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NUMB (human)

Overview NUMB Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. Interacts with CDH1 and TFAP2B. Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Cell development/differentiation; Tumor suppressor Cellular Component: extrinsic to plasma membrane; integral to plasma membrane; apical part of cell; basolateral plasma membrane; early endosome; plasma membrane; nucleus Molecular Function: cadherin binding; beta-catenin binding; alpha-catenin binding Biological Process: positive regulation of polarized epithelial cell differentiation; axon guidance; Notch signaling pathway; positive regulation of neurogenesis; negative regulation of Notch signaling pathway; neuroblast division in the subventricular zone; positive regulation of dendrite morphogenesis; lateral ventricle development Reference #:  P49757 (UniProtKB) Alt. Names/Synonyms: h-Numb; NUMB; numb homolog (Drosophila); Protein numb homolog; Protein S171; S171 Gene Symbols: NUMB Molecular weight: 70,804 Da Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states CST Pathways:  Notch Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NUMB 1WJ1 - A=19-172 (mouse)

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	Sites Implicated In
endocytosis, altered: T102‑p activation: T102‑p intracellular localization: T102‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
2	1		S7-p	_MNKLRQsFRRKKDV
0	22		Y15-p	FRRKKDVyVPEAsRP
0	2		S20-p	DVyVPEAsRPHQWQT
0	1		K63	HICEDAVKRLKAERK
0	2		S91-p	VKAVLWVsADGLRVV
1	0		T102-p	LRVVDEKtKDLIVDQ
0	1		K174	ERKQKREKECGVTAT
0	1		T187-p	ATFDASRtTFtREGs
0	1		T190-p	DASRtTFtREGsFRV
0	18		S194-p	tTFtREGsFRVTTAT
0	1		K211	AEREEIMKQMQDAKK
0	1		S238-p	APGNTAPsPssPtsP
0	1		S240-p	GNTAPsPssPtsPtS
0	8		S241-p	NTAPsPssPtsPtSD
0	9		T243-p	APsPssPtsPtSDAT
0	1		S244-p	PsPssPtsPtSDATt
0	1		T246-p	PssPtsPtSDATtSL
0	1		T250	tsPtSDATtSLEMNN
0	1		T251-p	sPtSDATtSLEMNNP
4	7		S276-p	EQLARQGsFRGFPAL
0	2		K286-u	GFPALSQkMsPFKRQ
0	4		S288-p	PALSQkMsPFKRQLs
4	17		S295-p	sPFKRQLsLRINELP
0	3		S361	VTVVAPQSPTFQANG
0	1		T363	VVAPQSPTFQANGTD
0	1		T415	IAATCSGTEWGQSSG
0	22		S425-p	GQSSGAAsPGLFQAG
0	34		T436-p	FQAGHRRtPsEADRW
0	65		S438-p	AGHRRtPsEADRWLE
0	5		T561-p	PSLVRQQtFPHYEAS
0	8		S634-p	SKQRTNPsPTNPFSS

	NUMB iso2
S7	_MNKLRQSFRRKKDV
Y15	FRRKKDVYVPEASRP
S20	DVYVPEASRPHQWQT
K63	HICEDAVKRLKAERK
S91	VKAVLWVSADGLRVV
T102	LRVVDEKTKDLIVDQ
K174	ERKQKREKECGVTAT
T187	ATFDASRTTFTREGS
T190	DASRTTFTREGSFRV
S194	TTFTREGSFRVTTAT
K211	AEREEIMKQMQDAKK
S238-p	APGNTAPsPSSPTSP
S240	GNTAPsPSSPTSPTS
S241	NTAPsPSSPTSPTSD
T243	APsPSSPTSPTSDAT
S244	PsPSSPTSPTSDATT
T246	PSSPTSPTSDATTSL
T250	TSPTSDATTSLEMNN
T251	SPTSDATTSLEMNNP
S276	EQLARQGSFRGFPAL
K286	GFPALSQKMsPFKRQ
S288-p	PALSQKMsPFKRQLS
S295	sPFKRQLSLRINELP
S361-p	VTVVAPQsPtFQGtE
T363-p	VVAPQsPtFQGtEWG
T367-p	QsPtFQGtEWGQSSG
S377-p	GQSSGAAsPGLFQAG
T388	FQAGHRRTPSEADRW
S390	AGHRRTPSEADRWLE
T513	PSLVRQQTFPHYEAS
S586	SKQRTNPSPTNPFSS

