a protein kinase of the WEE family. A nuclear protein which catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Other; EC 18.104.22.168; Protein kinase, Ser/Thr (non-receptor); Other group; WEE family
Molecular Function: protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; magnesium ion binding; non-membrane spanning protein tyrosine kinase activity; ATP binding
Biological Process: mitosis; peptidyl-tyrosine phosphorylation; regulation of cell cycle; establishment of cell polarity; mitotic cell cycle; microtubule cytoskeleton organization and biogenesis; blood coagulation; G2/M transition of mitotic cell cycle; neurite morphogenesis; G1/S transition of mitotic cell cycle
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.