oxidative-stress responsive 1 protein is a ubiquitously expressed protein kinase of the STE20 family. Regulates Na-K-Cl cotransporter (NKCC) activity. Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton. Binds to and phosphorylates PAK1. Interacts and is phosphorylated by WNK1. Knockdown of either WNK1 or OXSR1 reduces NKCC activity. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. An important paralog of this gene is STRADB. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, STE; Kinase, protein; EC 220.127.116.11; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; FRAY subfamily
Cellular Component: cytoplasm
Molecular Function: protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding; receptor signaling protein serine/threonine kinase activity
Biological Process: peptidyl-threonine phosphorylation; response to oxidative stress; protein amino acid phosphorylation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.