|
DNAJA3
Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. Interacts with JAK2, HSPA9B and IFN-gammaR2 chain. Interacts with Ras GTPase-activating protein 1 (RASA1). Isoform 2 interacts with MUSK (via the cytoplasmic domain). Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
|
| Protein type: Apoptosis; Chaperone; Mitochondrial; Cell cycle regulation |
|
Cellular Component: extrinsic to plasma membrane; postsynaptic membrane; mitochondrial matrix; cytoplasm; actin filament; IkappaB kinase complex; cytosol; cell junction; neuromuscular junction; nucleus
|
|
Molecular Function: NF-kappaB binding; protein binding; heat shock protein binding; metal ion binding; unfolded protein binding; interferon-gamma receptor binding; receptor tyrosine kinase binding; protein kinase binding; transcription factor binding; ATP binding; small GTPase regulator activity
|
|
Biological Process: caspase activation; protein folding; protein stabilization; positive regulation of apoptosis; T cell differentiation in the thymus; cell aging; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; embryonic development; positive regulation of protein ubiquitination; inhibition of NF-kappaB transcription factor; response to heat; small GTPase mediated signal transduction; negative regulation of protein kinase activity; positive regulation of T cell proliferation; mitochondrial DNA replication; activated T cell apoptosis; neuromuscular junction development; negative regulation of apoptosis
|
|
Reference #:
Q96EY1 (UniProtKB)
|
| Alt. Names/Synonyms: DnaJ (Hsp40) homolog, subfamily A, member 3; DnaJ homolog subfamily A member 3, mitochondrial; DnaJ protein Tid-1; DNAJA3; DNJA3; FLJ45758; HCA57; Hepatocellular carcinoma-associated antigen 57; hTid-1; TID1; tumorous imaginal discs homolog; Tumorous imaginal discs protein Tid56 homolog |
| Gene Symbols: DNAJA3 |
|
Molecular weight: 52,489 Da
|
|
Basal Isoelectric point: 9.37
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
|
