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Protein Page:
PSMA6 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PSMA6 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Belongs to the peptidase T1A family. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.25.1; Protease; Proteasome complex
Cellular Component: nucleoplasm; polysome; proteasome core complex; sarcomere; nuclear matrix; myofibril; cytosol; nucleus
Molecular Function: NF-kappaB binding; threonine endopeptidase activity; protein binding; RNA binding; endopeptidase activity
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; mRNA metabolic process; activation of NF-kappaB transcription factor; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteolysis involved in cellular protein catabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; RNA metabolic process; regulation of inflammatory response; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
Reference #:  P60900 (UniProtKB)
Alt. Names/Synonyms: 27 kDa prosomal protein; IOTA; Macropain iota chain; macropain subunit iota; MGC22756; MGC2333; MGC23846; Multicatalytic endopeptidase complex iota chain; p27K; PROS-27; PROS27; prosomal P27K protein; proteasome (prosome, macropain) subunit, alpha type, 6; Proteasome iota chain; Proteasome subunit alpha type-6; proteasome subunit iota; PSA6; PSMA6
Gene Symbols: PSMA6
Molecular weight: 27,399 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PSMA6

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S5-p ___MSRGsSAGFDRH
0 1 S5 ___MSRGSSAGFDRH
0 2 S17-p DRHITIFsPEGRLyQ
0 99 Y23-p FsPEGRLyQVEYAFk
0 6 K30-u yQVEYAFkAINQGGL
0 23 K45-u TSVAVRGkDCAVIVT
0 89 K55-u AVIVTQKkVPDkLLD
1 16 K59-u TQKkVPDkLLDssTV
0 2 S63-p VPDkLLDssTVTHLF
0 2 S64-p PDkLLDssTVTHLFK
0 16 Y96-p SQVQRARyEAANWky
0 1 K102-a RyEAANWkykyGYEI
0 93 K102-u RyEAANWkykyGYEI
0 11 Y103-p yEAANWkykyGYEIP
1 19 K104-a EAANWkykyGYEIPV
0 7 K104-u EAANWkykyGYEIPV
0 4 Y105-p AANWkykyGYEIPVD
0 14 K116-a IPVDMLCkRIADISQ
0 4 K116-u IPVDMLCkRIADISQ
0 2 K153-u EQGPQVYkCDPAGyy
0 47 Y159-p YkCDPAGyyCGFkAT
0 35 Y160-p kCDPAGyyCGFkATA
0 17 K164-u AGyyCGFkATAAGVk
0 15 K171-u kATAAGVkQTESTSF
0 4 K181-a ESTSFLEkKVKKKFD
0 15 K181-u ESTSFLEkKVKKKFD
  mouse

 
S5 ___MSRGSSAGFDRH
S5-gl ___MSRGsSAGFDRH
S17-p DRHITIFsPEGRLyQ
Y23-p FsPEGRLyQVEYAFK
K30 yQVEYAFKAINQGGL
K45-u TSVAVRGkDCAVIVT
K55-u AVIVTQKkVPDKLLD
K59 TQKkVPDKLLDssTV
S63-p VPDKLLDssTVTHLF
S64-p PDKLLDssTVTHLFK
Y96-p SQVQRARyEAANWky
K102 RyEAANWKykYGYEI
K102-u RyEAANWkykYGYEI
Y103-p yEAANWkykYGYEIP
K104-a EAANWkykYGYEIPV
K104 EAANWkyKYGYEIPV
Y105 AANWkykYGYEIPVD
K116 IPVDMLCKRIADISQ
K116 IPVDMLCKRIADISQ
K153 EQGPQVYKCDPAGyy
Y159-p YKCDPAGyyCGFKAT
Y160-p KCDPAGyyCGFKATA
K164 AGyyCGFKATAAGVk
K171-u KATAAGVkQTESTSF
K181-a ESTSFLEkKVKKKFD
K181-u ESTSFLEkKVKKKFD
  rat

 
S5 ___MSRGSSAGFDRH
S5 ___MSRGSSAGFDRH
S17 DRHITIFSPEGRLyQ
Y23-p FSPEGRLyQVEYAFK
K30 yQVEYAFKAINQGGL
K45 TSVAVRGKDCAVIVT
K55 AVIVTQKKVPDKLLD
K59 TQKKVPDKLLDSSTV
S63 VPDKLLDSSTVTHLF
S64 PDKLLDSSTVTHLFK
Y96-p SQVQRARyEAANWkY
K102 RyEAANWKYKYGYEI
K102-u RyEAANWkYKYGYEI
Y103 yEAANWkYKYGYEIP
K104 EAANWkYKYGYEIPV
K104 EAANWkYKYGYEIPV
Y105 AANWkYKYGYEIPVD
K116 IPVDMLCKRIADISQ
K116 IPVDMLCKRIADISQ
K153 EQGPQVYKCDPAGYY
Y159 YKCDPAGYYCGFKAT
Y160 KCDPAGYYCGFKATA
K164 AGYYCGFKATAAGVK
K171 KATAAGVKQTESTSF
K181 ESTSFLEKKVKKKFD
K181 ESTSFLEKKVKKKFD
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