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Protein Page:
OSR1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
OSR1 oxidative-stress responsive 1 protein is a ubiquitously expressed protein kinase of the STE20 family. Regulates Na-K-Cl cotransporter (NKCC) activity. Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton. Binds to and phosphorylates PAK1. Interacts and is phosphorylated by WNK1. Knockdown of either WNK1 or OXSR1 reduces NKCC activity. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. An important paralog of this gene is STRADB. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; FRAY subfamily
Cellular Component: cytoplasm
Molecular Function: protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding; receptor signaling protein serine/threonine kinase activity
Biological Process: response to oxidative stress; protein amino acid phosphorylation
Reference #:  O95747 (UniProtKB)
Alt. Names/Synonyms: KIAA1101; OSR1; Oxidative stress-responsive 1 protein; oxidative-stress responsive 1; OXSR1; Serine/threonine-protein kinase OSR1
Gene Symbols: OXSR1
Molecular weight: 58,022 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

OSR1

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: T185‑p, S325‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 K52-u IKRINLEkCQTSMDE
7 38 T185-p TRNKVRKtFVGtPCW
0 12 T189-p VRKtFVGtPCWMAPE
0 2 S263-p MLKKYGKsFRKMIsL
0 1 S269-p KsFRKMIsLCLQKDP
0 117 T310-p KTLQRAPtISERAKK
1 5 S324-p KVRRVPGssGRLHKt
6 2 S325-p VRRVPGssGRLHKtE
0 4 T331-p ssGRLHKtEDGGWEW
1 63 S339-p EDGGWEWsDDEFDEE
0 1 S347-p DDEFDEEsEEGKAAI
0 4 S355-p EEGKAAIsQLRsPRV
0 5 S359-p AAIsQLRsPRVKESI
0 1 S369-p VKESISNsELFPTTD
0 6 S427-p ALSSGSGsQETKIPI
0 1 S435-p QETKIPIsLVLRLRN
  mouse

 
K52 IKRINLEKCQTSMDE
T185-p TRNKVRKtFVGtPCW
T189-p VRKtFVGtPCWMAPE
S263 MLKKYGKSFRKMIsL
S269-p KSFRKMIsLCLQKDP
T310 KILQRAPTISERSKK
S324-p KVRRVPGssGRLHKt
S325-p VRRVPGssGRLHKtE
T331-p ssGRLHKtEDGGWEW
S339-p EDGGWEWsDDEFDEE
S347 DDEFDEESEEGRAAI
S355 EEGRAAISQLRSPRV
S359 AAISQLRSPRVKDSL
S369 VKDSLSSSELFAAAE
S427 AQSSGERSQETKIPI
S435 QETKIPISLVLRLRN
  rat

 
K52 IKRINLEKCQTSMDE
T185 TRNKVRKTFVGTPCW
T189 VRKTFVGTPCWMAPE
S263 MLKKYGKSFRKMISL
S269 KSFRKMISLCLQKDP
T310 KILQRAPTISERSKK
S324 KVRRVPGSsGRLHKT
S325-p VRRVPGSsGRLHKTE
T331 SsGRLHKTEDGGWEW
S339-p EDGGWEWsDDEFDEE
S347 DDEFDEESEEGKAAI
S355 EEGKAAISQLRSPRV
S359 AAISQLRSPRVKDSL
S369 VKDSLSNSELFSAAD
S427 ARSSGERSQETKVPI
S435 QETKVPISLVLRLRN
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