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PSMA6
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Belongs to the peptidase T1A family. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.25.1; Proteasome complex; Protease |
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Cellular Component: nucleoplasm; polysome; proteasome core complex; sarcomere; nuclear matrix; mitochondrion; myofibril; cytoplasm; cytosol; nucleus
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Molecular Function: NF-kappaB binding; threonine endopeptidase activity; protein binding; RNA binding; endopeptidase activity
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Biological Process: ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; activation of NF-kappaB transcription factor; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; proteolysis involved in cellular protein catabolic process; RNA metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; M/G1 transition of mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; mRNA metabolic process; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of inflammatory response; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; S phase of mitotic cell cycle; cell cycle checkpoint; G1/S transition of mitotic cell cycle
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Reference #:
P60900 (UniProtKB)
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| Alt. Names/Synonyms: 27 kDa prosomal protein; IOTA; Macropain iota chain; macropain subunit iota; MGC22756; MGC2333; MGC23846; Multicatalytic endopeptidase complex iota chain; p27K; PROS-27; PROS27; prosomal P27K protein; proteasome (prosome, macropain) subunit, alpha type, 6; Proteasome iota chain; Proteasome subunit alpha type-6; proteasome subunit iota; PSA6; PSMA6 |
| Gene Symbols: PSMA6 |
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Molecular weight: 27,399 Da
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Basal Isoelectric point: 6.35
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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