	NUMB iso3
S7-p	_MNKLRQsFRRKKDV
Y15	FRRKKDVYVPEASRP
S20	DVYVPEASRPHQWQT
K63-m1	HICEDAVkRLKATGK
S80	VKAVLWVSADGLRVV
T91	LRVVDEKTKDLIVDQ
K163	ERKQKREKECGVTAT
T176	ATFDASRTTFTREGS
T179	DASRTTFTREGSFRV
S183	TTFTREGSFRVTTAT
K200	AEREEIMKQMQDAKK
S227-p	APGNTAPsPSSPTSP
S229	GNTAPsPSSPTSPTS
S230	NTAPsPSSPTSPTSD
T232	APsPSSPTSPTSDAT
S233	PsPSSPTSPTSDATT
T235	PSSPTSPTSDATTSL
T239	TSPTSDATTSLEMNN
T240	SPTSDATTSLEMNNP
S265-p	EQLARQGsFRGFPAL
K275	GFPALSQKMsPFKRQ
S277-p	PALSQKMsPFKRQLs
S284-p	sPFKRQLsLRINELP
S350	VTVVAPQSPTFQANG
T352	VVAPQSPTFQANGTD
T404	IAATCSGTEWGQSSG
S414	GQSSGAASPGLFQAG
T425-p	FQAGHRRtPsEADRW
S427-p	AGHRRtPsEADRWLE
T550-p	PSLVRQQtFPHYEAS
S623	SKQRTNPSPTNPFSS

	mouse ► Hide Isoforms
S7	_MNKLRQSFRRKKDV
Y15	FRRKKDVYVPEASRP
S20	DVYVPEASRPHQWQT
K63	HICEDAVKRLKAERK
S91	VKAVLWVSADGLRVV
T102	LRVVDEKTKDLIVDQ
K174-u	ERKQKREkECGVTAT
T187	ATFDASRTTFTREGS
T190	DASRTTFTREGSFRV
S194	TTFTREGSFRVTTAT
K211-u	AEREEIMkQLQDAKK
S238	APGNTAPSPSsPtSP
S240	GNTAPSPSsPtSPTP
S241-p	NTAPSPSsPtSPTPD
T243-p	APSPSsPtSPTPDGt
S244	PSPSsPtSPTPDGtA
T246	PSsPtSPTPDGtASS
T250-p	tSPTPDGtASSEMNN
A251	SPTPDGtASSEMNNP
S276-p	EQLARQGsFRGFPAL
K286-u	GFPALSQkMsPFKRQ
S288-p	PALSQkMsPFKRQLs
S295-p	sPFKRQLsLRINELP
S362	VTLVAPQSPVLQANG
V364	LVAPQSPVLQANGTD
T417	IAAIHPGTEWGQSSG
S427-p	GQSSGAAsPGLFQAG
T438-p	FQAGHRRtPsEADRW
S440-p	AGHRRtPsEADRWLE
T563	PSLAKQQTFPQYETS
S636-p	SKQRTNPsPTNPFSS

	NUMB iso2
S7	_MNKLRQSFRRKKDV
Y15	FRRKKDVYVPEASRP
S20	DVYVPEASRPHQWQT
K63	HICEDAVKRLKAERK
S91	VKAVLWVSADGLRVV
T102	LRVVDEKTKDLIVDQ
K174	ERKQKREKECGVTAT
T187	ATFDASRTTFTREGS
T190	DASRTTFTREGSFRV
S194	TTFTREGSFRVTTAT
K211	AEREEIMKQLQDAKK
S238	APGNTAPSPSSPTSP
S240	GNTAPSPSSPTSPTP
S241	NTAPSPSSPTSPTPD
T243	APSPSSPTSPTPDGT
S244	PSPSSPTSPTPDGTA
T246	PSSPTSPTPDGTASS
T250	TSPTPDGTASSEMNN
A251	SPTPDGTASSEMNNP
S276	EQLARQGSFRGFPAL
K286	GFPALSQKMSPFKRQ
S288	PALSQKMSPFKRQLS
S295	SPFKRQLSLRINELP
S362-p	VTLVAPQsPVLQGTE
V364	LVAPQsPVLQGTEWG
T368	QsPVLQGTEWGQSSG
S378	GQSSGAASPGLFQAG
T389	FQAGHRRTPSEADRW
S391	AGHRRTPSEADRWLE
T514	PSLAKQQTFPQYETS
S587	SKQRTNPSPTNPFSS

	rat
S7	_MNKLRQSFRRKKDV
Y15	FRRKKDVYVPEASRP
S20	DVYVPEASRPHQWQT
K63	HICEDAVKRLKAERK
S91	VKAVLWVSADGLRVV
T102	LRVVDEKTKDLIVDQ
K174	ERKQKREKECGVTAT
T187	ATFDASRTTFTREGS
T190	DASRTTFTREGSFRV
S194	TTFTREGSFRVTTAT
K211	AEREEIMKQLQDAKK
S237	APGNSAPSPSSPTSP
S239	GNSAPSPSSPTSPTL
S240	NSAPSPSSPTSPTLD
T242	APSPSSPTSPTLDPT
S243	PSPSSPTSPTLDPTA
T245	PSSPTSPTLDPTASL
T249	TSPTLDPTASLEMNN
A250	SPTLDPTASLEMNNP
S275-p	EQLARQGsFRGFPAL
K285	GFPALSQKMSPFKRQ
S287	PALSQKMSPFKRQLs
S294-p	SPFKRQLsLRINELP
S361	VTLVAPQSPVLQANG
V363	LVAPQSPVLQANGTD
T416	IAAIHSGTEWGQSSG
S426	GQSSGAASPGLFQAG
T437	FQAGHRRTPSEADRW
S439	AGHRRTPSEADRWLE
T562	PSLAKQQTFPQYETS
S635-p	PKQRTNPsPTNPFSS

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