T389 FQAGHRRTPSEADRW
S391 AGHRRTPSEADRWLE
T514 PSLAKQQTFPQYETS
T584 ESKSKQRTNPSPTNP
S587 SKQRTNPSPTNPFSS
T589 QRTNPSPTNPFSSDL
4140 : Phospho-Numb (Ser276) Antibody
9878 : Phospho-Numb (Ser276) (D5C2) Rabbit mAb
  rat

 
S7 _MNKLRQSFRRKKDV
Y15 FRRKKDVYVPEASRP
S20 DVYVPEASRPHQWQT
K63 HICEDAVKRLKAERK
S91 VKAVLWVSADGLRVV
T102 LRVVDEKTKDLIVDQ
K174 ERKQKREKECGVTAT
T187 ATFDASRTTFTREGS
T190 DASRTTFTREGSFRV
S194 TTFTREGSFRVTTAT
K211 AEREEIMKQLQDAKK
T224 KKAETDKTVGPSVAP
S228 TDKTVGPSVAPGNSA
S237 APGNSAPSPSSPTSP
S239 GNSAPSPSSPTSPTL
S240 NSAPSPSSPTSPTLD
T242 APSPSSPTSPTLDPT
S243 PSPSSPTSPTLDPTA
T245 PSSPTSPTLDPTASL
T249 TSPTLDPTASLEMNN
A250 SPTLDPTASLEMNNP
S251 PTLDPTASLEMNNPH
L252 TLDPTASLEMNNPHA
S275-p EQLARQGsFRGFPAL
S283 FRGFPALSQKMSPFK
K285 GFPALSQKMSPFKRQ
S287 PALSQKMSPFKRQLs
S294-p SPFKRQLsLRINELP
S361 VTLVAPQSPVLQANG
V363 LVAPQSPVLQANGTD
T416 IAAIHSGTEWGQSSG
S426 GQSSGAASPGLFQAG
T437 FQAGHRRTPsEADRW
S439-p AGHRRTPsEADRWLE
T562 PSLAKQQTFPQYETS
T632-p ESKPKQRtNPsPTNP
S635-p PKQRtNPsPTNPFSS
T637 QRtNPsPTNPFSSDA
4140 : Phospho-Numb (Ser276) Antibody
9878 : Phospho-Numb (Ser276) (D5C2) Rabbit mAb
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