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Protein Page:
MLK1 (human)

Overview
MLK1 a TKL kinase of the MLK family. A dual leucine zipper kinase. Expressed in neuronal cells and may act between Rac1/Cdc42 and MKK4 and -7 in death signaling. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TKL; EC 2.7.11.25; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; MLK subfamily
Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; protein homodimerization activity; JUN kinase kinase kinase activity; protein-tyrosine kinase activity; ATP binding
Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; apoptosis; positive regulation of apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation; activation of JNK activity; activation of JNKK activity
Reference #:  P80192 (UniProtKB)
Alt. Names/Synonyms: M3K9; MAP3K9; MEKK9; Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1; mixed lineage kinase 1 (tyr and ser/thr specificity); MLK1; PRKE1
Gene Symbols: MAP3K9
Molecular weight: 121,895 Da
Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MLK1

Protein Structure Not Found.


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Sites Implicated In
activity, induced: T312‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 T312-p TKMSAAGtYAWMAPE
0 3 S519-p LKDGNRIsLPSDFQH
0 2 S533-p HKFTVQAsPtMDKRK
0 2 T535-p FTVQAsPtMDKRKSL
0 2 S547 KSLINSRSsPPAsPT
0 3 S548-p SLINSRSsPPAsPTI
0 9 S552-p SRSsPPAsPTIIPRL
0 2 T554 SsPPAsPTIIPRLRA
0 2 T565-p RLRAIQLtPGESSKT
0 2 S652-p GYKQWSSsAPNLVKG
0 1 S695-p SRLQHSPsQSYLCIP
0 1 T915-p QPSSHRRtPsDGALK
0 2 S917-p SSHRRtPsDGALKPE
  mouse

 
T305 TKMSAAGTYAWMAPE
S512-p LKDGNRIsLPSDFQH
S526 HKFTVQASPtMDKRK
T528-p FTVQASPtMDKRKSL
S540-p KSLISNRssPPAsPt
S541-p SLISNRssPPAsPtI
S545-p NRssPPAsPtIIPRL
T547-p ssPPAsPtIIPRLRA
T558 RLRAIQLTPGESSKT
S622-p GYKQWSSsAPNLGKG
N665 NHQQHSPNQSYLCIP
T885 QPSGHRRTPSDGALK
S887 SGHRRTPSDGALKPT
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