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Protein Page:
TAO2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TAO2 a serine/threonine-protein kinase of the STE20 family. Activates the p38 MAPK signaling pathway through the specific activation of the upstream kinases MKK3 and MKK6. A potential multi-pass membrane protein. Activated in the DNA damage response and regulates the G2/M transition DNA damage checkpoint. Interacts with tubulins through the C-terminal domain. Involved in apoptotic processes such as membrane blebbing and apoptotic body formation. Prevents TAK1-mediated activation of IKK-alpha, and thus NF-kappa-B activation. May play a role in the osmotic stress-JNK1 pathway. An autism spectrum disorder susceptibility gene. Affects basal dendrite formation and axonal projections in cortical pyramidal neurons. Interacts with NRP1 (neuropilin 1), a receptor for the secreted guidance protein semaphorin 3A (Sema3A). Influences the formation of basal dendrites through the activation of JNK. Three isoforms of the human protein are produced by alternative splicing. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus. Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, STE; Membrane protein, multi-pass; Kinase, protein; EC 2.7.11.1; Membrane protein, integral; Apoptosis; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; TAO subfamily
Cellular Component: cytoplasmic vesicle membrane; cytoskeleton; cytoplasmic membrane-bound vesicle; cytoplasm; dendrite; nucleolus; integral to membrane; nucleus; receptor complex
Molecular Function: protein serine/threonine kinase activity; MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding; ATP binding
Biological Process: focal adhesion formation; cell migration; activation of MAPKK activity; apoptosis; stress-activated MAPK cascade; positive regulation of JNK cascade; positive regulation of stress-activated MAPK cascade; regulation of cell shape; response to stress; regulation of cell growth; protein targeting to membrane; G2/M transition DNA damage checkpoint; actin cytoskeleton organization and biogenesis; response to DNA damage stimulus
Reference #:  Q9UL54 (UniProtKB)
Alt. Names/Synonyms: hKFC-C; KIAA0881; Kinase from chicken homolog C; MAP3K17; prostate derived STE20-like kinase PSK; Prostate-derived STE20-like kinase 1; PSK; PSK-1; PSK1; PSK1-BETA; Serine/threonine-protein kinase TAO2; TAO kinase 2; TAO1; TAO2; TAOK2; Thousand and one amino acid protein 2; thousand and one amino acid protein kinase
Gene Symbols: TAOK2
Molecular weight: 138,251 Da
Basal Isoelectric point: 6.84  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Microtubule Dynamics  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Select Structure to View Below

TAO2

Protein Structure Not Found.


STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 7 S9-p PAGGRAGsLKDPDVA
0 24 Y43-p HGSFGAVyFARDVRN
0 1 K153-u NMIHRDVkAGNILLS
1 3 S181-p SIMAPANsFVGTPYW
0 38 Y309-p RELDNLQyRKMKKIL
0 3 T344-p PYMHRAGtLTSLESS
0 4 Y426-p LPGSDNLyDDPyQPE
0 4 Y430-p DNLyDDPyQPEITPs
0 1 S437-p yQPEITPsPLQPPAA
0 1 S452-p PAPTSTTsSARRRAY
0 1 T468-p RNRDHFAtIRTASLV
0 2 S486-p IQEHEQDsALREQLS
0 4 S603-p EELQENPstPKREKA
0 3 T604-p ELQENPstPKREKAE
0 4 S656-p KMLLARHsLDQDLLR
0 1 S777-p PIEQQPCsPGQEAVL
0 2 S825-p GEESGAPsPsPQKHG
0 4 S827-p ESGAPsPsPQKHGSL
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 2 - gap
0 2 - gap
0 1 - gap
1 0 - gap
0 1 - gap
  TAO2 iso2  
S9 PAGGRAGSLKDPDVA
Y43 HGSFGAVYFARDVRN
K153 NMIHRDVKAGNILLS
S181 SIMAPANSFVGTPYW
Y309-p RELDNLQyRKMKKIL
T344 PYMHRAGTLTSLESS
Y426-p LPGSDNLyDDPyQPE
Y430-p DNLyDDPyQPEITPS
S437 yQPEITPSPLQPPAA
S452 PAPTSTTSSARRRAY
T468 RNRDHFATIRTASLV
S486 IQEHEQDSALREQLS
S603 EELQENPSTPKREKA
T604 ELQENPSTPKREKAE
S656 KMLLARHSLDQDLLR
- gap
- gap
- gap
S894-p GRSERIRsLLERQAR
R948-m1 WPSRPVPrSGAHWSH
R992 PTQSGTPRGGALLLL
R1000-m1 GGALLLLrNSPQPLR
R1000-m2 GGALLLLrNSPQPLR
S1011-p QPLRRAAsGGsGSEN
S1014-p RRAAsGGsGSENVGP
S1031 AAVPGPLSRSTSVAS
S1035 GPLSRSTSVASHILN
  mouse

