a TKL kinase of the MLK family. A dual leucine zipper kinase. Expressed in neuronal cells and may act between Rac1/Cdc42 and MKK4 and -7 in death signaling. Note: This description may include information from UniProtKB.
Protein type: EC 220.127.116.11; Protein kinase, TKL; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; MLK subfamily
Chromosomal Location of Human Ortholog: 14q24.2
Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; JUN kinase kinase kinase activity; protein homodimerization activity; protein-tyrosine kinase activity; ATP binding
Biological Process: peptidyl-tyrosine phosphorylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; apoptosis; positive regulation of apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation; activation of JNK activity; activation of JNKK activity
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.