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CARD11 (human)

Overview CARD11 a CARD (caspase recruitment domain) protein that belongs to the membrane-associated guanylate kinase (MAGUK) family. MAGUK proteins function as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. Contains an N-terminal CARD domain, a central coiled-coil domain, and a C-terminal region containing a PDZ, an SH3, and a GUK. Its CARD domain associates with the CARD domain of BCL10. BCL10 activates NF-kappaB through the IkappaB kinase complex in response to upstream stimuli. Apparently activates NF-kappaB and induce the phosphorylation of BCL10. Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold Cellular Component: T cell receptor complex; cytoplasm; plasma membrane; cytosol; lipid raft Molecular Function: guanylate kinase activity; protein binding; CARD domain binding Biological Process: positive regulation of cytokine production; regulation of apoptosis; thymic T cell selection; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-2 biosynthetic process; T cell costimulation; regulation of B cell differentiation; positive regulation of B cell proliferation; positive regulation of T cell proliferation; regulation of T cell differentiation; T cell receptor signaling pathway; activation of NF-kappaB transcription factor Reference #:  Q9BXL7 (UniProtKB) Alt. Names/Synonyms: bcl10-interacting maguk protein 3; BIMP3; CAR11; CARD-containing MAGUK protein 1; card-maguk protein 1; CARD11; Carma 1; CARMA1; caspase recruitment domain family, member 11; Caspase recruitment domain-containing protein 11; MGC133069 Gene Symbols: CARD11 Molecular weight: 133,284 Da Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CARD11 4I16 - A=18-110 (mouse)

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	Sites Implicated In
activation: S558‑p molecular association, regulation: S116‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y11-p	GGPEMDDyMETLKDE
1	1		S116-p	KEPTRRFstIVVEEG
1	3		T117-p	EPTRRFstIVVEEGH
0	1		Y202-p	VKVKDDNyNLAMRyA
0	1		Y208-p	NyNLAMRyAQLSEEK
0	1		R221	EKNMAVMRSRDLQLE
0	1		S433-p	ACIVNLEsKLRRLSK
0	2		S448-p	DSNNLDQsLPRNLPV
0	2		S459-p	NLPVTIIsQDFGDAs
0	4		S466-p	sQDFGDAsPRTNGQE
0	1		S487-p	SEESPEDsKyFLPyH
0	2		Y489-p	ESPEDsKyFLPyHPP
0	2		Y493-p	DsKyFLPyHPPQRRM
0	17		S512-p	IQLQRAKsPISLKRT
0	1		T532-p	KGHEEEGtDASPSsC
0	1		S535	EEEGtDASPSsCGsL
0	1		S538-p	GtDASPSsCGsLPIT
0	2		S541-p	ASPSsCGsLPITNsF
0	1		S547-p	GsLPITNsFtKMQPP
0	3		T549-p	LPITNsFtKMQPPRs
1	0		S556-p	tKMQPPRsRssIMsI
1	0		S558-p	MQPPRsRssIMsITA
4	1		S559-p	QPPRsRssIMsITAE
2	0		S562-p	RsRssIMsITAEPPG
1	1		S572-p	AEPPGNDsIVRRYKE
0	11		S593-p	TVEEDNDsGGFDALD
2	0		S615-p	RYSFGPSsIHSSSSS
2	1		S644	NLMFRKFSLERPFRP
4	0		S652	LERPFRPSVTSVGHV
1	0		K696-u	GSFVHSVkPGSLAEk
1	0		K703-u	kPGSLAEkAGLREGH
0	5		T864-p	EVDGTHHtLRALRNt
0	1		T871-p	tLRALRNtLQPEEAL
0	6		S886-p	STSDPRVsPRLSRAS
0	4		S925-p	RVRIISGsPLGSLAR
0	1		Y970-p	YSLVRAFyCERRRPV
0	1		S995-p	LVQRLLNsGGAMEFt
0	1		T1002-p	sGGAMEFtICKSDIV
0	1		C1079	IVLFIRVCEKNIKRF