► Hide Isoforms
 
S9-p PAGGRAGsLKDPDVA
Y43-p HGSFGAVyFARDVRN
K153 NMIHRDVKAGNILLS
S181 SIMAPANSFVGTPYW
Y309 RELDNLQYRKMKKIL
T350 PYTHRAGTLTSLESS
Y434 LPGSDNLYDDPYQPE
Y438 DNLYDDPYQPEMTPG
G445 YQPEMTPGPLQPPAA
S459 APPTSTSSSARRRAY
T475 RNRDHFATIRTASLV
S493 IQEHEQDSALREQLS
S610-p EELQENPstPKREKA
T611-p ELQENPstPKREKAE
S663-p KMLLARHsLDQDLLR
S782 PSEEQPCSSGQEAIL
S830 GEEMGTFSSSPQKHR
S832 EMGTFSSSPQKHRSL
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  TAO2 iso2  
S9 PAGGRAGSLKDPDVA
Y43 HGSFGAVYFARDVRN
K153 NMIHRDVKAGNILLS
S181 SIMAPANSFVGTPYW
Y309 RELDNLQYRKMKKIL
T350 PYTHRAGTLTSLESS
Y434 LPGSDNLYDDPYQPE
Y438 DNLYDDPYQPEMTPG
G445 YQPEMTPGPLQPPAA
S459 APPTSTSSSARRRAY
T475 RNRDHFATIRTASLV
S493 IQEHEQDSALREQLS
S610 EELQENPSTPKREKA
T611 ELQENPSTPKREKAE
S663 KMLLARHSLDQDLLR
- gap
- gap
- gap
S901-p GRSERIRsLLERQAR
R955 WPSRPVPRSGAHWSH
R999-m1 PTQSGTPrGGALLLL
R1007 GGALLLLRNSPQPLR
R1007 GGALLLLRNSPQPLR
S1018-p QPLRRAAsGGsSGEN
S1021-p RRAAsGGsSGENVGP
S1037 AAVPGPLSRSTsVAS
S1041-p GPLSRSTsVASHILN
  rat

► Hide Isoforms
 
S9 PAGGRAGSLKDPDVA
Y43-p HGSFGAVyFARDVRN
K153 NMIHRDVKAGNILLS
S181 SIMAPANSFVGTPYW
Y309 RELDNLQYRKMKKIL
T344 PYMHRAGTLTSLESS
Y428 LPGSDNLYDDPYQPE
Y432 DNLYDDPYQPEMTPG
G439 YQPEMTPGPLQPPAA
S454 PPTSTSSSSARRRAY
T470 RNRDHFATIRTASLV
S488 IQEHEQDSALREQLS
S605 EELQENPSTPKREKA
T606 ELQENPSTPKREKAE
S658 KMLLARHSLDQDLLR
S777 LSEEQPCSSGQEAIL
S825 GEEMGTFSSSPQKHR
S827 EMGTFSSSPQKHRSL
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  TAO2 iso2  
S9 PAGGRAGSLKDPDVA
Y43 HGSFGAVYFARDVRN
K153 NMIHRDVKAGNILLS
S181 SIMAPANSFVGTPYW
Y309 RELDNLQYRKMKKIL
T350 PYMHRAGTLTSLESS
Y434 LPGSDNLYDDPYQPE
Y438 DNLYDDPYQPEMTPG
G445 YQPEMTPGPLQPPAA
S460 PPTSTSSSSARRRAY
T476 RNRDHFATIRTASLV
S494 IQEHEQDSALREQLS
S611 EELQENPSTPKREKA
T612 ELQENPSTPKREKAE
S664 KMLLARHSLDQDLLR
- gap
- gap
- gap
S902 GRSERIRSLLERQAR
R956 WPSRPVPRSGAHWSH
S1000 PTQSGTPSGGALLLL
R1008 GGALLLLRNSPQPLK
R1008 GGALLLLRNSPQPLK
S1019 QPLKRAASGGSSGEN
S1022 KRAASGGSSGENVGP
S1038-p AAVPGPLsRSTSVAS
S1042 GPLsRSTSVASHILN
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