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Protein Page:
SHMT1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SHMT1 Interconversion of serine and glycine. Belongs to the SHMT family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; Mitochondrial; Other Amino Acids Metabolism - cyanoamino acid; Lyase; Cofactor and Vitamin Metabolism - one carbon pool by folate; Energy Metabolism - methane; Methyltransferase; EC 2.1.2.1
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: mitochondrion; cytoplasm; cytosol; nucleus
Molecular Function: L-allo-threonine aldolase activity; amino acid binding; protein homodimerization activity; glycine hydroxymethyltransferase activity; pyridoxal phosphate binding
Biological Process: purine base biosynthetic process; vitamin metabolic process; folic acid metabolic process; L-serine catabolic process; glycine biosynthetic process from serine; carnitine biosynthetic process; water-soluble vitamin metabolic process; protein tetramerization; protein homotetramerization
Reference #:  P34896 (UniProtKB)
Alt. Names/Synonyms: 14 kDa protein; CSHMT; cytoplasmic serine hydroxymethyltransferase; GLYC; Glycine hydroxymethyltransferase; MGC15229; MGC24556; serine hydroxymethyltransferase 1 (soluble); Serine hydroxymethyltransferase, cytosolic; Serine methylase; SHMT; SHMT1
Gene Symbols: SHMT1
Molecular weight: 53,083 Da
Basal Isoelectric point: 7.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SHMT1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K10-ac MPVNGAHkDADLWSS
0 1 K20 DLWSSHDKMLAQPLk
0 1 K20 DLWSSHDKMLAQPLk
0 1 K27 KMLAQPLKDsDVEVy
0 1 K27-ub KMLAQPLkDsDVEVy
0 1 S29-p LAQPLkDsDVEVyNI
0 242 Y34-p kDsDVEVyNIIkkES
0 3 N35 DsDVEVyNIIkkESN
0 2 K38-ub VEVyNIIkkESNRQR
1 0 K38-sm VEVyNIIkkESNRQR
0 1 K38 VEVyNIIKkESNRQR
1 0 K39-sm EVyNIIkkESNRQRV
0 2 K72-ub LGSCLNNkySEGYPG
0 25 Y73-p GSCLNNkySEGYPGQ
0 1 Y77 NNkySEGYPGQRYYG
0 1 K98-ub ELETLCQkRALQAYK
0 2 Y118-p WGVNVQPySGSPANF
0 1 K157-ac THGFMTDkkKIsATS
0 1 K158-ac HGFMTDkkKIsATSI
0 2 S161-p MTDkkKIsATSIFFE
0 1 K173-ub FFESMPYkVNPDTGy
0 1 Y180-p kVNPDTGyINyDQLE
0 1 Y183-p PDTGyINyDQLEENA
0 2 K271-ac AGMIFYRkGVkSVDP
0 1 K274-ac IFYRkGVkSVDPkTG
0 1 K279-ac GVkSVDPkTGKEILY
0 1 K375 TDGGRAEKVLEACSI
0 3 K386-ub ACSIACNkNTCPGDR
0 2 K416-ub TSRGLLEkDFQkVAH
