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Protein Page:
SPINK5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SPINK5 Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. Defects in SPINK5 are the cause of Netherton syndrome (NETH). NETH is an autosomal recessive congenital ichthyosis associated with hair shaft abnormalities and anomalies of the immune system. Typical features are ichthyosis linearis circumflexa, ichthyosiform erythroderma, trichorrhexis invaginata (bamboo hair), atopic dermatitis, and hayfever. High postnatal mortality is due to failure to thrive, infections and hypernatremic dehydration. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Inhibitor protein; Secreted
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; extracellular region; cell cortex; cytosol
Molecular Function: serine-type endopeptidase inhibitor activity
Biological Process: negative regulation of proteolysis; regulation of cell adhesion; extracellular matrix organization and biogenesis; negative regulation of angiogenesis; epithelial cell differentiation; negative regulation of immune response; hair cell differentiation; epidermal cell differentiation; regulation of T cell differentiation; anagen
Reference #:  Q9NQ38 (UniProtKB)
Alt. Names/Synonyms: DKFZp686K19184; FLJ21544; FLJ97536; FLJ97596; FLJ99794; Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665; ISK5; LEKTI; LETKI; Lympho-epithelial Kazal-type-related inhibitor; lymphoepithelial Kazal-type-related inhibitor; NETS; NS; serine peptidase inhibitor, Kazal type 5; Serine protease inhibitor Kazal-type 5; serine protease inhibitor, Kazal type 5; SPINK5; VAKTI
Gene Symbols: SPINK5
Molecular weight: 120,714 Da
Basal Isoelectric point: 8.45  Predict pI for various phosphorylation states
Select Structure to View Below

SPINK5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S147-p GSQIGVKsEGECKSS
0 1 T189-p VLGPDGKtHGNKCAM
0 1 E206 ELFLKEAENAKREGE
0 1 Y440-p FEELCSEyRKSRKNG
0 1 S725-p RLSCTREsDPVRDAD
0 1 T773-p GSESGKDtCDEFRSQ
0 1 N837 SNTGERSNtGERSND
0 1 T838-p NTGERSNtGERSNDK
  mouse

 
S148 QNHVDVKSEGECGSS
T190 ILGPDGRTHGNRCAM
K207-ac ELFLKEAkENATRNR
Y371 YAKLCDEYRKARKNG
S652 QLSCTRESDPVRGVD
V700 GSATGKDVCDQFRSQ
S764 RNTETNKSDKEDKCH
D765 NTETNKSDKEDKCHE
  rat

 
S130 QSHVEVKSEGECGSS
T172 IRGPDGRTHGNRCAM
Q189 ELFLKEAQVNATRDR
F420 FYDLCDEFRKVRKNG
S704 ELSCTRESDPVRGAD
V750 GTETRKDVCDQFRNQ
S814-p RNTGANKsNKKQGNS
N815 NTGANKsNKKQGNSN
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