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Protein Page:
DNAJA3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DNAJA3 Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. Interacts with JAK2, HSPA9B and IFN-gammaR2 chain. Interacts with Ras GTPase-activating protein 1 (RASA1). Isoform 2 interacts with MUSK (via the cytoplasmic domain). Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Chaperone; Mitochondrial; Apoptosis
Cellular Component: extrinsic to plasma membrane; postsynaptic membrane; intracellular membrane-bound organelle; mitochondrion; mitochondrial matrix; cytoplasm; actin filament; IkappaB kinase complex; neuromuscular junction; cell junction; cytosol; nucleus
Molecular Function: NF-kappaB binding; protein binding; metal ion binding; unfolded protein binding; interferon-gamma receptor binding; Hsp70 protein binding; receptor tyrosine kinase binding; protein kinase binding; transcription factor binding; ATP binding; small GTPase regulator activity
Biological Process: caspase activation; protein stabilization; protein folding; positive regulation of apoptosis; T cell differentiation in the thymus; cell aging; negative regulation of transcription from RNA polymerase II promoter; negative regulation of caspase activity; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of cell proliferation; embryonic development; positive regulation of protein ubiquitination; regulation of catalytic activity; response to heat; inhibition of NF-kappaB transcription factor; small GTPase mediated signal transduction; negative regulation of protein kinase activity; positive regulation of T cell proliferation; mitochondrial DNA replication; activated T cell apoptosis; neuromuscular junction development; negative regulation of apoptosis
Reference #:  Q96EY1 (UniProtKB)
Alt. Names/Synonyms: DnaJ (Hsp40) homolog, subfamily A, member 3; DnaJ homolog subfamily A member 3, mitochondrial; DnaJ protein Tid-1; DNAJA3; DNJA3; FLJ45758; HCA57; Hepatocellular carcinoma-associated antigen 57; hTid-1; TID1; tumorous imaginal discs homolog; Tumorous imaginal discs protein Tid56 homolog
Gene Symbols: DNAJA3
Molecular weight: 52,489 Da
Basal Isoelectric point: 9.37  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DNAJA3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S40-p GVVGAWLsRKLSVPA
0 3 K91-ac HTSAPLAkEDYYQIL
0 2 Y113-p QKEIKKAyyQLAKKY
0 2 Y114-p KEIKKAyyQLAKKYH
0 1 K118 KAyyQLAKKYHPDTN
0 1 K130-sc DTNKDDPkAKEkFSQ
0 1 K134-ac DDPkAKEkFSQLAEA
0 1 K152-ub LSDEVKRkQYDAYGS
0 1 S169-p FDPGASGsQHSYWKG
0 6 K242 TCERCNGKGNEPGTK
0 1 K385 PGTQTDQKIRMGGKG
0 1 S398-p KGIPRINsYGYGDHY
0 1 T417-p IRVPKRLtSRQQSLI
  mouse

 
C40 GVVATSLCRKLCVSA
K91 HTSASLAKDDYYQIL
Y113 QKDIKKAYYQLAkKY
Y114 KDIKKAYYQLAkKYH
K118-ac KAYYQLAkKYHPDTN
K130 DTNKDDPKAKEkFSQ
K134-ac DDPKAKEkFSQLAEA
K152 LSDEVKRKQYDAYGS
S169 FDPGTSSSGQGYWRG
K242-ac TCERCDGkGNEPGTK
K385-ac AGIQTDQkIRLTGKG
S398 KGIPRINSYGYGDHY
S417 IRVPKRLSSRQQNLI
  rat

 
C40 GVVAASLCRKLCVSA
K91 HTSASLAKDDYYQIL
Y113-p QKDIKKAyyQLAKKY
Y114-p KDIKKAyyQLAKKYH
K118 KAyyQLAKKYHPDTN
K130 DTNKDDPKAKEKFSQ
K134 DDPKAKEKFSQLAEA
K152 LSDEVKRKQYDAYGS
S169 FDPGASSSGQGYWRG
K242 TCERCDGKGNEPGTK
K385 AGIQTDQKIRLTGKG
S398 KGIPRINSYGYGDHY
S417 IRVPKRLSSRQQNLI
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