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Protein Page:
MLK1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MLK1 a TKL kinase of the MLK family. A dual leucine zipper kinase. Expressed in neuronal cells and may act between Rac1/Cdc42 and MKK4 and -7 in death signaling. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TKL; Kinase, protein; EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; MLK subfamily
Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; JUN kinase kinase kinase activity; protein homodimerization activity; protein-tyrosine kinase activity; ATP binding
Biological Process: peptidyl-tyrosine phosphorylation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; apoptosis; positive regulation of apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation; activation of JNK activity; activation of JNKK activity
Reference #:  P80192 (UniProtKB)
Alt. Names/Synonyms: M3K9; MAP3K9; MEKK9; Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1; mixed lineage kinase 1 (tyr and ser/thr specificity); MLK1; PRKE1
Gene Symbols: MAP3K9
Molecular weight: 121,895 Da
Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MLK1

Protein Structure Not Found.


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Sites Implicated In
activity, induced: T312‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y110-p VGIFPSNyVTPRSAF
1 0 T312-p TKMSAAGtYAWMAPE
0 1 T452-p RTWEEELtRAALQQK
0 3 S519-p LKDGNRIsLPSDFQH
0 2 S533-p HKFTVQAsPtMDKRK
0 2 T535-p FTVQAsPtMDKRKSL
0 2 S547 KSLINSRSsPPAsPT
0 3 S548-p SLINSRSsPPAsPTI
0 9 S552-p SRSsPPAsPTIIPRL
0 2 T554 SsPPAsPTIIPRLRA
0 2 T565-p RLRAIQLtPGESSKT
0 1 K593 EEEKRAPKkkGRTWG
0 1 K594-ac EEKRAPKkkGRTWGP
0 1 K595-ac EKRAPKkkGRTWGPG
0 1 K607-ac GPGTLGQkELASGDE
0 1 S616-p LASGDEGsPQRREKA
0 2 S652-p GYKQWSSsAPNLVKG
0 1 S695-p SRLQHSPsQSYLCIP
0 1 S807-p RSSRPRRstsPPsRK
0 1 T808-p SSRPRRstsPPsRKL
0 1 S809-p SRPRRstsPPsRKLF
0 2 S812-p RRstsPPsRKLFKKE
0 1 L823 FKKEEPMLLLGDPSA
0 1 T915-p QPSSHRRtPsDGALK
0 2 S917-p SSHRRtPsDGALKPE
0 2 S938-p SPSSNGLsPSPGAGM
0 1 T948-p PGAGMLKtPSPSRDP
  mouse

 
Y103 VGIFPSNYVTPRSAF
T305 TKMSAAGTYAWMAPE
T445 RTWEEELTRAALQQK
S512-p LKDGNRIsLPSDFQH
S526 HKFTVQASPtMDKRK
T528-p FTVQASPtMDKRKSL
S540-p KSLISNRssPPAsPt
S541-p SLISNRssPPAsPtI
S545-p NRssPPAsPtIIPRL
T547-p ssPPAsPtIIPRLRA
T558 RLRAIQLTPGESSKT
K586-ub EEEKRAPkKKGRTWG
K587 EEKRAPkKKGRTWGP
K588 EKRAPkKKGRTWGPG
K600 GPGTLGQKELTSGDE
- gap
S622-p GYKQWSSsAPNLGKG
N665 NHQQHSPNQSYLCIP
S777 RASRPRRSTSPPSRK
T778 ASRPRRSTSPPSRKL
S779 SRPRRSTSPPSRKLF
S782 RRSTSPPSRKLFKKE
T793-p FKKEEPMtLLGDPSA
T885 QPSGHRRTPSDGALK
S887 SGHRRTPSDGALKPT
S911 SPSSNGMSPSPGTGM
T921 PGTGMLKTPSPSRDP
  rat

 
Y103 VGIFPSNYVTPRSAF
T305 TKMSAAGTYAWMAPE
T445 RTWEEELTRAALQQK
S512 LKDGNRISLPSDFQH
S526-p HKFTVQAsPTMDKRK
T528 FTVQAsPTMDKRKSL
S540 KSLISNRSSPPASPT
S541 SLISNRSSPPASPTI
S545 NRSSPPASPTIIPRL
T547 SSPPASPTIIPRLRA
T558 RLRAIQLTPGESSKT
K586 EEEKRAPKKKGRTWG
K587 EEKRAPKKKGRTWGP
K588 EKRAPKKKGRTWGPG
K600 GPGTLGQKELTSGDE
- under review  
S622 GYKQWSSSAPNLGKG
N665 NHLQHSPNQSYLCIP
S777 RASRPRRSTSPPSRK
T778 ASRPRRSTSPPSRKL
S779 SRPRRSTSPPSRKLF
S782 RRSTSPPSRKLFKKE
T793 FKKEEPMTLLGDPSA
T885 QPSGHRRTPSDGALK
S887 SGHRRTPSDGALKPA
S911 SPSSNGVSPGPGAGM
T921 PGAGMLKTPSPSRDP
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