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Protein Page:
SLC25A5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SLC25A5 Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. Belongs to the mitochondrial carrier family. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Membrane protein, multi-pass; Transporter, SLC family; Transporter; Membrane protein, integral
Cellular Component: membrane; mitochondrion; integral to plasma membrane; mitochondrial inner membrane; nucleus
Molecular Function: protein binding; adenine transmembrane transporter activity
Biological Process: adenine transport; viral reproduction; transport; positive regulation of cell proliferation; energy reserve metabolic process; regulation of insulin secretion; transmembrane transport; chromosome segregation
Reference #:  P05141 (UniProtKB)
Alt. Names/Synonyms: 2F1; AAC2; Adenine nucleotide translocator 2; adenine nucleotide translocator 2 (fibroblast); adenine nucleotide translocator), member 5; ADP,ATP carrier protein 2; ADP,ATP carrier protein, fibroblast isoform; ADP/ATP carrier protein; ADP/ATP translocase 2; ADT2; ANT 2; ANT2; SLC25A5; solute carrier family 25 (mitochondrial carrier; Solute carrier family 25 member 5; T2; T3
Gene Symbols: SLC25A5
Molecular weight: 32,852 Da
Basal Isoelectric point: 9.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SLC25A5

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y195‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 T2-p ______MtDAAVsFA
0 5 S7-p _MtDAAVsFAkDFLA
1 44 K10-ac DAAVsFAkDFLAGGV
0 2 K10-ub DAAVsFAkDFLAGGV
0 1 K10 DAAVsFAKDFLAGGV
0 4 S22-p GGVAAAIskTAVAPI
1 4 K23-ac GVAAAIskTAVAPIE
0 5 K23-ub GVAAAIskTAVAPIE
0 2 K23-sc GVAAAIskTAVAPIE
0 5 K33-ac VAPIERVkLLLQVQH
0 3 K33-ub VAPIERVkLLLQVQH
0 5 S42-p LLQVQHAskQITADK
0 2 K43-ac LQVQHAskQITADKQ
0 8 K43-ub LQVQHAskQITADKQ
0 2 K43-sc LQVQHAskQITADKQ
0 1 K49 skQITADKQYkGIID
0 10 K52-ac ITADKQYkGIIDCVV
0 8 K52-m1 ITADKQYkGIIDCVV
0 7 K52-m2 ITADKQYkGIIDCVV
0 5 K52-m3 ITADKQYkGIIDCVV
0 3 K63-ac DCVVRIPkEQGVLsF
0 3 K63-ub DCVVRIPkEQGVLsF
0 1 K63 DCVVRIPKEQGVLsF
0 3 S69-p PkEQGVLsFWRGNLA
0 30 Y81-p NLANVIRyFPtQALN
0 47 T84-p NVIRyFPtQALNFAF
0 205 K92-ac QALNFAFkDkYkQIF
0 2 K92-ub QALNFAFkDkYkQIF
0 14 K94-ac LNFAFkDkYkQIFLG
0 35 K96-ac FAFkDkYkQIFLGGV
0 4 K96-ub FAFkDkYkQIFLGGV
0 2 K96-sc FAFkDkYkQIFLGGV
0 110 K105-ac IFLGGVDkRTQFWLy
0 19 K105-ub IFLGGVDkRTQFWLy
0 2 K105-sc IFLGGVDkRTQFWLy
0 32 Y112-p kRTQFWLyFAGNLAS
0 5 K147 RLAADVGKAGAEREF
0 1 K147-m1 RLAADVGkAGAEREF
0 15 K147-ub RLAADVGkAGAEREF
0 2 K147-sc RLAADVGkAGAEREF
0 27 R155 AGAEREFRGLGDCLV
