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Protein Page:
TAO2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TAO2 a serine/threonine-protein kinase of the STE20 family. Activates the p38 MAPK signaling pathway through the specific activation of the upstream kinases MKK3 and MKK6. A potential multi-pass membrane protein. Activated in the DNA damage response and regulates the G2/M transition DNA damage checkpoint. Interacts with tubulins through the C-terminal domain. Involved in apoptotic processes such as membrane blebbing and apoptotic body formation. Prevents TAK1-mediated activation of IKK-alpha, and thus NF-kappa-B activation. May play a role in the osmotic stress-JNK1 pathway. An autism spectrum disorder susceptibility gene. Affects basal dendrite formation and axonal projections in cortical pyramidal neurons. Interacts with NRP1 (neuropilin 1), a receptor for the secreted guidance protein semaphorin 3A (Sema3A). Influences the formation of basal dendrites through the activation of JNK. Three isoforms of the human protein are produced by alternative splicing. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus. Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Apoptosis; EC 2.7.11.1; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); Membrane protein, integral; STE group; STE20 family; TAO subfamily
Cellular Component: cytoskeleton; cytoplasmic vesicle membrane; cytoplasmic membrane-bound vesicle; cytoplasm; dendrite; integral to membrane; nucleolus; nucleus
Molecular Function: protein serine/threonine kinase activity; mitogen-activated protein kinase kinase binding; ATP binding
Biological Process: focal adhesion formation; cell migration; activation of MAPKK activity; apoptosis; stress-activated MAPK cascade; positive regulation of JNK cascade; positive regulation of stress-activated MAPK cascade; regulation of cell shape; response to stress; regulation of cell growth; protein targeting to membrane; G2/M transition DNA damage checkpoint; actin cytoskeleton organization and biogenesis; response to DNA damage stimulus
Reference #:  Q9UL54 (UniProtKB)
Alt. Names/Synonyms: hKFC-C; KIAA0881; Kinase from chicken homolog C; MAP3K17; prostate derived STE20-like kinase PSK; Prostate-derived STE20-like kinase 1; PSK; PSK-1; PSK1; PSK1-BETA; Serine/threonine-protein kinase TAO2; TAO kinase 2; TAO1; TAO2; TAOK2; Thousand and one amino acid protein 2; thousand and one amino acid protein kinase
Gene Symbols: TAOK2
Molecular weight: 138,251 Da
Basal Isoelectric point: 6.84  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Regulation of Actin Dynamics  |  Regulation of Microtubule Dynamics  |  SAPK/JNK Signaling Cascades  |  Signaling Pathways Activating p38 MAPK
