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Protein Page:
MRC1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MRC1 Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, integral
Cellular Component: integral to plasma membrane; plasma membrane; endosome membrane
Molecular Function: mannose binding; receptor activity
Biological Process: receptor-mediated endocytosis
Reference #:  P22897 (UniProtKB)
Alt. Names/Synonyms: C-type lectin domain family 13 member D; CD206; CLEC13D; Macrophage mannose receptor 1; mannose receptor C type 1; mannose receptor, C type 1; MMR; MRC1
Gene Symbols: MRC1
Molecular weight: 166,012 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MRC1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S62-p SQKFRWVsEsQIMSV
0 1 S64-p KFRWVsEsQIMSVAF
0 1 Y200-p WCGTTTDyDTDKLFG
0 1 T389-p KIQRDALttCRKEGG
0 1 T390-p IQRDALttCRKEGGD
0 1 T633-p KHWAEGVtHPPKPTT
0 1 K670-ac YAKGKHEkKTWFESR
0 1 T820-p YFSKEKEtMDNARAF
0 2 Y850-p EKKFLWKyVNRNDAQ
0 1 Y860-p RNDAQSAyFIGLLIS
0 1 T1023 SEHTFLWTDGRGVHY
0 1 Y1030 TDGRGVHYTNWGKGY
0 1 T1081-p KRGYICQtRSDPSLT
0 1 S1128-p TYCKLHNsLIASILD
0 1 S1268-p LECLRMGsSLVSIES
0 1 S1279-p SIESAAEssFLSYRV
0 1 S1280-p IESAAEssFLSYRVE
  mouse

 
S62 SQKFRWVSDSQIMSV
S64 KFRWVSDSQIMSVAF
Y200 WCGTTTDYDKDKLFG
Q389 KIQKYALQACRKEGG
A390 IQKYALQACRKEGGD
T633 KHWAEGVTRPPEPTT
K670 YAKGKHEKKTWFESR
T820 YFSKEKETMDNARAF
Y850 EKKFLWKYINKNGGQ
Y860 KNGGQSPYFIGMLIS
T1022-p AEHMFLWtAGQGVHy
Y1029-p tAGQGVHyTNWGKGY
T1080 KQGYICQTQTDPSLP
S1127 TYCKDHTSLLASILD
A1267 LECLRMGASLVSIET
S1278 SIETAAESSFLSYRV
S1279 IETAAESSFLSYRVE
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