0 1 R155 AGAEREFRGLGDCLV
0 1 R155 AGAEREFRGLGDCLV
0 9 K163-ac GLGDCLVkIYkSDGI
0 2 K163-ub GLGDCLVkIYkSDGI
0 2 K163-sc GLGDCLVkIYkSDGI
0 8 K166 DCLVkIYKSDGIKGL
0 2 K166-ub DCLVkIYkSDGIKGL
0 2 K166-sc DCLVkIYkSDGIKGL
0 360 Y191-p IIIYRAAyFGIyDtA
0 146 Y195-p RAAyFGIyDtAkGML
0 2 T197-p AyFGIyDtAkGMLPD
0 4 K199-ac FGIyDtAkGMLPDPK
0 2 K199-ub FGIyDtAkGMLPDPK
0 1 S213 KNTHIVISWMIAQTV
0 1 T219 ISWMIAQTVTAVAGL
1 0 K245 MMMQSGRKGtDIMYt
0 1 K245-ub MMMQSGRkGtDIMYt
0 3 T247-p MQSGRkGtDIMYtGt
0 1 T252-p kGtDIMYtGtLDCWR
0 1 T254-p tDIMYtGtLDCWRKI
0 2 K268-ac IARDEGGkAFFkGAW
0 3 K268-ub IARDEGGkAFFkGAW
0 2 K268-sc IARDEGGkAFFkGAW
0 105 K272-ac EGGkAFFkGAWsNVL
0 2 S276-p AFFkGAWsNVLRGMG
0 5 K295-ac LVLYDEIkKyT____
0 2 Y297-p LYDEIkKyT______
  mouse

 
T2-p ______MtDAAVsFA
S7-p _MtDAAVsFAkDFLA
K10-ac DAAVsFAkDFLAGGV
K10-ub DAAVsFAkDFLAGGV
K10-sc DAAVsFAkDFLAGGV
S22-p GGVAAAIskTAVAPI
K23-ac GVAAAIskTAVAPIE
K23-ub GVAAAIskTAVAPIE
K23-sc GVAAAIskTAVAPIE
K33-ac VAPIERVkLLLQVQH
K33-ub VAPIERVkLLLQVQH
S42-p LLQVQHAskQITADk
K43 LQVQHAsKQITADkQ
K43-ub LQVQHAskQITADkQ
K43-sc LQVQHAskQITADkQ
K49-sc skQITADkQYkGIID
K52 ITADkQYKGIIDCVV
K52-m1 ITADkQYkGIIDCVV
K52 ITADkQYKGIIDCVV
K52 ITADkQYKGIIDCVV
K63-ac DCVVRIPkEQGVLsF
K63-ub DCVVRIPkEQGVLsF
K63-sc DCVVRIPkEQGVLsF
S69-p PkEQGVLsFWRGNLA
Y81-p NLANVIRyFPtQALN
T84-p NVIRyFPtQALNFAF
K92-ac QALNFAFkDkYkQIF
K92-ub QALNFAFkDkYkQIF
K94-ac LNFAFkDkYkQIFLG
K96-ac FAFkDkYkQIFLGGV
K96-ub FAFkDkYkQIFLGGV
K96-sc FAFkDkYkQIFLGGV
K105-ac IFLGGVDkRTQFWRy
K105 IFLGGVDKRTQFWRy
K105-sc IFLGGVDkRTQFWRy
Y112-p kRTQFWRyFAGNLAS
K147-ac RLAADVGkAGAEREF
K147 RLAADVGKAGAEREF
K147-ub RLAADVGkAGAEREF
K147-sc RLAADVGkAGAEREF
K155-ac AGAEREFkGLGDCLV
K155-ub AGAEREFkGLGDCLV
K155-sc AGAEREFkGLGDCLV
K163-ac GLGDCLVkIYkSDGI
K163-ub GLGDCLVkIYkSDGI
K163-sc GLGDCLVkIYkSDGI
K166-ac DCLVkIYkSDGIKGL
K166 DCLVkIYKSDGIKGL
K166-sc DCLVkIYkSDGIKGL
Y191-p IIIYRAAyFGIyDTA
Y195-p RAAyFGIyDTAkGML
T197 AyFGIyDTAkGMLPD
K199-ac FGIyDTAkGMLPDPK
K199 FGIyDTAKGMLPDPK
S213 KNTHIFISWMIAQSV
S219 ISWMIAQSVTAVAGL
K245 MMMQSGRKGtDIMYT
K245 MMMQSGRKGtDIMYT
T247-p MQSGRKGtDIMYTGT
T252 KGtDIMYTGTLDCWR
T254 tDIMYTGTLDCWRKI
K268-ac IARDEGSkAFFkGAW
K268-ub IARDEGSkAFFkGAW
K268-sc IARDEGSkAFFkGAW
K272-ac EGSkAFFkGAWsNVL
S276-p AFFkGAWsNVLRGMG
K295 LVLYDEIKKYT____
Y297 LYDEIKKYT______
  rat

 
T2 ______MTDAAVSFA
S7 _MTDAAVSFAkDFLA
K10-ac DAAVSFAkDFLAGGV
K10 DAAVSFAKDFLAGGV
K10 DAAVSFAKDFLAGGV
S22 GGVAAAISkTAVAPI
K23-ac GVAAAISkTAVAPIE
K23 GVAAAISKTAVAPIE
K23 GVAAAISKTAVAPIE
K33 VAPIERVKLLLQVQH
K33 VAPIERVKLLLQVQH
S42 LLQVQHASKQITADK
K43 LQVQHASKQITADKQ
K43 LQVQHASKQITADKQ
K43 LQVQHASKQITADKQ
