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Protein Page:
SHMT1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SHMT1 Interconversion of serine and glycine. Belongs to the SHMT family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; EC 2.1.2.1; Mitochondrial; Other Amino Acids Metabolism - cyanoamino acid; Cofactor and Vitamin Metabolism - one carbon pool by folate; Lyase; Methyltransferase; Energy Metabolism - methane
Cellular Component: mitochondrion; cytosol
Molecular Function: L-allo-threonine aldolase activity; amino acid binding; protein homodimerization activity; glycine hydroxymethyltransferase activity; pyridoxal phosphate binding
Biological Process: purine base biosynthetic process; vitamin metabolic process; folic acid metabolic process; L-serine catabolic process; glycine biosynthetic process from serine; water-soluble vitamin metabolic process; carnitine biosynthetic process; protein tetramerization; protein homotetramerization
Reference #:  P34896 (UniProtKB)
Alt. Names/Synonyms: 14 kDa protein; CSHMT; cytoplasmic serine hydroxymethyltransferase; GLYC; Glycine hydroxymethyltransferase; MGC15229; MGC24556; serine hydroxymethyltransferase 1 (soluble); Serine hydroxymethyltransferase, cytosolic; Serine methylase; SHMT; SHMT1
Gene Symbols: SHMT1
Molecular weight: 53,083 Da
Basal Isoelectric point: 7.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SHMT1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K20 DLWSSHDKMLAQPLk
0 1 K27-u KMLAQPLkDsDVEVy
0 1 S29-p LAQPLkDsDVEVyNI
0 224 Y34-p kDsDVEVyNIIkkES
0 3 N35 DsDVEVyNIIkkESN
0 2 K38-u VEVyNIIkkESNRQR
1 0 K38-s VEVyNIIkkESNRQR
1 0 K39-s EVyNIIkkESNRQRV
0 2 K72-u LGSCLNNkySEGYPG
0 25 Y73-p GSCLNNkySEGYPGQ
0 2 Y118-p WGVNVQPySGSPANF
0 1 S161-p MTDKKKIsATSIFFE
0 1 K173-u FFESMPYkVNPDTGY
0 2 K271-a AGMIFYRkGVKSVDP
0 1 K375 TDGGRAEKVLEACSI
0 3 K386-u ACSIACNkNTCPGDR
0 2 K416-u TSRGLLEkDFQkVAH
0 1 K420-u LLEkDFQkVAHFIHR
0 1 K456 KERLAGDKYQAAVQA
0 4 K456-u KERLAGDkYQAAVQA
  SHMT1 iso2  
K20 DLWSSHDKMLAQPLK
K27 KMLAQPLKDSDVEVY
S29 LAQPLKDSDVEVYNI
Y34 KDSDVEVYNIIKKES
N35 DSDVEVYNIIKKESN
K38 VEVYNIIKKESNRQR
K38 VEVYNIIKKESNRQR
K39 EVYNIIKKESNRQRV
K72 LGSCLNNKYSEGYPG
Y73 GSCLNNKYSEGYPGQ
Y118 WGVNVQPYSGSPANF
S161 MTDKKKISATSIFFE
K173 FFESMPYKVNPDTGY
K271-a AGMIFYRkGVAVALK
K336 TDGGRAEKVLEACSI
K347 ACSIACNKNTCPGDR
K377 TSRGLLEKDFQKVAH
K381 LLEKDFQKVAHFIHR
K417 KERLAGDKYQAAVQA
K417 KERLAGDKYQAAVQA
  mouse

 
K14-u TLWASHEkMLSQPLK
K21 kMLSQPLKDSDAEVy
S23 LSQPLKDSDAEVysI
Y28-p KDSDAEVysIIkKES
S29-p DSDAEVysIIkKESN
K32-u AEVysIIkKESNRQR
K32 AEVysIIKKESNRQR
K33 EVysIIkKESNRQRV
K66-u LGSCLNNkYSEGYPG
Y67 GSCLNNkYSEGYPGQ
Y112 WGVNVQPYSGSPANF
S155-p MTDKKKIsATSIFFE
K167 FFESMPYKVYPETGY
K265 AGMIFYRKGVRSVDP
K369-u TDGGRAEkVLEACSI
K380-u ACSIACNkNTCPGDK
E410 TSRGLLEEDFQKVAH
K414 LLEEDFQKVAHFIHR
K451-a EKLAGDEkIQSAVAT
K451-u EKLAGDEkIQSAVAT
  rat

 
K217 TVWASHEKMLTQPLK
K224 KMLTQPLKESDAEVY
S226 LTQPLKESDAEVYSI
Y231 KESDAEVYSIIKKES
S232 ESDAEVYSIIKKESN
K235 AEVYSIIKKESNRQR
K235 AEVYSIIKKESNRQR
K236 EVYSIIKKESNRQRV
K269 LGSCLNNKYSEGYPG
Y270 GSCLNNKYSEGYPGQ
Y315 WGVNVQPYSGSPANF
S358 MTDKKKISATSIFFE
K370 FFESMPYKVYPDTGY
K468 AGMIFYRKGVRSVDP
K572 TDGGRAEKVLEACSI
K583 ACSIACNKNTCPGDK
E613 TSRGLLEEDFQKIAH
K617 LLEEDFQKIAHFIHR
K654 EKLTGDEKFQSAVAA
K654 EKLTGDEKFQSAVAA
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