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Protein Page:
OSR1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
OSR1 oxidative-stress responsive 1 protein is a protein kinase of the STE20 family. Thought to be involved in the response to oxidative stress. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; STE group; STE20 family; FRAY subfamily
Cellular Component: cytoplasm
Molecular Function: protein serine/threonine kinase activity; magnesium ion binding; ATP binding
Biological Process: protein kinase cascade; response to oxidative stress; protein amino acid phosphorylation
Reference #:  O95747 (UniProtKB)
Alt. Names/Synonyms: KIAA1101; OSR1; Oxidative stress-responsive 1 protein; oxidative-stress responsive 1; OXSR1; Serine/threonine-protein kinase OSR1
Gene Symbols: OXSR1
Molecular weight: 58,022 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

OSR1
Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: T185‑p, S325‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 K42-a YCAPKKEkVAIkRIN
0 1 K46-a KKEkVAIkRINLEkC
0 3 K52-u IkRINLEkCQTSMDE
5 38 T185-p TRNKVRKtFVGtPCW
0 12 T189-p VRKtFVGtPCWMAPE
0 2 S263-p MLKKYGKsFRKMIsL
0 1 S269-p KsFRKMIsLCLQKDP
0 116 T310-p KTLQRAPtIsERAKK
0 1 S312-p LQRAPtIsERAKKVR
0 4 S324-p KVRRVPGssGRLHKt
5 1 S325-p VRRVPGssGRLHKtE
0 3 T331-p ssGRLHKtEDGGWEW
0 58 S339-p EDGGWEWsDDEFDEE
0 1 S347-p DDEFDEEsEEGKAAI
0 4 S355-p EEGKAAIsQLRsPRV
0 4 S359-p AAIsQLRsPRVKESI
0 1 S369-p VKESISNsELFPTTD
0 5 S427-p ALSSGSGsQETKIPI
0 1 S435-p QETKIPIsLVLRLRN
  mouse

 
R42 YCAPKKERVAIKRIN
K46 KKERVAIKRINLEKC
K52 IKRINLEKCQTSMDE
T185-p TRNKVRKtFVGtPCW
T189-p VRKtFVGtPCWMAPE
S263 MLKKYGKSFRKMISL
S269 KSFRKMISLCLQKDP
T310 KILQRAPTISERSKK
S312 LQRAPTISERSKKVR
S324-p KVRRVPGssGRLHKt
S325-p VRRVPGssGRLHKtE
T331-p ssGRLHKtEDGGWEW
S339-p EDGGWEWsDDEFDEE
S347 DDEFDEESEEGRAAI
S355 EEGRAAISQLRSPRV
S359 AAISQLRSPRVKDSL
S369 VKDSLSSSELFAAAE
S427 AQSSGERSQETKIPI
S435 QETKIPISLVLRLRN
  rat

 
R42 YCAPKKERVAIKRIN
K46 KKERVAIKRINLEKC
K52 IKRINLEKCQTSMDE
T185 TRNKVRKTFVGTPCW
T189 VRKTFVGTPCWMAPE
S263 MLKKYGKSFRKMISL
S269 KSFRKMISLCLQKDP
T310 KILQRAPTISERSKK
S312 LQRAPTISERSKKVR
S324 KVRRVPGSsGRLHKT
S325-p VRRVPGSsGRLHKTE
T331 SsGRLHKTEDGGWEW
S339-p EDGGWEWsDDEFDEE
S347 DDEFDEESEEGKAAI
S355 EEGKAAISQLRSPRV
S359 AAISQLRSPRVKDSL
S369 VKDSLSNSELFSAAD
S427 ARSSGERSQETKVPI
S435 QETKVPISLVLRLRN
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