K49 SKQITADKQYKGIID
K52 ITADKQYKGIIDCVV
K52 ITADKQYKGIIDCVV
K52 ITADKQYKGIIDCVV
K52 ITADKQYKGIIDCVV
K63 DCVVRIPKEQGVLSF
K63 DCVVRIPKEQGVLSF
K63 DCVVRIPKEQGVLSF
S69 PKEQGVLSFWRGNLA
Y81 NLANVIRYFPtQALN
T84-p NVIRYFPtQALNFAF
K92-ac QALNFAFkDKYkQIF
K92 QALNFAFKDKYkQIF
K94 LNFAFkDKYkQIFLG
K96-ac FAFkDKYkQIFLGGV
K96 FAFkDKYKQIFLGGV
K96 FAFkDKYKQIFLGGV
K105-ac IFLGGVDkRTQFWRy
K105 IFLGGVDKRTQFWRy
K105 IFLGGVDKRTQFWRy
Y112-p kRTQFWRyFAGNLAS
K147 RLAADVGKAGAEREF
K147 RLAADVGKAGAEREF
K147 RLAADVGKAGAEREF
K147 RLAADVGKAGAEREF
K155 AGAEREFKGLGDCLV
K155 AGAEREFKGLGDCLV
K155 AGAEREFKGLGDCLV
K163 GLGDCLVKIYKSDGI
K163 GLGDCLVKIYKSDGI
K163 GLGDCLVKIYKSDGI
K166 DCLVKIYKSDGIKGL
K166 DCLVKIYKSDGIKGL
K166 DCLVKIYKSDGIKGL
Y191-p IIIYRAAyFGIyDTA
Y195-p RAAyFGIyDTAKGML
T197 AyFGIyDTAKGMLPD
K199 FGIyDTAKGMLPDPK
K199 FGIyDTAKGMLPDPK
S213-p KNTHIFIsWMIAQsV
S219-p IsWMIAQsVTAVAGL
K245-ac MMMQSGRkGTDIMYT
K245 MMMQSGRKGTDIMYT
T247 MQSGRkGTDIMYTGT
T252 kGTDIMYTGTLDCWR
T254 TDIMYTGTLDCWRKI
K268 IARDEGGKAFFkGAW
K268 IARDEGGKAFFkGAW
K268 IARDEGGKAFFkGAW
K272-ac EGGKAFFkGAWSNVL
S276 AFFkGAWSNVLRGMG
K295 LVLYDEIKKYT____
Y297 LYDEIKKYT______
  pig

 
T2 ______MTDAAVsFA
S7-p _MTDAAVsFAKDFLA
K10 DAAVsFAKDFLAGGV
K10 DAAVsFAKDFLAGGV
K10 DAAVsFAKDFLAGGV
S22-p GGVAAAIsKTAVAPI
K23 GVAAAIsKTAVAPIE
K23 GVAAAIsKTAVAPIE
K23 GVAAAIsKTAVAPIE
K33 VAPIERVKLLLQVQH
K33 VAPIERVKLLLQVQH
S42 LLQVQHASKQITADK
K43 LQVQHASKQITADKQ
K43 LQVQHASKQITADKQ
K43 LQVQHASKQITADKQ
K49 SKQITADKQYKGIID
K52 ITADKQYKGIIDCVV
K52 ITADKQYKGIIDCVV
K52 ITADKQYKGIIDCVV
K52 ITADKQYKGIIDCVV
K63 DCVVRIPKEQGVLSF
K63 DCVVRIPKEQGVLSF
K63 DCVVRIPKEQGVLSF
S69 PKEQGVLSFWRGNLA
Y81-p NLANVIRyFPtQALN
T84-p NVIRyFPtQALNFAF
K92 QALNFAFKDKYKQIF
K92 QALNFAFKDKYKQIF
K94 LNFAFKDKYKQIFLG
K96 FAFKDKYKQIFLGGV
K96 FAFKDKYKQIFLGGV
K96 FAFKDKYKQIFLGGV
K105 IFLGGVDKRTQFWRY
K105 IFLGGVDKRTQFWRY
K105 IFLGGVDKRTQFWRY
Y112 KRTQFWRYFAGNLAS
K147 RLAADVGKAGAEREF
K147 RLAADVGKAGAEREF
K147 RLAADVGKAGAEREF
K147 RLAADVGKAGAEREF
R155 AGAEREFRGLGDCLV
R155 AGAEREFRGLGDCLV
R155 AGAEREFRGLGDCLV
K163 GLGDCLVKIYKSDGI
K163 GLGDCLVKIYKSDGI
K163 GLGDCLVKIYKSDGI
K166 DCLVKIYKSDGIRGL
K166 DCLVKIYKSDGIRGL
K166 DCLVKIYKSDGIRGL
Y191 IIIYRAAYFGIYDTA
Y195 RAAYFGIYDTAKGML
T197 AYFGIYDTAKGMLPD
K199 FGIYDTAKGMLPDPK
K199 FGIYDTAKGMLPDPK
S213 KNTHIFISWMIAQSV
S219 ISWMIAQSVTAVAGL
K245 MMMQSGRKGTDIMYT
K245 MMMQSGRKGTDIMYT
T247 MQSGRKGTDIMYTGT
T252 KGTDIMYTGTLDCWR
T254 TDIMYTGTLDCWRKI
K268 IARDEGAKAFFKGAW
K268 IARDEGAKAFFKGAW
K268 IARDEGAKAFFKGAW
K272 EGAKAFFKGAWSNVL
S276 AFFKGAWSNVLRGMG
K295 LVLYDEIKKFT____
F297 LYDEIKKFT______
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