Select Structure to View Below

TAO2
Protein Structure Not Found.


STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 5 S9-p PAGGRAGsLKDPDVA
0 1 K11 GGRAGsLKDPDVAEL
0 1 S29-p DDPEKLFsDLREIGH
0 1 S38-p LREIGHGsFGAVyFA
0 24 Y43-p HGsFGAVyFARDVRN
0 1 Y61-p VAIKKMSySGkQSNE
0 1 K64-a KKMSySGkQSNEkWQ
0 1 K69-a SGkQSNEkWQDIIKE
0 1 Y107-p TAWLVMEyCLGSASD
0 1 K153-u NMIHRDVkAGNILLS
1 3 S181-p SIMAPANsFVGTPYW
0 38 Y309-p RELDNLQyRKMKKIL
0 1 Y338-p EEEEAEPyMHRAGtL
0 3 T344-p PyMHRAGtLTsLESS
0 1 S347-p HRAGtLTsLESSHSV
0 4 Y426-p LPGSDNLyDDPyQPE
0 4 Y430-p DNLyDDPyQPEITPs
0 1 S437-p yQPEITPsPLQPPAA
0 1 S452-p PAPTSTTsSARRRAY
0 1 T468-p RNRDHFAtIRTASLV
0 2 S486-p IQEHEQDsALREQLS
0 4 S603-p EELQENPstPKREKA
0 3 T604-p ELQENPstPKREKAE
0 4 S656-p KMLLARHsLDQDLLR
0 1 K668 LLREDLNKKQTQKDL
0 1 K731 REQELRQKHAAQVRQ
0 1 K741 AQVRQQPKSLKVRAG
0 1 S742 QVRQQPKSLKVRAGQ
0 1 S777-p PIEQQPCsPGQEAVL
0 2 S825-p GEESGAPsPsPQKHG
0 3 S827-p ESGAPsPsPQKHGSL
0 1 R1126-m1 NKDGFRSrLPVPGPr
0 1 R1133-m1 rLPVPGPrRRNPRTT
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 2 - gap
0 2 - gap
0 1 - gap
1 0 - gap
0 1 - gap
0 1 - gap
  TAO2 iso2  
S9 PAGGRAGSLKDPDVA
K11 GGRAGSLKDPDVAEL
S29 DDPEKLFSDLREIGH
S38 LREIGHGSFGAVYFA
Y43 HGSFGAVYFARDVRN
Y61 VAIKKMSYSGKQSNE
K64 KKMSYSGKQSNEKWQ
K69 SGKQSNEKWQDIIKE
Y107 TAWLVMEYCLGSASD
K153 NMIHRDVKAGNILLS
S181 SIMAPANSFVGTPYW
Y309-p RELDNLQyRKMKKIL
Y338 EEEEAEPYMHRAGTL
T344 PYMHRAGTLTSLESS
S347 HRAGTLTSLESSHSV
Y426-p LPGSDNLyDDPyQPE
Y430-p DNLyDDPyQPEITPS
S437 yQPEITPSPLQPPAA
S452 PAPTSTTSSARRRAY
T468 RNRDHFATIRTASLV
S486 IQEHEQDSALREQLS
S603 EELQENPSTPKREKA
T604 ELQENPSTPKREKAE
S656 KMLLARHSLDQDLLR
K668 LLREDLNKKQTQKDL
K731 REQELRQKHAAQVRQ
K741 AQVRQQPKsLKSKEL
S742-p QVRQQPKsLKSKELQ
- gap
- gap
- gap
- gap
- gap
S812 QSISEMLSSQALRLD
R870-m1 EQRVALRrALLEQrV
R876-m1 RrALLEQrVEEELLA
S889-p LALQTGRsERIRsLL
S894-p GRsERIRsLLERQAR
R1000-m2 GGALLLLrNSPQPLR
S1011-p QPLRRAAsGGsGSEN
S1014-p RRAAsGGsGSENVGP
S1031 AAVPGPLSRSTSVAS
S1035 GPLSRSTSVASHILN
Y1048-p LNGSSHFyS______
  mouse

► Hide Isoforms 		 
S9-p PAGGRAGsLKDPDVA
K11 GGRAGsLKDPDVAEL
S29 DDPEKLFSDLREIGH
S38 LREIGHGSFGAVyFA
Y43-p HGSFGAVyFARDVRN
Y61 VAIKKMSYSGKQSNE
K64 KKMSYSGKQSNEKWQ
K69 SGKQSNEKWQDIIKE
Y107 TAWLVMEYCLGSASD
K153 NMIHRDVKAGNILLS
S181 SIMAPANSFVGTPYW
Y309 RELDNLQYRKMKKIL
Y344 CSQEAEPYTHRAGTL
T350 PYTHRAGTLTSLESS
S353 HRAGTLTSLESSHSV
Y434 LPGSDNLYDDPYQPE
Y438 DNLYDDPYQPEMTPG
G445 YQPEMTPGPLQPPAA
S459 APPTSTSSSARRRAY
T475 RNRDHFATIRTASLV
S493 IQEHEQDSALREQLS
S610-p EELQENPstPKREKA
T611-p ELQENPstPKREKAE
S663-p KMLLARHsLDQDLLR
K675-a LLREDLNkKQTQKDL
K738-a REQELRQkHAAQVRQ
