Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
MARK4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MARK4 a member of the CAMKL family of protein kinases. Normally expressed in neural progenitors and is re-expressed in gliomas. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, CAMK; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; CAMK group; CAMKL family; MARK subfamily
Cellular Component: microtubule cytoskeleton; centrosome; neuron projection; microtubule organizing center
Molecular Function: protein serine/threonine kinase activity; gamma-tubulin binding; protein binding; ubiquitin binding; microtubule binding; tau-protein kinase activity; ATP binding
Biological Process: nervous system development; positive regulation of programmed cell death; microtubule cytoskeleton organization and biogenesis; protein amino acid phosphorylation; microtubule bundle formation
Reference #:  Q96L34 (UniProtKB)
Alt. Names/Synonyms: FLJ90097; KIAA1860; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase like 1; MAP/microtubule affinity-regulating kinase-like 1; MARK4; MARK4 serine/threonine protein kinase; MARKL1; Nbla00650; putative protein product of Nbla00650
Gene Symbols: MARK4
Molecular weight: 82,520 Da
Basal Isoelectric point: 9.7  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MARK4

Protein Structure Not Found.


STRING  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 S15-p APGNDRNsDtHGtLG
0 1 T17-p GNDRNsDtHGtLGsG
0 1 T20-p RNsDtHGtLGsGRsS
0 2 S23-p DtHGtLGsGRsSDKG
0 2 S26-p GtLGsGRsSDKGPSW
0 1 S45-p LGARCRNsIAsCPEE
0 1 S48-p RCRNsIAsCPEEQPH
0 1 R60-m1 QPHVGNYrLLRTIGK
0 1 K183-ub NIVHRDLkAENLLLD
1 55 T214-p TLGSKLDtFCGsPPY
0 17 S218-p KLDtFCGsPPYAAPE
0 1 T300 LNPAKRCTLEQIMKD
0 24 S391-p LARVRAPsDttNGTS
0 1 T393-p RVRAPsDttNGTSSS
0 1 T394-p VRAPsDttNGTSSSK
0 1 S404-p TSSSKGTsHSKGQRS
0 51 S423-p YHRQRRHsDFCGPSP
0 8 S438-p APLHPKRsPtstGEA
0 6 T440-p LHPKRsPtstGEAEL
0 2 S441-p HPKRsPtstGEAELK
0 2 T442-p PKRsPtstGEAELKE
0 1 S496-p ERRKDSTsTPNNLPP
0 1 S504-p TPNNLPPsMMTRRNt
0 6 T511-p sMMTRRNtYVCTERP
0 1 Y512 MMTRRNtYVCTERPG
0 1 T515 RRNtYVCTERPGAER
0 1 S543-p TPRVPPAsPssHSLA
0 1 S545-p RVPPAsPssHSLAPP
0 1 S546-p VPPAsPssHSLAPPS
0 6 S563-p RSRLARGstIRstFH
0 6 T564-p SRLARGstIRstFHG
0 1 S567-p ARGstIRstFHGGQV
0 1 T568-p RGstIRstFHGGQVR
0 2 S594-p VQNGPPAsPTLAHEA
0 1 T665 FPWSVKLTSSRPPEA
0 1 S666 PWSVKLTSSRPPEAL
0 1 S667 WSVKLTSSRPPEALM
0 1 - gap
  MARK4 iso2  
S15 APGNDRNSDTHGTLG
T17 GNDRNSDTHGTLGSG
T20 RNSDTHGTLGSGRSS
S23 DTHGTLGSGRSSDKG
S26 GTLGSGRSSDKGPSW
S45 LGARCRNSIASCPEE
S48 RCRNSIASCPEEQPH
R60 QPHVGNYRLLRTIGK
K183 NIVHRDLKAENLLLD
T214 TLGSKLDTFCGSPPY
S218 KLDTFCGSPPYAAPE
T300 LNPAKRCTLEQIMKD
S391 LARVRAPSDTTNGTS
T393 RVRAPSDTTNGTSSS
T394 VRAPSDTTNGTSSSK
S404 TSSSKGTSHSKGQRS
S423 YHRQRRHSDFCGPSP
S438 APLHPKRSPTSTGEA
T440 LHPKRSPTSTGEAEL
S441 HPKRSPTSTGEAELK
T442 PKRSPTSTGEAELKE
S496 ERRKDSTSTPNNLPP
S504 TPNNLPPSMMTRRNT
T511 SMMTRRNTYVCTERP
Y512 MMTRRNTYVCTERPG
T515 RRNTYVCTERPGAER
S543 TPRVPPASPSSHSLA
S545 RVPPASPSSHSLAPP
S546 VPPASPSSHSLAPPS
S563 RSRLARGSTIRSTFH
T564 SRLARGSTIRSTFHG
S567 ARGSTIRSTFHGGQV
T568 RGSTIRSTFHGGQVR
S594 VQNGPPASPTLAHEA
- gap
- gap
- gap
S650-p GASLPQGsKIRSQTN
  mouse

