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Protein Page:
CARD11 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CARD11 a CARD (caspase recruitment domain) protein that belongs to the membrane-associated guanylate kinase (MAGUK) family. MAGUK proteins function as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. Contains an N-terminal CARD domain, a central coiled-coil domain, and a C-terminal region containing a PDZ, an SH3, and a GUK. Its CARD domain associates with the CARD domain of BCL10. BCL10 activates NF-kappaB through the IkappaB kinase complex in response to upstream stimuli. Apparently activates NF-kappaB and induce the phosphorylation of BCL10. Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: T cell receptor complex; cytoplasm; plasma membrane; cytosol; lipid raft
Molecular Function: guanylate kinase activity; protein binding; CARD domain binding
Biological Process: positive regulation of cytokine production; thymic T cell selection; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-2 biosynthetic process; T cell receptor signaling pathway; activation of NF-kappaB transcription factor; regulation of apoptosis; T cell costimulation; regulation of B cell differentiation; positive regulation of B cell proliferation; innate immune response; regulation of T cell differentiation; positive regulation of T cell proliferation; nucleotide phosphorylation
Reference #:  Q9BXL7 (UniProtKB)
Alt. Names/Synonyms: bcl10-interacting maguk protein 3; BIMP3; CAR11; CARD-containing MAGUK protein 1; card-maguk protein 1; CARD11; Carma 1; CARMA1; caspase recruitment domain family, member 11; Caspase recruitment domain-containing protein 11; MGC133069
Gene Symbols: CARD11
Molecular weight: 133,284 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CARD11

Protein Structure Not Found.


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Sites Implicated In
activity, induced: S558‑p
molecular association, regulation: S116‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y11-p GGPEMDDyMETLKDE
1 1 S116-p KEPTRRFstIVVEEG
1 3 T117-p EPTRRFstIVVEEGH
0 1 Y202-p VKVKDDNyNLAMRyA
0 1 Y208-p NyNLAMRyAQLSEEK
0 1 R221 EKNMAVMRSRDLQLE
0 1 S433-p ACIVNLEsKLRRLSK
0 3 S448-p DSNNLDQsLPRNLPV
0 2 S459-p NLPVTIIsQDFGDAs
0 1 A465 IsQDFGDAsPRTNGQ
0 5 S466-p sQDFGDAsPRTNGQE
0 1 S487-p SEESPEDsKyFLPyH
0 2 Y489-p ESPEDsKyFLPyHPP
0 2 Y493-p DsKyFLPyHPPQRRM
0 19 S512-p IQLQRAKsPIsLKRT
0 1 S515-p QRAKsPIsLKRTSDF
0 1 T532-p KGHEEEGtDAsPSsC
0 2 S535-p EEEGtDAsPSsCGsL
0 1 S538-p GtDAsPSsCGsLPIT
0 2 S541-p AsPSsCGsLPITNsF
0 3 S547-p GsLPITNsFtKMQPP
0 5 T549-p LPITNsFtKMQPPRs
1 0 S556-p tKMQPPRsRssIMsI
2 0 S558-p MQPPRsRssIMsITA
5 1 S559-p QPPRsRssIMsITAE
3 0 S562-p RsRssIMsITAEPPG
1 1 S572-p AEPPGNDsIVRRYKE
0 12 S593-p TVEEDNDsGGFDALD
2 0 S615-p RYSFGPSsIHSSSSS
3 4 S644-p NLMFRKFsLERPFRP
5 0 S652-p LERPFRPsVTSVGHV
1 0 K696-ub GSFVHSVkPGSLAEk
1 0 K703-ub kPGSLAEkAGLREGH
0 5 T864-p EVDGTHHtLRALRNt
0 1 T871-p tLRALRNtLQPEEAL
0 7 S886-p STSDPRVsPRLSRAS
0 6 S925-p RVRIISGsPLGSLAR
0 1 R932 sPLGSLARSSLDATK
0 1 Y970-p YSLVRAFyCERRRPV
0 1 S995-p LVQRLLNsGGAMEFt
0 1 T1002-p sGGAMEFtICKSDIV
0 1 C1079 IVLFIRVCEKNIKRF
5189 : Phospho-CARD11 (Ser652) Antibody
  mouse

