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Protein Page:
MORF4L1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MORF4L1 Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Cellular Component: nucleoplasm; NuA4 histone acetyltransferase complex; Sin3 complex
Molecular Function: protein binding; protein N-terminus binding; chromatin binding
Biological Process: cell proliferation; establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent; regulation of growth; histone deacetylation; double-strand break repair via homologous recombination
Reference #:  Q9UBU8 (UniProtKB)
Alt. Names/Synonyms: Eaf3; Esa1p-associated factor 3 homolog; FWP006; HsT17725; MEAF3; MGC10631; MO4L1; MORF-related gene 15 protein; MORF-related gene on chromosome 15; MORF4L1; MORFRG15; mortality factor 4 like 1; Mortality factor 4-like protein 1; MRG15; Protein MSL3-1; S863-6; Transcription factor-like protein MRG15
Gene Symbols: MORF4L1
Molecular weight: 41,474 Da
Basal Isoelectric point: 9.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MORF4L1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K36 KCVKVAIKDKQVKYF
0 1 S47 VKYFIHYSGWNKKSA
0 4 K103-ub VPESRVLkYVDTNLQ
0 61 K111-ub YVDTNLQkQRELQkA
0 16 K117-ub QkQRELQkANQEQyA
0 6 Y123-p QkANQEQyAEGkMRG
0 11 K127-ub QEQyAEGkMRGAAPG
0 1 S138 AAPGKKTSGLQQkNV
0 1 K143-ac KTSGLQQkNVEVKTK
0 24 K143-ub KTSGLQQkNVEVKTK
0 1 T156-p TKKNKQKtPGNGDGG
0 2 T168-p DGGSTSEtPQPPRKK
0 1 K198 NRVEVKVKIPEELKP
0 29 K226-ub QLFYLPAkkNVDSIL
0 6 K227-ub LFYLPAkkNVDSILE
0 1 Y236-p VDSILEDyANykkSR
0 1 Y239-p ILEDyANykkSRGNT
0 3 K240-ub LEDyANykkSRGNTD
0 1 K241-ub EDyANykkSRGNTDN
0 24 K249-ub SRGNTDNkEYAVNEV
0 1 K339-ub DFLKYLAkNSATLFS
  MORF4L1 iso2  
K36 KCVKVAIKDKQVKYF
S47-p VKYFIHYsGWNKNWD
K64 VPESRVLKYVDTNLQ
K72 YVDTNLQKQRELQKA
K78 QKQRELQKANQEQYA
Y84 QKANQEQYAEGKMRG
K88 QEQYAEGKMRGAAPG
S99 AAPGKKTSGLQQKNV
K104 KTSGLQQKNVEVKTK
K104 KTSGLQQKNVEVKTK
T117 TKKNKQKTPGNGDGG
T129 DGGSTSETPQPPRKK
K159 NRVEVKVKIPEELKP
K187 QLFYLPAKKNVDSIL
K188 LFYLPAKKNVDSILE
Y197 VDSILEDYANYKKSR
Y200 ILEDYANYKKSRGNT
K201 LEDYANYKKSRGNTD
K202 EDYANYKKSRGNTDN
K210 SRGNTDNKEYAVNEV
K300 DFLKYLAKNSATLFS
  mouse

 
K36-ub KCVKVAIkDKQVKYF
S47 VKYFIHYSGWNKKSA
K103-ub VPESRVLkYVDTNLQ
K111-ub YVDTNLQkQRELQkA
K117-ub QkQRELQkANQEQYA
Y123 QkANQEQYAEGkMRG
K127-ub QEQYAEGkMRGAAPG
S138-p AAPGKKTsGLQQkNV
K143 KTsGLQQKNVEVKTK
K143-ub KTsGLQQkNVEVKTK
T156 TKKNKQKTPGNGDGG
T168 DGGSTSETPQPPRKK
K198-ub NRVEVKVkIPEELKP
K226-ub QLFYLPAkkNVDSIL
K227-ub LFYLPAkkNVDSILE
Y236 VDSILEDYANYkKSR
Y239 ILEDYANYkKSRGNT
K240-ub LEDYANYkKSRGNTD
K241 EDYANYkKSRGNTDN
K249-ub SRGNTDNkEYAVNEV
K339 DFLKYLAKNSATLFS
  rat

 
K36 KCVKVAIKDKQVKYF
S47 VKYFIHYSGWNKNWD
K64 VPESRVLKYVDANLQ
K72 YVDANLQKQRELQKA
K78 QKQRELQKANQEQYA
Y84 QKANQEQYAEGKMRG
K88 QEQYAEGKMRGAAPG
S99 AAPGKKTSGLQQKNV
K104 KTSGLQQKNVEVKTK
K104 KTSGLQQKNVEVKTK
T117 TKKNKQKTPGNGDGG
T129 DGGSTSETPQPPRKK
K159 NRVEVKVKIPEELKP
K187 QLFYLPAKKNVDSIL
K188 LFYLPAKKNVDSILE
Y197 VDSILEDYANYKKSR
Y200 ILEDYANYKKSRGNT
K201 LEDYANYKKSRGNTD
K202 EDYANYKKSRGNTDN
K210 SRGNTDNKEYAVNEV
K300 DFLKYLAKNSATLFS
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