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Protein Page:
BMPR1B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BMPR1B a kinase of the STKR family. A type I cell-surface receptor for bone morphogenetic protein. Expressed at ighest level in the prostate. May be upregulated by androgen stimulation in cells which expresses the androgen receptor. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Kinase, protein; Protein kinase, TKL; EC 2.7.1.37; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; TKL group; STKR family; Type1 subfamily
Cellular Component: integral to plasma membrane; plasma membrane; receptor complex
Molecular Function: protein serine/threonine kinase activity; protein binding; transforming growth factor beta receptor activity, type I; metal ion binding; SMAD binding; transmembrane receptor protein serine/threonine kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity
Biological Process: positive regulation of bone mineralization; limb morphogenesis; protein amino acid phosphorylation; BMP signaling pathway; positive regulation of osteoblast differentiation; ovulation cycle; dorsal/ventral pattern formation; eye development; retina development in camera-type eye; chondrocyte differentiation; ovarian cumulus expansion; positive regulation of cell differentiation; inflammatory response; skeletal development; retinal ganglion cell axon guidance; cartilage condensation
Reference #:  O00238 (UniProtKB)
Alt. Names/Synonyms: activin receptor-like kinase 6; ALK-6; ALK6; BMP type-1B receptor; BMPR-1B; BMPR1B; BMR1B; Bone morphogenetic protein receptor type-1B; bone morphogenetic protein receptor, type IB; CDw293; serine/threonine receptor kinase
Gene Symbols: BMPR1B
Molecular weight: 56,930 Da
Basal Isoelectric point: 7.78  Predict pI for various phosphorylation states
Select Structure to View Below

BMPR1B

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T97-p RRSIECCtERNECNK
0 1 T109-ga CNKDLHPtLPPLKNR
0 1 Y290-p ENGSLYDyLKSTTLD
0 1 S300-p STTLDAKsMLKLAYS
0 1 S402-p YIMADMYsFGLILWE
  mouse

 
T97 RRSIECCTERNECNK
T109 CNKDLHPTLPPLKDR
Y290 ENGSLYDYLKSTTLD
S300 STTLDAKSMLKLAYS
S402 YIMADMYSFGLILWE
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