 
S15 APGNDRNSDTHGTLG
T17 GNDRNSDTHGTLGSG
T20 RNSDTHGTLGSGRSS
S23 DTHGTLGSGRSSDKG
S26 GTLGSGRSSDKGPSW
S45 LGARCRNSIASCPEE
S48 RCRNSIASCPEEQPH
R60 QPHVGNYRLLRTIGK
K183 NIVHRDLKAENLLLD
T214-p TLGSKLDtFCGsPPY
S218-p KLDtFCGsPPYAAPE
T300-p LNPAKRCtLEQIMKD
S391 LARVRAPSDTTNGTS
T393 RVRAPSDTTNGTSSS
T394 VRAPSDTTNGTSSSK
S404 TSSSKGSSHNKGQRA
S423-p YHRQRRHsDFCGPSP
S438-p APLHPKRsPtstGDT
T440-p LHPKRsPtstGDTEL
S441-p HPKRsPtstGDTELK
T442-p PKRsPtstGDTELKE
S496 ERRKDSTSTPNNLPP
S504 TPNNLPPSMMTRRNt
T511-p SMMTRRNtYVCtERP
Y512 MMTRRNtYVCtERPG
T515-p RRNtYVCtERPGSER
S543 TSRVPPASPSSHSLA
S545 RVPPASPSSHSLAPP
S546 VPPASPSSHSLAPPS
S563 RSRLARGSTIRSTFH
T564 SRLARGSTIRSTFHG
S567 ARGSTIRSTFHGGQV
T568 RGSTIRSTFHGGQVR
S594 VQNGPPASPTLAHEA
T665-p FPWSVKLtssRPPEA
S666-p PWSVKLtssRPPEAL
S667-p WSVKLtssRPPEALM
- gap
  rat

 
S15 APGNDRNSDTHGTLG
T17 GNDRNSDTHGTLGSG
T20 RNSDTHGTLGSGRSS
S23 DTHGTLGSGRSSDKG
S26 GTLGSGRSSDKGPSW
S45 LGARCRNSIASCPEE
S48 RCRNSIASCPEEQPH
R60 QPHVGNYRLLRTIGK
K183 NIVHRDLKAENLLLD
T214-p TLGSKLDtFCGSPPY
S218 KLDtFCGSPPYAAPE
T300 LNPAKRCTLEQIMKD
S391 LARVRAPSDTTNGTS
T393 RVRAPSDTTNGTSSS
T394 VRAPSDTTNGTSSSK
S404 TSSSKGSSHNKGQRT
S423 YHRQRRHSDFCGPSP
S438 APLHPKRSPTSTGDT
T440 LHPKRSPTSTGDTEL
S441 HPKRSPTSTGDTELK
T442 PKRSPTSTGDTELKE
S496 ERRKDSTSTPNNLPP
S504 TPNNLPPSMMTRRNt
T511-p SMMTRRNtyVCTERP
Y512-p MMTRRNtyVCTERPG
T515 RRNtyVCTERPGSER
S543 TSRVPPASPSSHSLA
S545 RVPPASPSSHSLAPP
S546 VPPASPSSHSLAPPS
S563 RSRLARGSTIRSTFH
T564 SRLARGSTIRSTFHG
S567 ARGSTIRSTFHGGQV
T568 RGSTIRSTFHGGQVR
S594 VQNGPPASPTLAHEA
T665 FPWSVKLTSSRPPEA
S666 PWSVKLTSSRPPEAL
S667 WSVKLTSSRPPEALM
- gap
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.