K748-a AQVRQQPkSLKVRAG
S749 QVRQQPkSLKVRAGQ
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  TAO2 iso2  
S9 PAGGRAGSLKDPDVA
K11 GGRAGSLKDPDVAEL
S29 DDPEKLFSDLREIGH
S38 LREIGHGSFGAVYFA
Y43 HGSFGAVYFARDVRN
Y61 VAIKKMSYSGKQSNE
K64 KKMSYSGKQSNEKWQ
K69 SGKQSNEKWQDIIKE
Y107 TAWLVMEYCLGSASD
K153 NMIHRDVKAGNILLS
S181 SIMAPANSFVGTPYW
Y309 RELDNLQYRKMKKIL
Y344 CSQEAEPYTHRAGTL
T350 PYTHRAGTLTSLESS
S353 HRAGTLTSLESSHSV
Y434 LPGSDNLYDDPYQPE
Y438 DNLYDDPYQPEMTPG
G445 YQPEMTPGPLQPPAA
S459 APPTSTSSSARRRAY
T475 RNRDHFATIRTASLV
S493 IQEHEQDSALREQLS
S610 EELQENPSTPKREKA
T611 ELQENPSTPKREKAE
S663 KMLLARHSLDQDLLR
K675 LLREDLNKKQTQKDL
K738 REQELRQKHAAQVRQ
K748 AQVRQQPKSLKSKEL
S749 QVRQQPKSLKSKELQ
- gap
- gap
- gap
- gap
- gap
S819-p QSISEMLsSQALRLD
R877 EQRVALRRALLEQRV
R883 RRALLEQRVEEELLA
S896 LALQTGRSERIRsLL
S901-p GRSERIRsLLERQAR
R1007 GGALLLLRNSPQPLR
S1018 QPLRRAASGGSSGEN
S1021 RRAASGGSSGENVGP
S1037 AAVPGPLSRSTsVAS
S1041-p GPLSRSTsVASHILN
Y1054 LNGSSHFYS______
  rat

► Hide Isoforms 		 
S9 PAGGRAGSLkDPDVA
K11-u GGRAGSLkDPDVAEL
S29 DDPEKLFSDLREIGH
S38 LREIGHGSFGAVyFA
Y43-p HGSFGAVyFARDVRN
Y61 VAIKKMSYSGKQSNE
K64 KKMSYSGKQSNEKWQ
K69 SGKQSNEKWQDIIKE
Y107 TAWLVMEYCLGSASD
K153 NMIHRDVKAGNILLS
S181 SIMAPANSFVGTPYW
Y309 RELDNLQYRKMKKIL
Y338 EEEEAEPYMHRAGTL
T344 PYMHRAGTLTSLESS
S347 HRAGTLTSLESSHSV
Y428 LPGSDNLYDDPYQPE
Y432 DNLYDDPYQPEMTPG
G439 YQPEMTPGPLQPPAA
S454 PPTSTSSSSARRRAY
T470 RNRDHFATIRTASLV
S488 IQEHEQDSALREQLS
S605 EELQENPSTPKREKA
T606 ELQENPSTPKREKAE
S658 KMLLARHSLDQDLLR
K670 LLREDLNKKQTQKDL
K733 REQELRQKHAAQVRQ
K743 AQVRQQPKSLKVRAG
S744 QVRQQPKSLKVRAGQ
S777 LSEEQPCSSGQEAIL
S825 GEEMGTFSSSPQKHR
S827 EMGTFSSSPQKHRSL
R1128 NKNGFRSRLPVPWPR
R1135 RLPVPWPRQGNPRTT
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  TAO2 iso2  
S9 PAGGRAGSLkDPDVA
K11-u GGRAGSLkDPDVAEL
S29 DDPEKLFSDLREIGH
S38 LREIGHGSFGAVYFA
Y43 HGSFGAVYFARDVRN
Y61 VAIKKMSYSGKQSNE
K64 KKMSYSGKQSNEKWQ
K69 SGKQSNEKWQDIIKE
Y107 TAWLVMEYCLGSASD
K153 NMIHRDVKAGNILLS
S181 SIMAPANSFVGTPYW
Y309 RELDNLQYRKMKKIL
Y344 CSQEAEPYMHRAGTL
T350 PYMHRAGTLTSLESS
S353 HRAGTLTSLESSHSV
Y434 LPGSDNLYDDPYQPE
Y438 DNLYDDPYQPEMTPG
G445 YQPEMTPGPLQPPAA
S460 PPTSTSSSSARRRAY
T476 RNRDHFATIRTASLV
S494 IQEHEQDSALREQLS
S611 EELQENPSTPKREKA
T612 ELQENPSTPKREKAE
S664 KMLLARHSLDQDLLR
K676 LLREDLNKKQTQKDL
K739 REQELRQKHAAQVRQ
K749 AQVRQQPKSLKSKEL
S750 QVRQQPKSLKSKELQ
- gap
- gap
- gap
- gap
- gap
S820 QSISEMLSSQALRLD
R878 EQRVALRRALLEQRV
R884 RRALLEQRVEEELLA
S897 LALQTGRSERIRSLL
S902 GRSERIRSLLERQAR
R1008 GGALLLLRNSPQPLK
S1019 QPLKRAASGGSSGEN
S1022 KRAASGGSSGENVGP
S1038-p AAVPGPLsRSTSVAS
S1042 GPLsRSTSVASHILN
Y1055 LNGSSHFYS______
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