Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
MARK4 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
MARK4 a member of the CAMKL family of protein kinases. Normally expressed in neural progenitors and is re-expressed in gliomas. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, CAMK; CAMK group; CAMKL family; MARK subfamily
Cellular Component: microtubule cytoskeleton; centrosome; neuron projection; microtubule organizing center
Molecular Function: protein serine/threonine kinase activity; gamma-tubulin binding; protein binding; ubiquitin binding; microtubule binding; tau-protein kinase activity; ATP binding
Biological Process: nervous system development; positive regulation of programmed cell death; microtubule cytoskeleton organization and biogenesis; protein amino acid phosphorylation; microtubule bundle formation
Reference #:  Q96L34 (UniProtKB)
Alt. Names/Synonyms: FLJ90097; KIAA1860; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase like 1; MAP/microtubule affinity-regulating kinase-like 1; MARK4; MARK4 serine/threonine protein kinase; MARKL1; Nbla00650; putative protein product of Nbla00650
Gene Symbols: MARK4
Molecular weight: 82,520 Da
Basal Isoelectric point: 9.7  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MARK4

Protein Structure Not Found.


STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S23-p DTHGTLGsGRsSDKG
0 2 S26-p GTLGsGRsSDKGPSW
0 1 R60-m1 QPHVGNYrLLRTIGK
0 1 K183-u NIVHRDLkAENLLLD
1 49 T214-p TLGSKLDtFCGsPPY
0 14 S218-p KLDtFCGsPPYAAPE
0 1 T300 LNPAKRCTLEQIMKD
0 23 S391-p LARVRAPsDTTNGTS
0 30 S423-p YHRQRRHsDFCGPSP
0 7 S438-p APLHPKRsPtstGEA
0 6 T440-p LHPKRsPtstGEAEL
0 2 S441-p HPKRsPtstGEAELK
0 2 T442-p PKRsPtstGEAELKE
0 6 T511-p SMMTRRNtYVCTERP
0 4 Y512 MMTRRNtYVCTERPG
0 1 T515 RRNtYVCTERPGAER
0 1 S543-p TPRVPPAsPSSHSLA
0 6 S563-p RSRLARGstIRStFH
0 6 T564-p SRLARGstIRStFHG
0 1 T568-p RGstIRStFHGGQVR
0 2 S594-p VQNGPPAsPTLAHEA
  mouse

 
S23 DTHGTLGSGRSSDKG
S26 GTLGSGRSSDKGPSW
R60 QPHVGNYRLLRTIGK
K183 NIVHRDLKAENLLLD
T214-p TLGSKLDtFCGsPPY
S218-p KLDtFCGsPPYAAPE
T300-p LNPAKRCtLEQIMKD
S391 LARVRAPSDTTNGTS
S423-p YHRQRRHsDFCGPSP
S438-p APLHPKRsPtstGDT
T440-p LHPKRsPtstGDTEL
S441-p HPKRsPtstGDTELK
T442-p PKRsPtstGDTELKE
T511-p SMMTRRNtYVCtERP
Y512 MMTRRNtYVCtERPG
T515-p RRNtYVCtERPGSER
S543 TSRVPPASPSSHSLA
S563 RSRLARGSTIRSTFH
T564 SRLARGSTIRSTFHG
T568 RGSTIRSTFHGGQVR
S594 VQNGPPASPTLAHEA
  rat

 
S23 DTHGTLGSGRSSDKG
S26 GTLGSGRSSDKGPSW
R60 QPHVGNYRLLRTIGK
K183 NIVHRDLKAENLLLD
T214-p TLGSKLDtFCGSPPY
S218 KLDtFCGSPPYAAPE
T300 LNPAKRCTLEQIMKD
S391 LARVRAPSDTTNGTS
S423 YHRQRRHSDFCGPSP
S438 APLHPKRSPTSTGDT
T440 LHPKRSPTSTGDTEL
S441 HPKRSPTSTGDTELK
T442 PKRSPTSTGDTELKE
T511-p SMMTRRNtyVCTERP
Y512-p MMTRRNtyVCTERPG
T515 RRNtyVCTERPGSER
S543 TSRVPPASPSSHSLA
S563 RSRLARGSTIRSTFH
T564 SRLARGSTIRSTFHG
T568 RGSTIRSTFHGGQVR
S594 VQNGPPASPTLAHEA
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.