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Protein Page:
PSMD10 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PSMD10 Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protease; Proteasome complex
Cellular Component: nucleoplasm; proteasome complex; intermediate filament cytoskeleton; proteasome regulatory particle; cytoplasm; cytosol; nucleus
Molecular Function: protein binding; transcription factor binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; positive regulation of cyclin-dependent protein kinase activity; viral reproduction; apoptosis; negative regulation of transcription from RNA polymerase II promoter; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; negative regulation of DNA damage response, signal transduction by p53 class mediator; antigen processing and presentation of peptide antigen via MHC class I; cytoplasmic sequestering of NF-kappaB; RNA metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; negative regulation of MAPKKK cascade; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of cell growth; mRNA metabolic process; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; inhibition of NF-kappaB transcription factor; positive regulation of protein ubiquitination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
Reference #:  O75832 (UniProtKB)
Alt. Names/Synonyms: 26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; ankyrin repeat protein; dJ889N15.2; Gankyrin; hepatocellular carcinoma-associated protein p28-II; p28; proteasome (prosome, macropain) 26S subunit, non-ATPase, 10; proteasome 26S non-ATPase subunit 10; PSD10; PSMD10
Gene Symbols: PSMD10
Molecular weight: 24,428 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PSMD10

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 14 K23-ub SGKLEELkESILADk
0 56 K30-ub kESILADkSLATRTD
0 3 K90-ub AGRDEIVkALLGKGA
0 5 Y112 NGCTPLHYAASKNRH
0 19 Y138-p NPDAKDHyEATAMHR
0 1 K153-ub AAAKGNLkMIHILLY
0 1 T207-p IENKEEKtPLQVAkG
0 1 K213-ub KtPLQVAkGGLGLIL
0 3 K221-ac GGLGLILkRMVEG__
0 1 K221-ub GGLGLILkRMVEG__
  mouse

 
K23 SGKLDELKERILADk
K30-ub KERILADkSLATRTD
K90 AGRDEIVKALLVKGA
Y112-p NGCTPLHyAASKNRH
Y138-p NPDAKDHyDATAMHR
K153 AAAKGNLKMVHILLF
T207 IENKEEKTPLQVAKG
K213 KTPLQVAKGGLGLIL
K221 GGLGLILKRLAESEE
K221 GGLGLILKRLAESEE
  rat

 
K23 NGKLDELKESILADK
K30 KESILADKSLATRTD
K90 AGRDEIVKALLIKGA
Y112 NGCTALHYAASKNRH
Y138 NPDAKNHYDATAMHR
K153 AAAKGNLKMVHILLF
T207 IENKEEKTPLQVAKG
K213 KTPLQVAKGGLGLIL
K221 GGLGLILKRIAESEE
K221 GGLGLILKRIAESEE
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