0 1 K420 LLEkDFQKVAHFIHR
0 1 K420-ub LLEkDFQkVAHFIHR
0 2 K456 KERLAGDKYQAAVQA
0 4 K456-ub KERLAGDkYQAAVQA
  SHMT1 iso2  
K10 MPVNGAHKDADLWSS
K20 DLWSSHDKMLAQPLK
K20 DLWSSHDKMLAQPLK
K27 KMLAQPLKDSDVEVY
K27 KMLAQPLKDSDVEVY
S29 LAQPLKDSDVEVYNI
Y34 KDSDVEVYNIIKKES
N35 DSDVEVYNIIKKESN
K38 VEVYNIIKKESNRQR
K38 VEVYNIIKKESNRQR
K38 VEVYNIIKKESNRQR
K39 EVYNIIKKESNRQRV
K72 LGSCLNNKYSEGYPG
Y73 GSCLNNKYSEGYPGQ
Y77 NNKYSEGYPGQRYYG
K98 ELETLCQKRALQAYK
Y118 WGVNVQPYSGSPANF
K157 THGFMTDKKKISATS
K158 HGFMTDKKKISATSI
S161 MTDKKKISATSIFFE
K173 FFESMPYKVNPDTGY
Y180 KVNPDTGYINYDQLE
Y183 PDTGYINYDQLEENA
K271-ac AGMIFYRkGVAVALK
- gap
- gap
K336 TDGGRAEKVLEACSI
K347 ACSIACNKNTCPGDR
K377 TSRGLLEKDFQKVAH
K381 LLEKDFQKVAHFIHR
K381 LLEKDFQKVAHFIHR
K417 KERLAGDKYQAAVQA
K417 KERLAGDKYQAAVQA
  mouse

 
R4 ____MADRDATLWAS
K14-ac TLWASHEkMLSQPLk
K14-ub TLWASHEkMLSQPLk
K21-ac kMLSQPLkDSDAEVy
K21 kMLSQPLKDSDAEVy
S23 LSQPLkDSDAEVysI
Y28-p kDSDAEVysIIkKES
S29-p DSDAEVysIIkKESN
K32-ub AEVysIIkKESNRQR
K32 AEVysIIKKESNRQR
K32-sc AEVysIIkKESNRQR
K33 EVysIIkKESNRQRV
K66-ub LGSCLNNkYSEGyPG
Y67 GSCLNNkYSEGyPGQ
Y71-p NNkYSEGyPGQRYYG
K92 ELEMLCQKRALQAYH
Y112 WGVNVQPYSGSPANF
K151 THGFMTDKKKIsATS
K152 HGFMTDKKKIsATSI
S155-p MTDKKKIsATSIFFE
K167 FFESMPYKVYPETGY
Y174 KVYPETGYINYDQLE
Y177 PETGYINYDQLEENA
K265 AGMIFYRKGVRSVDP
R268 IFYRKGVRSVDPKTG
K273 GVRSVDPKTGKETYY
K369-ub TDGGRAEkVLEACSI
K380-ub ACSIACNkNTCPGDK
E410 TSRGLLEEDFQkVAH
K414-ac LLEEDFQkVAHFIHR
K414 LLEEDFQKVAHFIHR
K451-ac EKLAGDEkIQSAVAT
K451-ub EKLAGDEkIQSAVAT
  rat

 
R207 PRCAMAERDATVWAS
K217-ac TVWASHEkMLTQPLk
K217 TVWASHEKMLTQPLk
K224-ac kMLTQPLkESDAEVY
K224 kMLTQPLKESDAEVY
S226 LTQPLkESDAEVYSI
Y231 kESDAEVYSIIKKES
S232 ESDAEVYSIIKKESN
K235 AEVYSIIKKESNRQR
K235 AEVYSIIKKESNRQR
K235 AEVYSIIKKESNRQR
K236 EVYSIIKKESNRQRV
K269 LGSCLNNKYSEGYPG
Y270 GSCLNNKYSEGYPGQ
Y274 NNKYSEGYPGQRYYG
K295 ELETLCQKRALQAYH
Y315 WGVNVQPYSGSPANF
K354 THGFMTDKKKISATS
K355 HGFMTDKKKISATSI
S358 MTDKKKISATSIFFE
K370 FFESMPYKVYPDTGY
Y377 KVYPDTGYINYDQLE
Y380 PDTGYINYDQLEENA
K468 AGMIFYRKGVRSVDP
R471 IFYRKGVRSVDPKTG
K476 GVRSVDPKTGEETYY
K572 TDGGRAEKVLEACSI
K583 ACSIACNKNTCPGDK
E613 TSRGLLEEDFQKIAH
K617 LLEEDFQKIAHFIHR
K617 LLEEDFQKIAHFIHR
K654-ac EKLTGDEkFQSAVAA
K654 EKLTGDEKFQSAVAA
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