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VRK1 (human)

Overview VRK1 Serine/threonine kinase that phosphorylates Thr-18 of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Defects in VRK1 are the cause of pontocerebellar hypoplasia type 1 (PCH1); also called pontocerebellar hypoplasia with infantile spinal muscular atrophy or pontocerebellar hypoplasia with anterior horn cell disease. PCH1 is characterized by an abnormally small cerebellum and brainstem, central and peripheral motor dysfunction from birth, gliosis and anterior horn cell degeneration resembling infantile spinal muscular atrophy (SMA). Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily. Note: This description may include information from UniProtKB. Protein type: Protein kinase, CK1; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); CK1 group; VRK family Cellular Component: Golgi stack; cytoplasm; nucleolus; spindle; nucleus Molecular Function: protein serine/threonine kinase activity; identical protein binding; protein binding; ATP binding Biological Process: mitosis; cell division; protein amino acid autophosphorylation; protein amino acid phosphorylation Reference #:  Q99986 (UniProtKB) Alt. Names/Synonyms: MGC117401; MGC138280; MGC142070; PCH1; Serine/threonine-protein kinase VRK1; vaccinia related kinase 1; vaccinia virus B1R-related kinase 1; Vaccinia-related kinase 1; VRK1 Gene Symbols: VRK1 Molecular weight: 45,476 Da Basal Isoelectric point: 9.02  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below VRK1 2KTY - A=1-360 (human) 2KUL - A=1-360 (human) 2LAV - A=1-361 (human) 3OP5 - A/D/C/B=3-364 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2KTY 2KUL 2LAV 3OP5  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cytoskeletal reorganization: S342‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K16-u	AGRQSSAkRHLAEQF
0	1		K112-u	LKYLGVPkYWGSGLH
0	1		K140-a	RFGSDLQkIYEANAk
0	1		K147-a	kIYEANAkRFSRKtV
0	2		T153-p	AkRFSRKtVLQLsLR
0	2		S158-p	RKtVLQLsLRILDIL
0	3		K188-u	SNLLLNYkNPDQVYL
0	1		Y194	YkNPDQVYLVDYGLA
0	3		K301-u	NKPGEIAkYMETVKL
0	2		K329-u	DILLQGLkAIGSKDD
2	1		S342-p	DDGKLDLsVVENGGL
3	0		T355-p	GLKAKTItKKRKKEI
0	1		S376-p	GVEDTEWsNtQtEEA
0	16		T378-p	EDTEWsNtQtEEAIQ
0	8		T380-p	TEWsNtQtEEAIQTR
0	1		-	gap

	mouse
K16	AGRPGPAKRRLAEQF
K112	LKYLGVPKYWGSGLH
K140	RFGSDLQKIYEANAK
K147	KIYEANAKRFSRKTV
T153	AKRFSRKTVLQLSLR
S158	RKTVLQLSLRILDIL
K188	SNLLLSHKNPDQVyL
Y194-p	HKNPDQVyLVDYGLA
K301	NKPGEIAKYMESVKL
K329	DILLQGLKAIGSKDD
S342	DDGKLDFSAVENGSV
S355-p	SVKTRPAsKKRKKEA
S376	AVEDMECSDTQVQEA
T378	EDMECSDTQVQEAAQ
V380	MECSDTQVQEAAQTR
S411-p	AGCSSSDsSRRQQHL

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