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UBE2M (human)

Overview UBE2M Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. Interacts with UBA3, DCUN1D1 and RBX1. Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily. Note: This description may include information from UniProtKB. Protein type: Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.-; Ligase; Adaptor/scaffold; EC 6.3.2.19 Molecular Function: protein binding; ribosomal S6-glutamic acid ligase activity; ubiquitin-protein ligase activity; ATP binding; NEDD8 ligase activity Biological Process: protein neddylation; positive regulation of neuron apoptosis; protein ubiquitination; protein modification process Reference #:  P61081 (UniProtKB) Alt. Names/Synonyms: hUbc12; NEDD8 carrier protein; NEDD8 protein ligase; NEDD8-conjugating enzyme Ubc12; UBC-RS2; UBC12; UBE2M; ubiquitin carrier protein M; Ubiquitin-conjugating enzyme E2 M; ubiquitin-conjugating enzyme E2M; ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast); ubiquitin-protein ligase M; yeast UBC12 homolog Gene Symbols: UBE2M Molecular weight: 20,900 Da Basal Isoelectric point: 7.57  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below UBE2M 1TT5 - E/F=1-26 (human) 1Y8X - A=27-183 (human) 2NVU - C=1-183 (human) 3TDU - F/E=2-15 (human) 3TDZ - F/E=2-12 (human) 4GAO - H/F/C/E=1-12 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K3-a	_____MIkLFSLkQQ
0	2		K3-u	_____MIkLFSLkQQ
0	12		K8-u	MIkLFSLkQQKKEEE
0	1		T20-p	EEESAGGtKGsSKKA
0	3		S23-p	SAGGtKGsSKKAsAA
0	3		S28-p	KGsSKKAsAAQLRIQ
0	2		K36-u	AAQLRIQkDINELNL
0	23		K45-u	INELNLPkTCDIsFS
0	1		S50-p	LPkTCDIsFSDPDDL
0	1		K61-m2	PDDLLNFkLVICPDE
0	2		K61-u	PDDLLNFkLVICPDE
0	8		K72-u	CPDEGFYkSGkFVFS
0	9		K75-u	EGFYkSGkFVFSFkV
0	1		K81-u	GkFVFSFkVGQGyPH
0	1		Y86-p	SFkVGQGyPHDPPkV
0	14		K92-u	GyPHDPPkVkCETMV
0	4		K94-u	PHDPPkVkCETMVYH
0	29		R169-m1	QNVQRSMrGGyIGST
0	3		Y172-p	QRSMrGGyIGSTyFE
0	9		Y177-p	GGyIGSTyFERCLK_

	mouse
K3	_____MIKLFSLkQQ
K3-u	_____MIkLFSLkQQ
K8-u	MIkLFSLkQQKKEEE
T20	EEESAGGTKGSSKKA
S23	SAGGTKGSSKKAsAA
S28-p	KGSSKKAsAAQLRIQ
K36-u	AAQLRIQkDINELNL
K45-u	INELNLPkTCDISFS
S50	LPkTCDISFSDPDDL
K61	PDDLLNFKLVICPDE
K61	PDDLLNFKLVICPDE
K72-u	CPDEGFYkSGkFVFS
K75-u	EGFYkSGkFVFSFKV
K81	GkFVFSFKVGQGYPH
Y86	SFKVGQGYPHDPPkV
K92-u	GYPHDPPkVKCETMV
K94	PHDPPkVKCETMVYH
R169-m1	QNVQRSMrGGYIGST
Y172	QRSMrGGYIGSTYFE
Y177	GGYIGSTYFERCLK_

	rat
K3	_____MIKLFSLkQQ
K3	_____MIKLFSLkQQ
K8-u	MIKLFSLkQQKKEEE
T20	EEESAGGTKGSSKKA
S23	SAGGTKGSSKKASAA
S28	KGSSKKASAAQLRIQ
K36	AAQLRIQKDINELNL
K45	INELNLPKTCDISFS
S50	LPKTCDISFSDPDDL
K61	PDDLLNFKLVICPDE
K61	PDDLLNFKLVICPDE
K72	CPDEGFYKSGKFVFS
K75	EGFYKSGKFVFSFKV
K81	GKFVFSFKVGQGYPH
Y86	SFKVGQGYPHDPPKV
K92	GYPHDPPKVKCETMV
K94	PHDPPKVKCETMVYH
R169-m1	QNVQRSMrGGYIGST
Y172	QRSMrGGYIGSTYFE
Y177	GGYIGSTYFERCLK_

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