Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. Interacts with CDH1 and TFAP2B. Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor; Cell development/differentiation
Chromosomal Location of Human Ortholog: 14q24.3
Cellular Component: extrinsic to plasma membrane; apical part of cell; integral to plasma membrane; basolateral plasma membrane; early endosome; plasma membrane; nucleus
Molecular Function: protein binding; cadherin binding; beta-catenin binding; alpha-catenin binding
Biological Process: positive regulation of polarized epithelial cell differentiation; axon guidance; Notch signaling pathway; positive regulation of neurogenesis; negative regulation of Notch signaling pathway; neuroblast division in the subventricular zone; lateral ventricle development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.