 
Y11 GGPAMDDYMETLKDE
S116 KEPTRRFSTIVVEEG
T117 EPTRRFSTIVVEEGH
Y202 VKVKDDNYNLAMRYA
Y208 NYNLAMRYAQLSEEK
R221-m2 EKNMAVMrSRDLQLE
S433 ACIVNLESKLRRLSK
S448 DNGSLDQSLPRHLPA
S459 HLPATIISQNLGDts
T465-p ISQNLGDtsPRTNGQ
S466-p SQNLGDtsPRTNGQE
S487 SEESPEDSKYFLPYH
Y489 ESPEDSKYFLPYHPP
Y493 DSKYFLPYHPPRRRM
S512-p IQLQRAKsPISMKQA
S515 QRAKsPISMKQASEF
T537 KGHEEDFTDGsPSSS
S540-p EEDFTDGsPSSSRSL
S543 FTDGsPSSSRSLPVT
S546 GsPSSSRSLPVTSSF
S552 RSLPVTSSFsKMQPH
S554-p LPVTSSFsKMQPHRs
S561-p sKMQPHRsRssIMSI
S563-p MQPHRsRssIMSITA
S564-p QPHRsRssIMSITAE
S567 RsRssIMSITAEPPG
S577 AEPPGNDSIVRRCKE
S598-p TVEEDNDsCGFDALD
S620-p RYSFGPPsIHSSSSS
S649-p NLMLRKFsLERPFRP
S657-p LERPFRPsVTSGGHV
K701 GSFIHSVKPGSLAER
R708 KPGSLAERAGLREGH
T869 EADSAHHTLRSLRNT
T876 TLRSLRNTLQPEEML
S891-p STSDPRVsPRLSRAS
S930-p RVRIISGsPLGSLSr
R937-m1 sPLGSLSrSSLDATK
H975 YSLVRAFHCERRRPV
S1000 LVQKLLNSGGAMEFT
T1007 SGGAMEFTICKSDIV
S1084-p IVLLIRVsEKNIKRF
5189 : Phospho-CARD11 (Ser652) Antibody
  rat

 
Y11 GGPAMDDYMETLKDE
S116 KEPTRRFSTIVVEEG
T117 EPTRRFSTIVVEEGH
Y202 VKVKDDNYNLAMRYA
Y208 NYNLAMRYAQLSEEK
R221 EKNMAVMRSRDLQLE
S433 ACIVNLESKLRRLSK
S448 DSGSLDQSLPRHLPA
S459 HLPATIISQSLGDTS
T465 ISQSLGDTSPRTNGQ
S466 SQSLGDTSPRTNGQE
S487 SEESPEDSKYFLPYH
Y489 ESPEDSKYFLPYHPP
Y493 DSKYFLPYHPPRRRM
S512 IQLQRAKSPISMKQA
S515 QRAKSPISMKQASEF
T537 KGHEEDFTDGSPSSS
S540 EEDFTDGSPSSSRSL
S543 FTDGSPSSSRSLPVT
S546 GSPSSSRSLPVTSSF
S552 RSLPVTSSFSKMQPH
S554 LPVTSSFSKMQPHRS
S561 SKMQPHRSRSSIMSI
S563 MQPHRSRSSIMSITA
S564 QPHRSRSSIMSITAE
S567 RSRSSIMSITAEPPG
S577 AEPPGNDSIVRRCKE
S598 TVEEDNDSCGFDVLD
S620 RYSFGPPSIHSSSSS
S649 NLMFRKFSLERPFRP
S657 LERPFRPSVTSGGHV
K701 GSFIHSVKPGSLAEK
K708 KPGSLAEKAGLREGH
T867 EADSAHHTLRSLRNT
T874 TLRSLRNTLQPEEPL
S889 SASDPRVSPRLSRAS
S928 RVRIISGSPLGSLSR
R935 SPLGSLSRSSLDATK
- under review  
- under review  
- under review  
S1082 IVLLIRVSEKNIKRF
  chicken

 
C13 GEPEMDDCLETLKDE
S118 KEPTRRFStIVVEEG
T119-p EPTRRFStIVVEEGH
Y204 VKVKDENYNLAMRYA
Y210 NYNLAMRYAQLSDEK
R223 EKSMAVMRSRDLQLE
C435 ACIVNLECKLRRLSK
S450 DNNCHDQSLPRNLPI
S461 NLPITIISQTFGNSS
S467 ISQTFGNSSPKANGQ
S468 SQTFGNSSPKANGQE
N489 SEDSPEDNKFFLPDQ
F491 DSPEDNKFFLPDQAR
D495 DNKFFLPDQARLKRR
S516 QINPRAKSPVSMNRT
S519 PRAKSPVSMNRTSEF
A537 RAQDEDGANASNGRT
S540 DEDGANASNGRTDTS
S548 NGRTDTSSSNSVSIS
S551 TDTSSSNSVSISNSI
S557 NSVSISNSISSCEVS
S559 VSISNSISSCEVSKI
N571 SKIQTLRNRNDSIMs
N573 IQTLRNRNDSIMsTT
S575 TLRNRNDSIMsTTPE
S578-p NRNDSIMsTTPEPPG
S588 PEPPGNDSIVRRCKE
S609 MVEEDNDSFGFDALE
S631 RHSHGAPSVHSSSSS
S660 NSIFRKFSLERPFRP
S668-p LERPFRPsVTSVGRI
V712 GSFVSSVVSGSLAEK
K719 VSGSLAEKAGLREGH
T883 ETESSHNTLRALRNT
T890 TLRALRNTLQPEEPA
S905 PQSDPKTSPRLSRAS
W944 RVRIVTGWPSGLART
R950 GWPSGLARTASEAKK
H986 YSLVRPIHCERRRPV
S1011 LVQKLLNSGGALEFD
D1018 SGGALEFDICKPDIV
S1095 IVLFIRVSEKNIKRF
5189 : Phospho-CARD11 (Ser652) Antibody
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