	mouse
Y11	GGPAMDDYMETLKDE
S116	KEPTRRFSTIVVEEG
T117	EPTRRFSTIVVEEGH
Y202	VKVKDDNYNLAMRYA
Y208	NYNLAMRYAQLSEEK
R221-m2	EKNMAVMrSRDLQLE
S433	ACIVNLESKLRRLSK
S448	DNGSLDQSLPRHLPA
S459	HLPATIISQNLGDTs
S466-p	SQNLGDTsPRTNGQE
S487	SEESPEDSKYFLPYH
Y489	ESPEDSKYFLPYHPP
Y493	DSKYFLPYHPPRRRM
S512-p	IQLQRAKsPISMKQA
T537	KGHEEDFTDGsPSSS
S540-p	EEDFTDGsPSSSRSL
S543	FTDGsPSSSRSLPVT
S546	GsPSSSRSLPVTSSF
S552	RSLPVTSSFsKMQPH
S554-p	LPVTSSFsKMQPHRs
S561-p	sKMQPHRsRssIMSI
S563-p	MQPHRsRssIMSITA
S564-p	QPHRsRssIMSITAE
S567	RsRssIMSITAEPPG
S577	AEPPGNDSIVRRCKE
S598-p	TVEEDNDsCGFDALD
S620-p	RYSFGPPsIHSSSSS
S649-p	NLMLRKFsLERPFRP
S657-p	LERPFRPsVTSGGHV
K701	GSFIHSVKPGSLAER
R708	KPGSLAERAGLREGH
T869	EADSAHHTLRSLRNT
T876	TLRSLRNTLQPEEML
S891-p	STSDPRVsPRLSRAS
S930-p	RVRIISGsPLGSLSR
H975	YSLVRAFHCERRRPV
S1000	LVQKLLNSGGAMEFT
T1007	SGGAMEFTICKSDIV
S1084-p	IVLLIRVsEKNIKRF

	chicken
C13	GEPEMDDCLETLKDE
S118	KEPTRRFStIVVEEG
T119-p	EPTRRFStIVVEEGH
Y204	VKVKDENYNLAMRYA
Y210	NYNLAMRYAQLSDEK
R223	EKSMAVMRSRDLQLE
C435	ACIVNLECKLRRLSK
S450	DNNCHDQSLPRNLPI
S461	NLPITIISQTFGNSS
S468	SQTFGNSSPKANGQE
N489	SEDSPEDNKFFLPDQ
F491	DSPEDNKFFLPDQAR
D495	DNKFFLPDQARLKRR
S516	QINPRAKSPVSMNRT
A537	RAQDEDGANASNGRT
S540	DEDGANASNGRTDTS
S548	NGRTDTSSSNSVSIS
S551	TDTSSSNSVSISNSI
S557	NSVSISNSISSCEVS
S559	VSISNSISSCEVSKI
N571	SKIQTLRNRNDSIMs
N573	IQTLRNRNDSIMsTT
S575	TLRNRNDSIMsTTPE
S578-p	NRNDSIMsTTPEPPG
S588	PEPPGNDSIVRRCKE
S609	MVEEDNDSFGFDALE
S631	RHSHGAPSVHSSSSS
S660	NSIFRKFSLERPFRP
S668-p	LERPFRPsVTSVGRI
V712	GSFVSSVVSGSLAEK
K719	VSGSLAEKAGLREGH
T883	ETESSHNTLRALRNT
T890	TLRALRNTLQPEEPA
S905	PQSDPKTSPRLSRAS
W944	RVRIVTGWPSGLART
H986	YSLVRPIHCERRRPV
S1011	LVQKLLNSGGALEFD
D1018	SGGALEFDICKPDIV
S1095	IVLFIRVSEKNIKRF

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