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Protein Page:
MRC1 (human)

Overview
MRC1 Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis
Cellular Component: integral to plasma membrane; plasma membrane; endosome membrane
Molecular Function: mannose binding; protein binding; receptor activity
Biological Process: receptor-mediated endocytosis
Reference #:  P22897 (UniProtKB)
Alt. Names/Synonyms: C-type lectin domain family 13 member D; CD206; CLEC13D; Macrophage mannose receptor 1; mannose receptor C type 1; mannose receptor, C type 1; MMR; MRC1
Gene Symbols: MRC1
Molecular weight: 166,012 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MRC1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y850-p EKKFLWKyVNRNDAQ
0 1 S1128-p TYCKLHNsLIASILD
0 1 S1268-p LECLRMGsSLVSIES
0 1 S1279-p SIESAAEssFLSYRV
0 1 S1280-p IESAAEssFLSYRVE
  mouse

 
Y850 EKKFLWKYINKNGGQ
S1127 TYCKDHTSLLASILD
A1267 LECLRMGASLVSIET
S1278 SIETAAESSFLSYRV
S1279 IETAAESSFLSYRVE
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